BackgroundTo investigate the factors related to approval after review by an Institutional Review Board, the structure equation model was used to analyze the latent variables ‘investigators’, ‘vulnerability’ and ‘review process’ for 221 proposals submitted to our IRB.MethodsThe vulnerability factor included vulnerable cases, and studies that involved drug tests and genetic analyses. The principal investigator factor included the license level of the PI and whether they belonged to our institution. The review factor included administration time, total review time, and revision frequency. (...) The revision frequency and total review time influenced the efficiency of review.ResultsThe latent variable of reviewing was the most important factor mediating the PIs and vulnerability to IRB review approval. The local PIs moderated with genetic study and revision frequency had an impact on the review process and mediated non-approval.ConclusionsBetter guidance of the investigators and reviewers might improve the efficiency with which IRBs function. (shrink)

The experience of loss of agency is one of the reasons for clients to go for psychotherapy. Enhancing clients’ agency has been considered a fundamental factor for successful treatment in psychiatry and psychotherapy, yet few studies have investigated the interactional realization of how therapists do this in authentic psychotherapeutic encounters. Drawing on audio-recorded talk-in-interaction between clients and psychotherapists in cognitive behavioral therapy encounters at a mental health center in China, this paper uses the method of conversation analysis to demonstrate how (...) therapists ascribe agency positions to clients by issuing formulations of what the clients have just said. Two types of formulation were identified: affirmative formulations and challenging formulations. In the first type, the therapists highlight the positive aspect of the clients’ description of their experiences and ascribe an agentic position to the clients. In the second, the therapists challenge the clients’ implausible views and their non-agentic positioning of themselves. This study shows that the therapists’ formulation could be employed to manage the epistemic difficulties associated with claiming knowledge about the clients’ inner states and assessing their feelings. In this sense, the formulation is a robust interactional device in negotiating epistemic problems in addressing the clients’ experiences and promoting their agency in therapy. However, it is noteworthy that in the challenging formulation, therapists claim privileged access to the clients’ knowledge domain and challenge their prior epistemic status, which might run the risk of engendering clients’ resistance. (shrink)

Negative feedback is an important mechanism whereby the organism maintains its balance in a complicated system. It may beregarded as a modern version of the ancient Eastern wisdom of Yin and Yang balance. Control of pain and analgesia, is no exception: CCK seems to serve as a built-in mechanism for the modulation of opioid analgesia system [dickenson].

Patients with Wilson’s disease suffer from prospective memory impairment, and some of patients develop cognitive impairment. However, very little is known about how brain structure and function changes effect PM in WD. Here, we employed multimodal neuroimaging data acquired from 22 WD patients and 26 healthy controls who underwent three-dimensional T1-weighted, diffusion tensor imaging, and resting state functional magnetic resonance imaging. We investigated gray matter volumes with voxel-based morphometry, DTI metrics using the fiber tractography method, and RS-fMRI using the seed-based (...) functional connectivity method. Compared with HC, WD patients showed GM volume reductions in the basal ganglia and occipital fusiform gyrus, as well as volume increase in the visual association cortex. Moreover, whiter matter tracks of WD were widely impaired in association and limbic fibers. WM tracks in association fibers are significant related to PM in WD patients. Relative to HC, WD patients showed that the visual association cortex functionally connects to the thalamus and hippocampus, which is associated with global cognitive function in patients with WD. Together, these findings suggested that PM impairment in WD may be modulated by aberrant WM in association fibers, and that GM volume changes in the association cortex has no direct effect on cognitive status, but indirectly affect global cognitive function by its aberrant functional connectivity in patients with WD. Our findings may provide a new window to further study how WD develops into cognitive impairment, and deepen our understanding of the cognitive status and neuropathology of WD. (shrink)

Robust techniques critically improve bearing-only target localization when the relevant measurements are being corrupted by impulsive noise. Resistance to isolated gross errors refers to the conventional least absolute residual method, and its estimate can be determined by linear programming when pseudolinear equations are set. The LAR approach, however, cannot reduce the bias attributed to the correlation between system matrices and noise vectors. In the present study, perturbations are introduced into the elements of the system matrix and the data vector simultaneously, (...) and the total optimization problem is formulated based on least absolute deviations. Subsequently, an equivalent form of total least absolute residuals is obtained, and an algorithm is developed to calculate the robust estimate by dual ascent algorithms. Moreover, the performance of the proposed method is verified through the numerical simulations by using two types of localization geometries, i.e., random and linear. As revealed from the results, the TLAR algorithm is capable of exhibiting significantly higher localization accuracy as compared with the LAR method. (shrink)

