In the United States alone, the prevalence of AD is expected to more than double from six million people in 2019 to nearly 14 million people in 2050. Meanwhile, the track record for developing treatments for AD has been marked by decades of failure. But recent progress in genetics, neuroscience and gene editing suggest that effective treatments could be on the horizon. The arrival of such treatments would have profound implications for the way we diagnose, triage, study, and allocate resources (...) to Alzheimer’s patients. Because the disease is not rare and because it strikes late in life, the development of therapies that are expensive and efficacious but less than cures, will pose particular challenges to healthcare infrastructure. We have a window of time during which we can begin to anticipate just, equitable and salutary ways to accommodate a disease-modifying therapy Alzheimer’s disease. Here we consider the implications for caregivers, clinicians, researchers, and the US healthcare system of the availability of an expensive, presymptomatic treatment for a common late-onset neurodegenerative disease for which diagnosis can be difficult. (shrink)

In this article, the author examines the work of Boris Pasternak, primarily his novel Doctor Zhivago, in the context of his Marburg experience and Kantian ideas as the basis of his moral-aesthetic...

Avicenna says that intellectual cognition involves the emanation of an intelligible form by the ‘agent intellect’ upon the human mind. This paper argues that in order to understand why he says this, we need to think of intellectual cognition as a special case of a much more general phenomenon. More specifically, Avicenna's introduction of an agent intellect will be shown to be a natural consequence of certain assumptions about the temporality, the completion, and the teleology of the causal processes by (...) which things acquire forms. (shrink)

Книга является едва ли не первой попыткой отрефлектировать, как происходило становление философского самосознания в России.

Philosophy is traditionally understood as the search for universal truths, and philosophers are supposed to transmit those truths beyond the limits of their own culture. But, today, we have become skeptical about the ability of an individual philosopher to engage in "universal thinking," so philosophy seems to capitulate in the face of cultural relativism. In Introduction to Antiphilosophy, Boris Groys argues that modern "antiphilosophy" does not pursue the universality of thought as its goal but proposes in its place the (...) universality of life, material forces, social practices, passions, and experiences --angst, vitality, ecstasy, the gift, revolution, laughter or "profane illumination" --and he analyzes this shift from thought to life and action in the work of thinkers from Kierkegaard to Derrida, from Nietzsche to Benjamin. Ranging across the history of modern thought, Introduction to Antiphilosophy endeavors to liberate philosophy from the stereotypes that hinder its development. --Publisher. (shrink)

Merleau-Ponty's «Phenomenology of Perception» suggests perception to be the primary level of the giveness of the world. Perception appears as always an incomplete synthesis of the plural, bringing together bodily and material aspects. Such the simplest interpretation of perception as rendering a contact within the dyad «body-world» is a preliminary axiom for explaining the rest of the process of noematic sense formation. At the same time, Merleau-Ponty’s theoretical intuitions clearly presuppose more, and perception is also thought of as the final (...) point where sense is already given by some way. Thus, in Phenomenology, the second interpretation of perception presumes it to be sense-giving accompanied by the tacit cogito. Merleau-Ponty suggests that these interpretations are compatible with each other, but the transition between them seems really problematic. In the research author shos that the limit of the initial synthesis of perception - some sense of the perceived (exemplyfing meanings as «this horse», «the green density that rushed towards me») - is unattainable from within perception itself and by its means. Perception is itself mediated by other faculties, such as memory, reflection, and imagination. Argumentation for this thesis is carried out in several ways; the relations in the perception/imagination pair show us the most characteristic case, where Merleau-Ponty, judging by later works, himself comes close to recognizing the limitations of the hypothesis of «the world of perception», to the need for a phenomenological development of the topic of faculties. Based on the application of the phenomenological method and the analysis of the conceptual constructions of Merleau-Ponty, we can conclude the following: «the world of perception» does not exist, but the phenomenology of faculties is demanded. (shrink)

If definitive evidence concerning treatment effectiveness becomes available from an ongoing randomized clinical trial, then the trial could be stopped early, with the public release of results benefiting current and future patients. However, stopping an ongoing trial based on accruing outcome data requires methodological rigor to preserve validity of the trial conclusions. This has led to the use of formal interim monitoring procedures, which include inefficacy monitoring that will stop a trial early when the experimental treatment appears not to be (...) working. For participants, inefficacy monitoring is especially important as it ensures that they are not being treated worse than if they had not enrolled on the trial. We discuss the importance of reporting with trial results the formal interim inefficacy monitoring guidelines that were utilized, and, if none were used, the reasons for their absence. A survey of two leading medical journals suggests that this is not current practice. (shrink)

