BackgroundTo investigate the factors related to approval after review by an Institutional Review Board, the structure equation model was used to analyze the latent variables ‘investigators’, ‘vulnerability’ and ‘review process’ for 221 proposals submitted to our IRB.MethodsThe vulnerability factor included vulnerable cases, and studies that involved drug tests and genetic analyses. The principal investigator factor included the license level of the PI and whether they belonged to our institution. The review factor included administration time, total review time, and revision frequency. (...) The revision frequency and total review time influenced the efficiency of review.ResultsThe latent variable of reviewing was the most important factor mediating the PIs and vulnerability to IRB review approval. The local PIs moderated with genetic study and revision frequency had an impact on the review process and mediated non-approval.ConclusionsBetter guidance of the investigators and reviewers might improve the efficiency with which IRBs function. (shrink)

Patients with Wilson’s disease suffer from prospective memory impairment, and some of patients develop cognitive impairment. However, very little is known about how brain structure and function changes effect PM in WD. Here, we employed multimodal neuroimaging data acquired from 22 WD patients and 26 healthy controls who underwent three-dimensional T1-weighted, diffusion tensor imaging, and resting state functional magnetic resonance imaging. We investigated gray matter volumes with voxel-based morphometry, DTI metrics using the fiber tractography method, and RS-fMRI using the seed-based (...) functional connectivity method. Compared with HC, WD patients showed GM volume reductions in the basal ganglia and occipital fusiform gyrus, as well as volume increase in the visual association cortex. Moreover, whiter matter tracks of WD were widely impaired in association and limbic fibers. WM tracks in association fibers are significant related to PM in WD patients. Relative to HC, WD patients showed that the visual association cortex functionally connects to the thalamus and hippocampus, which is associated with global cognitive function in patients with WD. Together, these findings suggested that PM impairment in WD may be modulated by aberrant WM in association fibers, and that GM volume changes in the association cortex has no direct effect on cognitive status, but indirectly affect global cognitive function by its aberrant functional connectivity in patients with WD. Our findings may provide a new window to further study how WD develops into cognitive impairment, and deepen our understanding of the cognitive status and neuropathology of WD. (shrink)

The transition of gene switch induced by external noises and external signals is investigated in the genetic regulatory system. Results show that the state-to-state transition of gene switch as well as resonant behaviors, such as the explicit coherence resonance, implicit coherence resonance and control parameter coherence biresonance, can appear when noises are injected into the genetic regulatory system. The ECR is increased with the increase of the control parameter value when starting from the supercritical Hopf bifurcation parameter point, and there (...) exists a critical control parameter value for the occurrence of ECR. However, the ICR is decreased as the control parameter value is increased when starting from the subcritical Hopf bifurcation point. In particular, the coherence of ECR is higher and more sensitive to noise than that of ICR. When an external signal is introduced into the system, the enhancement or suppression of the CPCBR and the number of peaks strongly depend on the frequency and amplitude of the external signal. Furthermore, the gene regulation system can selectively enhance or decrease the noise-induced oscillation signals at preferred frequency and amplitude of an external signal. (shrink)

21世紀人類新科學、新文明的基礎——思維科學理論體系的建立 1687年英國科學家牛頓發表的《自然哲學的數學原理》一書，是近代自然科學完全確立的標誌，從而引領人類的科學邁入宏觀科學的時代，為現代文明奠定了理論和思想上的基礎；1905年德國科學家愛因斯坦發表的《相 對論》，更使得人類的科學邁入微觀科學的時代，讓人們對周圍世界有了一個更加深入和全面的了解。 雖然上述二者都有力地推動了人類科學和文明的巨大進步，卻都未能跳脫出現代科學的物質觀對人們思維上的限制，不能應用於高度複雜的人體和生命科學，更不能解決當前擺在人們面前諸於癌症、愛滋病、各種慢性病、遺傳病 、傳染病等形形色色的問題。 毫無疑問，21世紀將是人體和生命科學的世紀。然而，在人體和生命科學領域，尚未出現像牛頓的《自然哲學的數學原理》和愛因斯坦的《相對論》那樣具有劃時代意義，且與生命科學高度複雜的基本特點互相呼應的全新理論 體系；這就導致人體和生命科學在21世紀的發展將缺乏理論上的立足點，人體和生命科學新的大發展正在呼喚全新理論的出現。 2012年，《生命科學的哲學原理》一書的完成和發表，正是適應這一時代的需要而建立起來的全新科學理論體系，採用了與牛頓和愛因斯坦完全不同，更加高級、全新的思維方式，並突破了現代科學的物質觀對人們思維上的 限制，從而引領人類的科學從當前具體的物質科學邁入抽象的思維科學的新時代，進而有效地解決人體和生命科學領域中各種高度複雜的問題，整個人類的文明也將因此而再次發生翻天覆地的偉大轉變，為新的歷史時期之人類社 會的和平、穩定與快速發展提供理論和思想上的依據。.

