Pragmatic trials aim to directly inform health care decision-making through the collection of so-called ‘real world data’ from observations of comparative treatment effects in clinical practice. In order to ensure the applicability and feasibility of a pragmatic trial, design features may be necessary that deviate from standard research ethics requirements. Examples are traditional requirements to seek written informed consent and to perform extensive data and safety monitoring. Proposals for deviations from standard research ethics practice have resulted in controversy about their (...) ethical acceptability. One of the justifications for altered procedures is the allegedly high social value of pragmatic trials. In order to properly operationalize the concept in the ethical assessment of pragmatic trial designs, specification is warranted. We identified three determinants from common claims about a pragmatic trial's social value: the extent to which the research question has real world relevance, the trial design's ability to generate a real world answer and the probability of direct uptake of the results by decision-makers in practice. Subsequently, we discuss how these determinants should be applied to the practice of pragmatic trials, and to what extent they might be applicable to explanatory trials. (shrink)

As of October 23, 2020, almost 42 million cases of COVID-19 have been reported globally. Although many different treatments have been applied in infected...

This essay is about the ensuing problem that in general it is nothelpful to talk about non-standard knowledge practices as modeled after our Western ideas of what knowledge is. It negotiates this problem by arguing that artisanal knowledge is an independent and self-contained mode of knowledge and is arranged in three parts. In the first part an outline is given of the key assumptions of the interactionist conception of knowledge that needs to be put in place as an alternative to (...) the basically Kantian mixture of empiricist and rationalist assumptions of the folk model of Western academic thinking about knowledge. In this interactionist conception of knowledgeartisanal knowledge gets center stage. In the second part, the notion of craftknowledge is opened up as much as possible. The third and final part takes upthe question whether craft knowledge is a cultural universal. (shrink)

Modern epistomology has been dominated by an empiricist theory of knowledge that assumes a direct individualistic relationship between the knowing subject and the object of knowledge. Truth is held to be universal, and non-individualistic social and cultural factors are considered sources of distortion of true knowledge. Since the late 1950s, this view has been challenged by a cognitive relativism asserting that what is true is socially conditioned. This volume examines the far-reaching implications of this development for the social sciences. Recently, (...) cognitive relativism has become a key issue of debate in anthropology, philosophy, and sociology. In anthropology this is illustrated by a growing awareness of the similarity of all systems of knowledge. In philosophy it is exemplified by the realization that traditional monolithic and absolutist concepts of truth have increasingly lost any power to make sense and to convince. In sociology it is visible in a renewal of interest in a general sociology of knowledge. Yet, in spite of this convergence of interests, practitioners of these three disciplines have on the whole shown no inclination to reach a consensus on the terms of reference that could facilitate an interdisciplinary approach. "Cognitive Relativism and Social Science "aims to do just this. It is a working assumption of this volume that, as far as the subject of cognitive relativism is concerned, anthropologists, philosophers, and sociologists should join forces rather than try to deal with the challenges of cognitive relativism within strictly imposed boundaries that normally separate academic disciplines. Only when they work together will it be possible to treat the problems posed by cognitive relativism in an adequate way. This volume provides the results of attempts to communicate on cognitve relativism across disciplinary boundaries. This is must reading in the philosophy of social science and in social research theory. (shrink)

In April 2020, close to the start of the first U.K. COVID-19 lockdown, the U.K. government announced the development of a COVID-19 contact tracing app, which was later trialled on the U.K. island, the Isle of Wight, in May/June 2020. United Kingdom surveys found general support for the development of such an app, which seemed strongly influenced by public trust. Institutions developing the app were called upon to fulfil the commitment to public trust by acting with trustworthiness. Such calls presuppose (...) that public trust associated with the app can emerge if the conditions for trustworthiness are met and that public trust is simplistic, i.e., linearly the sum of each member of the publics’ individual – U.K. government trust relationship. Drawing on a synthesis of the trust literature and fifteen interviews with members of the public trialling the app on the Isle of Wight, this paper aims to explore what trust mechanisms and relationships are at play when thinking about public trust in the context of the U.K. COVID-19 app. We argue that public trust is a complex social phenomenon and not linearly correlated with institutional trustworthiness. As such, attention needs to widen from calls for trustworthy infrastructures as a way to build public trust, to a deeper understanding of those doing the trusting; in particular, what or whom do people place their trust in when considering whether using the app and why. An understanding of this will help when trying to secure public trust during the implementation of necessary public health measures. (shrink)

These essays originated from an international conference of the same name. The collection brings together philosophers and historians of philosophy for fruitful interchange to foster the current revival of interest in this important sector of 20th century philosophy. Contents: Empiricism: The Key Question, Wesley C. Salmon; Pragmatics and the Principle of Empiricism, Brian Skyrms; The Logic of 20th Century Empiricism, Joseph Hanna; Reduction Sentence "Meaning Postulates", James H. Fetzer; The Context of Justification, John Kekes; Logical Positivism and the Demise of (...) "Moral Science", Geoffrey Sayre-McCord; "The First Man who almost wholly understands me": Carnap, Dingler and Conventionalism; Conventionalism Reconsidered, Werner Diederick; Carnap's Scientific Realism: Irenic or Ironic?, Richard Creath; Idealism and the Aufbau, Alberto Coffa; The Neo-Kantian Origin of Hans Reichenbach's Principle of Induction, A. Kamlah. Co-published with the Center for Philosophy of Science. (shrink)