Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Le livre de Céline Roussel et de Soline Vennetier constitue un apport majeur à un champ en plein essor dans les études académiques françaises. Alors que les Disability Studies existent dans les pays anglo-saxons et en Europe du Nord depuis une quarantaine d’années, elles peinent encore à s’affirmer en France, un retard qui correspond sans doute à celui de toute la société française, de l’accessibilité matérielle des espaces à la place minime faite aux personnes porteuses de handicap dans l’em...

Adolescence is a moment when sexuality, identity, and relationships are heightened; at adolescence women begin to be vulnerable to losing touch with their own thoughts and feelings. Reporting from a larger study of adolescent girls' experiences of sexual desire, the author focuses on how adolescent girls who have different sexual orientations describe their experiences of sexuality and their responses to their own sexual desire. Cultural contexts that render girls' sexuality problematic and dangerous divert them from the possibilities of empowerment through (...) their sexual desire. (shrink)

This article is currently available as a free download on ingentaconnect.

Cheating is deeply embedded in everyday life. The costs of the most common forms of cheating total close to a trillion dollars annually. Part of the problem is that many individuals fail to see such behavior as a serious problem. "Everyone does it" is a common rationalization, and one that comes uncomfortably close to the truth. That perception is also self-perpetuating. The more that individuals believe that cheating is widespread, the easier it becomes to justify. Yet what is most notable (...) about analysis of the problem is how little there is of it. Whether or not Americans are cheating more, they appear to be worrying about it less. In Cheating, eminent legal scholar Deborah L. Rhode offers the only recent comprehensive account of cheating in everyday life and the strategies necessary to address it. Because cheating is highly situational, Rhode drills down on its most common forms in sports, organizations, taxes, academia, copyright infringement, marriage, and insurance and mortgages. Cheating also reviews strategies necessary to address the pervasiveness and persistence of cheating in these contexts. We clearly need more cultural reinforcement of ethical conduct. Efforts need to begin early, with values education by parents, teachers, and other role models who can display and reinforce moral behaviors. Organizations need to create ethical cultures, in which informal norms, formal policies, and reward structures all promote integrity. People also need more moral triggers that remind them of their own values. Equally important are more effective enforcement structures, including additional resources and stiffer sanctions. Finally, all of us need to take more responsibility for combatting cheating. We need not only to subject our own conduct to more demanding standards, but also to assume a greater obligation to prevent and report misconduct. Sustaining a culture that actively discourages cheating is a collective responsibility, and one in which we all have a substantial stake. (shrink)

In determining when sexual behavior in the workplace creates a hostile working environment, some courts have asked, Would a reasonableperson view this as a hostile environment? Two recent court decisions, recognizing male-female differences in the perception of social sexual behavior at work, modified this standard to ask, Would a reasonablevictim view this as a hostile environment? As yet, there is no consensus in the legal community regarding which of these standards is just.We propose that moral theory provides the framework from (...) which business people can construct just procedures regarding sexually hostile environments. We argue that the natural duty of mutual respect of persons and the natural duty not to harm the innocent compels business people to identify sexually hostile work environments from the perspective of the reasonable victim, usually from the woman's perspective. (shrink)

_The Cinematic City_ Edited by David B. Clarke London: Routledge, 1997 ISBN 0-415-12746-7 (pbk) 252 pp.

Musicians, like athletes, daily face the stark reality of physical and psychological health issues that can negatively affect or end their careers. Research shows compelling reasons for making changes to the value systems and in the educational process under which musicians are trained to help alleviate these problems. Changes would include teaching from a person-centered approach, including a broader understanding of music and adding wellness training into the music curriculum. This article outlines the evidence from the literature, overviews the resources (...) available to assist with these changes, and discusses the important role that music educators can play in creating this healthy paradigm shift within the profession. (shrink)

She concentrates on responses to the 'crisis' that currently confronts the American legal profession and legal education—including the increasing cost of legal services, the threat to lawyer income and the oversupply of law graduates. Rhode regards the response by the American Bar Association (ABA) through its Ethics 20/20 Commission as lacking innovation and achieving only modest reform. Surveying other countries' efforts at opening the provision of some traditional legal services to non-lawyers and outside investment in law practices, she argues that (...) the US 'is likely to lag behind other nations in its capacity to provide cost effective legal services'. She also proposes greater diversity in the options available for legal education. (shrink)

