Most of Terence Penelhum’s essays collected in his Themes in Hume are already recognized as classics in Hume scholarship. Bringing them together only reinforces their strengths: clarity and sensitivity in exposition combined with charity and acuity in criticism. Penelhum wrote them over a course of almost fifty years, and we can see in them the evolution in his attitude towards Hume. In the earliest essay — the 1955 ‘Hume on Personal Identity’ — Penelhum offers a quick and local diagnosis of (...) Hume’s errors: he has mistakenly assumed that an object must be unchanging for it to be identical through time. But in the later essays, especially the three new ones, Penelhum recognizes that his earlier local insights must be balanced by a wider reading of Hume. After all, he does not, for example, talk about the self only to say that it is a bundle of perceptions; it is also crucial to his treatment of the passions, especially the indirect, person-oriented passions, and is an essential component in his explanation of sympathy, the ultimate source of our moral judgments. Moreover, as Penelhum notes, seeing the self as constituted out of its perceptions, rather than standing over them so as to judge their legitimacy as guides to action or knowledge, is what allows Hume to attempt a ‘science of man’ — a quasi-Newtonian project of discovering the principles governing the perceptions in the mind-bundle. (shrink)

This article argues that Hannah Arendt’s controversial essay “Reflections on Little Rock,” when situated within her analysis of Jewish assimilation, has an astute insight: racial integration and the decrease of the racial gaps in material inequality, without taking seriously the political project of building a world in common, only intensify racism in racist polities. This occurs because attempts to extend formal equality to the racially dominated give rise to the rule of racial common sense, a result of a clash between (...) the political structures of equality and the racial inequality practiced in quotidian interracial exchanges occurring in civil society. Though Arendt’s work on racism echoes criticisms of racial integration leveled by racial realist and pessimistic accounts of the Civil Rights struggle, her work points to a more expansive practice of “the political” that calls for the institutional design of formal politics as an important strategy against racism. (shrink)

Machine generated contents note: Essay 1.

D. In doing x an agent acts incontinently if and only if: 1) the agent does x intentionally; 2) the agent believes there is an alternative action y open to him; and 3) the agent judges that, all things considered, it would be better to do y than to do x.

Problems of Rationality is the eagerly awaited fourth volume of Donald Davidson 's philosophical writings. From the 1960s until his death in August 2003 Davidson was perhaps the most influential figure in English-language philosophy, and his work has had a profound effect upon the discipline. His unified theory of the interpretation of thought, meaning, and action holds that rationality is a necessary condition for both mind and interpretation. Davidson here develops this theory to illuminate value judgements and how we (...) understand them; to investigate what the conditions are for attributing mental states to an object or creature; and to grapple with the problems presented by thoughts and actions which seem to be irrational. Anyone working on knowledge, mind, and language will find these essays essential reading. (shrink)

For over four decades, knowledge that symptoms of some inherited diseases can be prevented or reduced via early detection and treatment in newborns has underpinned state-funded screening programs in most developed countries. Conditions for which newborn screening is now a recognized preventative public health initiative include phenylketonuria, congenital hypothyroidism, and, more recently, cystic fibrosis and sickle cell disorder. The use of tandem mass spectrometry to detect conditions such as amino-acidopathies and fatty-acid oxidation defects is also becoming increasingly prevalent. a.

The author believes that large‐scale rationality on the part of the interpretant is essential to his interpretability, and therefore, in his view, to her having a mind. How, then are cases of irrationality, such as akrasia or self‐deception, judged by the interpretant's own standards, possible? He proposes that, in order to resolve the apparent paradoxes, one must distinguish between accepting a contradictory proposition and accepting separately each of two contradictory propositions, which are held apart, which in turn requires to conceive (...) of the mind as containing a number of semi‐independent structures of interlocking beliefs, desires, emotions, memories, and other mental states. (shrink)

Part 1. Introduction -- Introduction: Navigating the Perfect Moral Storm in Light of a Thirty-Five Year Debate -- Thirty-Five Year Climate Change Policy Debate -- Part 2. Priority Ethical Issues -- Ethical Problems with Cost Arguments -- Ethics and Scientific Uncertainty Arguments -- Atmospheric Targets -- Allocating National Emissions Targets -- Climate Change Damages and Adaptation Costs -- Obligations of Sub-national Governments, Organizations, Businesses, and Individuals -- Independent Responsibility to Act -- Part 3. The Crucial Role of Ethics in Climate (...) Change Policy Making -- Why Has Ethics Failed to Achieve Traction? -- Conclusion: Navigating the Perfect Moral Storm. (shrink)

