In many research studies, tumor biopsies are an unavoidable requirement for achieving key scientific aims. Yet some commentators view mandatory research biopsies as coercive and suggest they should be optional, or at least optional until further data are obtained regarding their scientific usefulness. Further complicating the ethical picture is the fact that some research biopsies offer a potential for clinical benefit to trial participants. We interviewed and surveyed a convenience sample of participants in phase I clinical trials at a single (...) institution. Our primary aim was to describe phase I participants’ understanding of whether a research biopsy offered them the prospect of medical benefit. We also endeavored to describe participants’ views about biopsies—specifically, the benefits of biopsies, if any, and whether biopsies were acceptable, risky, or discouraged trial participation. Finally, we collected data on demographics and attitudes to see if any strong correlations with misunderstanding, acceptability, or riskiness existed. Overall, the respondents tended to view research biopsies as acceptable, though they did not succeed in identifying the lack of benefit of a research biopsy. These findings call for renewed efforts in consent conversations and documents to carefully describe the benefits, or lack thereof, of research biopsies. (shrink)

This article is a review of Ilham Khuri-Makdisi’s bookThe Eastern Mediterranean and the Making of Global Capitalism, 1860–1914. I argue that this book is a valuable contribution to historiographies of the Left in the Middle East, a field that remains under-represented given the importance of labour to the nationalist movements as well as broader worker-activism in the region throughout the twentieth and twenty-first centuries. I review the main debates of the book, and raise critical questions about aspects that could have (...) been probed further, among them the questions of imperialism and race in contexts such as Egypt and Lebanon, and the relationship between workers and the radical intellectuals discussed throughout the book. (shrink)