PurposeTo evaluate the relationship between intraocular straylight perception and: (i) contrast sensitivity (CS), (ii) halo size, and (iii) hazard recognition distance, in the presence and absence of glare.Subjects and methodsParticipants were 15 (5 female) ophthalmologically healthy adults, aged 54.6–80.6 (median: 67.2) years. Intraocular straylight (log s) was measured using a straylight meter (C-Quant; Oculus GmbH, Wetzlar, Germany). CS with glare was measured clinically using the Optovist I device (Vistec Inc., Olching, Germany) and also within a driving simulator using Landolt Cs. (...) These were presented under both static or dynamic viewing conditions, and either with or without glare. Hazard detection distance was measured for simulated obstacles of varying contrast. For this, the participant was required to maintain a speed of 60 km/h within a custom-built nighttime driving simulator. Glare was simulated by LED arrays, moved by cable robots to mimic an oncoming car’s headlights. Halo size (“halometry”) was measured by moving Landolt Cs outward originating from the center of a static glare source. The outcome measure from “halometry” was the radius of the halo (angular extent, in degrees visual angle).ResultsThe correlation between intraocular straylight perception, log s, and hazard recognition distance under glare was poor for the low contrast obstacles (leading/subdominant eye: r = 0.27/r = 0.34). Conversely, log CS measured with glare strongly predicted hazard recognition distances under glare. This was true both when log CS was measured using a clinical device (Optovist I: r = 0.93) and within the driving simulator, under static (r = 0.69) and dynamic (r = 0.61) conditions, and also with “halometry” (r = 0.70). Glare reduced log CS and hazard recognition distance for almost all visual function parameters.ConclusionIntraocular straylight was a poor predictor of visual function and driving performance within this experiment. Conversely, CS was a strong predictor of both hazard recognition and halo extent. The presence of glare and motion lead to a degradation of CS in a driving simulator. Future studies are necessary to evaluate the effectiveness of all above-mentioned vision-related parameters for predicting fitness to drive under real-life conditions. (shrink)

According to the perspective developed in this article, widely shared, hegemonic cultural beliefs about gender and their impact in what the authors call “social relational” contexts are among the core components that maintain and change the gender system. When gender is salient in these ubiquitous contexts, cultural beliefs about gender function as part of the rules of the game, biasing the behaviors, performances, and evaluations of otherwise similar men and women in systematic ways that the authors specify. While the biasing (...) impact of gender beliefs may be small in any one instance, the consequences cumulate over individuals’ lives and result in substantially different outcomes for men and women. After describing this perspective, the authors show how it sheds newlight on some defining features of the gender system and illustrate its implications for research into specific questions about gender inequality. (shrink)

This research proposes and tests a new theoretical mechanism to account for a portion of the motherhood penalty in wages and related labor market outcomes. At least a portion of this penalty is attributable to discrimination based on the assumption that mothers are less competent and committed than other types of workers. But what happens when mothers definitively prove their competence and commitment? In this study, we examine whether mothers face discrimination in labor-market-type evaluations even when they provide indisputable evidence (...) that they are competent and committed to paid work. We test the hypothesis that evaluators discriminate against highly successful mothers by viewing them as less warm, less likable, and more interpersonally hostile than otherwise similar workers who are not mothers. The results support this “normative discrimination” hypothesis for female but not male evaluators. The findings have important implications for understanding the nature and persistence of discrimination toward mothers. (shrink)

We use Bub's (2016) correlation arrays and Pitowksy's (1989b) correlation polytopes to analyze an experimental setup due to Mermin (1981) for measurements on the singlet state of a pair of spin-12 particles. The class of correlations allowed by quantum mechanics in this setup is represented by an elliptope inscribed in a non-signaling cube. The class of correlations allowed by local hidden-variable theories is represented by a tetrahedron inscribed in this elliptope. We extend this analysis to pairs of (...) particles of arbitrary spin. The class of correlations allowed by quantum mechanics is still represented by the elliptope; the subclass of those allowed by local hidden-variable theories by polyhedra with increasing numbers of vertices and facets that get closer and closer to the elliptope. We use these results to advocate for an interpretation of quantum mechanics like Bub's. Probabilities and expectation values are primary in this interpretation. They are determined by inner products of vectors in Hilbert space. Such vectors do not themselves represent what is real in the quantum world. They encode families of probability distributions over values of different sets of observables. As in classical theory, these values ultimately represent what is real in the quantum world. Hilbert space puts constraints on possible combinations of such values, just as Minkowski space-time puts constraints on possible spatio-temporal constellations of events. Illustrating how generic such constraints are, the equation for the elliptope derived in this paper is a general constraint on correlation coefficients that can be found in older literature on statistics and probability theory. Yule (1896) already stated the constraint. De Finetti (1937) already gave it a geometrical interpretation. (shrink)

The accumulation and advancement of gender scholarship over past decades has led us to the point where gender scholars today can leverage our deep understanding of the reproduction of gender inequality to develop and test models of change. In this lecture, I present one such model designed to reduce the negative effects of stereotypic biases on women’s workplace outcomes. After synthesizing the literature on stereotyping and bias and showing the limits of past change efforts, I develop a “small wins” model (...) of change. Key to this model is that researchers work with teams of managers to produce concrete, implementable actions that produce visible results. I argue that small wins motivate further action and are the building blocks to larger organizational transformation. Preliminary results from several case studies show that this approach can produce important changes in the short run, such as reducing gender biases in workplace evaluations, and that these small wins can inspire longer run change, such as increases in the rate of hiring women. (shrink)

Just what you need to get up and running with Sony's new flagship dSLRs The Sony a77, with its 24.3 megapixel sensor, full HD video capability, and translucent mirror system, is poised to be Sony's flagship dSLR camera. With many of the same features but at a lower price point, the a65 is the economy version. This guide will cover all the important steps for getting the most from either model. It shows how to set up the camera to get (...) great shots immediately, explains all the controls and shooting modes, shows how to review images and make basic edits, and offers valuable advice on taking super photos using manual settings. Sony's new a65 and a77 dSLRs feature a huge megapixel sensor, HD video, generous ISO range, and the translucent mirror system unique to Sony This easy-to-follow guide helps you make the most of your investment with complete coverage of all the basic and advanced settings and shooting modes Covers shooting in auto mode, shooting HD video, and taking manual control over exposure, focus, and lighting Explains how to play back images and perform basic edits as well as how to manipulate flash, focus, and color to create top-quality photos With Sony a65/a77 For Dummies, bestselling photography author Robert Correll gives new Sony dSLR users confidence and helps them get everything they paid for in these exciting new Sony camera models. (shrink)

The ideal reference to Canon's EOS 5D Mark III for professionals and serious hobbyists The Canon EOS 5D Mark III offers professional photographers and advanced amateurs a wide range of top-flight dSLR capabilities. Canon users love For Dummies guides, with more than 100,000 copies of previous Canon camera guides sold. Like its predecessors, this one is packed with colorful examples that illustrate camera features and inspire you to capture your own super images. It explains the camera controls and menus, shows (...) you how to take full advantage of all the features, discusses output options and image editing, and much more. Geared to the needs of professional dSLR photographers and serious hobbyists, this guide covers all the features of the Canon EOS 5D Mark III Explores the camera body, menu screen, auto settings, and image settings Shows how to use the video modes, priority settings, manual settings, and focus modes to capture the best images Provides suggestions and inspiration with more than 300 full-color photos Covers image editing and output options Features tips, techniques, and projects to help you get the most from your camera's capabilities Canon EOS 5D Mark III For Dummies is the perfect partner for your new dSLR. (shrink)

This book will become your best friend! If you've just bought a dSLR, you can learn the basics in the first few minibooks.