本书主要内容包括:泛观博览、止心圣学;投荒万里、龙场悟心;职事屡迁、门生广进;南赣戎机、矢石书影、翦除宁藩、教揭良知;讲学越城、心目俱醒;总督两广、恩威兼行;夫复何言、此心光明;哲人往矣、尔思曷兴.

国家哲学社会科学创新基地浙江大学语言与认知研究中心研究成果本书为浙江省哲学社会科学规划课题成果.

柏格森(1859-1941),世界著名的法国哲学家,本书系统地介绍了他的生平、思想、著作。.

你是否認為，中國的儒道與易經哲學，高深莫測、遙不可及？與日常生活毫不相干？ 事實上，哲學的重點並不是高深的理論，哲學所談論的，正是人生的問題與解決的方案。體現哲學最好的方式，便是透過生活中的行動，進而提升生命的高度與廣度。俗話說，「坐而言不如起而行」，面對生活中的種種挑戰與困 境，「行動」就是最好的解答！正面迎擊人生中大大小小的問題吧！ 這是一本關於「人生」的哲學。全書共有兩大篇：「道德／哲學篇」與「易卦篇」。透過一篇篇生活的、簡要的短文，討論一個個中國哲學的核心觀念。透過本書，你將會了解，如何掌握人生的三種基本力：知識力、行動力與心 靈力，從而達到人生的三種境界：感性、理性與圓融。【秀威資訊科技股份有限公司製作】.

《一代直聲百年盡瘁：梁簌溟鄉村建設運動研究》系統梳理了20世紀30年代梁漱溟主持的山東鄉村建設實驗的相關內容，以及不同時期相關實踐者和學者對其鄉村建設實驗進行的各種討論和爭議，試圖全方位挖掘梁漱溟鄉建 思想與實踐的深層學術價值和現實借鑒意義，冀望對今天的農村現代化建設和農村改革，尤其是“三農”問題的解決和優化提供有益的借鑒。.

