Caretaking stability in the early life environment supports neurobehavioral development, while instability and neglect constitute adverse environments that can alter maturational processes. Research in humans suggests that different types of early life adversity can have differential effects on caretaker relationships and later cognitive and social development; however, identifying mechanistic underpinnings will require animal models with translational validity. Two common rodent models, maternal separation and limited bedding, influence the mother-infant relationship during a critical window of development. We hypothesized that these paradigms (...) may affect the development of communication strategies on the part of the pup. Ultrasonic vocalizations are a care-eliciting mechanism and ethologically relevant response to stressors in the rat pup. USV emission rates and acoustic parameters change throughout early development, presenting the opportunity to define developmental milestones in USVs that would reflect neurobehavioral aberrations if disrupted. This study investigated the effects of MS or LB on the dam-pup relationship by quantifying pup USVs, maternal behavior, and the relationship between the two. First, we used a generalized additive model approach to establish typical developmental trajectories of USV acoustic properties and determine windows of change in MS or LB rearing. Additionally, we quantified maternal behaviors and the predictability of maternal care sequences using an entropy rate calculation. MS and LB each shifted the developmental trajectories of USV acoustic parameters and call types in a sex-specific manner. MS more often impacted male USVs, while LB impacted female USVs. MS dams spent more time passive nursing, and LB dams spent more time on the nest. The predictability of maternal care was associated with the rate of USV emissions exclusively in females. Taken together, findings demonstrate sex- and model-specific effects of rearing environments on a novel developmental trajectory involving the mother-infant relationship, facilitating the translation of animal ELA paradigms to assess later-life consequences. (shrink)

This paper examines Aristotle’s account of the individuation of causal powers, which dominated much of scholastic thought about powers, and argues that John Buridan rejected it. It contends that Buridan criticizes Aristotle’s account on two counts. First, he attacks Aristotle’s view that we ought to individuate powers by appeal to their respective activities. Second, Buridan objects to Aristotle’s “single-track” account, which correlates one type of power with only one type of activity. Against this, it is argued, Buridan adopts a multi-track (...) approach, according to which a single power type may be correlated with many different types of activities. The paper claims that the basic idea of Buridan’s multi-track view is still defensible today, and can be viewed as a viable alternative to the contemporary single-track account of power individuation defended, for instance, by Jonathan Lowe. (shrink)

Fold‐switching proteins, which remodel their secondary and tertiary structures in response to cellular stimuli, suggest a new view of protein fold space. For decades, experimental evidence has indicated that protein fold space is discrete: dissimilar folds are encoded by dissimilar amino acid sequences. Challenging this assumption, fold‐switching proteins interconnect discrete groups of dissimilar protein folds, making protein fold space fluid. Three recent observations support the concept of fluid fold space: (1) some amino acid sequences interconvert between folds with distinct secondary (...) structures, (2) some naturally occurring sequences have switched folds by stepwise mutation, and (3) fold switching is evolutionarily selected and likely confers advantage. These observations indicate that minor amino acid sequence modifications can transform protein structure and function. Consequently, proteomic structural and functional diversity may be expanded by alternative splicing, small nucleotide polymorphisms, post‐translational modifications, and modified translation rates. (shrink)

Routine infant circumcision is one of the most common surgical procedures performed in the U.S. Despite its broad societal acceptance, the practice is not without controversy. The stories included in this symposium offer rich insight into the diverse set of attitudes, values, and beliefs related to the practice of circumcision. They additionally offer insight into the complex web of personal, interpersonal, and social dynamics that inform the circumcision choices parents make for their children, the reasons parents make them, and how (...) others can influence decisional choices. More broadly, these narratives raise important ethical questions mirrored today in broader contemporary bioethical and public discourse on the scope and limits of parental authority to make decisions for their children, power dynamics in medical decision making, and the ethics of healthcare activism. In this commentary, I discuss three sets of themes related to the ethics of circumcision running through the symposium narratives, comment on the ethical tensions and questions which emerge from each set of themes, gently problematize some of the rhetoric surrounding the ethical permissibility of circumcision, and gesture towards the future of bioethical inquiry on circumcision discourse. (shrink)