"Qu'est-ce que le droit?" est peut-être la plus essentielle des problématiques auxquelles les juristes doivent répondre. Or peu de questions touchant à l'homme et aux sociétés ont suscité des réponses aussi diverses et parfois antagonistes que "Qu'est-ce que le droit?". Dans le vaste paysage des théories juridiques, il est difficile de savoir avec précision ce qu'est le droit. Faut-il dès lors se résigner à ne jamais disposer d'un objet-droit homogène et stable, dont l'identité serait finement établie et les frontières nettement (...) tracées? Pour étudier le droit, il importe pourtant de connaître ses spécificités parmi les différents modes de régulation sociale, cela afin de délimiter le champ des normes juridiques et donc circonscrire et borner l'objet d'étude. La définition du droit exposée dans la première partie de ce livre est une définition lexicographique, une définition scientifique. Il s'agit de constater ce qu'est le droit, quelles sont ses propriétés, au terme d'une enquête objective et empirique, excluant tout jugement subjectif et toute proposition personnelle. Comme la religion romaine qui accueillait dans son Panthéon tous les dieux grecs et étrusques, la théorie syncrétique réunit toutes les définitions du droit actuellement en vigueur dans la pensée juridique. Dans ce cadre, les diverses théories du droit ne sont plus des concurrentes, mais des associées. Elles ne s'opposent plus, mais se complètent. Ensuite, en appliquant les critères de juridicité ainsi recensés à une norme donnée, on peut mesurer son niveau de force juridique sur l'échelle de juridicité. Cette échelle, expliquée et expérimentée dans la seconde partie du livre, permet d'interroger les dimensions du droit. Or son application à de multiples formes de normativité indique que, dans le monde des normes sociales, les normes fortement juridiques côtoieraient les normes moyennement juridiques et les normes faiblement juridiques. En revanche, il ne semble guère exister de normes sociales non juridiques - les différences entre normes seraient de degré et non de nature. Ainsi l'échelle de juridicité invite-t-elle à retenir une conception graduelle du droit et un panjuridisme modéré. L'intérêt de cette nouvelle forme de rationalité de la pensée juridique est d'autoriser le juriste à s'ouvrir à tout type de normes sociales tout en sauvegardant l'autonomie conceptuelle du droit. (shrink)

Si tout le propos de Kant, dans la Critique de la raison pure, est de légitimer les conditions de possibilité des jugements synthétiques a priori, il ne va pas s'agir pour nous, à travers la présente étude, de prendre pour objet de recherche les conditions de possibilité des jugements synthétiques a priori, mais de nous attarder sur l'idée même de synthèse a priori et d'ouvrir une discussion critique autour du problème du jugement qui lui est directement rattaché. L'idée même de (...) synthèse a priori inaugure chez Kant une nouvelle forme de connaissance ; or toute forme de connaissance semble toujours consubstantiellement liée à une forme de jugement, car émettre un jugement revient à participer d'un acte de connaissance au travers duquel on détermine un rapport entre concepts. Tenter ainsi de montrer comment l'idée kantienne de jugement synthétique a priori, nouvelle manière de comprendre les relations entre concepts déterminés et de concevoir un jugement, fait problème en elle-même constituera également notre objet de recherche"--Page 4 of cover. (shrink)

I propose a general alethic theory of epistemic risk according to which the riskiness of an agent’s credence function encodes her relative sensitivity to different types of graded error. After motivating and mathematically developing this approach, I show that the epistemic risk function is a scaled reflection of expected inaccuracy. This duality between risk and information enables us to explore the relationship between attitudes to epistemic risk, the choice of scoring rules in epistemic utility theory, and the selection of priors (...) in Bayesian epistemology more generally. (shrink)

Our essay examines Levinas's ideas of time and their relation to his ethical discourse. We read 'his' texts deconstructively and show how the notions of time and of the ethical are closely inter connected. We argue that Levinas deconstructs the concept of time, as it is traditionally developed by Western philosophy, and that this concept is part and parcel of and cannot be detached from his philo sophical venture. By following two major shibboleths, jouissance and language, we trace the deconstructive (...) effort of Levinas to dismantle Western philosophy's traditional conceptualization of time. Our dis cussion points not to the failure of Levinas's toil but rather to the aporetic structure of his itinerary and to the ethical significance of this aporia. (shrink)