因為現代醫藥之發達與進步，我們身體的痛已大多有了消解之道；但思想、心理與性靈的病卻是越來越讓我們感到憂傷，越來越教我們心生恐懼，也越來越侵犯到我們原本一心盼望單單純純地「活在此時此刻」這極其謙卑的權利 與心願。 顯然，現代科技仍然效力有限，而無端的生命苦難更是難以預期與估量。我們還是得時時回頭看看自己這一身，回頭想想自己這一生，並同時回頭思量自己這一顆心到底蘊藏著什麼寶貝，或許，這樣的自力救濟與自力更生纔是生 活的王道。 且讓我們一起來細細品味兩千多年前這一位東方的「生命療癒先行者」――莊子到底是怎麼看待他自己這一身、這一生、這一世以及時時刻刻跳動在「此時此刻」的這一顆心，而其中又有何特殊光景值得莊子大書特書，這也許是 人類千年不變的生命共業。 原本，我們一出生就無法自外於大自然，而「自然」原來就在我們完完整整的這一身，它的符碼（甚至是密碼）就藏在我們人人心底，就靠我們自己來記憶，來存取，來開啟我們與生俱來的自我療癒的能力，而莊子如是言，如是 行，如是思量，如是觀想，如是腳踏實地，如是心無旁鶩，如是存活於此時此刻──而他已然為我們落下這八個無比精采的篇章： ◆逍遙之遊──莊子一心渴望真自由，而他到底是如何滿足這心底深沉的渴望？又是如何從地面起身躍向那無邊無界的天空？ ◆齊物之論──莊子彷彿心無是非，口無虛言，而只是靜觀萬物，平等看待這世上的一切，他是如何能夠保有這份真真切切的「自知之明」？如何在夢醒之際清清楚楚地守著這僅有的清明之心？ ◆養生之主──莊子先是如同一般人，一心只盼望健健康康，無疾也無病，但他還深刻地警覺生命最大的痛──死亡隨時隨處在窺伺著我們，我們又能如何真正地跳出這幾乎無所不在的死亡的幽谷？ ◆人間之世──莊子深知世上難免無妄之災，更難防故意之敵，但我們還是得盡量避禍，盡力解厄，同時盡心地處理好所有與我們相連相繫的人際關係；不過，當不順心不如意之事迎面而來之際，我們又當如何舉重若輕地一肩承 擔？莊子顯然有他自己的法子。 ◆真人之身──莊子不是教主，也不想開宗立派，他只是始終關心本來無價無償的生命到底該怎麼被我們認真地看待，而那「無用之用」的奧妙又有誰能真正了解？ ◆渾沌之死──就莊子看來，「渾沌」本無生亦無死；而如果說我們總是自己在「找死」，並不是死亡找上我們，這雖然看似重話，卻可能有警醒人心的作用。原來，莊子的「生命之壺」暗藏玄機，而縱然生死之謎究竟無解，但 我們又何妨放下心來，自由自在地在這世上走上一回。 ◆自然之道──莊子當然不懂現代科技，但他已經知道運用機械的後遺症。設想時下所謂的「科技新貴」能夠放下「釣魚上鉤」的念頭，靜靜地佇立水岸，觀賞那魚兒水中游，大概就將別有一番生活情趣與生命體悟。 ◆幸福之夢──莊子應該和任何人一樣，都想幸幸福福過一生，但我們到底該怎麼尋找終生的伴侶（甚至是「絕配」）？日子又該怎麼過得舒適？而和自己又能如何做一輩子的至親好友？這些問題的解答，可能就是打開那幸福之 門的鑰匙吧！ 作者：葉海煙 輔仁大學哲學博士，美國哈佛大學訪問學人、東吳大學哲學系教授兼系主任、長榮大學哲學與宗教學系教授兼系主任、台灣哲學學會會長、錢穆故居執行長、台南市哲學學會會長。現任南神神學院神學研究所專任哲學教授、國立 成功大學兼任哲學教授。專長道家哲學，當代新儒學，當代倫理學比較研究，台灣文化研究。著有《莊子的生命哲學》、《老莊哲學新論》、《道德、理性與人文的向度》、《中國哲學的倫理觀》、《人文與哲學的對話》、《傳 統倫理的現代挑戰》、《莊子的處世智慧》、《老子診療室》、《臺灣學入門》、《道家倫理學：理論與實踐》、《哲學與人生》、《哲學在哪裡》等近二十種著作。.

內容簡介 本書主要以《賢良對策》作為研究對象，重新探討董仲舒在漢代儒學興盛中扮演的角色。本書並不追隨許多學者採取的理路，如根據《漢書》中的幾條記載，毫無懷疑地肯定漢武帝採納《對策》而定儒學於一尊，並看重董仲舒在 儒學興盛中的角色，或者在武帝採納《對策》的前提下，設想武帝將董仲舒思想當作治國指導思想，而從《春秋繁露》中尋出維護帝國體制的思想，以說明董仲舒在儒學興盛中扮演重要角色。其實在學術界，關於董仲舒和漢代儒 學興盛的關係存在著多樣的意見，本書則闡述雖然我們應當承認董仲舒《對策》的內容在他生前沒有發揮太大作用，但如若注意到儒學興盛即是一個階段性歷程，便還可以找出董仲舒思想在「儒學的主流化」中的積極意義。.

Zhongguo ren de sheng huo zhi hui -- Dong ya : Zhongguo wen hua quan de xing cheng yu bian qian -- Ren yu cun zai.

