Derk Pereboom has posed an empirical objection to agent-causal libertarianism: The best empirically confirmed scientific theories feature physical laws predicting no long-run deviations from fixed conditional frequencies that govern events. If agent-causal libertarianism were true, however, then it would be virtually certain, absent ‘wild coincidences’, that such long-run deviations would occur. So, current empirical evidence makes agent-causal libertarianism unlikely. This paper formulates Pereboom’s ‘Problem of Wild Coincidences’ as a five-step argument and considers two recent responses. Then, it offers (...) a different response: The Problem of Wild Coincidences does not show that current empirical evidence makes agent-causal libertarianism unlikely, even if all events are governed by physical laws featuring fixed long-run conditional frequencies and even if agents can ‘overrule’ normal physical laws. (shrink)

The original article has been corrected. Figures 1 and 2 have been replaced. During typesetting of the article, one of the five steps in section 4 was removed.

The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

Tracing a path opened by an enigmatic reference in Reiner Schürmann’s dissertation to the symbol of water in James Baldwin’s, this essay follows the thinking of Schürmann and Baldwin to the tragic denial that perverts the ideals of the United States from the moment of its founding. Drawing on Schürmann’s imperative hermeneutics, we attend to Baldwin’s essays from the 1960s as they call white citizens of the United States to take on the “hideously difficult” task of achieving our identity as (...) a nation by facing our history and transforming ourselves as human beings. The symbols of water, fire, and love point us to new ways of existing rooted in practices of love—sensual releasement, ethical candor, and ethical imagination—that just might enable us to create a more perfect union. (shrink)

Despite the emphasis on moral intuition in the research literature, little attention has been given to the ways in which moral intuition can be educated within management settings (Dane & Pratt 2007). In this paper, I discuss an experiential learning approach that links Robin Hogarth’s (2001, 2008) work on the learning of intuition with Mary Gentile’s (2010) educational program on values-based leadership, Giving Voice To Values (GVV). Building on Hogarth’s proposal that intuitions are primarily acquired and thus shaped by our (...) experiences, GVV offers a pedagogical framework for reflective, experiential learning. Specific attention is given to the themes of learning environments, how these structures shape intuitions, and how students can identify these structures using the GVV emphasis on examination of past experiences. (shrink)

Despite the emphasis on moral intuition in the research literature, little attention has been given to the ways in which moral intuition can be educated within management settings. In this paper, I discuss an experiential learning approach that links Robin Hogarth’s work on the learning of intuition with Mary Gentile’s educational program on values-based leadership, Giving Voice To Values. Building on Hogarth’s proposal that intuitions are primarily acquired and thus shaped by our experiences, GVV offers a pedagogical framework for reflective, (...) experiential learning. Specific attention is given to the themes of learning environments, how these structures shape intuitions, and how students can identify these structures using the GVV emphasis on examination of past experiences. (shrink)

Essays honoring the work of Catholic ethicist James F. Keenan.

A novel rereading of the relationship between ethics and ontology in Aristotle.

In the Gorgias, Socrates claims to practice the true art of politics, but the peculiar politics he practices involves cultivating in each individual he encounters an erotic desire to live a life animated by the ideals of justice, beauty and the good. Socratic and Platonic Political Philosophy demonstrates that what Socrates sought to do with those he encountered, Platonic writing attempts to do with readers. Christopher P. Long's attentive readings of the Protagoras, Gorgias, Phaedo, Apology, and Phaedrus invite us (...) to cultivate the habits of thinking and responding that mark the practices of both Socratic and Platonic politics. Platonic political writing is here experienced in a new way as the contours of a politics of reading emerges in which the community of readers is called to consider how a commitment to speaking the truth and acting toward justice can enrich our lives together. (shrink)