Descartes’ metaphysics lays the foundation for the special sciences, and the notion of consciousness (conscientia) belongs to metaphysics rather than to psychology. I argue that as a metaphysical notion, ‘consciousness’ refers to an epistemic version of moral conscience. As a consequence, the activity on which science is based turns out to be conscientious thought. The consciousness that makes science possible is a double awareness: the awareness of what one is thinking, of what one should be doing, and of the possibility (...) of a gap between the two. (shrink)

The leading art theorist takes on art in the age of the Internet In the early twentieth century, art and its institutions came under critique from a new democratic and egalitarian spirit. The notion of works of art as sacred objects was decried and subsequently they would be understood merely as things. This meant an attack on realism, as well as on the traditional preservative mission of the museum. Acclaimed art theorist Boris Groys argues this led to the development (...) of “direct realism”: an art that would not produce objects, but practices (from performance art to relational aesthetics) that would not survive. But for more than a century now, every advance in this direction has been quickly followed by new means of preserving art’s distinction. In this major new work, Groys charts the paradoxes produced by this tension, and explores art in the age of the thingless medium, the Internet. Groys claims that if the techniques of mechanical reproduction gave us objects without aura, digital production generates aura without objects, transforming all its materials into vanishing markers of the transitory present. (shrink)

In this paper we develop a general theory of algorithmic fairness. Drawing on Johnson King and Babic’s work on moral encroachment, on Gary Becker’s work on labor market discrimination, and on Strawson’s idea of resentment and indignation as responses to violations of the demand for goodwill toward oneself and others, we locate attitudes to fairness in an agent’s utility function. In particular, we first argue that fairness is a matter of a decision-maker’s relative concern for the plight of people from (...) different groups, rather than of the outcomes produced for different groups. We then show how an agent’s preferences, including in particular their attitudes to error, give rise to their decision thresholds. Tying these points together, we argue that the agent’s relative degrees of concern for different groups manifest in a difference in decision thresholds applied to these groups. (shrink)

In this handbook, I put into practice my philosophical views on children's mathematics. The handbook contains brief instructions and examples of mathematical activities. In the INSTRUCTIONS section, instructions are given on how, and in part why that way, to help preschool children in their mathematical development. In the ACTIVITIES section, there are examples of activities through which the child develops her mathematical abilities.

Wenn Tugenden Praxisformen sind, dann kann man einiges über Praxisformen lernen, indem man nachsieht, was Tugenden sind. Ich werde dies im Folgenden partiell und indirekt tun, indem ich die sprachliche Form untersuche, in der Aristoteles die ethischen Tugenden beschreibt. Er tut dies im Wesentlichen dadurch, dass er den derart Tugendhaften in der dritten Person Singular beschreibt. Dann werde ich kurz auf die Grenzen von Aristoteles’ Verfahren zu sprechen kommen, indem ich auf eine den Tugenden und anderen Praxisformen inhärente Pluralität hinweise. (...) Eine vergleichbare Untersuchung der sprachlichen Form in der Nikomachischen Ethik ist mir nicht bekannt; die Hinweise auf die Pluralität der Tugend dagegen beanspruchen keine besondere Originalität. (shrink)

Cet ouvrage propose une approche et une analyse scientifiques et statistiques du pluralisme juridique. Défini en tant que coexistence de sources étatiques et non étatiques de règles de droit, le pluralisme juridique appelle à la fois une réponse théorique et empirique. Ce livre procède à une enquête de terrain et de pose les jalons de ce travail scientifique visant à évaluer l'effectivité du pluralisme juridique en n'ayant d'égards que pour les seuls faits normatifs.

В книге прослежены разнообразные виды обманов, вплоть до парадоксально положительных, уточняется понимание терминов. Для специалистов и широкого круга читателей.