Justin D’Arms and Daniel Jacobson have argued that to evaluate the funniness of a joke based on the consideration of whether it is morally appropriate to feel amused commits the “moralistic fallacy.” We offer a new and empirically informed reply. We argue that there is a way to take morality into consideration without committing this fallacy, that is, it is legitimate to say that for some people, witty but immoral jokes can fail to be funny because they are immoral. In (...) our account, one has an intramural moral reason not to feel amused if one focuses on the moral feature itself of a joke rather than the moral consequence implied in one’s reaction to the joke. When one judges a joke as not funny because of the intramural moral reason, one is in a negative emotional state with high arousal, for example, moral disgust or anger. This state is psychologically incompatible with amusement. That one has an intramural reason not to feel amused thus implies that one does not have a reason to feel amused. Moral consideration thus plays an indirect and appropriate role in the evaluation of the funniness of a joke. (shrink)

In this paper, I develop an account of appreciation. I argue that appreciation is an epistemic emotion in which the subject grasps the object in an affective way. The “grasping” and “feeling” components implies that in appreciation, we make sense of the object by having cognitive control over it, are motivated to maintain the valuable epistemic state of understanding, and experience the “aha” or “eureka” moment. This account offers a unified account of the many types of appreciation, including the aesthetic, (...) the moral, and the epistemic. In all these cases, appreciation requires some other first-order emotions as prerequisite. (shrink)

Ben shu yi Ming ru Li Cai de jiang xue huo dong yu xue pai jian gou wei zhong xin, tan tao cong shi liu shi ji chu dao shi qi shi ji mo li xue qun ti zhong xin xing xue shuo he xue pai de chan sheng, chuan bo, kuo zhan yu chuan cheng de mo shi, bing zhuo zhong cong si xiang shi de jiao du jie shi zhe zhong mo shi chan sheng he (...) yun xing de si xiang gen yuan yu nei zai dong li. Quan shu zheng wen gong qi zhang, zhu yao nei rong fen wei shang xia liang bian, shang bian yi hong guan zong lun de fang shi, cong li xue jing dian "Da xue" de wen ben bian dong he quan shi jing zheng qie ru, tan tao zhong wan Ming li xue xue shuo he xue pai jian gou de li lun gen ju; xia bian yi Li Cai de "zhi xiu" xue shuo ji qi jiang xue huo dong zuo wei ge an yan jiu, tan tao li xue xue shuo he xue pai de chuan bo ji chuan cheng de she hui hua tu jing. (shrink)

The current study assessed the extent to which the use of referential prosody varies with communicative demand. Speaker–listener dyads completed a referential communication task during which speakers attempted to indicate one of two color swatches (one bright, one dark) to listeners. Speakers' bright sentences were reliably higher pitched than dark sentences for ambiguous (e.g., bright red versus dark red) but not unambiguous (e.g., bright red versus dark purple) trials, suggesting that speakers produced meaningful acoustic cues to brightness when the accompanying (...) linguistic content was underspecified (e.g., “Can you get the red one?”). Listening partners reliably chose the correct corresponding swatch for ambiguous trials when lexical information was insufficient to identify the target, suggesting that listeners recruited prosody to resolve lexical ambiguity. Prosody can thus be conceptualized as a type of vocal gesture that can be recruited to resolve referential ambiguity when there is communicative demand to do so. (shrink)

In this paper I argue that there is a structural parallelism between law and physics in Leibniz since his early years, which has significant influence on the formation of his views. I start by examining Leibniz's early physical system and an analogy with juridical laws that he uses to explain the structure of physical laws. Then, I argue that this analogy stems from an envisioned parallelism between law and physics. Finally, I illustrate the significance of this legal-physical parallelism by arguing (...) that it underlies some of Leibniz's mature views. Most importantly, I argue that the parallelism explains the origin of architectonic principles or optimality principles in Leibniz's mature physics. (shrink)

Emotion is closely associated with language, but we know very little about how children express emotion in their own writing. We used a large‐scale, cross‐sectional, and data‐driven approach to investigate emotional expression via writing in children of different ages, and whether it varies for boys and girls. We first used a lexicon‐based bag‐of‐words approach to identify emotional content in a large corpus of stories (N>100,000) written by 7‐ to 13‐year‐old children. Generalized Additive Models were then used to model changes in (...) sentiment across age and gender. Two other machine learning approaches (BERT and TextBlob) validated and extended these analyses, converging on the finding that positive sentiments in children's writing decrease with age. These findings echo reports from previous studies showing a decrease in mood and an increased use of negative emotion words with age. We also found that stories by girls contained more positive sentiments than stories by boys. Our study shows the utility of large‐scale data‐driven approaches to reveal the content and nature of children's writing. Future experimental work should build on these observations to understand the likely complex relationships between written language and emotion, and how these change over development. (shrink)