_Memory, Myth, and Seduction_ reveals the development and evolution of Jean-Georges Schimek's thinking on unconscious fantasy and the interpretive process derived from a close reading of Freud as well as contemporary psychoanalysis. Contributing richly to North American psychoanalytic thought, Schimek challenges local views from the perspective of continental discourse. A practicing psychoanalyst, teacher, and consummate Freud scholar, Schimek sought to clarify Freud's concepts and theories and to disentangle complexities borne of inconsistencies in Freud's assumptions and expositions. This book is divided (...) thematically into three sections. The first concerns fantasy and interpretation as they play out in the analytic situation, and the manner in which analyst and patient coconstruct meaning and reconstruct and recover memory. The second consists of two seminal papers which provide the sequence of steps in the five revisions in Freud's seduction theory. Schimek's careful scholarship lays out the data of Freud's writing, which allows one to draw one's own conclusions about the implications of the changes in the theory that he made. In the third, more theoretical section, he provides a foundation for understanding many of today's discussions about unconscious fantasy, dreaming, remembering, consciousness, affect, self-reflection, mentalization, and implicit relational knowing. He clarifies and illustrates Freud's original formulations through a careful reading of sections of _The Interpretation of Dreams_, and a study of Freud's famous Signorelli parapraxis. Skillfully arranged and carefully edited by Deborah Browning and including a foreword by Alan Bass, this collection of Schimek's published and unpublished papers will be of interest to practicing psychoanalysts, psychoanalytically-oriented psychotherapists, and students of the history of ideas and philosophy who have a particular interest in fantasy, interpretation, and Freud. (shrink)

Have social media sites like Facebook become such a significant part of our social fabric that people face negative consequences for not joining and sharing? What role does a right to privacy play in circumstances where self-disclosure is the norm? We surveyed students about teammate preferences for team members based on information availability and Facebook membership. Students report a strong preference for teammates for whom there is information and Facebook participation.

General Series Editors: Gay Wilson Allen and Sculley Bradley Originally published between 1961 and 1984, and now available in paperback for the first time, the critically acclaimed Collected Writings of Walt Whitman captures every facet of one of America's most important poets. In discussing letter-writing, Whitman made his own views clear. Simplicity and naturalness were his guidelines. ”I like my letters to be personal—very personal—and then stop.“ The six volumes in The Correspondence comprise nearly 3,000 letters written over a half (...) century, revealing Whitman the person as no other documents can. This volume, together with Volume V, covers the last seven years of Whitman’s life, giving an almost day-by-day account of his long struggle with various ailments, his stoical acceptance of constant pain, but also his continuing energy. This period saw his supervision and publication of two complete editions of Leaves of Grass, as well as November Boughs and Good-bye My Fancy. Although Whitman himself admitted that many of his later poems were “pot boilers,” designed primarily to make money, his recognition and popularity continued to grow as his health declined. His poems were printed seemingly everywhere and the volume of critical commentary increased. Unlike many of his contemporaries, Whitman did not suffer from neglect of indifference. (shrink)

The purpose of this paper is to describe an empirical study aimed at examining whether a student’s competitiveness orientation in a negotiation class could be shifted to a more socially responsible collaborative orientation. Several subtle manipulations were made between two different sections of the same undergraduate negotiation class. Data on competitiveness, empathy and perspective taking were collected at the beginning and again at the conclusion of the class. While sample size limited the impact of the findings, the data suggested that (...) the manipulations may have had a positive effect. (shrink)

In classical Arabic philosophy, the topic of consciousness is commonly associated with Avicenna's ‘Flying Man’ thought experiment. But Avicenna's explorations of the nature of consciousness are not confined to the Flying Man, and he is by no means the only classical Islamic thinker to deem consciousness an important feature of our experience. Consciousness also plays a important role in the epistemology and moral psychology of Avicenna's intellectual rivals, the theologians (mutakallumūn), who represent important sources for Avicenna's own theorizing about consciousness. (...) And while Avicenna's philosophical successor and critic, Averroes, seems to banish consciousness from the core of his cognitive psychology, in doing so he seems to anticipate contemporary efforts to expand the scope of consciousness through the notion of the ‘extended’ mind. This paper examines the varieties of consciousness recognized by Avicenna and several other classical Islamic thinkers with a view to understanding the extent to which their accounts can be mapped on to some of the concepts of consciousness delineated by contemporary philosophers of mind. (shrink)

This chapter contains sections titled: Logic and language Psychology and metaphysics Political philosophy.

