Misconduct in science is often viewed and analyzed through the lenses of normative ethics and moral philosophy. However, notions and methods in the philosophy of science could also provide rather penetrative explanatory insights into the nature and causes of scientific misconduct. A brief illustration in this regard, using as examples the widely popular Popperian falsification and the Kuhnian scientific paradigm, is provided. In multiple areas of scientific research, failure to seek falsification in a Popperian manner constitutes a questionable research practice (...) and could lead to “falsification” in the context of research misconduct. On the other hand, scientific misconduct is often facilitated by its perpetrators using the familiarity, expectations and confines of a Kuhnian paradigm to blend in fabricated data/results. A rudimentary application of these philosophical notions could be useful in our understanding of the nature and cause of research misconduct, and facilitate mitigation of the latter through educational means. (shrink)

The graduate course in research ethics in the Graduate School for Integrative Sciences and Engineering at the National University of Singapore consists of a semester long mandatory course titled: “Research Ethics and Scientific Integrity.” The course provides students with guiding principles for appropriate conduct in the professional and social settings of scientific research and in making morally weighted and ethically sound decisions when confronted with moral dilemmas. It seeks to enhance understanding and appreciation of the moral reasoning underpinning various rules (...) and legislative constraints associated with research subjects and procedures. Further, students are trained to critically analyse cases and issues associated with scientific misconduct preparing them to act in a responsible and effective manner should they encounter such cases. The diverse background and training of the cohort also provide a unique setting and opportunity for student-initiated collaborative interdisciplinary learning. This article offers a reflective account of the course and some preliminary insights into learning outcomes. (shrink)

The recent emergence of reprogramming technologies to convert brain cell types or epigenetically alter neurons and neural progenitors in vivo and in situ hold significant promises in brain repair and neuronal aging reversal. However, given the significant epigenetic and transcriptomic changes to components of the existing neuronal cells and network, we question if these reprogramming technology might inadvertently alter or erase memory engrams, conceivably resulting in changes in narrative identity or personality. We suggest that the nature of these alterations might (...) be less predictable compared to memory and personality changes known to be associated with diseases, drugs or brain stimulation therapies. While research in applying reprogramming technologies to neurological ailments and aging should continue, more targeted analyses should be put in place in animal experiments to gauge the severity and degree of memory alterations, and appropriate risk and benefit analyses should be conducted before these technologies move into human trials. (shrink)

Zusammenfassung Zahlreiche Fußballvereine der 1. und 2. Bundesliga sind aus Fusionen hervorgegangen, doch bislang ist kaum etwas über dieses Phänomen in der Sportwissenschaft bekannt. Ziel des Aufsatzes ist es, mittels einer organisationssoziologischen Brille den SC Paderborn 07, als Bundesligaverein, der aus mehreren Fusionen hervorgegangen ist und als solcher verschiedene Traditionslinien in sich vereint, zu beleuchten. Dabei werden insbesondere die sozialen Folgen in den Blick genommen.

Bülow and Helgesson discussed the practice of gift/honorary authorships and expounded on a most devious form of these, termed ‘hostage authorship’. The authors drew a parallel of such situations in research and publishing with the problem of ‘dirty hands’. In this case, acceding, albeit with regrets, may well be ‘… what we ought to do, even if it requires us to do something that is intrinsically bad’, especially if ‘this is both practically necessary and proportionate to the end’. Here, I (...) caution against this being a morally cogent, normative course of action. Tangible benefits from research not yet performed or published could not be predicted with any certainty, and as such could not be deemed sufficiently important to override moral constraints of justice and fairness. The utilitarian argument for any measure of beneficence with ‘dirty hands’ could therefore be nothing more than a self-serving act, or a self-exonerating form of moral disengagement. Such actions could have lasting ill effects on junior... (shrink)

Scientific research is supposed to acquire or generate knowledge, but such a purpose would be severely undermined by instances of research misconduct (RM) and questionable research practices (QRP). RM and QRP are often framed in terms of moral transgressions by individuals (bad apples) whose aberrant acts could be made conducive by shortcomings in regulatory measures of organizations or institutions (bad barrels). This notion presupposes, to an extent, that the erring parties know exactly what they are doing is wrong and morally (...) culpable, but had nonetheless proceeded to commit wrongful acts. However, a confession of intent to deceived is often not readily admitted by perpetrators of RM. I posit that beyond the simplistic notion of conscious moral transgression, deficits in epistemic virtues and/or the prevalence of epistemic vices have important roles to play in initiating and driving RM/QRP. For the individual perpetrator, deficits in epistemic virtues could lead to or amplify errors in one’s desperate attempt to be accomplished or to excel, and pushes one across the ethical line or down the slippery slope of misconduct. Likewise, a lack of epistemic virtue within perpetrators’ institution or organization could make it conducive for deceitful acts and suppress indications and warning signs for the former. Furthermore, epistemic vices exhibited by reviewers, editors and journals could also promote RM/QRP. In this view, epistemic failings, rather than widespread moral deficiencies of individuals within the research ecosystem, may underlie the prevalence of RM/QRP. (shrink)

