The one great quality of Socratic gift is that thinking as an activity continues but not repetitively but every time thinking takes place, it takes place a new. Thinking is the one activity that cannot be repeated like prayers and other pieties. All philosophical thinking is new thinking; it has to be new in order to be thinking. Philosophy had to become the handmaid of sociology and could not be allowed to remain surrogate sociology. When this happened new concepts or (...) new conceptualizations became the need of the hour: in the place of the age-old hierarchic social stratification a novel concept of materialism had to be inducted - after all matter is what matters. And in India morally entangled sociology was holding down the rich human resources of the sub-continent and a development-oriented ideology had to convert this moral society into a legal society: An unlegislated, unlegislatable society is condemned to be unstable andcollapsible; in its place a stable, legislatable society had to be created. With this felt-need Dr. Ambedkar came into the Indian political arena and gave a modernist rethinking to the outmoded Indian social structure: His hallmark was think to change. (shrink)

The one great quality of Socratic gift is that thinking as an activity continues but not repetitively but every time thinking takes place, it takes place a new. Thinking is the one activity that cannot be repeated like prayers and other pieties. All philosophical thinking is new thinking; it has to be new in order to be thinking. Philosophy had to become the handmaid of sociology and could not be allowed to remain surrogate sociology. When this happened new concepts or (...) new conceptualizations became the need of the hour: in the place of the age-old hierarchic social stratification a novel concept of materialism had to be inducted - after all matter is what matters. And in India morally entangled sociology was holding down the rich human resources of the sub-continent and a development-oriented ideology had to convert this moral society into a legal society: An unlegislated, unlegislatable society is condemned to be unstable andcollapsible; in its place a stable, legislatable society had to be created. With this felt-need Dr. Ambedkar came into the Indian political arena and gave a modernist rethinking to the outmoded Indian social structure: His hallmark was think to change. (shrink)

The one great quality of Socratic gift is that thinking as an activity continues but not repetitively but every time thinking takes place, it takes place a new. Thinking is the one activity that cannot be repeated like prayers and other pieties. All philosophical thinking is new thinking; it has to be new in order to be thinking. Philosophy had to become the handmaid of sociology and could not be allowed to remain surrogate sociology. When this happened new concepts or (...) new conceptualizations became the need of the hour: in the place of the age-old hierarchic social stratification a novel concept of materialism had to be inducted - after all matter is what matters. And in India morally entangled sociology was holding down the rich human resources of the sub-continent and a development-oriented ideology had to convert this moral society into a legal society: An unlegislated, unlegislatable society is condemned to be unstable andcollapsible; in its place a stable, legislatable society had to be created. With this felt-need Dr. Ambedkar came into the Indian political arena and gave a modernist rethinking to the outmoded Indian social structure: His hallmark was think to change. (shrink)

On Vedanta philosophy based on Śaṅkarācārya's commentary on Bhagavadgītā, Brahmasūtra, and Upanishads.

The present paper is primarily concerned with the application of the transformative approach within the Western philosophical context. My aim is to show how the idea of a transformation is present in Platonic thought based on John Taber’s work on transformative philosophy. According to Taber, transformative thinkers tell us that the unreflecting mind lives in a dream and, if it is to know the truly real, one “must awaken from the dream, enliven slumbering faculties, make a transition to a new (...) state of awareness.” I will use the Platonic dialogue to illustrate how some of the main features of transformative philosophy developed by Taber are exhibited there, if only to emphasize the transformative aspect of Platonic philosophy, although not dismiss the systematic reading of Platonic texts. (shrink)

Many targets of the Wnt/β-catenin signaling pathway are regulated by TCF transcription factors, which play important roles in animal development, stem cell biology, and oncogenesis. TCFs can regulate Wnt targets through a “transcriptional switch,” repressing gene expression in unstimulated cells and promoting transcription upon Wnt signaling. However, it is not clear whether this switch mechanism is a general feature of Wnt gene regulation or limited to a subset of Wnt targets. Co-repressors of the TLE family are known to contribute to (...) the repression of Wnt targets in the absence of signaling, but how they are inactivated or displaced by Wnt signaling is poorly understood. In this mini-review, we discuss several recent reports that address the prevalence and molecular mechanisms of the Wnt transcription switch, including the finding of Wnt-dependent ubiquitination/inactivation of TLEs. Together, these findings highlight the growing complexity of the regulation of gene expression by the Wnt pathway. Wnt targets are regulated by a “switch” where TLE co-repressors are displaced from TCFs by β-catenin, leading to activation of transcription. Recent reports challenge this view and suggest that additional processes, including exchange of specific TCF proteins and Wnt-dependent ubiquitination of TLEs, play important roles in the Wnt transcriptional switch. (shrink)