Do you want dynamic photos that bring a scene to life? With this book, your camera, and a little practice, you'll be able to create amazing HDR images.

This paper serves three specific goals. First, it reports the development of an Indian Asian face set, to serve as a free resource for psychological research. Second, it examines whether the use of pre-tested U.S.-specific norms for stimulus selection or weighting may introduce experimental confounds in studies involving non-U.S. face stimuli and/or non-U.S. participants. Specifically, it examines whether subjective impressions of the face stimuli are culturally dependent, and the extent to which these impressions reflect social stereotypes and ingroup favoritism. Third, (...) the paper investigates whether differences in face familiarity impact accuracy in identifying face ethnicity. To this end, face images drawn from volunteers in India as well as a subset of Caucasian face images from the Chicago Face Database were presented to Indian and U.S. participants, and rated on a range of measures, such as perceived attractiveness, warmth, and social status. Results show significant differences in the overall valence of ratings of ingroup and outgroup faces. In addition, the impression ratings show minor differentiation along two basic stereotype dimensions, competence and trustworthiness, but not warmth. We also find participants to show significantly greater accuracy in correctly identifying the ethnicity of ingroup faces, relative to outgroup faces. This effect is found to be mediated by ingroup-outgroup differences in perceived group typicality of the target faces. Implications for research on intergroup relations in a cross-cultural context are discussed. (shrink)

Learn the intricacies of High Dynamic Range photography from experts and get feedback on your work High Dynamic Range photography offers a new range of creative possibilities to the photographer who is skilled in the technique. HDR requires specific camera skills as well as the use of specialized software, and the photographers who wrote this book are experts in both. They explain the process of shooting the same subject at different exposures, combining those shots into a single HDR image, fine-tuning (...) brightness and contrast, minimizing noise, layering images, and more, including creative techniques with Photoshop and Lightroom. You can submit your HDR images for feedback at photoworkshop.com. High Dynamic Range photography offers creative possibilities through specific camera and software techniques that produce highly detailed and imaginative images Two professional photographers team up to provide expert instruction in HDR camera and software techniques for those new to HDR Covers the latest software and concepts, a comprehensive exploration of HDR basics, various techniques for shooting and merging images, and creative tricks with Photoshop and Lightroom Lavishly illustrated with new examples and full of suggestions for developing a personal HDR style Students can upload their own images for feedback at photoworkshop.com Any photographer who is new to HDR will find this guide loaded with helpful instructions and encouraging advice. (shrink)

This book offers a thorough technical elaboration and philosophical defense of an objectivist informational interpretation of quantum mechanics according to which its novel content is located in its kinematical framework, that is, in how the theory describes systems independently of the specifics of their dynamics. -/- It will be of interest to researchers and students in the philosophy of physics and in theoretical physics with an interest in the foundations of quantum mechanics. Additionally, parts of the book may be used (...) as the basis for courses introducing non-physics majors to quantum mechanics, or for self-study by those outside of the university with an interest in quantum mechanics. (shrink)

The question of whether conscious experience is restricted by cognitive access and exhausted by report, or whether it overflows it—comprising more information than can be reported—is hotly debated. Recently, we provided evidence in favor of Overflow, showing that observers discriminated the color‐diversity (CD) of letters in an array, while their working‐memory and attention were dedicated to encoding and reporting a set of cued letters. An alternative interpretation is that CD‐discriminations do not entail conscious experience of the underlying colors. Here we (...) argue, based on conceptual considerations and consistency with neuroscience and phenomenology, in favor of the Overflow interpretation. (shrink)

This paper outlines a critique of the use of the genetic variance–covariance matrix (G), one of the central concepts in the modern study of natural selection and evolution. Specifically, I argue that for both conceptual and empirical reasons, studies of G cannot be used to elucidate so-called constraints on natural selection, nor can they be employed to detect or to measure past selection in natural populations – contrary to what assumed by most practicing biologists. I suggest that the search for (...) a general solution to the difficult problem of identifying causal structures given observed correlation’s has led evolutionary quantitative geneticists to substitute statistical modeling for the more difficult, but much more valuable, job of teasing apart the many possible causes underlying the action of natural selection. Hence, the entire evolutionary quantitative genetics research program may be in need of a fundamental reconsideration of its goals and how they correspond to the array of mathematical and experimental techniques normally employed by its practitioners. (shrink)

We argue that emotion cannot only be conceived of as a short-lived and intrapersonal phenomenon. Rather, based on five theoretical arguments, we propose that the social sharing of an emotional experience forms an integral part of the emotional processes. A series of six studies investigated different aspects of this hypothesis. Study 1 showed that an overwhelming majority of people reported sharing their emotional experiences and that the memories of these experiences tended to come back spontaneously to their consciousness. No difference (...) was found among emotions. Using a different procedure, Studies 2 and 3 replicated these findings in two different populations. In addition, these studies provided indications that women share their experiences with a wider array of individuals than do men. The first three studies did not find any differences among emotions, but they did not include shame. It could be argued that people are less inclined to socially share shame experiences which are typically elicited by breaking social rules. Study 4 specifically investigated this hypothesis. No differences among shame and other emotions were found except for the delay of the first sharing of the experience. Study 5 constituted a first investigation of whether the social sharing of emotion is also a significant process in now Western cultures. A comparison between Dutch and Surinamese people failed to reveal any significant difference. Based on the findings of the first five studies, a correlational model was designed in Study 6. It tested the interrelationships among disruptiveness of the emotion, social sharing, mental rumination, and recovery from the emotion disruption. A coherent pattern of findings emerged, showing that social sharing can be conceived as a bi-dimensional concept defined by features of amount and delay of sharing. In addition, both social sharing and mental rumination varied according to the disruptiveness of the emotion. Surprisingly, however, recovery could not be related to social sharing, mental rumination, or to the time elapsed since the episode. (shrink)

In the last fifteen years, there has been significant interest in studying the brain structures involved in moral judgments using novel techniques from neuroscience such as functional magnetic resonance imaging. Many people, including a number of philosophers, believe that results from neuroscience have the potential to settle seemingly intractable debates concerning the nature, practice, and reliability of moral judgments. This has led to a flurry of scientific and philosophical activities, resulting in the rapid growth of the new field of moral (...) neuroscience. There is now a vast array of ongoing scientific research devoted towards understanding the neural correlates of moral judgments, accompanied by a large philosophical literature aimed at interpreting and examining the methodology and the results of this research. This is the first volume to take stock of fifteen years of research of this fast-growing field of moral neuroscience and to recommend future directions for research. It features the most up-to-date research in this area, and it presents a wide variety of perspectives on this topic. (shrink)