Modeling metastasis in animal systems has been an important focus for developing cancer therapeutics. Xenopus laevis is a well‐established model, known for its use in identifying genetic mechanisms underlying diseases and disorders in humans. Prior literature has suggested that the drug, ivermectin, can be used in Xenopus to induce melanocytes to convert into a metastatic melanoma‐like state, and thus could be ideal for testing possible melanoma therapies in vivo. However, there are notable inconsistencies between ivermectin studies in Xenopus and the (...) application of ivermectin in mammalian systems, that are relevant to cancer and melanoma research. In this review, we examine the ivermectin‐induced phenotypes in Xenopus, and we explore the current uses of ivermectin in human research. We conclude that while ivermectin may be a useful drug for many biomedical purposes, it is not ideal to induce a metastatic melanocyte phenotype in Xenopus for testing the effects of potential melanoma therapeutics. (shrink)

Two things become one thing, something having parts, and something becoming something else, are cases of many things being identical with one thing. This apparent contradiction introduces others concerning transitivity of identity, discernibility of identicals, existence, and vague existence. I resolve the contradictions with a theory that identity, number, and existence are relative to standards for counting. What are many on some standard are one and the same on another. The theory gives an account of the discernibility of identicals using (...) phrases like “insofar as”. And it holds that standards for counting remain or shift depending on our purposes. (shrink)

Applies and extends the conclusions of the preceding chapters by examining cases of self‐deception of a puzzling sort emerging from cases of fantasizing and imagining, found in Joyce's Portrait of the Artist as a Young Man and Flaubert's Madame Bovary. The author is particularly interested in what can be described as the ‘divided mind of self‐deception’, the mind that produces an imagination due to its realising the state of the world that motivates the fantasy construct and the possessor's eventual acquisition (...) of the belief that the fantasy construct represents reality accurately. In the process of deceiving oneself, he holds, no clear line can be drawn between imaginative activities that are not yet self‐deceptive and those that are. (shrink)

The Twentieth Century has seen a dramatic rise in the use of probability and statistics in almost all fields of research. This has stimulated many new philosophical ideas on probability. _Philosophical Theories of Probability_ is the first book to present a clear, comprehensive and systematic account of these various theories and to explain how they relate to one another. Gillies also offers a distinctive version of the propensity theory of probability, and the intersubjective interpretation, which develops the subjective theory.

Repr. as Essay 14 in Davidson, Donald, _Inquiries into Truth and Interpretation_, 2nd ed. Oxford, UK (Clarendon, 2001). 215-226.

This essay is part of a special issue celebrating 50 years of Political Theory. The ambition of the editors was to mark this half century not with a retrospective but with a confabulation of futures. Contributors were asked: What will political theory look and sound like in the next century and beyond? What claims might political theorists or their descendants be making in ten, twenty-five, fifty, a hundred years’ time? How might they vindicate those claims in their future contexts? How (...) will the consistent concerns of political theorists evolve into the questions critical for people decades or centuries from now? What new problems will engage the political theorists (or their rough equivalents) of the future? What forms might those take? What follows is one of the many confabulations published in response to these queries. (shrink)

No one who reads Derrida closely could accuse him of “technophobia.” More than any other contemporary thinker, on the contrary, he has shown the limit of attempts to protect thinking and even being itself from technē. Yet, Derrida nevertheless insists that “deconstruction” is neither a “technique” nor the technology of thinking that modern philosophy calls “method.” What allows Derrida to exclude “technique” and “method” when he himself shows, in relation to Heidegger above all, that a certain technicity and methodicity always (...) remain irreducible? After outlining its stakes (§I), this article seeks to raise this question by reconstructing Derrida’s engagement with Heidegger concerning the questions of technology (§II) and of method (§III) before turning to the techno-methodicity that Derrida attempts to dissociate from deconstruction in turn (§IV). (shrink)

The law often calls on the concept of public interest for assistance. Privacy law makes use of this concept in several ways, including to justify consent waivers for secondary research on health information. Because the law sees information privacy as a means for individuals to control their personal information, consent can only be set aside in special circumstances. Ballantyne and Schaefer argue that only public interest, and only a broad conception of public interest, can do the special ‘normative justificatory work’ (...) to override consent requirements. Other, similar-sounding concepts, such as public benefit, public good and social value, also provide useful services. But none more so than public interest. In fact, they argue, public interest is the superior concept precisely because it can capture those concepts as well as a range of other interests. Our response focuses on this claim. We argue their strategy is not as promising as it might first seem. Ballantyne and Schaefer construe the important role that public interest plays in this context as their endpoint. They claim that unless the concept is open and content-rich, it will lose some of its importance. But by refusing to place limits around it, their inquiry leads us back to a catch-all concept that lacks clear focus or meaning. In reply, we argue that, for practically minded theorists, a narrow conception of public interest is more useful. Further, the narrowing of public interest in this context can be achieved by first analysing it in its legal, rather than ethical, sense. (shrink)