A retraction notice is a formal announcement for the removal of a paper from the literature, which is a weighty matter. Xu et al. (Science and Engineering Ethics, 29(4), 25 2023) reported that 73.7% of retraction notices indexed by the Web of Science (1927–2019) provided no information about institutional investigations that may have led to the retractions, and recommended that Committee on Publication Ethics (COPE) retraction guidelines should make it mandatory to disclose institutional investigations leading to retractions in such notices. (...) While this recommendation would add to the transparency of the retraction process, a blanket mandate as such could be potentially problematic. For research misconduct (RM)-positive cases, a mandatory investigative disclosure may be abused by some to deflect responsibility. More importantly, a mandatory disclosure could harm authors and institutions in RM-negative cases (i.e. those stemming from honest errors with no misconduct). I illustrate with case vignettes the potential epistemic injustice and confusion that a mandate for investigation disclosure in retraction notices could incur, and suggest a more nuanced approach to its implementation. (shrink)

Irregularities in data/results of scientific research might be spotted pre-publication by co-workers and reviewers, or post-publication by readers typically with vested interest. The latter might consist of fellow researchers in the same subject area who would naturally pay closer attention to a published paper. However, it is increasingly apparent that there are readers who interrogate papers in detail with a primary intention to identify potential problems with the work. Here, we consider post-publication peer review (PPPR) by individuals, or groups of (...) individuals, who perform PPPRs with a perceptible intention to actively identify irregularities in published data/results and to expose potential research fraud or misconduct, or intentional misconduct exposing (IME)-PPPR. On one hand, such activities, when done anonymously or pseudonymously with no formal discourse, have been deemed as lacking in accountability, or perceived to incur some degree of maleficence, and have been labelled as vigilantism. On the other, these voluntary works have unravelled many instances of research misconduct and have helped to correct the literature. We explore the tangible benefits of IME-PPPR in detecting errors in published papers and from the perspectives of moral permissibility, research ethics, and the sociological perspective of science. We posit that the benefits of IME-PPPR activities that uncover clear evidence of misconduct, even when performed anonymously or pseudonymously, outweigh their perceived deficiencies. These activities contribute to a vigilant research culture that manifests the self-correcting nature of science, and are in line with the Mertonian norms of scientific ethos. (shrink)

Cases of research misconduct in the ecological and environmental sciences appear to be relatively rare. A controversial paper published in Science in 2016 documenting the effects of microplastics on the feeding and innate behaviours of fish larvae has recently been retracted, with the authors found guilty of scientific misconduct. In addition to the expected fallout, such as individual and institutional reputational damage from a research misconduct finding, this case has two possibly wider-ranging ramifications. Firstly, there may be a presumptive notion (...) that a strong negative effect could be more successfully published than a neutral effect. This presumption would belie the true stringency and rigor of research adopted by workers in the field. Secondly, the case may have a negative impact on the public’s perception of and trust in legitimate and good science that addresses critical environmental issues, such as anthropogenic climate change. (shrink)

Az ELTE filozófiaoktatójának új könyve, ahogy alcíme világosan állítja a vallás filozófiai alapjainak feltárására vállalkozik. Vagyis a következő alapvető kérdéseket igyekszik megválaszolni: Mi a vallás? Mi a vallási hit; és mi lehet ennek a hitnek a tartalma? (Ez utóbbit nevezi könyvében “vallási reprezentációnak”.) Tömör, de rendkívül intenzív vizsgálódása vérbeli filozófia, fogalmi megismerés és elemzés, amelynek egyik lábát a középkori filozófia beható ismerete, másik lábát pedig a kortárs, ún. angolszász filozófia nyelvfilozófiai alapú módszerei adják, amint a megismeréstudomány és evolúcióbiológia felismerései támogatnak. (...) A végeredmény egy elegáns és világos érvelés, nem apológia és nem bálványdöntés, hanem egy igen eredeti vallásfilozófiai alapozás, amely a vallás, a hit, mint antropológiai jellemző megértéséhez is közelebb visz. A szándékoltan rövid, de jól hasznosítható irodalomjegyzékkel záruló kiadvány filozófiai jártasságot feltételez olvasójáról. (shrink)

