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Dan Kabonge Kaye [7]Dan K. Kaye [1]
  1.  5
    Why ‘Understanding’ of Research May Not Be Necessary for Ethical Emergency Research.Dan Kabonge Kaye - 2020 - Philosophy, Ethics, and Humanities in Medicine 15 (1):1-8.
    Background Randomized controlled trials are central to generating knowledge about effectiveness of interventions as well as risk, protective and prognostic factors related to diseases in emergency newborn care. Whether prospective participants understand the purpose of research, and what they perceive as the influence of the context on their understanding of the informed consent process for RCTs in emergency obstetric and newborn care are not well documented. Methods Conceptual review. Discussion Research is necessary to identify how the illnesses may be prevented, (...)
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  2.  2
    Ethical Challenges of the Healthcare Transition to Adult Antiretroviral Therapy (ART) Clinics for Adolescents and Young People with HIV in Uganda.Dan Kabonge Kaye, Philippa Musoke, Eleanor Namusoke Magongo, Derrick Lusota Amooti, Sabrina Bakeera-Kitaka & Scovia Nalugo Mbalinda - 2021 - BMC Medical Ethics 22 (1):1-14.
    BackgroundWhereas many adolescents and young people with HIV require the transfer of care from paediatric/adolescent clinics to adult ART clinics, this transition is beset with a multitude of factors that have the potential to hinder or facilitate the process, thereby raising ethical challenges of the transition process. Decisions made regarding therapy, such as when and how to transition to adult HIV care, should consider ethical benefits and risks. Understanding and addressing ethical challenges in the healthcare transition could ensure a smooth (...)
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  3.  4
    Navigating Ethical Challenges of Conducting Randomized Clinical Trials on COVID-19.Dan Kabonge Kaye - 2022 - Philosophy, Ethics, and Humanities in Medicine 17 (1):1-11.
    BackgroundThe contemporary frameworks for clinical research require informed consent for research participation that includes disclosure of material information, comprehension of disclosed information and voluntary consent to research participation. There is thus an urgent need to test, and an ethical imperative, to test, modify or refine medications or healthcare plans that could reduce patient morbidity, lower healthcare costs or strengthen healthcare systems.MethodsConceptual review.DiscussionAlthough some allocation principles seem better than others, no single moral principle allocates interventions justly, necessitating combining the moral principles (...)
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  4.  8
    The Moral Imperative to Approve Pregnant Women’s Participation in Randomized Clinical Trials for Pregnancy and Newborn Complications.Dan Kabonge Kaye - 2019 - Philosophy, Ethics, and Humanities in Medicine 14 (1):1-11.
    Background There is longstanding consensus on the need to include pregnant women in research. The goal of clinical research is to find highly regulated, carefully controlled, morally responsible ways to generate evidence about how to effectively and safely prevent illness or treat sick people. This manuscripts present a conceptual analysis of the ethicality of clinical trials in 3 scenarios: where the pregnant is involved in clinical trials as a participant during pregnancy for data that addresses pregnancy complications, where the pregnant (...)
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  5.  5
    Ethical Tensions in the Informed Consent Process for Randomized Clinical Trials in Emergency Obstetric and Newborn Care in Low and Middle-Income Countries.Dan K. Kaye, Gershom Chongwe & Nelson K. Sewankambo - 2019 - BMC Medical Ethics 20 (1):27.
    There is unanimous agreement regarding the need to ethically conduct research for improving therapy for patients admitted to hospital with acute conditions, including in emergency obstetric care. We present a conceptual analysis of ethical tensions inherent in the informed consent process for randomized clinical trials for emergency obstetric care and suggest ways in which these could be mitigated. A valid consenting process, leading to an informed consent, is a cornerstone of this aspect necessary for preservation and maintenance of respect for (...)
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  6.  5
    Lay Persons’ Perception of the Requirements for Research in Emergency Obstetric and Newborn Care.Dan Kabonge Kaye - 2021 - BMC Medical Ethics 22 (1):1-13.
    Background Factors that could potentially act as facilitators and barriers to successful recruitment strategies in perinatal clinical trials are not well documented. The objective was to assess lay persons’ understanding of the informed consent for randomized clinical trial in emergency obstetric and newborn care. Methods This was a qualitative study conducted among survivors of severe obstetric complications who were attending the post-natal clinic of Kawempe National Referral Hospital, Uganda, 6–8 weeks after surviving severe obstetric complications during pregnancy or childbirth. The (...)
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  7.  2
    The Moral Imperative to Approve Pregnant Women’s Participation in Randomized Clinical Trials for Pregnancy and Newborn Complications.Dan Kabonge Kaye - forthcoming - Most Recent Articles: Philosophy, Ethics, and Humanities in Medicine.
    There is longstanding consensus on the need to include pregnant women in research. The goal of clinical research is to find highly regulated, carefully controlled, morally responsible ways to generate evidence...
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  8.  2
    The Moral Imperative to Approve Pregnant Women’s Participation in Randomized Clinical Trials for Pregnancy and Newborn Complications.Dan Kabonge Kaye - 2019 - Philosophy, Ethics, and Humanities in Medicine 14 (1):1-11.
    Background There is longstanding consensus on the need to include pregnant women in research. The goal of clinical research is to find highly regulated, carefully controlled, morally responsible ways to generate evidence about how to effectively and safely prevent illness or treat sick people. This manuscripts present a conceptual analysis of the ethicality of clinical trials in 3 scenarios: where the pregnant is involved in clinical trials as a participant during pregnancy for data that addresses pregnancy complications, where the pregnant (...)
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