In Europe ≈15,000 patients receive larval therapy for wound treatment annually. Over the past few years, clinical studies have demonstrated the success of larvae of Lucilia sericata as debridement agents. This is based on a combination of physical and biochemical actions. Laboratory investigations have advanced our understanding of the biochemical mechanisms underlying the beneficial effects of larval secretions, including removal of dead tissue, reduction of the bacterial burden, and promotion of tissue regeneration. The present article summarizes our current understanding of (...) the microbiological, immunological, and wound healing actions of larval therapy, and the molecules involved in these beneficial effects. Future studies will focus on the isolation, identification, and (pre)clinical testing of the effective molecules of L. sericata larvae. These molecules may be candidates for the development of new agents for the treatment of several infectious and inflammatory diseases, including chronic wounds. (shrink)

This article considers the state of research on the two-way relationship of causation between politics and war in ancient Athens from the attempted coup of Cylon in 632 BC to the violent overthrow of its democracy by the Macedonians in 322. Also canvassed is how a closer integration of Ancient History and Political Science can enhance the research of each discipline into the important problem of democracy's effect on war- making. Classical Athens is well known for its full development of (...) popular politics and its cultural revolution, which clearly was a dependent variable of the democracy. By contrast, few are aware of its contemporaneous military revolution, which saw the classical Athenians intensify the waging of war and gain an unrivalled record of military success and innovation. Although a prima facie case exists for these military changes being due to popular government, ancient historians have conducted very little research on the impact of democracy on war. In the last decade our discipline has also witnessed the collapse of the longstanding understanding of the affect of military changes on political developments in ancient Greece, which means we can no longer explain why Athenian democracy emerged and was consolidated during the classical period. For the sake of ameliorating this situation the article proposes new directions and a social-science approach for research into the military and non-military causes of Athenian democratisation and the relative effect of Athenian democracy on warfare. At a time when established democracies face complex challenges of foreign policy such research into the case study of ancient Athens is of real contemporary relevancy. (shrink)

Greg Anderson, The Athenian Experiment: Building an Imagined Political Community in Ancient Attica, 508-490 B.C. , xvii + 310 pp., 16 plates, $60/?37.50, ISBN 0 472 11320 8 . This article reviews the recent book of Greg Anderson and contributes to ongoing debates about the significance of Kleisthenes and the development of Athenian democracy.