Mucopolysaccharidosis VI is an autosomal recessive lysosomal storage disorder associated with severe disability and premature death. The presence of a mucopolysaccharidosis-like disease in indigenous ethnic groups in Colombia can be inferred from archaeological findings. There are several indigenous patients with mucopolysaccharidosis VI currently receiving enzyme replacement therapy. We discuss the ethical and economic considerations, regarding both direct and indirect costs, of a high-cost orphan disease in a marginalised minority population in a developing country.

South Africa shared with the world the warning of a new strain of SARS-CoV2, Omicron, in November 2021. As a result, many high-income countries (HICs) instituted complete travel bans on persons leaving South Africa and other neighbouring countries. These bans were unnecessary from a scientific standpoint, and they ran counter to the International Health Regulations. In short, South Africa was penalized for sharing data. Data sharing during pandemics is commonly justified by appeals to solidarity. In this paper, we argue that (...) solidarity is, at best, an aspirational ideal to work toward but that it cannot ground an obligation to share data. Instead, low-and-middle income countries (LIMCs) should be guided by the principle of reciprocity, which states that we ought to return good for good received. Reciprocity is necessarily a conditional principle. LMICs, we argue, should only share data during future pandemics on the condition that HICs provide enforceable assurances that the benefits of data sharing will be equitably distributed and that LMICs won’t be penalized for sharing information. (shrink)

En este conciso estudio se explicará la concepción de la luz que encontramos en Francisco Suárez. Si bien distinta, y por cierto distante, de las teorías modernas (corpuscular y ondulatoria), encontramos en Suárez un corpus de principios, de base y raigambre aristotélica, que dan cuenta de una mecánica del todo exótica para nuestra men- talidad, pero abundante y enriquecida en contenido lógico y filosófico: la filosofía natural de Francisco Suárez está basada, en términos generales, en los conceptos de virtud, necesidad, (...) esfera de acción y energía en el sentido originario de esta palabra. Para sorpresa del lector mínimamente aficionado a estos temas, encontraremos en la física de Suárez explicaciones por momentos mucho más naturales, más claras y más satisfactorias sobre la propagación de la luz y sobre la acción a distancia de lo que han propuesto hasta hoy las teorías en vigencia. Francisco Suárez, desde ya, queda excluido del proyecto de Galileo y de Francis Bacon; no ofrece ni persigue resultados mate- máticos, sino un conocimiento ontológico del Universo y una interesante mecánica esencialista. (shrink)

Estudio preliminar. I. La era de Darwin. II. Las coordenadas españolas de la polémica darwinista. III. Algunos datos sobre la introducción del darwinismo en España. IV. Breve historia de la controversia ideológica. V. Implicaciones filosóficas e ideológicas del darwinismo. Nota sobre los textos. ANTOLOGÍA DE TEXTOS. I. Un debate largo y virulento. I.1. Defensores. I.2. Adversarios. I.3. Posturas conciliadoras. II. Tres acontecimientos polémicos. II.1. El drawinismo en Granada. II.2. El I Congreso Católico Español. II.3. El cementerio del nacimiento de Darwin. (...) III. Darwinismo social. IV. Darwinismo y socialismo. IV.1. Anarquismo. IV.2. Socialismo marxista. V. La muerte de Darwin en la Prensa. V.1. Prensa católico-tradicional. V.2. Prensa liberal. V.3. Prensa obrera. Bibliografía y cronología del darwinismo en España [1859-1900]. (shrink)

Esse texto propõe a hipótese da “máquina s’imaginante” como sendo o constructo fundamental da teoria da imaginação de Spinoza e pretende justificar certa leitura que permita tal denominação. Para tanto, parte-se da noção de _contemplari externè_ para, em seguida, explanar a noção interpretativa de _simul desconcertante_, a qual desempenha importante papel a fim de forjar a noção de _centramento em si_, noção que permite captar os efeitos de interioridade e exterioridade relativas ao indivíduo humano e cujo engendramento faz a natureza (...) das coisas ser apreendida teleologicamente. A partir do _centramento em si _são examinadas e interpretadas categorias relevantes da imaginação, sendo a mais importante delas a _concatenatio_. Por fim, são indicados alguns desdobramentos da hipótese de leitura proposta. (shrink)