This paper considers Thomas Aquinas’s claim that we can use certain habitus at will. Focusing on moral habitus, this claim is interpreted as a claim about the freedom human beings have with regard to their character traits: they can freely choose to act or not act according to their character traits. After giving a brief account of how, for Aquinas, character traits influence our actions via our emotions, the paper examines whether this freedom is of a libertarian or of a (...) compatibilist kind. A libertarian reading is defended on the basis of certain remarks of Aquinas’s about the act of contrition. (shrink)

This introductory chapter summarises key findings of the twenty-two book chapters in terms of five propositions. These propositions, each building on relevant findings linked to forward-looking suggestions for research, policy and practice, reflect the architecture of the book, whose sections proceed from setting the stage to critical issues, followed by a section on methods and tools, to chapters that provide geographic perspectives, and finally to a section that identifies potential policy options. The propositions comprise (1) Risk management can be an (...) effective entry point for aligning perspectives and debates, if framed comprehensively, coupled with climate justice considerations and linked to established risk management and adaptation practice; (2) Attribution science is advancing rapidly and fundamental to informing actions to minimise, avert, and address losses and damages; (3) Climate change research, in addition to identifying physical/hard limits to adaptation, needs to more systematically examine soft limits to adaptation, for which we find some evidence across several geographies globally; (4) Climate risk insurance mechanisms can serve the prevention and cure aspects emphasised in the L&D debate but solidarity and accountability aspects need further attention, for which we find tentative indication in applications around the world; (5) Policy deliberations may need to overcome the perception that L&D constitutes a win-lose negotiation “game” by developing a more inclusive narrative that highlights collective ambition for tackling risks, mutual benefits and the role of transformation. [Open access]. (shrink)

The debate on “Loss and Damage” (L&D) has gained traction over the last few years. Supported by growing scientific evidence of anthropogenic climate change amplifying frequency, intensity and duration of climate-related hazards as well as observed increases in climate-related impacts and risks in many regions, the “Warsaw International Mechanism for Loss and Damage” was established in 2013 and further supported through the Paris Agreement in 2015. Despite advances, the debate currently is broad, diffuse and somewhat confusing, while concepts, methods and (...) tools, as well as directions for policy remain vague and often contested. This book, a joint effort of the Loss and Damage Network—a partnership effort by scientists and practitioners from around the globe—provides evidence-based insight into the L&D discourse by highlighting state-of-the-art research conducted across multiple disciplines, by showcasing applications in practice and by providing insight into policy contexts and salient policy options. This introductory chapter summarises key findings of the twenty-two book chapters in terms of five propositions. These propositions, each building on relevant findings linked to forward-looking suggestions for research, policy and practice, reflect the architecture of the book, whose sections proceed from setting the stage to critical issues, followed by a section on methods and tools, to chapters that provide geographic perspectives, and finally to a section that identifies potential policy options. The propositions comprise (1) Risk management can be an effective entry point for aligning perspectives and debates, if framed comprehensively, coupled with climate justice considerations and linked to established risk management and adaptation practice; (2) Attribution science is advancing rapidly and fundamental to informing actions to minimise, avert, and address losses and damages; (3) Climate change research, in addition to identifying physical/hard limits to adaptation, needs to more systematically examine soft limits to adaptation, for which we find some evidence across several geographies globally; (4) Climate risk insurance mechanisms can serve the prevention and cure aspects emphasised in the L&D debate but solidarity and accountability aspects need further attention, for which we find tentative indication in applications around the world; (5) Policy deliberations may need to overcome the perception that L&D constitutes a win-lose negotiation “game” by developing a more inclusive narrative that highlights collective ambition for tackling risks, mutual benefits and the role of transformation. (shrink)