Seven studies explored the empirical basis for claims that infants represent cardinal values of small sets of objects. Many studies investigating numerical ability did not properly control for continuous stimulus properties such as surface area, volume, contour length, or dimensions that correlate with these properties. Experiment 1 extended the standard habituation/dishabituation paradigm to a 1 vs 2 comparison with three-dimensional objects and confirmed that when number and total front surface area are confounded, infants discriminate the arrays. Experiment 2 revealed (...) that infants dishabituated to a change in front surface area but not to a change in number when the two variables were pitted against each other. Experiments 3 through 5 revealed no sensitivity to number when front surface area was controlled, and Experiments 6 and 7 extended this pattern of findings to the Wynn (1992) transformation task. Infants’ lack of a response to number, combined with their demonstrated sensitivity to one or more dimensions of continuous extent, supports the hypothesis that the representations subserving object-based attention, rather than those subserving enumeration, underlie performance in the above tasks. (shrink)

It is hypothesized that human faces judged to be attractive by people possess two features—averageness and symmetry—that promoted adaptive mate selection in human evolutionary history by way of production of offspring with parasite resistance. Facial composites made by combining individual faces are judged to be attractive, and more attractive than the majority of individual faces. The composites possess both symmetry and averageness of features. Facial averageness may reflect high individual protein heterozygosity and thus an array of proteins to which parasites (...) must adapt. Heterozygosity may be an important defense of long-lived hosts against parasites when it occurs in portions of the genome that do not code for the essential features of complex adaptations. In this case heterozygosity can create a hostile microenvironment for parasites without disrupting adaptation. Facial bilateral symmetry is hypothesized to affect positive beauty judgments because symmetry is a certification of overall phenotypic quality and developmental health, which may be importantly influenced by parasites. Certain secondary sexual traits are influenced by testosterone, a hormone that reduces immunocompetence. Symmetry and size of the secondary sexual traits of the face (e.g., cheek bones) are expected to correlate positively and advertise immunocompetence honestly and therefore to affect positive beauty judgments. Facial attractiveness is predicted to correlate with attractive, nonfacial secondary sexual traits; other predictions from the view that parasite-driven selection led to the evolution of psychological adaptations of human beauty perception are discussed. The view that human physical attractiveness and judgments about human physical attractiveness evolved in the context of parasite-driven selection leads to the hypothesis that both adults and children have a species-typical adaptation to the problem of identifying and favoring healthy individuals and avoiding parasite-susceptible individuals. It is proposed that this adaptation guides human decisions about nepotism and reciprocity in relation to physical attractiveness. (shrink)

In this paper we examine the role the Dutch gymnasium continues to play in the institutional maintenance of educational inequality. To that end we examine the relational and spatial features of state-sponsored elite education in the Dutch system: the unique identity the gymnasium seeks to cultivate; its value to its consumers; its geographic significance; and its market position amidst a growing array of other selective forms of schooling. We argue that there is a strong correlation between a higher social (...) class background and the concern to transmit one’s cultural habitus. We further speculate on the moral implications of state-sponsored elite education, both as it concerns the specific role of the gymnasium in the reproduction of social inequality as well as the curious tendency among its supporters to rationalise the necessity of its existence. (shrink)

I argue that racism is a form of necro-being entrapped in necro-tragedy. Necro-being, as I present it, is a condition that kills and prevents persons from being born. I defend a conception of tragedy: absolute necrotragedy; absolute irredeemable suffering in a non-moral universe. Explanations of racism are commonly subject to anomalies, for example, volitional accounts offer special desiderata to account for institutional racism; conversely for institutional accounts. I offer a way to see racism, given the existence of a vast array (...) of kinds of racism: a descriptive actuarial approach. The account is intended to avoid the quandaries and anomalies of ‘explanation.’ I use rational-intentional explanations (including accounts by Jorge Garcia and Charles Mills) and social kind racial realism as inadequate explanations and examples of explanations with anomalies. These accounts also help demonstrate that logical systems of racism are inadequate. All such accounts explain racism as a coherent system and offer correlative reasons for its wrongness. I consider death, mortality, morbidity, and irredeemable misery as primary indicators of racism across an array of types of racism globally: racial necro-being. (shrink)

After reviewing the literature on current knowledge about consciousness in humans, we present a state-of-the art discussion on consciousness and related key concepts in animals. Obviously much fewer publications are available on non-human species than on humans, most of them relating to laboratory or wild animal species, and only few to livestock species. Human consciousness is by definition subjective and private. Animal consciousness is usually assessed through behavioural performance. Behaviour involves a wide array of cognitive processes that have to be (...) assessed separately using specific experimental protocols. Accordingly, several processes indicative of the presence of consciousness are discussed: perception and cognition, awareness of the bodily-self, self-related knowledge of the environment (including social environment). When available, specific examples are given in livestock species. Next, we review the existing evidence regarding neuronal correlates of consciousness, and emphasize the difficulty of linking aspects of consciousness to specific neural structures across the phyla because high-level cognitive abilities may have evolved independently along evolution. Several mammalian brain structures (cortex and midbrain) are involved in the manifestations of consciousness, while the equivalent functional structures for birds and fishes would likely be the pallium/tectum and midbrain. Caution is required before excluding consciousness in species not having the same brain structures as the mammalian ones as different neural architectures may mediate comparable processes. Finally, specific neurophysiological mechanisms appear to be strongly linked to the emergence of consciousness, namely neural synchrony and neural feedback. Considering the limited amount of data available and the few animal species studied so far, we conclude that different manifestations of consciousness can be observed in animals but that further refinement is still needed to characterize their level and content in each species. Further research is required to clarify these issues, especially in livestock species. (shrink)

Because the term ‘epigenetics’ has been used in a wide array of inquires within the life-sciences, it has come to bear a significant number of meanings. And just as biologists cannot come to an univocal understanding on what epigenetics connotes, the effect that its study has had in challenging contemporary neo-Darwinian, genecentred paradigms is also unclear. Some scientists and philosophers go as far as to say epigenetics has eroded dichotomies central to modern western thought, such as nature and nurture, or (...) genotype and phenotype – but the matter ignites a great deal of controversy. What seems unquestionable, however, is that the notion that genetic material is a ‘programme’ that simply manifests itself in an external correlative, thus accounting for the development of a living organism, seems to have – at the very least – shifted. Rather than attempting to pinpoint the implications of epigenetics in contemporary biology, this article focuses on the ‘literary’ dimension of scientific debate: instability of meaning, metaphorical shifts, a redrawing of margins and limits. Furthermore, it will be argued that metaphor does not merely have a pedagogical value in the field but rather works proactively throughout the genesis, development and morphology of science and theory. By outlining a ‘literary’ dimension in discussions around genetics one can identify what Squier refers to as ‘the epistemological value of the imprecise’, which in the case of epigenetics seems to have jeopardized not only the boundaries between genes and their external correlatives, but even challenged the frontiers of traditional disciplinary discourse. (shrink)

