An increasing body of evidence indicates that the response to genotoxic agents such as radiation or drugs is a group phenomenon, rather than the summed response of individual independent cells to injury. Thus, a complex contagion-like response may spread beyond the initial impact of an agent to enlarge its effect. This indirect effect, termed “Bystander Effect,” is multifaceted and may play a significant role in the therapy of tumors and in carcinogenesis. A better understanding of this phenomenon is needed in (...) order to modulate treatment protocols to therapeutic advantage and to provide more rational guidelines for the evaluation of environmental hazards. BioEssays 22:286–290, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

This paper argues that grieving a profound loss is a transformative experience, specifically an unchosen transformative experience, understood as an event‐based transformation not chosen by the agent. Grief transforms the self (i) cognitively, by forcing the agent to alter a large set of beliefs and desires, (ii) phenomenologically, by altering their experience in a diffuse or global manner, (iii) normatively, by requiring the agent to revise their practical identity, and (iv) existentially, by confronting the agent with a structuring condition of (...) their life. Grief is a disruption to one's identity that an agent addresses by making sense of the world after the loss, remaking the practical significance of various situations in their lives through their activity. Transformative grief is both an “activity” and a “revelation” (Callard, 2020): Some parts of the grieving process are active (the agent must actively work to become a new kind of person), while others are irreducibly passive (the agent passively undergoes them). (shrink)

Rad ukazuje na kljucne momente razvoja teorije aktera-mreze kroz nekoliko najznacajnih dela Bruna Latura. Uocavaju se promene pocetne pozicije autora u odnosu na dela kasnijeg datuma nastanka. Teorija aktera-mreze je prikazana kroz niz?neuralgicnih? tacaka koje se u njoj mogu uociti. Na samom kraju rada su razmatrana resenja koje teorija aktera-mreze nudi za odredjeni broj fundamentalnih problema sociologije, koje je definisao Latur.

Kids will discover the stories of people like Jeff Boyer, an Iowa farmer who was forced to evacuate his farm and leave behind his 3,500 pigs.

There is an emerging awareness of the possibility of conflicts of interest in the practice of medicine in Croatia. The paper examines areas within the medical profession where conflicts of interest can and have occurred, probably not only in Croatia. Particularly addressed are situations when a doctor may have dual obligations and how independent ethics committees can help in decreasing the influence of a conflict of interest. The paper also presents extracts from the Croatian Code of Ethics for the medical (...) profession that address problems of conflict of interest. (shrink)

The Helsinki Declaration is the ‘gold standard’ — a directive, not a law, on how to conduct controlled studies in humans in conformity with ethical principles. In spite of many discussions about their unsuitability some articles have remained unchanged in the most recent (sixth) revision of the Declaration. The demand to use “the best treatment” excludes use of placebo in the control group and presents an obstacle to the scientific evaluation of a number of drugs and treatments in general. The (...) use of placebo is justified whenever its use does not cause irreversible damage or considerable suffering to the well informed patient. It must be, is, and will be used in the controlled clinical trials of treatments of a great number of diseases especially those which have a tendency to spontaneous improvement, even healing, or have a pronounced psychological component. (shrink)

Based on the understanding of the term rhetoric that transcends the notion of literary genre, this book offers new answers to the questions of the provenance and the role of the main rhetorical strategies in Lucretius' De rerum natura.

We present the basic concepts of space and time, the Galilean and pseudo-Euclidean geometry. We use an elementary geometric framework of affine spaces and groups of affine transformations to illustrate the natural relationship between classical mechanics and theory of relativity, which is quite often hidden, despite its fundamental importance. We have emphasized a passage from the group of Galilean motions to the group of Poincaré transformations of a plane. In particular, a 1-parametric family of natural deformations of the Poincaré group (...) is described. We also visualized the underlying groups of Galilean, Euclidean, and pseudo-Euclidean rotations within the special linear group. (shrink)