This paper is an initial attempt to develop a dynamic conception of being which is not anarchic. It does this by returning to Aristotle in order to begin the process of reinterpreting the meaning of ousia, the concept according to which western ontology has been determined. Such a reinterpretation opens up the possibility of understanding the dynamic nature of ontological identity and the principles according to which this identity is established. The development of the notions of energeia, dynamis and entelecheia (...) in the middle books of Aristotle’s Metaphysics will be discussed in order to suggest that there is a dynamic ontological framework at work in Aristotle’s later writing. This framework lends insight into the dynamic structure of being itself, a structure which does justice as much to the concern for continuity through change as it does to the moment of difference. The name for this conception of identity which affirms both continuity and novelty is "legacy." This paper attempts to apprehend the meaning of being as legacy. (shrink)

Ontology has been traditionally guided by sophia, a form of knowledge directed toward that which is eternal, permanent, necessary. This tradition finds an important early expression in the philosophical ontology of Aristotle. Yet in the Nicomachean Ethics, Aristotle's intense concern to do justice to the world of finite contingency leads him to develop a mode of knowledge, phronsis, that implicitly challenges the hegemony of sophia and the economy of values on which it depends. Following in the tradition of the early (...) Heidegger's recognition of the ontological significance of Aristotle's Ethics and of Gadamer's appropriation of phronsis for hermeneutics, this article argues that an ontology guided by phronsis is preferable to one governed by sophia. Specifically, it suggests that by taking sophia as its paradigm, traditional philosophical ontology has historically been determined by a kind of knowledge that is incapable of critically considering the concrete historico-ethico-political conditions of its own deployment. This critique of sophia is accomplished by uncovering the economy of values that led Aristotle to privilege sophia over phronsis. It is intended to open up the possibility of developing an ontology of finite contingency based on phronsis. Such an ontology, because it is guided by and must remain responsible to the concrete individual with which it is engaged, would be ethical at its very core. (shrink)

PDZ (also called DHR or GLGF) domains are found in diverse membraneassociated proteins including members of the MAGUK family of guanylate kinase homologues, several protein phosphatases and kinases, neuronal nitric oxide synthase, and several dystrophin‐associated proteins, collectively known as syntrophins. Many PDZ domain‐containing proteins appear to be localised to highly specialised submembranous sites, suggesting their participation in cellular junction formation, receptor or channel clustering, and intracellular signalling events. PDZ domains of several MAGUKs interact with the C‐terminal polypeptides of a subset (...) of NMDA receptor subunits and/or with Shaker‐type K+ channels. Other PDZ domains have been shown to bind similar ligands of other transmembrane receptors. Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand‐binding and the structural bases for sequence conservation among diverse PDZ domains. (shrink)