What general conclusions can be drawn about the reception of zymase, its relation to the larger shift from a protoplasm to an enzyme theory of life, and its status as a social phenomenon?The most striking and to me unexpected pattern is the close correlation between attitude toward zymase and professional background. The disbelief of the fermentation technologists, Will, Delbrück, Wehmer, and even Stavenhagen, was as sharp and unanimous as the enthusiasm of the immunologists and enzymologists, Duclaux, Roux, Fernback, and (...) Bertrand, and of Pfeffer, the experimental plant physiologist. Other skeptics—Voit, Kupffer, and Fischer—were conservatives in traditional fields. In all these cases it seems clear that professional commitments and outlook profoundly influenced the reception of zymase.In some cases there is a correlation with a specific earlier statement favoring the protoplasm theory or predicting a fermentation enzyme. Reynolds Green is a striking case of both. In 1893 he stated his belief that life processes in higher plants and fungi were identical, both being mediated by protoplasm.109 Thus he claimed that digestion was not carried out by enzymes, as in higher animals, but by the whole protoplasm, and so too fermentation in yeast: “All the metabolic processes must be carried out in the unicellular organism in the same mass of protoplasm.”110 But Green also insisted that there was no essential difference between “organized” and “unorganized ferments”; enzymes were simply more highly differentiated and specialized forms of primitive protoplasm. He spoke of “the alcoholic ferment” (that is, enzyme), and of intracellular enzymes—very advanced beliefs for 1893. Thus it is understandable why Green saw no reason to doubt his first negative results with yeast juice, and rushed into print. But it is also understandable that he persisted and soon became an outspoken advocate of Buchner's view; like Wroblewski and Pfeffer, he had already accepted the idea of an intracellular fermentation enzyme.The physiological chemists also fit the pattern in a special way. Physiological chemistry is generally regarded as the source of biochemistry; indeed, many early biochemists were trained in physiological chemistry, and imbibed there a progressive interest in enzymes and metabolism. It is not surprising, therefore, that on the whole Neumeister, Madfadyen, Wroblewski, and Loew accepted cell-free fermentation. But what is surprising, and significant, is the diversity of opinion in this group, from Abeles' living protoplasm to Wroblewski's organized array of active proteins. The feelings of the physiological chemists were mixed, and there was enough of the old protoplasm view in Macfadyen's and even Wroblewski's views to allow Buchner to see them as attacks on zymase. The ideas of physiological chemistry were also changing; the idea of protoplasm was already adjusting to the new interest in enzymes in the early 1890's. But in contrast to immunochemistry, the change in physiological chemistry was gradual, uneven, undramatic, and relatively invisible. For the new biochemistry, the tradition of physiological chemistry was the source of traditional conservatism as well as of new ideas of enzymes.In general, then, I claim that it was not experimental facts that determined attitudes toward zymase so much as previous commitments, experience, and expectations. Initially, at least, zymase was less a determinant of opinion than a touchstone of pre-existing opinion. Like a prism, it revealed the spectrum of existing attitudes toward vital phenomena.Also relevant here is the fact that the experimental evidence was entirely ambiguous; the interpretation of Buchner's experiments with antiseptics or dried yeast depended entirely on how far one was willing to stretch the scope of the terms “protoplasm” and “enzyme”. Likewise, how important one judged the instability of zymase to be, or the low level of in vitro activity, depended largely on one's point of view. There was no crucial experiment, no certain proof. Logically zymase could be regarded as protoplasm. A. Fischer did so in 1900;111 Macfadyen was still wavering in 1907;112 and Beijerinck was holding out as late as 1916.113 There were undoubtedly others. Besides the special case of Reynolds Green and the technologists, there are no recorded cases of conversion.But if there was no evidence to convert a dedicated protoplasmist, there was plenty to encourage a dedicated belief in the enzyme theory, and that, I believe, is precisely what happened. The arguments of Buchner et al in support of zymase had the greatest effect not on the protoplasmists but on those who were already predisposed toward the biochemical view. The zymase debate enabled the emerging group of biochemists to recognizethemselves as a group with a community of out-look and objectives; it brought the issue of protoplasm vs. enzyme into the open and gave it a specific and concrete issue on which to turn. The debate sharpened the biochemists' awareness that their point of view was becoming the new mainstream of biochemical thought.All this of course had an important secondary effect on those who opposed the new view, or who were not immediately concerned with it. After the zymase debate, it would have been almost impossible to ignore the new ideas; the dramatic and wide publicity the debate enjoyed would have made it difficult not to take sides. Buchner's successful defense of zymase itself became an important influence on opinion; the new movement had to be looked at with respect. But the primary effect of the debate, I assert, was on those who were already inclined to the new view. The outcome was not a mass conversion of individuals, nor the ejection of one idea by another. The sides probably did not change much; the real change was in the way each side regarded itself and its place in history. The zymase debate may perhaps best be regarded as a process of selection. Buchner's party became aware of itself as the new progressive point of view, while those holding the traditional view could no longer expound it publicly without appearing obstinate or old-fashioned. Thus the way was clear for the gradually wider establishment of the new ideas, especially among the new generation of biochemists. In this specific sense, the acceptance of zymase was a social phenomenon.This way of looking at the zymase debate also illuminates its coincidence with the emergence of biochemistry as a profession. The new professional trappings and organizations were the social manifestation of the new self-awareness gained from the zymase controversy. One of the most important effects on those disposed toward the new view was the awareness of an intellectual community and of the need to give that community social forms. The almost mythical importance of Buchner's “victory” over the old protoplasm theory that later became current is readily understandable. It was a useful ideology for a group anxious to assert the novelty of their approach, a novelty which they in fact felt quite keenly.But if the primary effect of the zymase controversy was on those predisposed to accept zymase, then obviously the success of zymase depended on the fact that change had already begun to occur. Indeed, one of the most striking, and again unexpected, results of this study is the extent to which the importance of enzymes was already recognized in the early 1890's. The new immunology clearly pointed the way. Macfadyen and Hans Buchner were looking for active proteins inside the cell in 1893. Reynolds Green, Wroblewski, and Pfeffer had all anticipated the discovery of a fermentation enzyme. Other discoveries in enzymology in the 1890's pointed the same way.114 Moreover, it is clear from this study that the old protoplams theory was adapting to the new discoveries concerning the importance of enzymes. The sidechains of the old protoplasm molecule were simply reinterpreted as enzymes, as in Wroblewski's theory, for example, or in Paul Ehrlich's extremely influential “sidechain theory” of antibody formation (1897). Despite the later views of Hopkins et al., the old protoplasm and the new enzyme theories were not irreconcilable; a continuity of development had already begun when zymase came so dramatically on the scene. Buchner himself observed that the difference between the two views had become largely verbal; in retrospect we might say, not verbal, but social and historical. The gap between the continuous change in ideas and the contemporary feeling of sharply discontnuous change is a measure of the elusive but real social and historical implications of the zymase debate, of the demise of an old establishment, and the emergence of a new.In retrospect, then, it is clear that a trend was already under way in various quarters when zymase appeared. But it was still a collection of isolated and dispersed events. The zymase controversy made the trend visible and gave it a dramatic unity. The debate influenced those who had already begun to change. It was so effective because things had begun to change and because it coincided with the direction of that trend. (shrink)

Brain evolution is a complex weave of species similarities and differences, bound by diverse rules and principles. This book is a detailed examination of these principles, using data from a wide array of vertebrates but minimizing technical details and terminology. It is written for advanced undergraduates, graduate students, and more senior scientists who already know something about “the brain,” but want a deeper understanding of how diverse brains evolved. The book's central theme is that evolutionary changes in absolute brain size (...) tend to correlate with many other aspects of brain structure and function, including the proportional size of individual brain regions, their complexity, and their neuronal connections. To explain these correlations, the book delves into rules of brain development and asks how changes in brain structure impact function and behavior. Two chapters focus specifically on how mammal brains diverged from other brains and how Homo sapiens evolved a very large and “special” brain. Key Words: basal ganglia; cladistics; development; hippocampus; homology; lamination; mammal; neocortex; neuromere; parcellation; primate. (shrink)

