The computational genomics community has come increasingly to rely on the methodology of creating annotations of scientific literature using terms from controlled structured vocabularies such as the Gene Ontology (GO). We here address the question of what such annotations signify and of how they are created by working biologists. Our goal is to promote a better understanding of how the results of experiments are captured in annotations in the hope that this will lead to better representations of biological reality through (...) both the annotation process and ontology development, and in more informed use of the GO resources by experimental scientists. (shrink)

Paul Virilio passed away on the 10th of September 2018. This article surveys his considerable legacy to cultural theory in order to locate a largely dormant contribution to questions of moral respo...

(1984). The projection argument in Galileo and Copernicus: Rhetorical strategy in the defence of the new system. Annals of Science: Vol. 41, No. 2, pp. 109-133.

Currently, the widely used notion of activity is increasingly present in computer science. However, because this notion is used in specific contexts, it becomes vague. Here, the notion of activity is scrutinized in various contexts and, accordingly, put in perspective. It is discussed through four scientific disciplines: computer science, biology, economics, and epistemology. The definition of activity usually used in simulation is extended to new qualitative and quantitative definitions. In computer science, biology and economics disciplines, the new simulation activity definition (...) is first applied critically. Then, activity is discussed generally. In epistemology, activity is discussed, in a prospective way, as a possible framework in models of human beliefs and knowledge. (shrink)

: Catholic teaching has no moral difficulties with research on stem cells derived from adult stem cells or fetal cord blood. The ethical problem comes with embryonic stem cells since their genesis involves the destruction of a human embryo. However, there seems to be significant promise of health benefits from such research. Although Catholic teaching does not permit any destruction of human embryos, the question remains whether researchers in a Catholic institution, or any researchers opposed to destruction of human embryos, (...) could participate in research on cultured embryonic stem cells, or whether a Catholic institution could use any therapy that ultimately results from such research. This position paper examines how such research could be conducted legitimately in a Catholic institution by using an ethical analysis involving a narrative context, the nature of the moral act, and the principle of material cooperation, along with references to significant ethical assessments. It also offers tentative guidelines that could be used by a Catholic institution in implementing such research. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps, and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may (...) freely copy and distribute this work, as no entity has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Early embryogenesis of Caenorhabditis elegans provides a striking example of the generation of polarity and the partitioning of cytoplasmic factors according to this polarity. Microfilaments (MFs) appear to play a critical role in these processes. By visualizing the distribution of MFs and by studying the consequences of disrupting MFs for short, defined periods during zygote development, we have generated some new ideas about when and how microfilaments function in the zygote.

It has been suggested that we turn to solar geoengineering to counter global warming, which would consequently transform the relationship of terrestrial plant-life to the sun. This is an article not about geoengineering as such, but instead what is called photosynethics, or, thinking about our moral relationship to the light – in particular, as it is mediated by plants. Working from within but then extending the idea of responsibility found in the work of Emmanuel Levinas, it is argued here that, (...) since the plant cultivates the conditions of life on earth by photosynthesis, its relationship to the sun is then a relation of giving to others that is properly moral. The plant’s existence is an exposure so out of kilter with human ways of understanding existence that it interrupts our own and brings us into a relation of responsibility. It is concluded that rather than redirecting the sun’s radiation, we should turn to plants to reconsider how we live with the light on a heating planet. This first means separating moral responsibility from human vision so that we might encounter light on its own terms, and not simply as an element of rationality or sentiment or discipline. (shrink)

This paper examines the prevalent assumption that when people interact online via proxies—avatars—they encounter each other. Through an exploration of the ontology of users and their avatars we argue that, contrary to the trend within current discussions of interaction online, this cannot be unproblematically assumed. If users could be considered in some sense identical to their avatars, then it would be clear how an encounter with an avatar could ground an encounter with another user. We therefore engage in a systematic (...) investigation of several conceptions of identity, concluding that in none of these senses can users and avatars be identified. We go on to explore how current accounts of identity-as-selfhood online might resolve this problem by appealing to narrativity or authorship, ultimately concluding that as these accounts stand they are unable to provide grounds for the claim that users encounter each other online and so supplementary work is required. (shrink)

Media analyses of the aesthetic presentation of news frequently and persuasively demonstrate the skewed ethics of news production, where those in need who are distant and dissimilar are often presented in ways that do not fully humanize their condition. However, it is argued here, they also locate too fully the locus of moral responsibility in the production and presentation of the media text. This article explores the moral demands inherent in two kinds of media presentation: the explicit focus on shock (...) and awe over intimacy; and minimal presentations that substitute bare information for affective stories. It is argued that in both cases a moral encounter with the other can be motivated despite the news presentation and it is concluded that an excessive emphasis on the role of the news in generating moral responsibility justifies a spectatorish inertia that should be resisted. (shrink)

Die Untersuchung verschiedener Spätwcrkc Lessmgs zeigt seine Tendenz, innerhalb des Textes von argumentativ-diskursiven, abstrakten Redeformen in fiktionale Erzählungen hinüberzuleiten. Diese Tendenz reflektiert das Problem der Erkenntnis und der Vermittlung transzendenter Wahrheiten.

This review of Medium, Messenger, Transmission outlines and introduces the media philosophy of Sybille Krämer. Her argument that communication initiates a relationship with the other as an ethical act is read alongside the work of Emmanuel Levinas, before exploring the impact of our contemporary obligation to be available for communication in working environments that seem not to encourage or instantiate this moral encounter.

The release of a reader’s edition of the critical text of Essays, First Series and Essays, Second Series, in which readers can trace Emerson’s growing awareness that his true interest is in the constitution of consciousness rather than in ontological questions, is a welcomed fulfillment of the promise of the textual “industry” of the last twenty-five years. The textual accuracy of the Harvard texts is documented in the fuller Collected Works of Ralph Waldo Emerson, where one can reconstruct copy-texts. While (...) even a serious student would find an accurate text without textual apparatus sufficient for all by the last stages of serious reading and thinking, the omission of the informational annotations of the Collecte Works edition could raise problems of interpretation, since Emerson’s particular sources often determine the direction toward which his striking word-plays point. The listing of parallel journal passages in the Collected Works is an even more important tool, which opens to the student of Emerson the extensive source-studies which went into the ongoing Lectures series and the now-completed Journals and Miscellaneous Notebooks series. (shrink)