The concept of complexity has become very important in theoretical biology. It is a many faceted concept and too new and ill defined to have a universally accepted meaning. This review examines the development of this concept from the point of view of its usefulness as a criteria for the study of living systems to see what it has to offer as a new approach. In particular, one definition of complexity has been put forth which has the necessary precision and (...) rigor to be considered as a useful categorization of systems, especially as it pertains to those we call living. This definition, due to Robert Rosen, has been developed in a number of works and involves some deep new concepts about the way we view systems. In particular, it focuses on the way we view the world and actually practice science through the use of the modelling relation. This mathematical object models the process by which we assign meaning to the world we perceive. By using the modelling relation, it is possible to identify the subjective nature of our practices and deal with this issue explicitly. By so doing, it becomes clear that our notion of complexity and especially its most popular manifestations, is in large part a product of the historical processes which lead to the present state of scientific epistemology. In particular, it is a reaction to the reductionist/mechanistic view of nature which can be termed the Newtonian Paradigm. This approach to epistemology has dominated for so long that its use as a model has become implicit in most of what we do in and out of science. The alternative to this approach is examined and related to the special definition of complexity given by Rosen. Some historical examples are used to emphasize the dependence of our view of what is complex in a popular sense on the ever changing state of our knowledge. The role of some popular concepts such as chaotic dynamics are examined in this context. The fields of artificial life and related areas are also viewed from the perspective of this rigorous view of complexity and found lacking. The notion that in some way life exists at the edge of chaos is examined from the perspective of the second law of thermodynamics given by Schneider and Kay. Finally, the causal elements in complex systems are explored in relation to complexity. Rosen has shown that a clear difference in causal relations exists between complex and simple systems and that this difference leads to a uniquely useful definition of what we mean by living. Rosen makes it very clear that the class of systems which are complex is a much larger class than those which we call living. For that reason, the focus of this review will be on complexity as a stepping stone towards the deeper question of what makes a system alive. (shrink)

This chapter contains section titled: Notes.

Human attitudes to animals have changed as non-humans have become more widely incorporated in the category of moral agents who deserve some respect. Parallels between the functioning of humans and non-humans have been made for thousands of years but the idea that the animals that we keep can suffer has spread recently. An improved understanding of motivation, cognition and the complexity of social behaviour in animals has led in the last 30 years to the rapid development of animal welfare science. (...) Early attempts to define welfare referred to individuals being in harmony with nature but the first usable definition incorporated feelings and health as part of attempts to cope with the environment. Others considered that welfare is only about feelings but it is argued that as feelings are mechanisms that have evolved they are a part of welfare rather than all of it. Most reviews of welfare now start with listing the needs of the animal, including needs to show certain behaviours. This approach has used sophisticated studies of what is important to animals and has replaced the earlier general guidelines described as freedoms. Many measures of welfare are now used and indicate how good or how poor the welfare is. Naturalness is not a part of the definition of welfare but explains why some needs exist. In recent years, welfare has become established as one of various criteria used to decide on whether a system is sustainable because members of the public will not accept systems that cause poor welfare. The study of welfare has become part of the scientific basis upon which important political decisions are made. (shrink)

Clinical ethics committees (CECs) in the United Kingdom (UK) have developed significantly over the past 15 years. The issue of access to and participation in clinical ethics consultation by patients and family members has, however, gone largely unrecognized. There are various dimensions to this kind of contact, including patient notification, consent and participation. This study reports the first specific investigation of patient contact with UK CECs. A questionnaire study was carried out with representatives from UK CECs. Results suggest that patient (...) participation in clinical ethics consultation is low and unlikely to change significantly in the near future. Attitudes towards patients having a role in clinical ethics consultation are mixed, with a variety of reasons put forward both for and against patient participation. These results are discussed in the light of common themes in the literature and the practical and political context of clinical ethics support in the UK. (shrink)

Mystery: the scalpel that split consciousness -- Beauty: sirens of the gene -- Reality: capers of the unseen sun -- Sensory: fitness beats truth -- Illusory: the bluff of a desktop -- Gravity: spacetime is doomed -- Virtuality: inflating a holoworld -- Polychromy: mutations of an interface -- Scrutiny: you get what you need, in both life and business -- Community: the network of conscious agents -- Precisely: the right to be wrong.