The Pyrrhonian skeptic’s stance, as described by Sextus Empiricus, is in good part defined by his suspending judgment or belief about all the matters he has so far investigated. Most interpreters of Pyrrhonism maintain that it is a mistake to understand this form of skepticism in terms of doubt because suspension as conceived of by the Pyrrhonist is markedly different from the state of doubt. In this article, I expound the reasons that have been offered in support of that prevailing (...) view and assess their strength. (shrink)

As an instrument for participatory technology development, Scenario-Based Design offers significant potential for an early inclusion of future users. Over the course of a 3-year research project, this method was examined as a procedure for participatory technology development. Methods and instruments aimed at achieving a potential user’s participation, and the resulting cooperation of heterogeneous social groups can be seen as translation tools. Their purpose is to act as translators between different social fields and the specific knowledge associated with them. These (...) translation capabilities and participatory methods should result in the best possible convergence of different orientations and purposes. In this paper, attempting to achieve the best possible convergence is described as a dilemma of alignment. Several approaches will be used to describe the dynamic of the alignment dilemma within the above-mentioned project. The reconstruction follows one question that is proposed as a heuristic pattern to meet the requirements of an accurate analysis of holistic participatory methods: Who or what has to adjust to whom or what, why, when, and in which way? The main conclusions include the finding that the alignment dilemma is not equally balanced, that the agency of epistemic objects within the process has to be captured, and that it is easy for translation—provided primarily by core instruments of the participatory method used—to begin to overwrite the needs and purposes of one social group with the interests and orientations of another. (shrink)

This book concerns the soul/body problem in Plato and Aristotle. Established as well as early career scholars actually working on Plato and Aristotle explore - under different points of view as well as through original readings and interpretations - the manifold dimensions involved in the conception of the soul/body relation articulated by the two greatest founders of Western Thought. The book starts with an exploration of the relation between cause and matter in Plato and Aristotle, then some papers on Plato's (...) theory of soul and body are presented, which involve new advancements in the research about Platonic epistemology, moral and political theory, metaphysics of mind, even about his religious and 'theological' view. Some papers on Aristotle's model follow, which are focused on his so-called "hylomorphism" as an alternative view to Plato's alleged "dualism": the ontology of the soul/body relation in Aristotle is explored, as well as the implications of this theoretical framework for his theory of knowledge, his moral theory, his cognitive psychology. Finally, two papers critically assess the philosophical connections between Aristotle's hylomorphism and its modern and contemporary Wirkungsgeschichte. (shrink)

This paper explores the notion of reciprocity in the context of active pulmonary and laryngeal tuberculosis treatment and related control policies and practices. We seek to do three things: First, we sketch the background to contemporary global TB care and suggest that poverty is a key feature when considering the treatment of TB patients. We use two examples from TB care to explore the role of reciprocity: isolation and the use of novel TB drugs. Second, we explore alternative means of (...) justifying the use of reciprocity through appeal to different moral and political theoretical traditions. We suggest that each theory can be used to provide reasons to take reciprocity seriously as an independent moral concept, despite any other differences. Third, we explore general meanings and uses of the concept of reciprocity, with the primary intention of demonstrating that it cannot be simply reduced to other more frequently invoked moral concepts such as beneficence or justice. We argue that reciprocity can function as a mid-level principle in public health, and generally, captures a core social obligation arising once an individual or group is burdened as a result of acting for the benefit of others. We conclude that while more needs to be explored in relation to the theoretical justification and application of reciprocity, sufficient arguments can be made for it to be taken more seriously as a key principle within public health ethics and bioethics more generally. (shrink)

Some authors have called into question the normativity of logic, using as an argument that the bridge principles for logical normativity (MacFarlane, In what sense (in any) is logic normative for thought, 2004 )? are just by-products of general epistemic principles for belief. In this paper, I discuss that suggestion from a formal point of view. I show that some important bridge principles can be derived from usual norms for belief. I also describe some possible ways to block this derivation (...) by modifying the epistemic norms or weakening the bridge principles. Finally, I discuss different philosophical interpretations of these results. (shrink)