The transition of gene switch induced by external noises and external signals is investigated in the genetic regulatory system. Results show that the state-to-state transition of gene switch as well as resonant behaviors, such as the explicit coherence resonance, implicit coherence resonance and control parameter coherence biresonance, can appear when noises are injected into the genetic regulatory system. The ECR is increased with the increase of the control parameter value when starting from the supercritical Hopf bifurcation parameter point, and there (...) exists a critical control parameter value for the occurrence of ECR. However, the ICR is decreased as the control parameter value is increased when starting from the subcritical Hopf bifurcation point. In particular, the coherence of ECR is higher and more sensitive to noise than that of ICR. When an external signal is introduced into the system, the enhancement or suppression of the CPCBR and the number of peaks strongly depend on the frequency and amplitude of the external signal. Furthermore, the gene regulation system can selectively enhance or decrease the noise-induced oscillation signals at preferred frequency and amplitude of an external signal. (shrink)

国家哲学社会科学创新基地浙江大学语言与认知研究中心研究成果本书为浙江省哲学社会科学规划课题成果.

The coronavirus disease 2019 pandemic has fueled anti-Asian, especially anti-Chinese sentiments worldwide, which may negatively impact diasporic Chinese youths’ adjustment and prosocial development. This study examined the association between compassion, discrimination and prosocial behaviors in diasporic Chinese youths during the COVID-19 pandemic. 360 participants participated and completed the multi-country, cross-sectional, web-based survey between April 22 and May 9, 2020, the escalating stage of the pandemic. This study found compassion as prosocial behaviors’ proximal predictor, while discrimination independently predicted participation in volunteering, (...) and could potentially enhance the association between compassion and charitable giving. These findings suggest that prosociality among young people is sensitive to social context, and that racial discrimination should be considered in future prosocial studies involving young members of ethnic and racial minorities. (shrink)

论述了春秋时期法家思想的萌芽和先驱人物,战国前期和中期和法家学派的形成与勃兴,战国末期法家学派思想的总结与秦王朝法家政治的终结及法家思想对后世的影响。.

Discussing how to use philosophy as a tool of communist ideological propaganda in China.

什么样的人生才算是幸福完满的人生,按季羡林的说法是和谐人生,那么怎样的人生才算是和谐,我们该如何面对压力,如何消防除人与人之间的可怕的隔膜,如何处理友情与爱情等,大师季羡林将为读者揭开其中的奥秘,告诉 您如何好好的度过一生.

本书内容包括:人生、再谈人生、三论人生、人生的意义与价值,不完满才是人生、世态炎凉、走运与倒霉、缘分与命运、牵就与适应、谦虚与虚伪等。.

21世紀人類新科學、新文明的基礎——思維科學理論體系的建立 1687年英國科學家牛頓發表的《自然哲學的數學原理》一書，是近代自然科學完全確立的標誌，從而引領人類的科學邁入宏觀科學的時代，為現代文明奠定了理論和思想上的基礎；1905年德國科學家愛因斯坦發表的《相 對論》，更使得人類的科學邁入微觀科學的時代，讓人們對周圍世界有了一個更加深入和全面的了解。 雖然上述二者都有力地推動了人類科學和文明的巨大進步，卻都未能跳脫出現代科學的物質觀對人們思維上的限制，不能應用於高度複雜的人體和生命科學，更不能解決當前擺在人們面前諸於癌症、愛滋病、各種慢性病、遺傳病 、傳染病等形形色色的問題。 毫無疑問，21世紀將是人體和生命科學的世紀。然而，在人體和生命科學領域，尚未出現像牛頓的《自然哲學的數學原理》和愛因斯坦的《相對論》那樣具有劃時代意義，且與生命科學高度複雜的基本特點互相呼應的全新理論 體系；這就導致人體和生命科學在21世紀的發展將缺乏理論上的立足點，人體和生命科學新的大發展正在呼喚全新理論的出現。 2012年，《生命科學的哲學原理》一書的完成和發表，正是適應這一時代的需要而建立起來的全新科學理論體系，採用了與牛頓和愛因斯坦完全不同，更加高級、全新的思維方式，並突破了現代科學的物質觀對人們思維上的 限制，從而引領人類的科學從當前具體的物質科學邁入抽象的思維科學的新時代，進而有效地解決人體和生命科學領域中各種高度複雜的問題，整個人類的文明也將因此而再次發生翻天覆地的偉大轉變，為新的歷史時期之人類社 會的和平、穩定與快速發展提供理論和思想上的依據。.