Die Untersuchung rekonstruiert das Subjekt in seinen kulturhistorischen Formationen als kooperationsorientierten Bewährungssucher, der sich den jeweiligen Formen des Zusammenlebens gemäß formiert, um sich in ihnen bewähren zu können. Die systematisch entwickelte Bezogenheitstheorie erlaubt die Rekonstruktion der universalen und kulturspezifischen Aspekte des Subjekts. die Untersuchung zeigt auf der Subjektebene die Bedingungen der Entfaltung modernen Zusammenlebens auf und kann von daher als eine empirisch durchgeführte Mikrosoziologie der Moderne gelten. Aus dieser kulturhistorisch gesättigten Subjekttheorie werden schließlich Schlussfolgerungen für die pädagogische Professionalität gezogen (Zum (...) Umgang mit Bewährungssuchern).​. (shrink)

This book examines Aristotle's four causes (material, formal, efficient, and final), offering a systematic discussion of the relation between form and matter, causation, taxonomy, and teleology. The overall aim is to show that the four causes form a system, so that the form of a natural thing relates to its matter as the final cause of a natural process relates to its efficient cause. Aristotle's Four Causes reaches two novel and distinctive conclusions. The first is that the formal cause or (...) essence of a natural thing is not a property of this thing but a generic natural thing. The second is that the final cause of a process is not its purpose but the course that processes of its kind typically take. (shrink)

Boris Kment takes a new approach to the study of modality that emphasises the origin of modal notions in everyday thought. He argues that the concepts of necessity and possibility originate in counterfactual reasoning, which allows us to investigate explanatory connections. Contrary to accepted views, explanation is more fundamental than modality.

Many philosophers have argued that statistical evidence regarding group char- acteristics (particularly stereotypical ones) can create normative conflicts between the requirements of epistemic rationality and our moral obligations to each other. In a recent paper, Johnson-King and Babic argue that such conflicts can usually be avoided: what ordinary morality requires, they argue, epistemic rationality permits. In this paper, we show that as data gets large, Johnson-King and Babic’s approach becomes less plausible. More constructively, we build on their project and develop (...) a generalized model of reasoning about stereotypes under which one can indeed avoid normative conflicts, even in a big data world, when data contain some noise. In doing so, we also articulate a general approach to rational belief updating for noisy data. (shrink)

We further investigate a divisibility relation on the set of BN ultrafilters on the set of natural numbers. We single out prime ultrafilters (divisible only by 1 and themselves) and establish a hierarchy in which a position of every ultrafilter depends on the set of prime ultrafilters it is divisible by. We also construct ultrafilters with many immediate successors in this hierarchy and find positions of products of ultrafilters.

Approximate coherentism suggests that imperfectly rational agents should hold approximately coherent credences. This norm is intended as a generalization of ordinary coherence. I argue that it may be unable to play this role by considering its application under learning experiences. While it is unclear how imperfect agents should revise their beliefs, I suggest a plausible route is through Bayesian updating. However, Bayesian updating can take an incoherent agent from relatively more coherent credences to relatively less coherent credences, depending on the (...) data observed. Thus, comparative rationality judgments among incoherent agents are unduly sensitive to luck. (shrink)

Vladimir Arnold, an eminent mathematician of our time, is known both for his mathematical results, which are many and prominent, and for his strong opinions, often expressed in an uncompromising and provoking manner. His dictum that "Mathematics is a part of physics where experiments are cheap" is well known. This book consists of two parts: selected articles by and an interview with Vladimir Arnold, and a collection of articles about him written by his friends, colleagues, and students. The book is (...) generously illustrated by a large collection of photographs, some never before published. The book presents many a facet of this extraordinary mathematician and man, from his mathematical discoveries to his daredevil outdoor adventures. (shrink)

This essay is meant to shed light on a discourse that spans centuries and includes different voices. To be aware of such trans-textual resonances can add a level of historical understanding to the reading of philosophical texts. Specifically, we intend to demonstrate how the notion of the ineffable Dao 道, prominently expressed in the Daodejing 道德經, informs a long discourse on incongruent names in distinction to a mainstream paradigm that demands congruity between names and what they designate. Thereby, we trace (...) the development of the idea of the ineffable Dao quite differently from modern mystical interpretations. We show how, in an early Chinese context, it first gives rise to a sociopolitical critique of the incongruity underlying socially constructed names in the Zhuangzi 莊子, then to a discourse on the incongruity between moral virtues and names in Xuanxue 玄學 philosophy, and eventually to Sengzhao’s 僧肇 claim that a perceived congruence of names with things does not entail actual congruence between names and reality. (shrink)