The focus of the article is the self-predication principle, according to which the/a such-and-such is such-and-such. We consider contemporary approaches (Frege, Russell, Meinong) to the self-predication principle, as well as fourteenth-century approaches (Burley, Ockham, Buridan). In crucial ways, the Ockham-Buridan view prefigures Russell’s view, and Burley’s view shows a striking resemblance to Meinong’s view. In short the Russell-Ockham-Buridan view holds: no existence, no truth. The Burley-Meinong view holds, in short: intelligibility suffices for truth. Both views approach self-predication in a uniform (...) way. We were unable to find a medieval philosopher who, like Frege, approaches self-predication in a non-uniform way. We do not want to dispute that there are also considerable differences between the contemporary and the fourteenth-century approach to self-predication. Importantly, fourteenth-century accounts of self-predication rely strongly on the identity theory of predication, and this theory is not endorsed by contemporary philosophers of language. Nevertheless, some basic tenets seem to us to be clearly shared between fourteenth-century and contemporary thinkers. (shrink)

Many realists have maintained that the success of scientific theories can be explained only if they may be regarded as approximately true. Laurens Laudan has in turn contended that a necessary condition for a theory's being approximately true is that its central terms refer, and since many successful theories of the past have employed central terms which we now understand to be non-referential, realism cannot explain their success. The present paper argues that a realist can adopt a view of (...) reference according to which a theory might plausibly be said to be approximately true even though its central terms do not refer, or alternatively, he may construe reference in such a way as to assign reference to a range of successful older theories which includes Laudan's purported counterexamples. (shrink)

Perception is not an independent, in‐the‐moment event. Instead, perceiving involves integrating prior expectations with current observations. How does this ability develop from infancy through adulthood? We examined how prior visual experience shapes visual perception in infants, children, and adults. Using an identical task across age groups, we exposed participants to pairs of colorful stimuli and implicitly measured their ability to discriminate relative saturation levels. Results showed that adult participants were biased by previously experienced exemplars, and exhibited weakened in‐the‐moment discrimination between (...) different levels of saturation. In contrast, infants and children showed less influence of memory in their perception, and they actually outperformed adults in discriminating between current levels of saturation. Our findings suggest that as humans develop, their perception relies more on prior experience and less on current observation. (shrink)

L.A. Paul has recently argued that, on the standard model of rationality, individuals cannot make rational decisions about whether to have a child or not. In this paper, I show that Paul’s arguments do not plausibly demonstrate that the standard model of rationality precludes rational decisions to have a child. I argue that there are phenomenal and non-phenomenal values that can be used to determine the value that having a child will have for us and, in turn, that can be (...) used to make rational decisions about whether to have a child or not. I also argue that we can have an approximate idea of what it is like for us to have a child, even before we have a child and that, on the standard model, this is sufficient to make rational decisions to have a child. (shrink)

Those who aim to give an account of modal knowledge face two challenges: the integration challenge of reconciling an account of what is involved in knowing modal truths with a plausible story about how we can come to know them, and the reliability challenge of giving a plausible account of how we could have evolved a reliable capacity to acquire modal knowledge. I argue that recent counterfactual and dispositional accounts of modal knowledge cannot solve these problems regarding specifically metaphysical modal (...) truths—leaving us with the threat of skepticism about large portions of metaphysics, and certain other areas of philosophy. I argue, however, that both of these problems look insuperable only if we assume that metaphysical modal discourse serves a describing or tracking function. If we adopt instead a normativist approach to metaphysical modal discourse, which sees the basic function of modal discourse as giving us perspicuous ways of conveying, reasoning with, and renegotiating semantic rules, the problems show up very differently. The modal normativist can give a plausible response to both of the classic problems of how we can come to know metaphysical modal truths. (shrink)

Cognitive Science, Volume 46, Issue 6, June 2022.