At least since the appearance of Aristotle’s Politics, Plato’s Republic has been read as arguing for a politics of unity in which difference is understood as a threat to the polis. By focusing on the musical imagery of the Republic, and specifically on its compositional organization around three ‘preludes’, this essay seeks an understanding of Socratic politics that moves beyond the hypothesis of unity. In the first ‘prelude’, Thrasymachus and his insistence that justice is the self-interest of the stronger threatens (...) to subject the harmony of the community to the tyrannical whims of the individual. In the second, the perfected justice of Adeimantus’s city threatens to destroy the erotic rhythm of difference that is the very condition for the possibility of the polis. It is only in the song of dialectic, which itself is called a ‘prelude’, that the tension between the rhythm of plurality and the rational homophony of unity is dynamically tuned in such a way that both the anarchic politics of self-interest and the totalitarian politics of rationalized oppression are equally muted. This conception of politics is embodied in the relationship that emerges between Glaucon and Socrates. Ultimately, the true political community is established here, between rational, erotic individuals seeking justice in concrete, living dialogue. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 34.4 (2001) 292-307 [Access article in PDF] The Rhetoric of the Geometrical Method Spinoza's Double Strategy Christopher P. Long A double strategy may be apprehended in the first definitions, axioms and propositions of Spinoza's Ethics: the one is rhetorical, the other, systematic. Insofar as these opening passages constitute a geometrical argument that leads ultimately to the strict monism that lies at the heart of Spinoza's (...) philosophy, they function systematically as grounding principles. However, insofar as they are designed to uncover errors at the heart of the Cartesian system, they function rhetorically as a critique of Descartes's equivocal theory of substance. The geometrical mode of presentation lends an aura of necessity to the systematic strategy and tends to eclipse the rhetorical strategy that functions as a critique of Cartesian dualism. 1 To this extent, the systematic strategy itself functions rhetorically. On the other hand, to the extent that any seventeenth-century attempt to establish a monistic system would inevitably have had to involve a critique of Cartesian dualism, the rhetorical strategy itself functions systematically. Thus, although two distinct strategies are simultaneously discernible in the opening passages of the Ethics, the two work together, each arguing on a different front, to establish Spinoza's monism. By focusing on the rhetorical side of this double strategy, the underlying nature of Spinoza's critique of Descartes can be clarified and certain gaps in the systematic, geometrical argument for monism can be explained. Descartes's theory of substance The rhetorical strategy Spinoza employs at the outset of the Ethics involves a brilliant use of equivocation and ambiguity designed to draw a reader dedicated to Cartesian dualism into the heart of an argument designed to [End Page 292] undermine this dualism itself. The impetus behind this rhetorical critique is surely Spinoza's dissatisfaction with Descartes's theory of substance. 1. Descartes's equivocation Descartes's theory rests upon a fundamental equivocation: on the one hand, the term "substance" is meant strictly to designate that which is absolutely self-sufficient, namely, God; on the other hand, Descartes allows for a weaker understanding of substance, which pertains to those things (specifically res cogitans and res extensa) that require only the concurrence of God in order to exist (Principles I, 51-52; AT VIIIA24-25). 2 Thus, for Descartes, although God is, strictly speaking, the only substance, there remains a sense in which both res cogitans and res extensa may be understood as substances as well.Ultimately, this equivocal understanding of substance may be traced to a tension internal to Descartes between the Aristotelian notion of substance as underlying subject and the seventeenth-century mutation of that notion, which came to be defined in terms of causal self-sufficiency. 3 Jonathan Bennett traces the source of this mutation back to the view held by Aristotle that the existence of some property depends upon its being instantiated--that is, there can be no courage unless there exists someone courageous. He continues his interesting argument thus: This suggests that there is a relation of dependence running from properties to the things that have them and not conversely. The dependence would be logical: the thesis must be that "existent but uninstantiated property" is conceptually defective, not merely contrary to physics. Thus, one mark of a genuine thing, or substance, is its not being logically dependent for its existence on anything else. (Bennett 1984, 56) The development of this line of thinking leads to the conception of substance we find both in Descartes's Principles and in Spinoza's Ethics, namely, that a substance must not causally depend on anything outside of itself for its existence. 4 However, with Descartes, what emerges out of this tradition is a hybrid understanding of substance in which the term "substance" is not reserved simply for that which is utterly self-sufficient (God), but extends to those things that depend only upon the concurrence of God for their existence (rescogitans and resextensa). This bifurcated understanding of substance seems to stem from the distinction at work in [End Page 293] Aristotle... (shrink)

One aspiration of an analytic jurisprudential theory is to provide an account of how legal obligations arise, including the legal obligation of judges to apply only legally valid norms when adjudicating cases. Also, any fully adequate theory should enable a solution to a ‘chicken-egg’ puzzle regarding legal authority: legal authority can exist only in virtue of rules that authorize it, but such rules require a legal authority as their source. Which came first? This article argues that it is difficult to (...) see how a particular type of positivist theory (featuring a fundamental norm that plays certain roles) can solve the puzzle and also account for the aforementioned adjudicative duty. The challenge can be framed in terms of the need to be able to derive a legal ‘ought’ (applying to courts) from only ‘is’-statements expressing social facts, where the requisite derivation cannot rely on what John Searle has called ‘institutional facts’. (shrink)