The last decades of research have consistently found strong associations between divorce and adverse health outcomes among adults. However, limitations of a majority of this research include lack of “real-time” research, i.e., research employing data collected very shortly after juridical divorce where little or no separation periods have been effectuated, research employing thoroughly validated and population-normed measures against which study results can be compared, and research including a comprehensive array of previously researched sociodemographic- and divorce-related variables. The current cross-sectional study, (...) including 1,856 recently divorced Danes, was designed to bridge these important gaps in the literature. Mental and physical health were measured using the Short Form 36 -2. Analyses included correlational analyses, t-test comparisons, and hierarchical multiple regression analyses. The study found that the health-related quality of life of Danish divorcees was significantly worse than the comparative background population immediately following divorce. Across gender, higher levels of divorce conflict were found to predict worse mental health, and worse physical health for women, even when controlling for other socio-demographic variables and divorce characteristics. Among men, lower age and higher income predicted better physical health, while more children, more previous divorces, participant divorce initiation, new partner status, and lower levels of divorce conflict predicted better mental health. Among women, higher income, fewer previous divorces, new partner status, and lower levels of divorce conflict predicted better physical health while higher income, participant divorce initiation, new partner status, and lower levels of divorce conflict predicted better mental health. The findings underscore the relevance of providing assistance to divorcees who experience higher levels of divorce conflict immediately following divorce, in seeking to reduce potential long-term negative health effects of divorce. (shrink)

Complex diseases involve both a genetic component and a response to environmental factors or lifestyle changes. Recently, genome-wide association studies (GWAS) have succeeded in identifying hundreds of polymorphisms that are statistically associated with complex diseases. However, the association is usually weak and none of the associated allelic forms is either necessary or sufficient for the disease occurrence. We argue that this promotes a network view, centred on functional redundancy. We adapted reliability theory to the concerned sub-network, modelled as a parallel (...) array of functional modules. In our model, as long as one module remains active, the function correlated with the respective disease is ensured and disease does not occur. Genetic factors reduce the initial number of available modules while environment, contingent surroundings, personal history, epigenetics, and some intrinsic stochasticity influence their persistence time. This model reproduces age-specific incidence curves and explains the influence of environmental changes. It offers a new paradigm, according to which disease occurs due to a lack of functional elements, depending on many idiosyncratic factors. Genetic risk assessed from GWAS is only a statistical notion with no direct interpretation at the individual level. However, genomic profiling could be useful at population level in devising models to guide decisions in health care policy. (shrink)

How can adverse experiences in early life, such as maltreatment, exert such powerful negative effects on health decades later? The answer may lie in changes to DNA. New research suggests that exposure to stress can accelerate the erosion of DNA segments called telomeres. Shorter telomere length correlates with chronological age and also disease morbidity and mortality. Thus, telomere erosion is a potential mechanism linking childhood stress to health problems later in life. However, an array of mechanistic, methodological, and basic biological (...) questions must be addressed in order to translate telomere discoveries into clinical applications for monitoring health and predicting disease risk. This paper covers the current state of the science and lays out new research directions. (shrink)

I propose that human experience of matter provides the source domain for the metaphor that motivates the grammatical category of aspect in Russian. This model is a version of the universal TIME IS SPACE metaphor, according to which SITUATIONS ARE MATERIAL ENTITIES, and, more specifically, PERFECTIVE IS A DISCRETE SOLID OBJECT versus IMPERFECTIVE IS A FLUID SUBSTANCE. The contrast of discrete solid objects with fluid substances reveals a rich array of over a dozen properties; the isomorphism observed between those properties (...) and the complex uses of aspect in Russian is compelling. This model presents a more finely articulated account of Russian aspect than feature analysis can achieve. Although some of these properties overlap significantly with the count versus mass distinction often associated with aspect, the properties provide more detail and ground the metaphor to concrete experience. Properties of matter can be divided into three groups: inherent properties such as edges, shape, and integrity (which correspond to inherent situation aspect); interactional properties such as juxtaposition, dynamism, and salience (which correspond to discourse phenomena of aspect); and human interactional properties such as graspability and impact (which correspond to pragmatic phenomena of aspect). The interactional and human interactional properties can be used to motivate subjective construal, whereas the inherent properties serve as default motivators. The model will be demonstrated in detail using Russian data, followed by a survey comparing Russian with the other Slavic languages, which will show that deviations consist of either non-implementation of a given property, or the implementation of an inherent (default) property in place of an interactional or human interactional property. This model will be contrasted with a brief discussion of a selection of non-Slavic languages. The specific metaphor in this model does not apply beyond Slavic, but perhaps it will encourage investigation into the source domain of aspect in other languages. There appears to be a correlation between the relatively heavy morphological investment Slavic languages make in nominal individuation and the individuation of situations presented in this metaphorical model. (shrink)

In an effort to further explore ostensible macroscopic psychokinesis (macro-PK) effects like those previously reported by Batcheldor (1966), Bourgeois (1994), Owen and Sparrow (1976), and Ullman (2001) in a sitter group setting, the first author designed and conducted a series of fifteen experimental sessions in which sitters claiming exceptional abilities attempted to generate a pseudo-spirit named "Daniel," to whom physical phenomena were attributed. To explore possible physical correlates of macro-PK, two approaches to measurement were utilized. In the first, sample data (...) from a local random number generator (RNG) continuously running as part of the Global Consciousness Project were extracted and examined for statistical deviations from randomness occurring in conjunction with the sitter group sessions. In the second, the Multi-Energy Sensor Array (MESA) was used to collect onsite environmental data during one of the sessions. While displays of ostensible macro-PK were observed during several of the sitter group sessions, the RNG data did not show a significant overall correlation with the sessions. The MESA data indicated notable drops in infrared and visual light, as well as changes in DC magnetic field strength, that are comparable to those observed in field studies of haunts. Keywords: sitter groups--macroscopic psychokinesis (macro-PK)--random number generator (RNG)--Multi-Energy Sensor Array (MESA). (shrink)

Like most philosophers, Heidegger gave little attention to childhood, but his philosophical emphasis on pre-reflective practice and understanding seems uniquely qualified to help make sense of a child’s experience and development. Moreover, it seems to me that many central Heideggerian concepts are best defended, exemplified, and articulated by bringing child development into the discussion. A Heideggerain emphasis on pre-theoretical world-involvement opens up a rich array of phenomena for studying child development, which can improve upon standard theories that have over-emphasized exclusive (...) conditions or criteria. I begin by laying out some basic features of Heidegger’s conception of being-in-the-world as a preparation for understanding the world of the child. Then I will briefly discuss some of Heidegger’s remarks on childhood, followed by some reflections on language acquisition and the correlation of anxiety and meaning. (shrink)