ABSTRACTA ‘sceptical’ approach to easy arguments involves reducing our confidence in the supposedly uncontroversial premise with which the arguments begin. Here I address the question: if we accept Yablo's new version of a sceptical proposal, what difference might that make for the relevant meta-ontological debates? I argue that serious difficulties remain for even this ‘best’ version of a sceptical approach. Noting these difficulties might motivate us to look again at the alternative strategy—of reading the uncontroversial premise straightforwardly and thinking that (...) doubts about the conclusion were based on artificial inflation or confusion. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Les récents débats autour du délit de manipulation mentale amènent à s'interroger sur la notion d'influence et sur l'impact des recherches faites dans ce domaine. Ce délit repose sur l'idée que des techniques de manipulation efficaces existent et que par leur utilisation, on pourrait manipuler autrui. Suivant cette conception asymétrique de l'influence, la cible devient l'instrument du désir de la source et dans ce cas, il est nécessaire de se protéger de ces influences qui peuvent être néfastes. Si des travaux (...) expérimentaux de psychologie sociale montrent l'efficacité de certaines techniques d'influence et de manipulation, ils doivent cependant être mis en perspective. Nombre d'expériences et de théories montrent que l'influence n'est fondamentalement pas un rapport asymétrique. Mais hélas, ces travaux sont négligés tant ils ne cadrent pas avec ce prototype de l'influence qui domine à la fois en psychologie sociale et dans le sens commun.Recent debate on the abuse of mental manipulation has raised questions about the concept of influence and the impact of the research in this field. This abuse is based on the idea that with effective techniques of manipulation can be used to mentally control others. According to this asymmetrical model of influence, the target becomes the instrument of the desire of the source and therefore must be protected from such dangerous and negative influences. If certain experiments in social psychology show the effectiveness of certain techniques of influence and manipulation, such effects must be analyzed with due care. Many experiments and theories show that influence is not essentially asymmetrical. Unfortunately, such studies tend to be ignored because they differ from the accepted model of influence which dominates both in social psychology and in common sense. (shrink)

Subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead “anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the (...) STN produces similar clinical efficacy.” These discrepancies likely result from methodological differences including targeting preferences, imaging acquisition and the use of brain atlases that do not account for patient-specific anatomic variability. We present a first-in-kind within-patient demonstration of severe mood side effects and minimal motor improvement in a Parkinson’s disease patient following placement of a DBS lead in the limbic/associative territory of the STN who experienced marked improvement in motor benefit and resolution of mood side effects following repositioning the lead within the STN sensorimotor territory. 7 Tesla magnetic resonance imaging data were used to generate a patient-specific anatomical model of the STN with parcellation into distinct functional territories and computational modeling to assess the relative degree of activation of motor, associative and limbic territories. (shrink)

In the TV series, Joe Miller is the stop‐cap which keeps James Holden occupied so he does not have time to send constant broadcasts out to the world. When we think about Holden helping others, why he's always in the midst of things, it's helpful to think about what distinguishes Holden from other characters in the series and what makes him unique—that he grew up on a farm. Holden is the exact opposite of Dresden, Strickland, Mao, and Marco. And that's (...) what Naomi loves about him. The Expanse is dark science fiction whose references are to a war of all against all (Thomas Hobbes’ Leviathan), to the massacre of American Indians, and to a dark intelligence that maybe intended the ultimate domination of nature. And one of their protagonists is a guy who thinks he's a knight tilting at windmills. (shrink)

The author considers the plausibility of granting a “right to place” as an entitlement of citizenship in a nation such as the United States. Such a right would afford people the capacity to live in the places they choose. To explore whether granting such a right is plausible, the author identifies and examines the salient barriers now preventing Americans from choosing their place communities. The final section suggests that these myriad barriers, while formidable, are not insurmountable—a conclusion that, in turn, (...) suggests that an RTP could be plausibly granted to Americans in the twenty-first century. (shrink)

This book review essay discusses Principles of Animal Research Ethics (2020), by Tom L. Beauchamp and David DeGrazia.

Previous research shows that manipulations (e.g. levels-of-processing) that facilitate true memory often increase susceptibility to false memory. An exception is the generation effect. Using the Deese/Roediger–McDermott (DRM) paradigm, Soraci et al. found that generating rather than reading list items led to an increase in true but not false memories. They argued that generation led to enhanced item-distinctiveness that drove down false memory production. In the current study, we investigated the effects of generative processing on valenced stimuli and after a delayed (...) retention interval to examine factors that may lead to a generation effect that increases false memories. At the immediate test, false recognition rates for both negative and neutral valanced critical lures were similar across read and generate conditions. However, after a one-week delay, we saw a valence differentiation, with a generation effect for false recognition but only for negative stimuli. The roles of item-specific and relational processing during encoding and their interaction with long-term retention are discussed. (shrink)