Introduction: Although deep brain stimulation often improves levodopa-responsive gait symptoms, robust therapies for gait dysfunction from Parkinson's disease remain a major unmet need. Walking speed could represent a simple, integrated tool to assess DBS efficacy but is often not examined systematically or quantitatively during DBS programming. Here we investigate the reliability and functional significance of changes in gait by directional DBS in the subthalamic nucleus.Methods: Nineteen patients underwent unilateral subthalamic nucleus DBS surgery with an eight-contact directional lead in the most (...) severely affected hemisphere. They arrived off dopaminergic medications >12 h preoperatively and for device activation 1 month after surgery. We measured a comfortable walking speed using an instrumented walkway with DBS off and at each of 10 stimulation configurations at the midpoint of the therapeutic window. Repeated measures of ANOVA contrasted preoperative vs. maximum and minimum walking speeds across DBS configurations during device activation. Intraclass correlation coefficients examined walking speed reliability across the four trials within each DBS configuration. We also investigated whether changes in walking speed related to modification of step length vs. cadence with a one-sample t-test.Results: Mean comfortable walking speed improved significantly with DBS on vs. both DBS off and minimum speeds with DBS on. Pairwise comparisons showed no significant difference between DBS off and minimum comfortable walking speed with DBS on. Intraclass correlations were ≥0.949 within each condition. Changes in comfortable walk speed were conferred primarily by changes in step length.Conclusion: Acute assessment of walking speed is a reliable, clinically meaningful measure of gait function during DBS activation. Directional and circular unilateral subthalamic DBS in appropriate configurations elicit acute and clinically significant improvements in gait dysfunction related to PD. Next-generation directional DBS technologies have significant potential to enhance gait by individually tailoring stimulation parameters to optimize efficacy. (shrink)

As histories of nanotechnology are created, one question arises repeatedly: how influential was Richard Feynman’s 1959 talk, “There’s Plenty of Room at the Bottom”? It is often said by knowledgeable people that this talk was the origin of nanotech. It preceded events like the invention of the scanning tunneling microscope, but did it inspire scientists to do things they would not have done otherwise? Did Feynman’s paper directly influence important scientific developments in nanotechnology? Or is his paper being retroactively read (...) into the history of nanotechnology? To explore those questions, I trace the history of “Plenty of Room,” including its publication and republication, its record of citations in scientific literature, and the comments of eight luminaries of nanotechnology. This biography of a text and its life among other texts enables us to articulate Feynman’s paper with the history of nanotechnology in new ways as it explores how Feynman’s paper is read. (shrink)

. Human capabilities theory has emerged as an important framework for measuring whether various social systems promote human flourishing. The premise of this theory is that human beings share some nearly universal capabilities; what makes a human life fulfilling is the opportunity to exercise these capabilities. This essay proposes that the use of human capabilities theory can be expanded to assess whether a company has organized the work environment in such a way that allows workers to develop a variety of (...) human capabilities. This mode of analysis is put forward as a complement to the work of Mihaly Csikszentmihalyi, who has suggested that the key to promoting human well-being in the workplace is the maximization of flow experiences. (shrink)

The First Catilinarian, in comparison with other Ciceronian political speeches commonly considered invectives, is extraordinarily sparing in its use of the standard invective themes. This article will first demonstrate the remarkable paucity in the speech of the invective loci that Cicero's audiences would properly expect. Then it will offer an explanation for Cicero's restraint grounded in the circumstances of the speech and the expectations of Cicero's audience for the veracity of invective.