Metaphysics and the Modern World makes the abiding questions of the nature of the self, world, and God available for the modern reader. Donald Phillip Verene presents these questions in both their systematic and historical dimensions, beginning with Aristotle's claim in his Metaphysics that philosophy begins in wonder. The first three chapters concern the origin of metaphysics as the transformation of the conception of reality in ancient Greek mythology, the ontological argument as the basis of Christian metaphysics, and the (...) Renaissance cosmology of infinite worlds and the coincidence of contraries. The final four chapters present the central issues of the metaphysics of history through the New Science of Vico, the principle of true infinity of Hegel's Logic, the dialectic of spirit and life in Cassirer's Metaphysics of Symbolic Forms, and the conception of actual entities and God in Whitehead's Process and Reality. In these discussions, the reader will find a lively and learned account of a field of philosophy that is often thought difficult to access, but in this work becomes most accessible and a pleasure to read. -- back cover. (shrink)

What is phenomenology? That is precisely the question this book seeks to answer. In an age of information overload, complex topics must be simplified to make them accessible to a wider audience. Phenomenology: A Basic Introduction in the Light of Jesus Christ not only presents the basic building blocks of phenomenology, it also gives body to voice by putting abstract ideas in contact with the Word made flesh, Jesus of Nazareth. In five manageable chapters, Donald Wallenfang introduces major themes (...) such as the natural attitude, givenness, interpretation, paradox, and ethics. Each subject is considered in how it applies to daily life and relates to the gospel of Jesus Christ. Several biblical scenes are tapped to harvest their sweet nectars of meaning through phenomenology. At its limit, philosophy gives way to the revelatory rationality of theology as expressed by Jesus the phenomenologist. (shrink)

Multiple studies show that periodic reanalysis of genomic test results held by clinical laboratories delivers significant increases in overall diagnostic yield. However, while there is a widespread consensus that implementing routine reanalysis procedures is highly desirable, there is an equally widespread understanding that routine reanalysis of individual patient results is not presently feasible to perform for all patients. Instead, researchers, geneticists and ethicists are beginning to turn their attention to one part of reanalysis—reinterpretation of previously classified variants—as a means of (...) achieving similar ends to large-scale individual reanalysis but in a more sustainable manner. This has led some to ask whether the responsible implementation of genomics in healthcare requires that diagnostic laboratories routinely reinterpret their genomic variant classifications and reissue patient reports in the case of materially relevant changes. In this paper, we set out the nature and scope of any such obligation, and analyse some of the main ethical considerations pertaining to a putative duty to reinterpret. We discern and assess three potential outcomes of reinterpretation—upgrades, downgrades and regrades—in light of ongoing duties of care, systemic error risks and diagnostic equity. We argue against the existence of any general duty to reinterpret genomic variant classifications, yet we contend that a suitably restricted duty to reinterpret ought to be recognised, and that the responsible implementation of genomics into healthcare must take this into account. (shrink)

This target article considers the ethical implications of providing prenatal diagnosis (PND) and antenatal screening services to detect fetal abnormalities in jurisdictions that prohibit abortion for these conditions. This unusual health policy context is common in the Latin American region. Congenital conditions are often untreated or under-treated in developing countries due to limited health resources, leading many women/couples to prefer termination of affected pregnancies. Three potential harms derive from the provision of PND in the absence of legal and safe abortion (...) for these conditions: psychological distress, unjust distribution of burdens between socio-economic classes, and financial burdens for families and society. We present Iran as a comparative case study where recognition of these ethical issues has led to the liberalization of abortion laws for fetuses with thalassemia. We argue that physicians, geneticists and policymakers have an ethical and professional duty of care to advocate for change in order to ameliorate these harms. (shrink)

Engaging Eriugena, Eckhart and Cusanus contains two new essays and nine others published between 2005 and 2019. The essays explore Eriugena, Eckhart and Cusanus as bold thinkers deeply engaged with their times and culture. John Scottus Eriugena, Meister Eckhart and Nicholas of Cusa are key figures in the medieval Christian Neoplatonic tradition. This book focuses on their engagement with practical, experiential issues and controversies. Eriugena revises Genesis' Adam and Eve narrative and makes sexual difference and overcoming it central to his (...) Periphyseon. Eckhart's Annunciation sermons urge his hearers to give birth to God's son within their lives, and he develops a distinctive approach to pain and suffering. His radical preaching on the Eucharist and mystical union was judged heretical, but was later taken up by Nicholas of Cusa. Coins and banking became key symbols in Cusanus' exploration of humanity as created in God's image, and he used mechanical clocks in reflecting on time and eternity. 'Engagement' also describes these thinkers' reception of their predecessors and how later readers appropriated their works. Eriugena struggled with the legacy of Augustine and the Greek Fathers. Eckhart's theology of suffering provoked varied responses from his students Henry Suso and Johannes Tauler, and the twentieth-century therapist Ursula Fleming. Cusanus provides the volume's lynchpin as two articles analyse his reading of Eriugena and Eckhart, and a third discusses how he deftly countered Johannes Wenck's accusations of heresy. The book will be of interest to students of Medieval Philosophy, Theology, Spirituality and their place within Cultural History. (shrink)

