We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Monografii︠a︡ posvi︠a︡shchena tvorchestvu Petra Evgenʹevicha Astafʹeva (1846-1893), zamechatelʹnogo russkogo filosofa, psikhologa i publit︠s︡ista iz plei︠a︡dy mysliteleĭ kont︠s︡a XIX veka -- "zolotogo veka" russkoĭ kulʹtury. V knige detalʹno rassmotreny osnovnye dostizhenii︠a︡ P.E. Astafʹeva, svi︠a︡zannye s obosnovaniem spiritualisticheskogo mirovozzrenii︠a︡: ego uchenie o dukhovnoĭ lichnosti i svobode voli, paradoksalʹnai︠a︡ traktovka chuvstva li︠u︡bvi, originalʹnai︠a︡ kont︠s︡ept︠s︡ii︠a︡ "bessoznatelʹnogo", predstavlenie o vere cheloveka v sebi︠a︡ kak pochve estestvennogo bogopoznanii︠a︡ i t.d. V edinstve s filosofsko-psikhologicheskim ucheniem P.E. Astafʹeva rassmotrena ego publit︠s︡istika (vkli︠u︡chai︠a︡ novyĭ i gluboko aktualʹnyĭ variant "troĭstvennoĭ (...) formuly") i namechena vozmozhnostʹ metafizicheskogo ponimanii︠a︡ nat︠s︡ionalʹnoĭ prirody cheloveka. V prilozhenii︠a︡ k knige vkli︠u︡cheny dva ėti︠u︡da avtora, posvi︠a︡shchennye poni︠a︡tii︠a︡m narodnosti i sobornosti. (shrink)

Inspired and in honor of the work of noted political theorist Mary P. Nichols, the essays in this volume explore political ideas and implications in a range of works of philosophy, literature, and film from classical antiquity to the present day, creating an interdisciplinary conversation across genres.

Festschrift honoring P.F. Strawson; includes contributed articles on his contributions in logic and on logic.

This is a transcript of a conversation between P F Strawson and Gareth Evans in 1973, filmed for The Open University. Under the title 'Truth', Strawson and Evans discuss the question as to whether the distinction between genuinely fact-stating uses of language and other uses can be grounded on a theory of truth, especially a 'thin' notion of truth in the tradition of F P Ramsey.

A compilation of all previously published writings on philosophy and the foundations of mathematics from the greatest of the generation of Cambridge scholars that included G.E. Moore, Bertrand Russell, Ludwig Wittgenstein and Maynard Keynes.

제1부 대화문명시대의 불교 제1장 불교연구를 위한 종교학의 의미 제2장 태고의 원융사상과 종교다원주의 제3장 테라바다와 대승불교의 창조적 대화 제4장 불교포괄주의와 한국민속종교 제5장 정토신앙과 그리스도교와의 대화 제6장 포스트모던시대의 종교적 영성과 불교 제2부 인간의 보편적 종교성과 불교교육 제7장 종교와 교육에서의 자유의 의미 제8장 붓다의 교육원리와 교수법 제9장 불교에서 본 죽음과 종교교육 제10장 불교종립학교와 종교교재 제11장 불교 오계의 지구윤리적 지평.

Pv~P: Cambridge Journal of Undergraduate Philosophy, Issue 1, 1982.