A $\Pi _{1}^{0}$ class is the set of paths through a computable tree. Given classes P and Q, P is Medvedev reducible to Q, P ≤M Q, if there is a computably continuous functional mapping Q into P. We look at the lattice formed by $\Pi _{1}^{0}$ subclasses of 2ω under this reduction. It is known that the degree of a splitting class of c.e. sets is non-branching. We further characterize non-branching degrees, providing two additional properties which guarantee non-branching: inseparable (...) and hyperinseparable. Our main result is to show that non-branching iff inseparable if hyperinseparable if homogeneous and that all unstated implications do not hold. We also show that inseparable and not hyperinseparable degrees are downward dense. (shrink)

Leibniz standardly associates “mechanism” with extended material bodies and their aggregates. In this paper, I identify and analyze a further distinct sense of “mechanism” in Leibniz that extends, by analogy, beyond the domain of material bodies and applies to the operations of immaterial substances such as the monads that serve, for Leibniz, as the metaphysical foundations of physical reality. I argue that in this sense, Leibniz understands “mechanism” as an intelligible process that is capable of providing a sufficient reason for (...) a series of changes. I then apply these findings to enrich our understanding of Leibniz’s well-known mill argument in Monadology ¶17: although material machines and mechanisms cannot produce perceptions, the perceptual activity of immaterial monads is to be understood as “mechanical” according to this analogical sense. (shrink)

(2008). The Framework of Essences in Spinoza's Ethics. British Journal for the History of Philosophy: Vol. 16, No. 3, pp. 489-509. doi: 10.1080/09608780802200489.

The mad scientist stories of fiction and film are exercises in antirationalism, particularly its Gothic horror variant. As such, they convey the argument that rationalist secular science is dangerous, and their principal device for doing so is to invest the evil of science in the personality of the scientist. To understand this cultural critique of science, it is necessary to understand how the symbols of the scientist's personality are manipulated. This article argues that mad scientists become increasingly amoral as nineteenth-century (...) texts are adapted to twentieth-century films. The consequence is that this cultural critique is becoming even more severe, due to external reasons independent of the glories or the crimes of real scientists. (shrink)

Using a subliminal priming lexical decision task, the present research investigated whether individuals who show negative implicit evaluations of an ex-partner immediately after a break-up show superior post-break-up emotional adjustment. As expected, individuals whose reaction times indicated negative implicit evaluations of their ex-partner showed reduced depressive affect immediately after the break-up. Individuals who did not initiate their break-up demonstrated less negative implicit evaluations of their ex-partners as well as more depressive affect. Finally, increased negative implicit evaluations of ex-partners over a (...) one-month period were associated with corresponding improvements in adjustment. The findings demonstrate a critical role for implicit evaluations in post-break-up adjustment. (shrink)

The discovery of a second genesis of life besides the one on Earth, this time on Mars, would have profound scientific and philosophical implications. Scientifically, it would provide a second example of biochemistry and of evolutionary history. Many important biological questions may be answerable through the comparison of biochemistry between the life forms on the two planets. Philosophically, the discovery of a second genesis of life in our solar system would suggest that the phenomenon of life is distributed throughout the (...) universe. We could finally be confident that we are not alone. To protect a second genesis as we search for it, the robotic and human exploration of Mars should be done in a way that is biologically reversible, i.e., we must be able to undo our contamination of Mars if we discover a second genesis of life there. It is important to note that human exploration can be done in a way that is biologically reversible. Further, the discovery of a second genesis of life on Mars poses new questions in ethics. One question is: what ethical consideration is due to an alien life form when that life is distinctly different from Earth life, and the members of that life are no more advanced than microorganisms? Will we choose to terraform Mars to enhance the richness and diversity of the indigenous life we find there? In considering our answers to these questions, we should note that for most of Earth’s history our ancestors were microscopic. (shrink)

Digital media technology, when deployed in ways that cultivate shared learning communities in which students and teachers are empowered to participate as partners in conjoint educational practices, can transform the way we teach and learn philosophy. This essay offers a model for how to put blogging and podcasting in the service of a cooperative approach to education that empowers students to take ownership of their education and enables teachers to cultivate in themselves and their students the excellences of dialogue. The (...) essay is organized around a compelling story of how the students in an Ancient Greek Philosophy course responded to an anonymous, belligerent commenter on the blog from outside of the class. The incident brings the pedagogy of cooperative education into sharp relief. (shrink)