Facial muscle activities are essential for the appearance and communication of human beings. Therefore, exploring the activation patterns of facial muscles can help understand facial neuromuscular disorders such as Bell’s palsy. Given the irregular shape of the facial muscles as well as their different locations, it should be difficult to detect the activities of whole facial muscles with a few electrodes. In this study, a high-density surface electromyogram system with 90 electrodes was used to record EMG signals of facial muscles (...) in both healthy and Bell’s palsy subjects when they did different facial movements. The electrodes were arranged in rectangular arrays covering the forehead and cheek regions of the face. The muscle activation patterns were shown on maps, which were constructed from the Root Mean Square values of all the 90-channel EMG recordings. The experimental results showed that the activation patterns of facial muscles were distinct during doing different facial movements and the activated muscle regions could be clearly observed. Moreover, two features of the activation patterns, 2D correlation coefficient and Centre of Gravity were extracted to quantify the spatial symmetry and the location of activated muscle regions respectively. Furthermore, the deviation of activated muscle regions on the paralyzed side of a face compared to the healthy side was quantified by calculating the distance between two sides of CGs. The results revealed that corr2 of the activated facial muscle region in Bell’s palsy subjects was significantly lower than that in healthy subjects, while CG distance of activated facial region in Bell’s palsy subjects was significantly higher than that in healthy subjects. The correlation between corr2 of these regions and Bell’s palsy [assessed by the Facial Nerve Grading Scale 2.0] was also significant in Bell’s palsy subjects. The spatial information on activated muscle regions may be useful in the diagnosis and treatment of Bell’s palsy in the future. (shrink)

High-spin states in the odd-odd N = Z nucleus Co-54 have been investigated by the fusion-evaporation reaction Si-28(S-32,1 alpha 1p1n)Co-54. Gamma-ray information gathered with the Ge detector array Gammasphere was correlated with evaporated particles detected in the charged particle detector system Microball and a 1 pi neutron detector array. A significantly extended excitation scheme of Co-54 is presented, which includes a candidate for the isospin T = 1, 6(+) state of the 1f(7/2)(-2) multiplet. The results are compared to large-scale shell-model (...) calculations in the fp shell. Effective interactions with and without isospin-breaking terms have been used to probe isospin symmetry and isospin mixing. A quest for deformed high-spin rotational cascades proved negative. This feature is discussed by means of cranking calculations. (shrink)

The unprecedented development of medical informatics is constantly transforming the concept of expertise in medical sciences in a way that has far-reaching consequences for both the theory of knowledge and the philosophy of informatics. Deep medicine is based on the assumption that medical diagnosis should take into account the wide array of possible health factors involved in the diagnostic process, such as not only genome analysis alone, but also the metabolome (analysis of all body metabolites important for e.g. drug-drug interactions), (...) microbiome (i.e. analysis of all bodily microorganisms interacting with host cells) or exposome (analysis of all environmental factors triggering potentially harmful cell mutations, such as UV radiation, heavy metals, various carcinogens, etc.). Deep data analysis is of tantamount importance for personalized diagnosis but, at the same time, hardly achievable by a regular human being. However, adequately designed artificial intelligence (e.g. a deep neural network) can undeniably be of great help for finding correlations between symptoms and underlying diseases. Nowadays AI applies to nearly every aspect of medicine, starting from the data analysis of scientific literature, through the diagnostic process, to the act of communication between physicians and their patients. Medical image processing algorithms greatly enhance the chances of successful recognition of melanoma or intestinal polyps. Communication tools designed for physicians use techniques known from social media to provide users with an opportunity to consult the case with colleagues from the same discipline. Natural language processing tools significantly improve doctor-patient communication by the automation of note-taking. Is this enough to support the claim that the non-epistemic competences in medicine are becoming more and more important? Can we attribute expertise only to a person? How is medical informatics changing the way most people usually understand human-computer interactions? (shrink)

Eukaryotes organize certain chromosomal intervals into domains capable of si lencing most genes. Examples of silencing domains include the HML/HMR loci and subtelomeric chromatin in yeast, the Barr body X chromosome in mammals, and the pericentric heterochromatin of Drosophila. Silencing chromatin is often correlated with more regularized nucleosomal array than that found in active chromatin, and transcriptional activators appear to be missing from their target sites in silent chromatin. In Drosophila, gene silencing by heterochromatin is often variegated, indicating that a (...) gene may escape silencing in some cells. In a recent study, Ahmad and Henikoff(1) show that a yeast activator can compete successfully with Drosophila heterochromatic silencing factors for target sites in DNA. This competition, together with developmental change in the stability of heterochromatin itself, decides the transcriptional state for a gene subject to heterochromatin repression. BioEssays 23:767–771, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Introduction of human plasma protein genes into the mouse genome to produce transgenic mice furnishes an in vivo model for correlating chromosomal DNA sequences with developmental and tissue‐specific expression. The liver produces an array of plasma proteins that circulate throughout the body contributing to homeostasis. Non‐hepatic tissue sites of synthesis have been identified where a local provision of plasma proteins in needed. Analysis of expression of human plasma protein genes in ageing transgenic mice appears especialy promising in identifying DNA sequences (...) that respond to environmental adversities such as inflammatory factors, hormonal changes and metal toxicity. The results indicate that human genes encoding and controlling liver plasma proteins serve as useful models for studying genetic regulation in the background of development and ageing. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Art and Evolution:Spiegelman's The Narrative CorpseBrian BoydIHas art evolved, like opposable thumbs and the whites of our eyes? If it has, will knowing so help us understand better not just art in general but particular works, even works of avant-garde art? Over recent decades many have come to accept that not only have humans evolved from other animals but that many features of their minds and behavior can be (...) explained by the deep past of evolution.1 Yet art remains a puzzle for biocultural analysis. How can we explain art in the hard-nosed terms of biological advantage, especially if it lacks analogies or precursors in other species and seems so pleasurably part of being distinctly human?2Nevertheless we have good reasons to examine whether art might be an adaptation. All cognitively normal individuals in all known societies engage in some form of art, actively or at least passively: music and dance, story, visual art. No one has to be pressured into listening to music on a radio or an iPod. And like language but unlike reading and writing, art develops reliably to a basic level without special training.Art could be what evolutionary biologists call a byproduct, a mere side-effect of our bigger brains or of culture. Yet that seems unlikely. Byproducts by definition do not offer advantages in terms of survival and reproduction: a bodily or behavioral feature whose design offers such advantages we classify as an adaptation. But if art were a byproduct, if it offered on average no advantage in terms of survival and reproduction, many generations of intense evolutionary competition would have eliminated it. If art offered no benefits but exacted the costs it does in time, [End Page 31] energy and resources, it would over many generations have been selected against through the superior fitness of those less inclined to pay such costs, those who preferred to devote their time and energy to securing material or social advantage or simply to save energy by resting.We can understand art in all its varieties, I suggest, as cognitive play with pattern, with multiple, high-intensity patterns. Play exists throughout much of the animal kingdom: in all mammals in which it has been looked for, in birds, and even in invertebrates like octopi. Play, like sleep and dreaming, puzzles and fascinates biologists because it is so widespread and so highly conserved (evolutionary lineages in which play has arisen do not lose it as they continue to evolve) that it must fulfill some function, because it has high costs in energy and risk, and because its functions are not as evident as those of "serious" behavior.3The amount of play in a species correlates highly with the flexibility of its behavior. In all species in which it occurs, play seems remarkably self-rewarding. Animals like pigs and rats play compulsively. In fact this seems the core of play: the self-rewarding nature of play makes animals engage in exuberant, intense behaviors that, under conditions of relative security, allow them to extend their capacities and improve their competence in situations of minimal risk. The skills honed will prove of advantage in real world situations where it is too late to learn on the job, in situations like fight or flight. Because play is compulsive, animals engage in it again and again, incrementally altering their neural wiring, strengthening and speeding up synaptic pathways, improving their capacity and performance.Humans uniquely inhabit what has been called "the cognitive niche":4 we gain most of our advantages from intelligence. We have an appetite for information, and especially for pattern, for information that falls into meaningful arrays from which we can make rich inferences. We therefore like bright, distinct colors, crisp outlines, complex shape or surface design: think of our special fondness for butterflies and flowers. And we have an appetite for open-ended pattern, new kinds of patterns, not only the patterns we have evolved to detect automatically. Vervet monkeys signal to one another in different ways when they see snakes, or leopards, or eagles, because they need to react in different ways to different threats, but they never learn to associate... (shrink)