L'Angleterre est la première destination des Français au XVIIIe siècle, mais le voyage d'Angleterre reste peu étudié. Avec ce livre, Gábor Gelléri comble un vide historiographique, au moyen d'un corpus de plus de soixante-dix sources et d'une étude chronologique s'étendant sur cent-trente ans. Il dresse la liste des implications philosophiques, politiques, religieuses, sociales et littéraires que ce voyage comporte. Contestant l'idée que Voltaire aurait 'découvert' l'Angleterre, il remet au premier plan le rôle qu'a joué la Suisse protestante comme intermédiaire dans (...) la découverte de ce pays par les Français, en analysant notamment la polémique suscitée par le récit de Béat de Muralt, qui voyagea avant Voltaire. Le voyage outre-Manche, et les récits qui en sont faits, sont cruciaux dans les interactions entre la France et l'Angleterre. L'Angleterre est l'un des miroirs dans lesquels la France se regarde. Comparant les discours aux pratiques avérées, l'auteur réévalue certaines catégories majeures, notamment l'opposition souvent mal interprétée entre anglomanie et anglophobie. Il interroge les motivations des voyageurs, à une époque où la pratique du voyage commence à se démocratiser, ce qui conduira à la naissance du tourisme. Dépassant la simple étude des discours, il met en lumière les usages du voyage, en rappelant qu'avant de devenir l'objet d'un acte d'écriture le voyage constitue une pratique sociale. Qu'il soit philosophique, anti-philosophique, scientifique, pittoresque ou de plaisance, le voyage d'Angleterre est un champ d'exploration permettant aux voyageurs de mettre à l'épreuve toutes les idées importantes du siècle et cristallisant les polémiques du temps. Gábor Gelléri démontre que ce voyage est un phénomène majeur: un laboratoire d'idées et un portrait vivant de la complexité intellectuelle et idéologique du XVIIIe siècle européen. L'ouvrage a été publié avec le soutien du Department of Modern Languages de Aberystwyth University. (shrink)

Proteins of the exocytotic (secretory) pathway are initially targeted to the endoplasmic reticulum (ER) and then translocated across and/or inserted into the membrane of the ER. During their anterograde transport with the bulk of the membrane flow along the exocytotic pathway, some proteins are selectively retained in various intracellular compartments, while others are sorted to different branches of the pathway. The signals or structural motifs that are involved in these selective targeting processes are being revealed and investigations into the mechanistic (...) nature of these processes are actively underway. (shrink)

Extreme conditions like savantism, autism or synaesthesia, which have a neurological 2AH, UK basis, challenge the idea that other minds are similar to our own. In this paper we report a single case study of a man in whom all three of these conditions co-occur. We suggest, on the basis of this single case, that when savantism and synaesthesia co- occur, it is worthwhile testing for an undiagnosed Autism Spectrum Condition (ASC). This is because savantism has an established association with (...) ASC, and the combination of ASC with synaesthesia may increase the likelihood of savantism. The implications of these conditions for philosophy of mind are introduced. (shrink)

Kur’an tasavvuru belli kavramlardan meydana gelmektedir. İnsanın fiziki ve manevî yönünü ifade eden fıtrat kavramı, Kur’an tasavvurunu ifade eden önemli kavramlarından biridir. Fıtrat kavramının ilk günden itibaren tefsircilerin ilgi odağı olması da bundandır. Genellikle fıtrat, İslam dini, ilk yaratılış ve insanın dini kabul etme potansiyeli olarak yorumlanmış ve bunların değişip değişmeyeceği üzerinde durulmuştur. Rum sûresinde geçen “khalqullah” ile Nisâ sûresinde geçen “khalqullah” terkiplerinin bulunduğu âyetler arasında bu çerçevede bağlantı kurulmuştur. Bu çalışmamızda fıtratın mahiyeti ile fıtratla ilgili âyetlerin birbiriyle ilişkilendirilmesi irdelenecek (...) ve fıtratın temel unsurları üzerinde durulacaktır. Akıl, sevgi, aşk, güzel şeylere ilgi duyma ve çirkinliklerden kaçınmanın, insan fıtratının temel bileşenleri arasında yer alıp almadığı tartışılacaktır. Ayrıca fıtrat âyetinde geçen tebdîl kavramı ile Nisâ sûresinde geçen tağyir kavramının, aynı manayı ifade edip etmediği üzerinde durulacaktır. (shrink)