Legal Judgment Prediction (LJP) is an essential component of legal assistant systems, which aims to automatically predict judgment results from a given criminal fact description. As a vital subtask of LJP, researchers have paid little attention to the numerical LJP, i.e., the prediction of imprisonment and penalty. Existing methods ignore numerical information in the criminal facts, making their performances far from satisfactory. For instance, the amount of theft varies, as do the prison terms and penalties. The major challenge is how (...) the model can obtain the ability of numerical comparison and magnitude perception, e.g., 400 < 500 < 800, 500 is closer to 400 than to 800. To this end, we propose a judicial knowledge-enhanced magnitude-aware reasoning architecture, called NumLJP, for the numerical LJP task. Specifically, we first implement a contrastive learning-based judicial knowledge selector to distinguish confusing criminal cases efficiently. Unlike previous approaches that employ the law article as external knowledge, judicial knowledge is a quantitative guideline in real scenarios. It contains many numerals (called anchors) that can construct a reference frame. Then we design a masked numeral prediction task to help the model remember these anchors to acquire legal numerical commonsense from the selected judicial knowledge. We construct a scale-based numerical graph using the anchors and numerals in facts to perform magnitude-aware numerical reasoning. Finally, the representations of fact description, judicial knowledge, and numerals are fused to make decisions. We conduct extensive experiments on three real-world datasets and select several competitive baselines. The results demonstrate that the macro-F1 of NumLJP improves by at least 9.53% and 11.57% on the prediction of penalty and imprisonment, respectively. (shrink)

Not for the academic value of some of the situational events, often with a comprehensive, decisive, Yan'an new philosophy will the home of its columns. Will establish a new philosophy, a lot of grand strategy is one of the actions in Yan'an. This paper examines a new philosophy will be the basic process, an analysis of its membership and the subsequent effects, assessing its characteristics in the formation of contemporary Chinese culture, the unique role, made ​​a number of issues need (...) to be further explored. This paper shows that the new philosophy will not academics, but the educational organization. It is the ideology of expert training, knowledge and control of legal rights, the implementation of the regulatory action of self-sufficiency and closed culture strategy. New philosophy will be mainly in the construction and maintenance of highly exclusive mode of thinking to make contributions, as the full value of its effect remains to be thorough and reasonable debate. Some situational events, which have been neglected by academics, may be of significant importance. The Yan'an New Philosophy Association is an example. Its establishment was one of the ambitious strategic actions of the CCP in Yan'an. This paper examines the process of the YNPA's establishment, analyses the composition of its membership, assesses its unique effect on the formation of contemporary Chinese ideology, and raises some issues that are in need of further research. This study shows that the YNPA was an educational institution instead of an academic society, and that the experts in ideology it produced had exclusive power in the cultural domain and implemented the party's cultural policies. We can see that the YNPA greatly contributed to the construction and maintenance of a high degree of cultural exclusivity. A full picture of this association, however, requires much more in-depth studies. (shrink)

Although language has long been regarded as a primarily arbitrary system, sound symbolism, or non-arbitrary correspondences between the sound of a word and its meaning, also exists in natural language. Previous research suggests that listeners are sensitive to sound symbolism. However, little is known about the specificity of these mappings. This study investigated whether sound symbolic properties correspond to specific meanings, or whether these properties generalize across semantic dimensions. In three experiments, native English-speaking adults heard sound symbolic foreign words for (...) dimensional adjective pairs and for each foreign word, selected a translation among English antonyms that either matched or mismatched with the correct meaning dimension. Listeners agreed more reliably on the English translation for matched relative to mismatched dimensions, though reliable cross-dimensional mappings did occur. These findings suggest that although sound symbolic properties generalize to meanings that may share overlapping semantic features, sound symbolic mappings offer semantic specificity. (shrink)

[English abstract] In his last metaethical statement, Parfit revisits his earlier arguments for non-metaphysical normative non-naturalism , and points to the possibility of convergence between his view and Railton's non-analytical normative naturalism. I examine the basis of this convergence claim and find it unpersuasive, mainly because if their views converge on the same position, Parfit's non-natural norms exist only as predicates. In order to avoid this consequence, he needs to present a reason for believing in the existence of normative properties (...) . There is an indispensability argument implicit in his text, with concepts of sui generis normative ground and necessity at its centre. I discuss their main features and present problems besetting these concepts. (shrink)