C. A. Campbell has for many years defended vigorously, and often persuasively, the following libertarian claims: that the libertarian concept of freedom of choice is meaningful; that the libertarian variety of freedom of choice is necessary for moral responsibility; and that the libertarian variety of freedom of choice is a reality. This paper will be concerned with Campbell's effort of will argument for the last claim.

BackgroundRandomized controlled trials are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative databases, have been proposed to address these challenges and are being rapidly adopted. These designs, however, are relatively recent innovations, and published RCT reports often do not describe important aspects of their methodology in a (...) standardized way. Our objective is to extend the Consolidated Standards of Reporting Trials statement with a consensus-driven reporting guideline for RCTs using cohorts and routinely collected health data.MethodsThe development of this CONSORT extension will consist of five phases. Phase 1 consisted of the project launch, including fundraising, the establishment of a research team, and development of a conceptual framework. In phase 2, a systematic review will be performed to identify publications that describe methods or reporting considerations for RCTs conducted using cohorts and routinely collected health data or that are protocols or report results from such RCTs. An initial “long list” of possible modifications to CONSORT checklist items and possible new items for the reporting guideline will be generated based on the Strengthening the Reporting of Observational Studies in Epidemiology and The REporting of studies Conducted using Observational Routinely-collected health Data statements. Additional possible modifications and new items will be identified based on the results of the systematic review. Phase 3 will consist of a three-round Delphi exercise with methods and content experts to evaluate the “long list” and generate a “short list” of key items. In phase 4, these items will serve as the basis for an in-person consensus meeting to finalize a core set of items to be included in the reporting guideline and checklist. Phase 5 will involve drafting the checklist and elaboration-explanation documents, and dissemination and implementation of the guideline.DiscussionDevelopment of this CONSORT extension will contribute to more transparent reporting of RCTs conducted using cohorts and routinely collected health data. (shrink)

The climate of epistemological opinion is rapidly changing in the direction of an increasing concern with the substantive results of the empirical sciences of man, such as psychology and biology. This change is of a comparatively recent date: as late as in 1964, Chauncey Wright’s seminal speculations on the biology of knowledge-processes were shrugged off by one commentator as “nineteenth-century impedimenta and paraphernalia”. Today, such a judgment seems strangely out of date. Our knowledge of man as an animal has been (...) broadened and deepened, both by the dramatic advances of molecular biology and by the recent appearance of the ‘sociobiology’ represented by Edward O. Wilson. To the philosopher, the question inevitably arises of how far this knowledge extends and, in particular, to what extent it can account for peculiarly human intellectual phenomena, such as the growth of scientific knowledge. The study of man as an animal and the study of man as a knower can no longer be simply assumed to be two distinct and separate departments of thought. (shrink)

The climate of epistemological opinion is rapidly changing in the direction of an increasing concern with the substantive results of the empirical sciences of man, such as psychology and biology. This change is of a comparatively recent date: as late as in 1964, Chauncey Wright’s seminal speculations on the biology of knowledge-processes were shrugged off by one commentator as “nineteenth-century impedimenta and paraphernalia”. Today, such a judgment seems strangely out of date. Our knowledge of man as an animal has been (...) broadened and deepened, both by the dramatic advances of molecular biology and by the recent appearance of the ‘sociobiology’ represented by Edward O. Wilson. To the philosopher, the question inevitably arises of how far this knowledge extends and, in particular, to what extent it can account for peculiarly human intellectual phenomena, such as the growth of scientific knowledge. The study of man as an animal and the study of man as a knower can no longer be simply assumed to be two distinct and separate departments of thought. (shrink)

We tested the hypothesis that choices determined by Type 1 processes are compelling because they are fluent, and for this reason they are less subject to analytic thinking than other answers. A total of 104 participants completed a modified version of Wason's selection task wherein they made decisions about one card at a time using a two-response paradigm. In this paradigm participants gave a fast, intuitive response, rated their feeling of rightness for that response, and were then allowed free time (...) to reconsider their answers. As we predicted, answers consistent with a matching heuristic were made more quickly than other answers, were given higher FOR ratings, and received less subsequent analysis as measured by rethinking time and the probability of changing answers. These data suggest that reasoning biases may be compelling because they are fluently generated; this is turn creates a strong FOR, which acts as a signal that further analysis is not necessary. (shrink)

This case describes an adolescent in a crisis of a chronic medical condition whose situation is complicated by substance abuse and mental illness. D. Micah Hester provides an analytic approach, teasing apart the multiple layers of medical, developmental, and moral issues at hand and describing possible responses and outcomes. Amy T. Campbell examines existing legal guidelines for adolescent decision making, arguing that greater space exists for clinical discretion in these matters than commonly thought. Cheryl D. Lew discusses the development (...) of agency in adolescent patients, the ideal of autonomous decision making in the context of impairment and chronic illness, and the obligation of healthcare teams to examine an adolescent patient’s decisions in relation to her identity. (shrink)

Donald Campbell has long advocated a naturalist epistemology based on a general selection theory, with the scope of knowledge restricted to vicarious adaptive processes. But being a vicariant is problematic because it involves an unexplained epistemic relation. We argue that this relation is to be explicated organizationally in terms of the regulation of behavior and internal state by the vicariant, but that Campbell's selectionist approach can give no satisfactory account of it because it is opaque to organization. We (...) show how organizational constraints and capacities are crucial to understanding both evolution and cognition and conclude with a proposal for an enriched, generalized model of evolutionary epistemology that places high-order regulatory organization at the center. (shrink)

Editors of Pliny's Naturalis Historia have not had to deplore the paucity of the MS. tradition, but rather its value; while MSS. belonging to the ordo recentiorum are numerous and fairly complete, those of the ordo uetustiorum are very few, and never contain more than a few books, often with considerable gaps. They are A ii 196–vi 51, M xi–xv, P and H parts of xviii, I xxiii, xxv, B xxxii–xxxvii . There are also some scattered fragments. Detlefsen indeed claimed (...) that the restoration of the original text of the N.H. is more difficult than that of any other Latin author owing to the mutilated and defective transmission of considerable parts. (shrink)

Editors of Pliny's Naturalis Historia have not had to deplore the paucity of the MS. tradition, but rather its value; while MSS. belonging to the ordo recentiorum are numerous and fairly complete, those of the ordo uetustiorum are very few, and never contain more than a few books, often with considerable gaps. They are A ii 196–vi 51, M xi–xv, P and H parts of xviii, I xxiii, xxv, B xxxii–xxxvii. There are also some scattered fragments. Detlefsen indeed claimed that (...) the restoration of the original text of the N.H. is more difficult than that of any other Latin author owing to the mutilated and defective transmission of considerable parts. (shrink)