The subject of “the last pagans” or “the end of paganism” in the Greco-Roman world has interested scholars for over a century but begs the question “What is paganism?” Is the term usable as a tool of analysis? It originates from the Latin paganus, meaning “villager,” “rustic,” and reflects the way that Latin speakers viewed early Christianity as a phenomenon of the countryside, much as the English heathen, or German Heide, derives from a root meaning “heath.” Greek-speaking Christians, by contrast, (...) used a variety of terms, but their favored one was Hellene, which reflected the perception that their main opposition came from Greeks who remained faithful to their traditional culture and beliefs. Hence paganism, when used by a modern author, is implicitly one-sided and also obscures the very real gap in perception between Greek speakers and Latin speakers of antiquity. Accordingly, some recent authors have tried to replace pagan with polytheist, but the latter term has the disadvantage that many pagans tended toward monotheism, or to a modified monotheism that regarded one god as vastly superior to all others (“henotheism”). Heathen is similar in being an insider's term, current when Christianity was the default position of religious discourse, and now largely obsolete. It is best to retain the word pagan but to concede that it is merely a pis aller. (shrink)

A $\Pi^0_1$ class can be defined as the set of infinite paths through a computable tree. For classes $P$ and $Q$, say that $P$ is Medvedev reducible to $Q$, $P \leq_M Q$, if there is a computably continuous functional mapping $Q$ into $P$. Let $\mathcal{L}_M$ be the lattice of degrees formed by $\Pi^0_1$ subclasses of $2^\omega$ under the Medvedev reducibility. In "Non-branching degrees in the Medvedev lattice of $\Pi \sp{0}\sb{1} classes," I provided a characterization of nonbranching/branching and a classification of (...) the nonbranching degrees. In this paper, I present a similar classification of the branching degrees. In particular, $P$ is separable if there is a clopen set $C$ such that $P \cap C \neq \emptyset \neq P \cap C^c$ and $P \cap C \perp_M P \cap C^c$. By the results in the first paper, separability is an invariant of a Medvedev degree and a degree is branching if and only if it contains a separable member. Further define $P$ to be hyperseparable if, for all such $C$, $P \cap C \perp_M P \cap C^c$ and totally separable if, for all $X,Y \in P$, $X \perp_T Y$. I will show that totally separable implies hyperseparable implies separable and that the reverse implications do not hold, that is, that these are three distinct types of branching degrees. Along the way I will show some related results and present a combinatorial framework for constructing $\Pi^0_1$ classes with priority arguments. (shrink)

At the beginning of his book, Methode und Beweisziel im ersten Buch der “Physikvorlesung” des Aristoteles, Johannes Fritsche announces that the theme of the work is to be more or less Aristotle’s Physics. It is to be less about the Physics insofar as it treats only two sentences of its first book—the first sentence of chapter one and a sentence taken from its decisive seventh chapter. It is to be more about the Physics insofar as it explicates these two sentences (...) in order to establish the principle according to which the entire Physics is constructed. Fritsche’s book is impressive both in its breadth and its depth. He situates his own position within a broad historical tradition by addressing both ancient commentators, like Simplicius and Philoponus, and modern commentators, like Wieland and Guzzoni. He argues, however, the unpopular position that the books of the Physics do have a systematic relationship to one another, that they are not merely an amalgamation of individual thoughts on the general subject of natural philosophy. One of the most intriguing aspects of Fritsche’s account is his suggestion that the main goal of the first two books of the Physics is to establish the condition for the possibility that there are principles of natural beings. In this, he distinguishes his own position from many in the tradition who claim that Aristotle assumes the existence of such principles without ever actually arguing for them. (shrink)