Checklists have been used to improve quality in many industries, including healthcare. The use of checklists, however, has not been extensively evaluated in clinical ethics consultation. This article seeks to fill this gap by exploring the efficacy of using a checklist in ethics consultation, as tested by an empirical investigation of the use of the checklist at a large academic medical system (Cleveland Clinic). The specific aims of this project are as follows: (1) to improve the quality of ethics consultations (...) by providing reminders to ethics consultants about process steps that are important for most patient-centered ethics consultations, (2) to create consistency in the ethics consultation process across the medical system, and (3) to establish an effective educational tool for trainers and trainees in clinical ethics consultation. The checklist was developed after a thorough literature review and an iterative process of revising and testing by a group of experienced ethics consultants. To pilot test the checklist, it was distributed to 46 ethics consultants. After a six-month pilot period in which ethics professionals used the checklist during their clinical activities, a survey was distributed to all of those who used the checklist. The 10-item survey examined consultants’ perceptions regarding the three aims listed above. Of the 25 survey respondents, 11 self-reported as experts in ethics consultation, nine perceived themselves to have mid-level expertise, and five self-reported as novices. The majority (68 percent) of all respondents, regardless of expertise, believed that the checklist could be a “helpful” or “very helpful” tool in the consultation process generally. Novices were more likely than experts to believe that the checklist would be useful in conducting consultations. The limitations of this study include: reduced generalizability given that this project was conducted at one medical system, utilized a small sample size, and used self-reported quality outcome measures. Despite these limitations, to the authors’ knowledge this is the first investigatation of the use of a checklist systematically to improve quality in ethics consultation. Importantly, our findings shed light on ways this checklist can be used to improve ethics consultation, including its use as an educational tool. The authors hope to test the checklist with consultants in other healthcare systems to explore its usefulness in different healthcare environments. (shrink)

Can God Be Free? is a penetrating study of a central problem in philosophy of religion: can it be right to regard God as free, and as praiseworthy for being perfectly good? Allowing that he has perfect knowledge and perfect goodness, if there is a best world for God to create he would have no choice other than to create it. But if God could not do otherwise than create the best world, he created the world of necessity, not freely, (...) and we have no reason to be thankful to God for creating us, since he couldn't do otherwise. William Rowe proposes the need for some substantial revision in contemporary thinking about the nature of God. (shrink)

The health policy community has a growing interest in the impact of nonmedical determinants of health, such as housing, nutrition, and social supports, on both health outcomes and costs. This interest has been spurred by the Affordable Care Act’s emphasis on prevention, Robert Wood Johnson’s grant‐making focus on a Culture of Health, and an uptick of research demonstrating the potential returns to health care from investments in social services. Much of this policy‐making, grant making, and research has focused on older (...) Americans.The direct policy implications of this strategy can be elusive. It has become clear that more than medicine will be necessary to improve older Americans’ health status. Real improvement likely requires the development of additional social service offerings, including housing that is accessible to people with disabilities, Meals on Wheels‐type nutrition supports, and transportation. But who should bear the costs and control the finances associated with these programs? In this essay, I explore the question of how policy‐makers should consider financing nonmedical investments in older Americans’ health. As the reader will recognize, I stop short of arguing for what will work. Rather, I identify the strands of an emerging strategy—namely, for health care dollars to be diverted into social service programming—and offer several cautions. It may be that policy‐makers still wish to continue down this path, but my hope is that this essay will allow them to so with greater attention to the risks and unintended consequences of that strategy. (shrink)

Background Financial relationships between physicians and industry are extensive and public reporting of industry payments to physicians is now occurring. Our objectives were to describe physician recipients of large total payments from these seven companies, and to examine discrepancies between these payments and conflict of interest (COI) disclosures in authors’ concurrent publications. Methods The investigative journalism organization, ProPublica, compiled the Dollars for Docs database of payments to individuals from publically available data from seven US pharmaceutical companies during the period 2009 (...) to 2010. We examined the cohort of 373 physicians in this database who each received USD $100,000 or more in the reporting period 2009 to 2010. Results These physicians received a total of $52,600,624 during this period (mean payment per physician $141,020). The predominant specialties were internal medicine and psychiatry. 147 of these physicians authored a total of 134 publications in the first quarter of 2011 and 77% (103) of these publications provided a COI disclosure. 69% of the 103 publications did not contain disclosures of the payment listed in the Dollars for Docs database. Conclusions With increased public reporting of industry payments to physicians, it is apparent that large sums are being paid for services such as consulting and peer education. In over two-thirds of publications where COI disclosures were provided, the disclosures by physician authors did not include industry payments that were documented in the Dollars for Docs database. (shrink)

