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  1.  9
    mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential.Guang Lei, Li Zhuang & Boyi Gan - 2021 - Bioessays 43 (8):2100093.
    Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation, has an important role in a variety of diseases and pathological conditions, such as cancer. Targeting ferroptosis is emerging as a promising means of therapeutic intervention in cancer treatment. Polyunsaturated fatty acids, reactive oxygen species, and labile iron constitute the major underlying triggers for ferroptosis. Other regulators of ferroptosis have also been discovered recently, among them the mechanistic target of rapamycin complex 1 (mTORC1), a central controller of cell (...)
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    Long non‐coding RNAs in cancer metabolism.Zhen-Dong Xiao, Li Zhuang & Boyi Gan - 2016 - Bioessays 38 (10):991-996.
    Altered cellular metabolism is an emerging hallmark of cancer. Accumulating recent evidence links long non‐coding RNAs (lncRNAs), a still poorly understood class of non‐coding RNAs, to cancer metabolism. Here we review the emerging findings on the functions of lncRNAs in cancer metabolism, with particular emphasis on how lncRNAs regulate glucose and glutamine metabolism in cancer cells, discuss how lncRNAs regulate various aspects of cancer metabolism through their cross‐talk with other macromolecules, explore the mechanistic conceptual framework of lncRNAs in reprogramming metabolism (...)
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    Long non‐coding RNAs in cancer metabolism.Zhen-Dong Xiao, Li Zhuang & Boyi Gan - 2016 - Bioessays 38 (10):991-996.
    Altered cellular metabolism is an emerging hallmark of cancer. Accumulating recent evidence links long non‐coding RNAs (lncRNAs), a still poorly understood class of non‐coding RNAs, to cancer metabolism. Here we review the emerging findings on the functions of lncRNAs in cancer metabolism, with particular emphasis on how lncRNAs regulate glucose and glutamine metabolism in cancer cells, discuss how lncRNAs regulate various aspects of cancer metabolism through their cross‐talk with other macromolecules, explore the mechanistic conceptual framework of lncRNAs in reprogramming metabolism (...)
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