The concept of ‘‘certitude” is central in Arabic discussions of the theory of demonstration advanced by Aristotle in the Posterior Analytics. In the Arabic tradition it is ‘‘certitude,” rather than ‘‘knowledge”, that is usually identified as the end sought by demonstrations. Al-Fārābī himself devotes a short treatise, known as the Conditions of Certitude, to determining the criteria according to which a subject can claim to have absolute certitude of any proposition. In this article the author traces the roots of the (...) concept of certitude to the Arabic translation of the Posterior Analytics. She then offers a close reading of the text of al-Fārābī's Conditions and its parallels in his Epitome of the Posterior Analytics. She argues that the identification of certitude as a cognitive state distinct from knowledge enabled al-Fārābī to introduce a number of interesting and sometimes problematic innovations into Arabic epistemology. Foremost amongst his positive innovations is the recognition that contingent as well as necessary propositions allow for an attenuated form of certitude, and the introduction of reliabilism into the justification of claims to certitude. But al-Fārābī is also one of the first philosophers to articulate explicitly the idea that certitude must include an element of ‘‘knowing that one knows,” a controversial principle that tends to undermine both al-Fārābī’s reliabilism and his efforts to loosen some of the strictures in traditional Aristotelian epistemology. (shrink)

In classical Arabic philosophy, the topic of consciousness is commonly associated with Avicenna's ‘Flying Man’ thought experiment. But Avicenna's explorations of the nature of consciousness are not confined to the Flying Man, and he is by no means the only classical Islamic thinker to deem consciousness an important feature of our experience. Consciousness also plays a important role in the epistemology and moral psychology of Avicenna's intellectual rivals, the theologians (mutakallumūn), who represent important sources for Avicenna's own theorizing about consciousness. (...) And while Avicenna's philosophical successor and critic, Averroes, seems to banish consciousness from the core of his cognitive psychology, in doing so he seems to anticipate contemporary efforts to expand the scope of consciousness through the notion of the ‘extended’ mind. This paper examines the varieties of consciousness recognized by Avicenna and several other classical Islamic thinkers with a view to understanding the extent to which their accounts can be mapped on to some of the concepts of consciousness delineated by contemporary philosophers of mind. (shrink)

This book examines a widespread, and often misunderstood, doctrine within the medieval Aristotelian tradition, namely the inclusion of Aristotle's Rhetoric and Poetics within the scope of the Organon. It studies this doctrine, as presented by the Islamic philosophers Al- Fārābī, Avicenna, and Averroes, from a purely philosophical perspective, and argues that the logical construal of the arts of rhetoric and poetics is both interesting and illuminating. The book begins by examining some prevalent misconceptions regarding the logical interpretation of the Rhetoric (...) and Poetics. Chapter two considers the Greek background of the doctrine, first through an examination of the Aristotelian divisions of the sciences, and then through an examination of the beginnings of the logical classification of the Rhetoric and Poetics among the Greek commentators from the school of Alexandria. The remainder of the work is devoted to a detailed consideration of the Arabic philosophers' development of the doctrine, both their understanding of its general epistemological and logical underpinnings, and their elaboration of the specific logical structures upon which poetical and rhetorical discourse is based. Consideration is also given to the relationship between contemporary philosophical views of rhetoric and poetics, and the views of these medieval authors. (shrink)

Research on detrimental workplace behaviors has increased recently, predominantly focusing on justice issues. Research from the integrity testing literature, which is grounded in trait theory, has not received as much attention in the management literature. Trait theory, agency theory, and psychological contracts theory each have different predictions about employee performance that is harmful to the organization. While on the surface they appear contradictory, this paper describes how each can be integrated to increase our understanding of detrimental workplace behaviors.