Horgan believes that the truth of the statement “Beethoven’s fifth symphony has four movements” does not require that there be some “dedicated object” answering to the term “Beethoven’s fifth simphony”. To the contrary, the relevant language/world correspondence relation is less direct than this. Especially appropriate is the behavior by Beethoven that we would call “composing his fifth symphony”. Our objections go along two directions: (1) is the process ontology (a) really a right kind of ontology for artworks (symphonies, novels) and, (...) (b) more important, is this kind of ontology compatible with Parmenidian approach to ontology? The answer to (a) is negative. With reference to point (1b) we might say that Parmenides was a typical staunch advocate of substance metaphysics rather than process metaphysics. Traditionally, substances are individuated by their properties, namely, there are assumed two sorts of properties: primary and secondary. Primary properties describe the substance as it is in and by itself; secondary properties underlie the impact of substances upon others and the responses they elicit from them. (2) The claim that it is most unlikely to suppose that we can have some kind of cognitive contact “with an entity which has no spatio-temporal location and does not causally interact with anything” does not hold. We underpin the claim that there is some cognitive access to entity such as Beethoven’s fifth symphony with Bender’s theory of realization relation between musical work and performance. (shrink)

There is widespread view among numerous aestheticians that aesthetic and value properties are response-dependent. According to some philosophers the dependence has a rich and multilayered structure: value qualities (e.g. beauty) depend on our response to aesthetic properties (e.g. harmonious), which in turn depend on our response to a pattern of primary and secondary qualities (shapes and colors). Secondary qualities are themselves response-dependent. The basic dependence relation is thus iterated. The resulting structure is one of iterated response-dependence. The integral part of (...) such a position is a relational view, best captured by the response-dispositional analysis: My states of being appeared to magnificently in front of a painting manifests the disposition of painting to induce such experience in the normal viewer.There are two main objections against the dispositional analysis: (1) argument from circularity and (2) argument from introducing two kinds of quality, one categorical, for experiential states, and one dispositional for objects. In this paper we will suggest the arguments against second objection. (shrink)

The paper deals with the topic of empty terms as considered in chapter six of Devitt’s book Designation. Devitt’s proposal is that a statement about fiction is (usually) implicitly preceded by a fiction operator roughly paraphrasable by “it is pretended that” or “in fiction”. The causal chain that forms the network for a fictitious name are not d(esignational)-chains, for they are not grounded in an object. Nevertheless, although the fictitious name does not designate, we could say that it stands in (...) some other referential relationship to the world: it ‘F(ictionally)-designates’. It seem that we could then state truth conditions of a F-sentence using F-designation: the F-operator direct us to look not for the designatum of name but for its F-designatum. The name (for example, “Napoleon” in War and Peace), though nonempty, is just like a fictitious name. In proposing that nonempty names in fiction refer to real items, I argue against the view that “Napoleon” in the War and Peace designates the famous general, Napoleon, and F-designates parts of War and Peace. The referent of F-designation is Napoleon, famous general, too. At the end of the paper I claim that Devitt, if he wants to remain a modal fictionalist, has to renounce the view of one-world metaphysics. (shrink)

The present study aims to identify contextual and psychological factors of proneness to radicalization and violent extremism operationalized through the Militant Extremist Mindset scale consisting of three distinct aspects: Proviolence, Vile World beliefs, and trust in Divine Power. A community sample of 271 high school students from Belgrade and Sandžak regions in Serbia completed: a 24-item MEM scale; contextual measures including a 6-item scale of family dysfunction and a 4-item composite measure capturing exposure to a harsh school environment and peer (...) abuse ; psychological measures including the 9-item Right-Wing Authoritarianism scale, the 5-item Social Dominance Orientation scale, and the 20-item UCLA Loneliness scale. A path analysis was conducted with contextual factors on the first and psychological factors on the second level of the model predicting the three factors of MEM. LON was positively predicted by FDys and HSE, SDO by HSE only, while RWA was positively predicted by FDys only. Contextual and psychological factors accounted for 27% of the variance in PV, 15% of the variance in VW, and 31% of the variance in DP. Obtained findings reveal a complex interplay of contextual and psychological drivers in the prediction of different aspects of RVE and build upon existing knowledge on risk factors associated with RVE. (shrink)