Prema teoriji holona stvarnost se ne sastoji ni od, samo, cjelina, niti od, samo, dijelova, nego od međuprožimajućih cjelina i dijelova, odnosno od holona , koje nalazimo unutar materijalnih i idejnih okvira stvarnosti. S obzirom na to da potpuno izolirani i neinteraktivni entiteti ne mogu opstojati holoni se udružuju, čineći tako zajednice holona, odnosno holarhije. Unutar holarhije naročit značaj imaju holoni s velikim brojem veza prema ostalim holonima. Takve holone nazivamo koncentratorima, s time da možemo razlikovati koncentratore prvog reda i (...) koncentratore drugog reda. U konačnici, ako neki holon zapostavlja svoju dijelost, u cilju dominiranja nad ostatkom holarhije, tada govorimo o neprirodnim hijerarhijama, a ukoliko zapostavlja svoju cijelost, što dovodi do toga da se jednostavno stopi s ostatkom holarhije, tada govorimo o neprirodnim heterarhijama.According to the theory of holons reality does not only consist of parts or wholes, but also from inter-permeating wholes and parts, that is, holons; which are found within material and ideological framework of reality. Given that fully isolated and uninteractive entities cannot exist, holons associate, in this way forming a community of holons, that is, holarchies. Within the holarchy special significance have holons that contains a large number of connections to other holons. Such holons are called hubs, thus we can distinguish first-order hubs and second-order hubs. In the end, if one holon neglects his communion, for the purpose of overdomination over the rest of the holarchy, then we talk about unnatural hierarchies, but if one holon neglects his agency, which leads him to simply fuse with the rest of the holarchy, then we talk about unnatural heterarchies. (shrink)

Mon évasion (2008) de Benoîte Groult est une autobiographie de femme qui s’inscrit non seulement dans l’histoire du féminisme, mais représente ici une féminité complexe et nuancée constituant l’axe du développement de la personnalité et aussi une certaine manière de se raconter. La femme y est généralement représentée à travers ses relations humaines, en tant que membre d’un « couple ». Cette nouvelle manière (féminine ?) de se raconter a aussi des conséquences sur l’écriture : outre l’alternance constante entre le (...) récit et le discours du narrateur, la discontinuité structurelle (insertion des interviews, réécriture d’une bande dessinée), et les problèmes de dénomination du personnage, le texte de Groult présente des emplois variés des temps verbaux et des pronoms personnels : en fait, on y trouve des passages écrits au passé composé, au présent, au passé simple combinés aux pronoms personnels à la première, à la troisième ou à la deuxième personne. Il s’ensuit que l’espace autobiographique de Mon évasion revêt une complexité inédite : récit, interviews, bande dessinée et une photo sur la couverture contribuent tous, en tant que supports variés, à une pluralité des temporalités qui amènent de nouvelles formes des représentations de la féminité. (shrink)

Name der Zeitschrift: Frühmittelalterliche Studien Jahrgang: 36 Heft: 2 Seiten: 423-425.

Cicero is increasingly recognised as a highly intelligent contributor to the ongoing ethical debates between Epicureans, Stoics and other schools. In this work on the fundamentals of ethics his learning as a scholar, his skill as a lawyer and his own passion for the truth result in a work which dazzles us in its presentation of the debates and at the same time exhibits the detachment of the ancient sceptic. Many kinds of reader will find themselves engaged with Cicero as (...) well as with the ethical theories he presents. This collection takes the reader further into the debates, opening up new avenues for exploring this fascinating work. (shrink)

Medical students' professional identity formation is an adaptive, developmental process. PIF is shaped by values implicit in educational practices and in the culture of the learning environment. In 2003, educational leaders at Harvard Medical School created the Cambridge Integrated Clerkship as a new model of clinical education to support PIF intentionally. The CIC, a longitudinal integrated clerkship, differs in structure, processes, and venues from traditional block rotations, while...

Cicero is increasingly recognised as a highly intelligent contributor to the ongoing ethical debates between Epicureans, Stoics and other schools. In this work on the fundamentals of ethics his learning as a scholar, his skill as a lawyer and his own passion for the truth result in a work which dazzles us in its presentation of the debates and at the same time exhibits the detachment of the ancient sceptic. Many kinds of reader will find themselves engaged with Cicero as (...) well as with the ethical theories he presents. This collection takes the reader further into the debates, opening up new avenues for exploring this fascinating work. (shrink)

Alzheimer’s disease (AD), the devastating and most prevailing underlying cause for age-associated dementia, has no effective disease-modifying treatment. The last approved drug for the relief of AD symptoms was in 2003. The recent approval of sodium oligomannate (GV-971, 2019) in China and the human antibody aducanumab in the USA (ADUHELM, 2021) therefore represent significant breakthroughs, albeit ones that are fraught with controversy. Here, we explore potential scientific ethics issues associated with GV-971 and aducanumab’s development and approval. While these issues may (...) be belied by socioeconomic and political complexities in the heady business of commercial drug development, they are of fundamental importance to scientific integrity and ultimately, welfare of patients. We posit that the push for approval of both AD drugs based on incomplete research and unconvincing marginal effectiveness is ethically unsound. Regardless of how both these drugs shall perform in the market for the years to come, the scientific ethics issues and potentially questionable research practices should therefore be duly noted and lessons learned. (shrink)