Artificial intelligence and robotics have increasingly been adopted in agri-food systems—from milking robots to self-driving tractors. New projects extend these technologies in an effort to automate skilled work that has previously been considered dependent on human expertise due to its complexity. In this paper, we draw on qualitative research carried out with farm managers on apple orchards and winegrape vineyards in Aotearoa New Zealand. We investigate how agricultural managers’ perceptions of future agricultural automation relates to their approach to expertise, or (...) the degree to which they think specialised skills and knowledge are required to perform agricultural work on their orchards and vineyards. Our research generates two insights: the perceived potential for work to be automated is related to the degree to which it is seen to require technical or embodied expertise, with technical expertise being more automatable; and, while embodied expertise is perceived to be more difficult to automate, it is sometimes attributed more exclusively to those in positions of power, such that embodied expertise can be highly valued while the majority of embodied work is viewed as non-expert and thus automatable. Our analysis illustrates that a robot can be an expert when expertise is technical. It also shows variability in the conceptualization of skilled or unskilled work, and that those conceptualizations can set the stage for the future effects of new technologies. This generates new insights into the conditions under which automation might reproduce existing inequalities in agriculture, and also raises new questions about responsibility in the context of automation. (shrink)

It is estimated that 300,000 children 0–14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, it is the leading cause of death due to disease in children in high‐income countries. In spite of this, the etiologies of pediatric cancer are largely unknown. Environmental exposures have long been thought to play an etiologic role. However, to date, there are few well‐established environmental risk factors for pediatric malignancies, likely due to (...) technical barriers in collecting biological samples prospectively in pediatric populations for direct measurements. In this review, we propose the use of novel or underutilized biospecimens (dried blood spots and teeth) and molecular approaches for exposure assessment (epigenetics, metabolomics, and somatic mutational profiles). Future epidemiologic studies of pediatric cancer should incorporate novel exposure assessment methodologies, data on molecular features of tumors, and a more complete assessment of gene‐environment interactions. (shrink)

Cet essai développe une approche «trichotomique» du désir transcendantal de l'être humain pour la croissance et le développement. Le but principal de l'article est de s'enquérir du monde «après la vertu», pour citer les paroles de Alasdair MacIntyre. On le fait en montrant qu'après la réalisation légitime du bien-être psycho-physique, la recherche de la justice humaine poussera l'humanité jusqu'au point où cette recherche se supprime elle-même. Les biens, en effet, auxquels nous ne pouvons qu'aspirer - comme une connaissance définitive, une (...) jouissance inconditionnée d'une identité authentique, une justice pleinement satisfaisante - sont en soi et pour soi au-delà de notre capacité. De cette façon, la recherche produit un résultat strictement mystico-théologique: nous sommes incapables de nous assurer du Dieu que nous cherchons naturellement. Dans l'angoisse qui s'ensuit, il ne reste qu'une option, et elle est radicale: l'abandon aimant de soi-même en Dieu ou l'entretien moral de soi-même. Nous nous trouvons donc devant la porte qui ouvre sur le chemin de la forme la plus radicale du péché, qui n'est pas seulement morale, mais proprement théologique: il devient impossible de vivre avec le Dieu vivant, et l'humanité s'installera dans l'idolâtrie et l'athéisme comme options religieuses. Mais laissée à soi-même, la religiosité humaine deviendra une recherche troublante, capable de rendre acceptable des actes immoraux inouïs: 'Tantum religio p. (shrink)