Music training is associated with enhanced executive function but little is known about the extent to which harmonic aspects of musical training are associated with components of executive function. In the current study, an array of cognitive tests associated with one or more components of executive function, was administered to young adult musicians and non-musicians. To investigate how harmonic aspects of musical training relate to executive function, a test of the ability to compose a four-part harmony was developed and administered (...) to musicians. We tested the working hypothesis that musicians would outperform non-musicians on measures of executive function, and that among musicians, the ability to harmonize would correlate positively with measures of executive function. Results indicate that musicians outperformed non-musicians on the Tower of London task, a measure of planning and problem-solving. Group differences were not detected on tasks more selective for inhibitory control, conflict resolution, or working memory. Among musicians, scores on the harmony assessment were positively correlated with performance of the Tower of London task. Taken together, the current results support a strong relationship between musicianship and planning and problem solving abilities, and indicate that the ability to harmonize is associated with components of executive function contributing to planning and problem solving. (shrink)

The most pressing issues of the twenty-first century—climate change and persistent hunger in a world of food surpluses, to name only two—are not problems that can be solved from within individual disciplines, nation-states, or cultural perspectives. They are predicaments that can only be resolved by generating sustained and globally robust coordination across value systems. The scale of the problems and necessity for coordinated global solutions signal a world historical transit as momentous as the Industrial Revolution: a transition from the predominance (...) of technical knowledge to that of ethical deliberation. This volume brings together leading thinkers from around the world to deliberate on how best to correlate worth (value) with what is worthwhile (values), pairing human prosperity with personal, environmental, and spiritual flourishing in a world of differing visions of what constitutes a moral life. Especially in the aftermath of what is now being called the Great Recession, awareness has mounted of the imperative to question the modern divorce of economics from ethics. While the domains of economics and ethics were from antiquity through at least the eighteenth century understood in many cultures to be coterminous and mutually entailing, the modern assumption has been that the goal of maximizing human prosperity and the aim of justly enhancing our lives as persons and as communities were functionally and practically distinct. Working from a wide array of perspectives, the contributors to this volume offer a set of challenges to the assumed independence of the quantitative and qualitative dimensions of human and planetary well-being. Reflecting on the complex interrelationship among economics, justice, and equity, the book resists "one size fits all" approaches and struggles to revitalize the marriage of economics and ethics by activating cultural differences as the basis of mutual contribution to shared human flourishing. The publication of this important collection will stimulate or extend critical debates among scholars and students working in a number of disciplines in the social sciences and humanities, including philosophy, history, environmental studies, economics, and law. Contributors: Roger T. Ames, James Behuniak Jr., Steve Bein, Nalini Bhushan, Purushottama Bilimoria, Steven Burik, Amita Chatterjee, Baoyan Cheng, Gordon Davis, Jay L. Garfield, Steven F. Geisz, Peter D. Hershock, Larry A. Hickman, Kathleen M. Higgins, Heidi M. Hurd, Thomas P. Kasulis, Workineh Kelbessa, Lori Keleher, Oliver Leaman, James McRae, Jin Y. Park, James Peterman, Naoko Saito, May Sim, Robert Smid, Paul Standish, Kenneth W. Stikkers, Karsten J. Struhl, Meera Sushila Viswanathan, Wu Shiu- Ching, Xu Di, T. Yamauchi, Yang Liuxin. (shrink)

O Brasil é o país com a maior população católica. A evolução de variáveis socioeconômicas na década de 1990, aí incluindo casamentos, fertilidade, renda, moradia entre outras, revelam que nenhuma mudou tanto quanto a composição religiosa da população brasileira. O Censo é a base de dados mais usada nos estudos no tema, porém, as estatísticas estão hoje paradas no Censo 2000. A Pesquisa de Orçamentos Familiares 2009 – POF/IBGE permite medir a religiosidade brasileira recente detalhando subgrupos religiosos com classificação comparável (...) a do Censo e possibilidade de cruzamentos com uma gama maior de variáveis. Este estudo processa microdados da POF de 2003 e 2009, quando o contexto econômico difere das décadas anteriores, permitindo estudar as relações entre economia e religiosidade num contexto de expansão. Mostramos que: i) há velocidade de queda do catolicismo dez vezes mais rápida do que a observada entre 1872 e 1980, mas similar à dos anos 1990, embora as novas filiações sejam não apenas nos grupos evangélicos pentecostais, mas mais nos protestantes tradicionais; ii) ao contrário dos países europeus mais católicos que vivem contração econômica (PIIGS), as localidades brasileiras mais católicas vivem expansão mais forte que as demais; iii) os brasileiros se mostram na mediana de frequência a cultos religiosos em 150 países; iv) as mulheres, embora mais religiosas que os homens, tornaram-se menos católicas; v) os jovens mostram uma fuga mais acelerada do catolicismo. Palavras-chave: Religião. Economia. Max Weber. Mapa das Religiões no Brasil.Brazil is the country with the biggest Catholic population in the world. The evolution of socio-economic variables during the 1990s such as marriage, fertility, incomes, housing among others, revealed that no other variable changed as much as the religious composition of Brazilian population. Demographic Census is the mostly widely used survey in religious studies. However, these statistics are today only available until 2000. Microdata from national Family Expenditure Surveys (POF/IBGE) allow us to measure the recent Brazilian religious evolution by detailing religious subgroups and also by exploring a richer array of correlated variables. This study processes microdata from POF in 2003 and 2009 when the economic context differs from the previous decades. It allows us to study the relation between economy and religion during a boom. This article aims to show that: i) The speed of the fall in Catholicism in Brazil is two times faster than the one observed in 1990, although similar to the one observed in the 1990s; the destinies of the Catholics however are less the Pentecostal Evangelicals and more the Traditional Protestants. ii) In contrast to major European Catholic countries that are facing a recession, the Brazilian localities with a catholic population have experienced an economic expansion. iii) Brazilians are on the World median in terms of attendance to religious activities. iv) Although females are more religious than males, they are less catholic. v) There is a faster reduction of Catholics among the youth in Brazil. Key words: Religion. Economy. Max Weber. Maps of Religions in Brazil. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.2 (2003) 415-427 [Access article in PDF] Wisdom, Wine, and Wonder-Lust in Plato's Symposium M. Andrew Holowchak PLATO EMPLOYS A VARIETY of literary and philosophical tools in Symposium to show how eroticism, properly understood, is linked to the good life. These have been a matter of great debate among scholars. Cornford, for instance, argues that Symposium must be read along with Republic, in that the latter (...) examines mostly the lower education of gymnastics and music (the "lesser mysteries"), while the former elucidates principally the higher education of philosophers (the "greater mysteries"). 1 Thus, stylistic differences correspond to differences in philosophical aims between the two works. Neumann says that Diotima's teaching is essentially sophistic. Eros by nature aims at the good without the "guidance of reason," which subserves eros. There is no need of conceptual oneness with the good as an independent formal entity, for the aim is reproduction is "always the particular good of a particular being." 2 Dover states that Symposium presents a consilience of reason and desire, which then continually reinforce each other, through a quest for good, which, if reached, is a fusion of reason and desire. Eros, then, is the cosmic force that "propels us on that road." 3 Bretlinger says that the eulogies of Symposium proceed in the manner of the Dionysian cycle of birth, struggle, death, and rebirth. 4 Markus maintains that the confusion of philosophical and literary exposition [End Page 415] and aim is a result of Plato insisting on a philosophy of love, based on eros, that greatly transcends eros in interest and scope. 5 Socrates' own perplexity in the dialogue as well as his insistence that he knows what he is talking about are perfect illustrations of a dialectical growth that eventually even transcends language. In short, the literary style mimics the philosophical maturation and understanding of Socrates' transcendent path. Thus, scholars themselves are far from general consensus on just what Plato was trying to do in this work.This difficulty is compounded by there being, as Dover observes, "so much unjustified and implausible assertion and so little rigorous argument." 6 These are reasons enough why many philosophers neglect the work. The problem is that in Symposium the rich philosophy of love that Plato expounds is nearly eclipsed by his multifold array and skillful use of literary tools. This makes bringing to light the philosophical merits of the work a much more difficult task than with other works. In consequence, a precise articulation of Plato's own thoughts on love seems an impossible task, or nearly so.In this article, I argue that Plato's philosophy of love unfolds primarily, though not exclusively, through his exposition of two sets of erotic contrasts: one concerning the proper method of eulogizing (rhetoric versus Socratic dialectic, Socratic dialectic versus "Platonic" eroticism); another concerning character (Socrates versus Alcibiades). If so, then Symposium distinguishes itself from the ethically driven, "Socratic" dialogues of Platoin two ways. First, not only does Plato in Symposium appeal to a much broader spectrum of philosophical interests, he also gives a non-dialectical account of love that is passed on to the symposiasts through Socrates qua "pupil" (and messenger) of the priestess Diotima. Second, in Symposium, Plato uses Socrates the man, not Socrates the dialectician, as a model of excellence of character in order to illustrate the very ideals sketched within the work. I A correlate of my thesis is that Symposium itself reads like an act of copulation that climaxes both in literary and philosophical senses. On the one hand, Plato artfully builds sexual tension through the story line. First, Socrates delays in seeing the Lenaian victor Agathon by one day. This lends itself to erotic frustration both in the obvious sense of Socrates not being able to see the handsome young orator immediately after his success and in terms of Socrates having to put off practice of [End Page 416] his true love—philosophy. Second, when he does go to see Agathon, Socrates' preparation is uncommon: he bathes and even puts on sandals. 7 Furthermore... (shrink)

