High-resolution neuroimaging modalities are used often in studies involving healthy volunteers. Subsequently, a significant increase in the incidental discovery of asymptomatic intracranial abnormalities raised the important ethical issues of when follow-up and treatment may be necessary. We examined the literature to establish a practical set of criteria for approaching incidental findings. Our objective is to develop an algorithm for when follow-up may be important and to provide recommendations that would increase the likelihood of follow-up. A systematic literature search was performed (...) using the PubMed and MEDLINE databases to identify articles describing brain tumors and intracranial aneurysms. The treatment algorithm we present suggests that incidental intracranial masses suspicious for glioma should be biopsied or resected, while other masses are to be followed with serial imaging based on the expected growth pattern. Lack of follow-up can result in adverse outcomes that can be mitigated by using technology to facilitate communication and improve follow-up care. The importance of training physicians to be good communicators is also stressed. New technology including automated telephone systems, texting and email will improve access to patients and hopefully encourage compliance and follow-up. (shrink)

We begin this chapter with a review of the history of synaesthesia and a comparison of what we consider to be either genuine or inauthentic manifestations of the phenomenon. Next, we describe the creation and development of synaesthetic consistency tests and explore reasons why assessing consistency became the most widely used method of confirming the genuineness of synaesthesia. We then consider methodologies that demonstrate synaesthesia's authenticity by capitalizing on properties other than consistency. Finally, we discuss how together, consistency tests and (...) other methodologies are helping researchers determine prevalence and elucidate the mechanisms of synaesthesia. (shrink)