Increasing ethical attention and debate is focusing on whether individuals who take part in clinical trials should be given access to post-trial care. However, the main focus of this debate has been upon drug trials undertaken in low-income settings. To broaden this debate, we report findings from interviews with individuals (n = 24) who participated in a clinical trial of a closed-loop system, which is a medical device under development for people with type 1 diabetes that automatically adjusts blood glucose (...) to help keep it within clinically recommended ranges. Individuals were recruited from UK sites and interviewed following trial close-out, at which point the closed-loop had been withdrawn. While individuals were stoical and accepting of the requirement to return the closed-loop, they also conveyed varying degrees of distress. Many described having relaxed diabetes management practices while using the closed-loop and having become deskilled as a consequence, which made reverting back to pre-trial regimens challenging. Participants also described unanticipated consequences arising from using a closed-loop. As well as deskilling, these included experiencing psychological and emotional benefits that could not be sustained after the closed-loop had been withdrawn and participants reevaluating their pre- and post-trial life in light of having used a closed-loop and now perceiving this life much more negatively. Participants also voiced frustrations about experiencing better blood glucose control using a closed-loop and then having to revert to using what they now saw as antiquated and imprecise self-management tools. We use these findings to argue that ethical debates about post-trial provisioning need to be broadened to consider potential psychological and emotional harms, and not just clinical harms, that may result from withdrawal of investigated treatments. We also suggest that individuals may benefit from information about potential nonclinical harms to help make informed decisions about trial participation. (shrink)

Athenagoras : philosopher and theologian -- Athenagoras' Corpus -- Athenagoras and contemporary theological and philosophical conversations -- How do we know about God? : epistemology -- What do we know about God? : first principles -- Subordinate topics -- Influences on Athenagoras -- Conclusions.

This book explores the life-history of the individual within the context of Plato’s social thought. The author examines Plato’s treatment of the principal crises in an individual life - birth, educational selection, sex, the individual’s contract with society, old age, death, and life after death – and provides an unprecedented analysis of Plato’s theory of genetics as it appears in the Timaeus. Comparisons are made with contemporary developments in anthropology, sociology, and comparative myth but without losing sight of the fact (...) that Plato, whilst having much to say to the modern world, was not a modern. (shrink)

The Sophists, the Socratics and the Cynics had one important characteristic in common: they mainly used spoken natural language as their instrument of investigation, and they were more concerned to discover human nature in its various practical manifestations than the facts of the physical world. The Sophists are too often remembered merely as the opponents of Socrates and Plato. Rankin discusses what social needs prompted the development of their theories and provided a market for their teaching. Five prominent Sophists – (...) Protagoras, Gorgias, Prodicus, Hippias and Thrasymachus – are looked at individually. The author discusses their origins, aims and arguments, and relates the issues they focussed on to debates apparent in contemporary literature. Sophists, Socratics and Cynics, first published in 1983, also traces the sophistic strand in Greek thought beyond the great barrier of Plato, emphasising continuity with the Cynics, and concludes with a look forward to Epicureans and Stoics. (shrink)