Thought, according to Hegel, is not only the product of a faculty of a subject, or a means by which a thinking subject tries to grasp a world that is alien to him. It is also the very structure of the world, that is disclosed to a subject through the thinking activity of a subject. The fundamental question that crosses the whole post-Kantian philosophy is that of the relation between thought and reality, i.e. the question of whether reality depends on (...) the categorial requirements imposed by the thinking subject, or whether reality maintains some form of independence from the thinking subject. Seen from this standpoint, Hegel can be read both as an author who radicalizes Kant’s transcendental perspective, and also as a critic of that perspective. In other words, he can be seen as an idealist: according to Hegel, any philosophy is idealist if it claims that something finite, qua finite, is essentially connected with something other. He can also be seen as an anti-idealist: insofar as his philosophy aims to overcome a hyper-transcendentalist perspective, i.e. it is so since it rejects idealism as subjective idealism. Moreover, Hegel’s anti-idealism can be characterized as realism. This is because, if we admit that overcoming transcendentalism without falling back again on a pre-critical conception of thought and of reality involves an idea of thought which is not reducible to a "mentalistic" conception of it, we need to conceive of thought as something that is not alien to reality. Hegel conceives of thought as intimately connected with the world, as its own rational structure. This “realism” of thought is what makes Hegelian idealism, so to speak, anti-idealistic. Through this "realism" of thought Hegel pursues two goals. On the one hand, Hegel attempts to overcome a subjectivistic and instrumentalistic conception of thought, according to which a subject talks and relates to a reality that is always only a construction of him, and so it is necessarily the simulacrum of something that remains inaccessible in its truth. On the other hand, Hegel attempts to overcome a conception of reality characterized merely as alien and opposite to thought itself, and which is the counterpart of the subjectivistic and instrumentalistic conception of thought. By pursuing these two goals it should be gained a conception of reality which could warrant some form of objectivity, but which cannot be equated with the substantialistic conception of the pre-Kantian metaphysics. (shrink)

Memory is modified through the act of retrieval. Although retrieving a target piece of information may strengthen the retrieved information itself, it may also serve to weaken retention of related information. This phenomenon, termed retrieval-induced forgetting, has garnered substantial interest for its implications as to why forgetting occurs. The present study attempted to replicate the seminal work by Anderson, Bjork, and Bjork (1994) on retrieval-induced forgetting, given the apparent sensitivity of the effect to certain deviations from the original paradigm developed (...) to study the phenomenon. The study extends the conditions under which retrieval-induced forgetting has been examined by utilizing both a traditional college undergraduate sample (Experiment 1), along with a more diverse internet sample (Experiment 2). In addition, Experiment 3 details a replication attempt of retrieval-induced forgetting using Anderson and Spellman’s (1995) independent cue procedure. Retrieval-induced forgetting was observed when using the traditional retrieval practice paradigm with undergraduate (Experiment 1) and internet (Experiment 2) samples, though the effect was not found when using the independent cue procedure (Experiment 3). Thus, the study can provide an indication as to the robustness of retrieval-induced forgetting to deviations from the traditional college undergraduate samples that have been used in the majority of existing research on the effect. (shrink)

Introduction: Schools have become a primary setting for providing mental health care to youths in the U.S. School-based interventions have proliferated, but their effects on mental health and academic outcomes remain understudied. In this study we will implement and evaluate the effects of a flexible multidiagnostic treatment called Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, or Conduct Problems on students' mental health and academic outcomes.Methods and Analysis: This is an assessor-blind randomized controlled effectiveness trial conducted across five (...) school districts. School clinicians are randomized to either MATCH or usual care treatment conditions. The target sample includes 168 youths referred for mental health services and presenting with elevated symptoms of anxiety, depression, trauma, and/or conduct problems. Clinicians randomly assigned to MATCH or UC treat the youths who are assigned to them through normal school referral procedures. The project will evaluate the effectiveness of MATCH compared to UC on youths' mental health and school related outcomes and assess whether changes in school outcomes are mediated by changes in youth mental health.Ethics and Dissemination: This study was approved by the Harvard University Institutional Review Board. We plan to publish the findings in peer-reviewed journals and present them at academic conferences.Clinical Trial Registration:ClinicalTrials.gov ID: NCT02877875. Registered on August 24, 2016. (shrink)