Haunted People Syndrome denotes individuals who recurrently report various “supernatural” encounters in everyday settings ostensibly due to heightened somatic-sensory sensitivities to dis-ease states, which are contextualized by paranormal beliefs and reinforced by perceptual contagion effects. This view helps to explain why these anomalous experiences often appear to be idioms of stress or trauma. We tested the validity and practical utility of the HP-S concept in an empirical study of an active and reportedly intense ghostly episode that was a clinical referral. (...) The case centered on the life story of the primary percipient, a retired female healthcare worker. Secondary percipients included her husband and adult daughter, all of whom reported an array of benign and threatening anomalies across five successive residences. Guided by prior research, we administered the family online measures of transliminality, sensory-processing sensitivity, paranormal belief, locus of control, desirability for control, and a standardized checklist of haunt-type phenomena. The primary percipient also completed a measure of adverse childhood events and supplied an event diary of her anomalous experiences. We found reasonably consistent support for HP-S from a set of quantitative observations that compared five proposed syndrome features against the family members’ psychometric profiles and the structure and contents of their anomalous experiences. Specifically, the reported anomalies both correlated with the family’s scores on transliminality and paranormal belief, as well as elicited attributions and reaction patterns aligned with threat detection. There was also some evidence of perceptual congruency among the family members’ anomalous experiences. Putative psi cannot be ruled out, but we conclude that the family’s ordeal fundamentally involved the symptoms and manifestations of thin mental boundary functioning in the face of unfavorable circumstances or overstimulating environments and subsequently acerbated by poor emotion regulation, histrionic and catastrophizing reactions, and active confirmation biases. (shrink)

Although DNA microarrays are now widely used in research settings, they have been slow to penetrate clinical practice in spite of their apparent advantages. This is due to the very different requirements for a clinical test in contrast to a research tool, and to a strict necessity for demonstrated clinical utility. There is a clear differentiation between two types of DNA array tests: “genomic” diagnostics, developed to ascertain the presence or absence of mutations, deletions or duplications, and for which clinical (...) evidence is already established, and tests using expression profiling for prognosis or predictive purposes, in which case the clinical correlate must be proven. Most array diagnostics currently used belong, understandably, to the “genomic” variety. It is to be expected that future improvements in tailored technology, as well as a logical trend towards measuring an ever‐increasing number of parameters, will ensure an important diagnostic role for DNA arrays in the coming decade. BioEssays 29:699–705, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Large numbers of cells with unique neuronal specificity are generated during development of the central nervous system of animals. Here we discuss the events that generate cell diversity during early development of the ventral nerve cord of different arthropod groups. Neural precursors are generated in a spatial array in the epithelium of each hemisegment over a period of time. Spatial cues within the epithelium are thought to evolve as embryogenesis proceeds. This spatiotemporal information might generate diversity among the neural precursors (...) in all arthropod groups, although the mechanisms regulating the positioning of individual precursors have diverged. However, distinct strategies for the generation of neuronal diversity have evolved in the different arthropod lineages that appear to correlate with specific modes of ontogenesis. We hypothesize that an evolutionary trend towards reduced cell numbers and possibly rapid embryogenesis in insects has culminated in the appearance of stereotyped neuroblast lineages. BioEssays 27:874–883, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

With a vast majority of the land in the Driftless Region of the Midwestern United States dedicated to agricultural production, the future of farming has significant economic, social, recreational, agricultural, and ecological implications. An important literature stream has developed on ways agriculture can change to impact both human and ecological communities positively. In this study, we examine the processes and extent to which community narratives assert and inform regional identities that shape the meaning of being a good farmer. Using a (...) mixed methods approach, we examine what farmers consider good farming and how they utilize community narratives to assert their perspective of good farming. Employing a correlational analysis, we examined the relative importance of the four dimensions of good farming (productivist, conservationist, civic-minded, and naturalist). In addition, we used narrative analysis to explore the development of community narratives that assert a multi-dimensional view of good farming. Data for this study was collected through 21 semi-structured interviews with farmers, two focus groups of farmers, and a survey of farmers with 82 survey participants. The mean scores for conservationist, civic-minded, and naturalist dimensions were significantly higher than those for productivists. There was no significant correlation between the productivists dimension and the three other dimensions of good farming. Through analysis of transcripts, we identified a community narrative that actively problematized a dominant cultural narrative centered on production agriculture. Collectively, a community narrative is emerging in the Driftless Region that sought to normalize agricultural practices that promote profitable farms, vibrant communities, and a wide array of ecosystem services. (shrink)