One of the chief innovations in medieval adaptations of Aristotelian psychology was the expansion of Aristotle's notion of imagination orphantasiato include a variety of distinct perceptual powers known collectively as the internal senses. Amongst medieval philosophers in the Arabic world, Avicenna offers one of the most complex and sophisticated accounts of the internal senses. Within his list of internal senses, Avicenna includes a faculty known as “estimation”, to which various functions are assigned in a wide variety of contexts. Although many (...) philosophers in the Arabic world as well as in the Latin West accepted Avicenna's positing of an estimative faculty, Avicenna's best-known critics, al-Ghazâlî and Averroes, found Avicenna's arguments in support of a distinct estimative faculty problematic. For different reasons, both Averroes and Ghazâlî raised the basic question of whether one needed to posit a distinct faculty of estimation to supplement the perceptual abilities of the other internal senses, and whether the notion of an estimative power as defined by Avicenna was internally coherent. Such criticisms suggest that the Avicennian conception of estimation is not entirely unambiguous, and that a correct understanding of Avicenna's motivations for delineating an estimative power requires a careful study of the diverse activities assigned to it throughout Avicenna's philosophical writings. (shrink)

It is considered the right of children to have their pain managed effectively. Yet, despite extensive research findings, policy guidelines and practice standard recommendations for the optimal management of paediatric pain, clinical practices remain inadequate. Empirical evidence definitively shows that unrelieved pain in children has only harmful consequences, with no benefits. Contributing factors identified in this undermanaged pain include the significant role of nurses. Nursing attitudes and beliefs about children’s pain experiences, the relationships nurses share with children who are suffering, (...) and knowledge deficits in pain management practices are all shown to impact unresolved pain in children. In this article, a relational ethics perspective is used to explore the need for nurses to engage in authentic relationships with children who are experiencing pain, and to use evidence-based practices to manage that pain in order for this indefensible suffering of children to end. (shrink)

This article uses the NetCorps Jordan project as a case study of the ways in which Information Technology transforms social and economic life at the grass roots. Particular attention is paid to the role of gender in shaping such processes. In the end, this essay explores the motivations, the hopes and the results of one Arab country’s IT4 D experiment using the narratives of the participants as a guide. It is clear from the analysis below that culture, context and gender (...) play a significant role in who gets to do what with IT. (shrink)

Essays cover historical, sociological, psychological and anthropological approaches, ethics and politics, and the policy implications of the real and perceived differences between the sexes.

It has long been a truism of the history of philosophy that intentionality is an invention of the medieval period, and within this standard narrative, the central place of Arabic philosophy has always been acknowledged. Yet there are many misconceptions surrounding the theories of intentionality advanced by the two main Arabic thinkers whose works were available to the West, Avicenna and Averroes. In the first part of this paper I offer an overview of the general accounts of intentionality and intentional (...) being found in the linguistic, psychological, and metaphysical writings of Avicenna and Averroes, and I trace the terminology of “intentions” to a neglected passage from Avicenna’s logic. In the second part of the paper I examine the way that Avicenna and Averroes apply their general theories of intentionality to the realm of sense perception. I offer an explanation of why Avicenna might have chosen to denominate the objects of the internal sense faculty of estimation as “intentions”, and I explore the implications of Averroes’s decision to attribute intentionality to the external senses and the media of perception. (shrink)

Mr. Galanas, an eighty‐six‐year‐old man, intentionally shot himself in the chest and abdomen. Surprisingly, the bullet damaged only his distal pancreas and part of his colon, requiring a diverting colostomy to prevent leakage of bowel fluids into his abdomen. After being admitted, he lies intubated in the intensive care unit awaiting surgery to repair his colon. He is responsive but does not demonstrate clear decision‐making capacity. He grudgingly accepts pain medications but refuses antibiotics and antidepressants. He has a living will (...) that gives his wife durable power of attorney and also explicitly states a desire to refuse all medical interventions if he is permanently unconscious or in an end‐stage condition. Mrs. Galanas reports frequent conversations in which her husband said he would not want to be sustained on life support. She also says that he often mentioned he would not want an ostomy bag—a likely, albeit temporary, outcome of the proposed surgery. His physicians are nervous about withholding medical interventions when Mr. Galanas's injury is the result of a suicide attempt and his prognosis is good. Should the care team surgically repair his injured colon, regardless of the patient's capacity, his advance directive, and his wife's statement that he would not want surgery or other life‐sustaining treatment? (shrink)