How is it possible for David Hume to be both withering skeptic and constructive theorist? I recommend an answer like the Pyrrhonian answer to the question how it is possible to suspend all judgment yet engage in active daily life. Sextus Empiricus distinguishes two kinds of assent: one suspended across the board and one involved with daily living. The first is an act of will based on appreciation of reasons; the second is a causal effect of appearances. Hume makes the (...) same distinction, only he extends the sort of assent involved in daily life to theoretical matters as well. He is a skeptic both in finding no reason to grant the first sort of assent and in being subject to the second. (shrink)

The use of genomic testing in pregnancy is increasing, giving rise to questions over how the information that is generated should be offered and returned in clinical practice. While these tests provide important information for prenatal decision-making, they can also generate information of uncertain significance. This paper critically examines three models for approaching the disclosure of variants of uncertain significance (VUS), which can arise from forms of genomic testing such as prenatal chromosomal microarray analysis (CMA). Contrary to prevailing arguments, we (...) argue that respect for reproductive autonomy does not justify adopting a model on which an offer to disclose VUS is a routine part of genetic counselling. Instead, we contend that a commitment both to solidarity between healthcare providers and pregnant women and to the acceptance of a novel principle of caution under normative uncertainty means that we should instead adopt a model of VUS disclosure that imposes a strong presumption against offering to disclose VUS. The upshot of this is that it should be standard practice to only offer to disclose VUS when this is requested by the woman undergoing CMA. We defend our position against claims that arise from an alleged right to such information and that a presumption against an offer will lead to inequity. (shrink)

This work approaches texts in the history of philosophy as the repository of a kind of literature that brings together rational thought and rhetorical principles.

Emile Benvcniste may be used to introduce the topic. The French linguist begins an essay on “Euphemisms Ancient and Modern” with a paradox about the early Greek definitions of euphemism. “To speak words which augur well” is one meaning given, but another is “to maintain silence”. This initial contradiction is further compounded by yet a third expression, “to shout in triumph”. The dilemma is. however, easily dissolved. To speak words which augur well implies, for special occasions, an exhortation even to (...) shout triumphantly, “to assent by an, auspicious outcry”: it further implies, again depending on the circumstances, “to avoid words which augur ill”, hence, if necessary, to say nothing. As one definition explains “avoid all unlucky words during sacred rites: hence, as the surest mode of avoiding them, keep a religious silence” (original emphasis). Paradox terminates; we are merely dealing with “a euphemism for a euphemism” taking an expression of Benveniste out of context. (shrink)

This book is based on the work done by a group of British and Italian psychoanalysts who have been meeting twice yearly since 2003 to study clinically the relationship between the mind and the body of their patients The analytical dyad became the focus of a dialectical movement between body and mind and between subject and object. Containing contributions from a range of distinguished British and Italian analysts, this book covers such key topics as somatic symptoms, the embodied unconscious, bodily (...) expressions of affect, sexuality, violence, self-harm, suicide attempts, hypochondria, hysteria, anorexia and bulimia, splits and fragmentation associated with the body. The theoretical understanding is inspired by various psychoanalytic theoreticians, including Freud, M. Klein, Winnicott and Bion and their theories on sexuality, infantile sexuality, libido, aggressiveness, dead instinct, Oedipus complex and mother-child relationship. Offering new advances in theoretical thinking and practical applications for clinical work, this book will be essential for all psychoanalysts and mental health clinicians interested in understanding serious mental disturbance that is represented in the body. (shrink)

The historical literature of the past two centuries testifies to disputes about what historical knowledge is and the relationship of the historian to it. The disputes have been fierce enough for each side to declare that any position other than its own is untenable. It would be futile to try to convince those who so staunchly defend their own ground that the other side might have a legitimate contribution to make. Yet, it might be worthwhile to classify the positions so (...) as to focus the arguments on legitimate issues, and, in some measure, to begin to resolve them. (shrink)