本书主要内容包括:泛观博览、止心圣学;投荒万里、龙场悟心;职事屡迁、门生广进;南赣戎机、矢石书影、翦除宁藩、教揭良知;讲学越城、心目俱醒;总督两广、恩威兼行;夫复何言、此心光明;哲人往矣、尔思曷兴.

1. Xin yi shu chuang zuo lun, Xin yi shu lun ji -- 2. Mian xiang sheng huo, Lun yi shu de ji qiao -- 3. Yi yi dang shi -- 4. Xi wen le jian -- 5. Ge er bu ge -- 6. Lun Feng jie -- 7. Kai xin yue shi -- 8. Bu dao ding dian, Shen mei de min gan -- 9. Zai zai tan suo -- 10. Liao ran yu xin -- 11. Shen mei (...) tan -- 12. Si zeng xiang shi, Yi shen er ren -- 13. Shen mei xin tai -- 14. Hui jian zi ji -- 15. Diao su diao su -- 16. "Fu huo" de fu huo -- 17. Dong fang ji bai -- 18. Shen yu wu you -- 19. Tu na ying hua -- 20. Qu yu wu xie -- 21. Shu xin, ti ci xuan -- 22. Duan jian can pian. (shrink)

di 1 juan. Lun yu bie cai -- di 2 juan. Laozi ta shuo, Mengzi pang tong -- di 3 juan. Yi jing za shuo, Yi jing xi zhuan bie jiang -- di 4 juan. Chan zong yu dao jia, Dao jia, Mi zong yu dong fang shen mi xue, Jing zuo xiu dao yu chang sheng bu lao -- di 5 juan. Chan hai li ce, Chan hua, Zhongguo fo jiao fa zhan shi lüe, Zhongguo dao jiao (...) fa zhan shi lüe -- di 6 juan. Li shi de jing yan, Yi xin yi jiu de yi dai, Zhongguo wen hua fan yan -- di 7 juan. Ru he xiu zheng fo fa, Yao shi jing de ji shi guan, Xue fo zhe de ji ben xin nian -- di 8 juan. Jin gang jing shuo shen mo, Leng yan da yi jin shi -- di 9 juan. Yuan jue jing lüe shuo, Ding hui chu xiu, Leng qie da yi jin shi -- di 10 juan. Yuan ben da xue wei yan. (shrink)

Ben shu yi Ming ru Li Cai de jiang xue huo dong yu xue pai jian gou wei zhong xin, tan tao cong shi liu shi ji chu dao shi qi shi ji mo li xue qun ti zhong xin xing xue shuo he xue pai de chan sheng, chuan bo, kuo zhan yu chuan cheng de mo shi, bing zhuo zhong cong si xiang shi de jiao du jie shi zhe zhong mo shi chan sheng he (...) yun xing de si xiang gen yuan yu nei zai dong li. Quan shu zheng wen gong qi zhang, zhu yao nei rong fen wei shang xia liang bian, shang bian yi hong guan zong lun de fang shi, cong li xue jing dian "Da xue" de wen ben bian dong he quan shi jing zheng qie ru, tan tao zhong wan Ming li xue xue shuo he xue pai jian gou de li lun gen ju; xia bian yi Li Cai de "zhi xiu" xue shuo ji qi jiang xue huo dong zuo wei ge an yan jiu, tan tao li xue xue shuo he xue pai de chuan bo ji chuan cheng de she hui hua tu jing. (shrink)

v. 1. Sheng ji tu -- v. 2. Mengzi sheng ji tu.