This review addresses the 100-year-old Hill equation (published in January 22, 1910), the first formula relating the result of a reversible association (e.g., concentration of a complex, magnitude of an effect) to the variable concentration of one of the associating substances (the other being present in a constant and relatively low concentration). In addition, the Hill equation was the first (and is the simplest) quantitative receptor model in pharmacology. Although the Hill equation is an empirical receptor model (its parameters have (...) only physico-chemical meaning for a simple ligand binding reaction), it requires only minor a priori knowledge about the mechanism of action for the investigated agonist to reliably fit concentration-response curve data and to yield useful results (in contrast to most of the advanced receptor models). Thus, the Hill equation has remained an important tool for physiological and pharmacological investigations including drug discovery, moreover it serves as a theoretical basis for the development of new pharmacological models. (shrink)

Recensendo nel 1923 il film Phantom di Murnau (1922), Balazs lo descrive come «un buon film tedesco»: tedesco non a causa del luogo in cui è stato prodotto ma del suo «stile» particolare, caratterizzato dal tentativo di «spiritualizzare la tecnica cinematografica». Questa possibilità di conciliare spirito e tecnica si fonda, secondo Balazs, sulla capacità del film di captare fotograficamente la Stimmung - termine intraducibile, che renderemo a volte con ‘tonalità affettiva’, ‘situazione’ o ‘a...

This book argues for the case that governments develop with inherent constraints. These constraints support the case for the normative political theoretical defense of moderate governing.

Hawthorne, Landes, Wallmann and Williamson argue that the Principal Principle implies a version of the Principle of Indifference. We show that what the Authors take to be the Principle of Indifference can be obtained without invoking anything which would seem to be related to the Principal Principle. In the Appendix we also discuss several Conditions proposed in the same paper.

In this paper I highlight two opposing models of the notion of divine revelation: the propositional and the radical. The propositional understanding of revelation was central to theology and philosophy until the 19th century. Since then, a number of other models of revelation have emerged. I define as radical the understanding of revelation which emphasizes two features of revelation: (1) God’s existence is per se revelatory; (2) God’s revelation is per se self-revelation. I propose too an assessment of the notion (...) of propositional revelation as presented by Richard Swinburne. And I offer detailed analyses of two representatives of the early understanding of divine revelation as self-revelation: the views of Bernard Bolzano and Anton Günther. Bolzano, the renowned mathematician, was also a philosopher of religion; and Günther, one of the most ingenious writers in Austrian philosophy, was not only a theologian but also a philosopher comparable to the important figures of 19th-century Ge. (shrink)

ABSTRACTThe general assumption that people fail to notice discrepancy between their answer and the normative answer in the conjunction fallacy task has been challenged by the theory of Logical Intuition. This theory suggests that people can detect the conflict between the heuristic and normative answers even if they do not always manage to inhibit their intuitive choice. This theory gained support from the finding that people report lower levels of confidence in their choice after they commit the conjunction fallacy compared (...) to when their answer is not in conflict with logic. In four experiments we asked the participants to give probability estimations to the options of the conflict and no-conflict versions of the tasks in the original set-up of the experiment or in a three-option design. We found that participants perceive probabilities for the options of the conflict version less similar than for the no-conflict version. As people are less confident when choosing between more similar options, this simil.. (shrink)

Physicalism is often characterized as an empirical hypothesis. But according to an alternative conceptualization, it is instead a stance or an attitude. I analyze Roy Wood Sellars’s materialist philosophy in order to show that it is a counterexample to a specific physicalist empirical hypothesis: the minimal completeness of the physical. However, it is arguably not reducible to a stance: it is a meaningful metaphysical thesis with substantive cognitive content.

The notion of common cause closedness of a classical, Kolmogorovian probability space with respect to a causal independence relation between the random events is defined, and propositions are presented that characterize common cause closedness for specific probability spaces. It is proved in particular that no probability space with a finite number of random events can contain common causes of all the correlations it predicts; however, it is demonstrated that probability spaces even with a finite number of random events can be (...) common cause closed with respect to a causal independence relation that is stronger than logical independence. Furthermore it is shown that infinite, atomless probability spaces are always common cause closed in the strongest possible sense. Open problems concerning common cause closedness are formulated and the results are interpreted from the perspective of Reichenbach's Common Cause Principle. (shrink)

Words can mean different things to different people. This can be problematic, mainly for those working together in a bureaucratic institution, such as the secret service. Shared, certified, explicit and codified definitions offer a counter to subjective, solitary and/or culturally dominant definitions. It’s true that codified secrecy terms for secret services can be seen to involve a number of political, cultural, subcultural “languages”, but if words come from unclassified or declassified files, memorandums and/or records, one needs a deep understanding of (...) the secret services. A remarkable feature of this bureaucratic language is the evolving nature of, certain “keywords” as important signifiers of historical transformation. Thus, the changes in the language of the secret services depends at least as much on the internal changes of the secret services as on the transformation in the external political-social environment. In spite of the confusion of Hungarian secret services in the revolutions of 1918–1919 and the disintegration of the Austrian-Hungarian Monarchy, in the early 1920’s became a stable system. Between the two World Wars, the Hungarian State Police directed by the Ministry of Internal Affairs, the Military Intelligence and Counter-Espionage directed by the Ministry of Defence, and the Hungarian Royal Gendarmerie directed by both of the Ministries had their own operational service. This structure existed unchanged until 1945. Simultaneously with the forward advance of the soviet troops, government began to re-establish the former system of the secret services in the eastern part of the country. After WWII, in 1946, the “State-protection Department” as political police became independent from the police. However, from the beginning, they remained under the control of the Communist Party. After 1950, the State Security Authority provided special services for the MIA and the Military Political Directorate of the MoD. After quashing the revolution in 1956, in the spring of 1957, the MIA Political Investigation Department was established which—with slight modifications—kept the structure created during the “state protection era”. The MIA III. The State-Protection General Directorate was established in 1962. The reorganization was finalized in the middle of the 1960’s, which resulted in the new system, which—with the structure of Directorates—became the ultimate structure of the state secret police until the abolishment of the MIA General Directorate III in January 1990. These organizational transformations were largely the result of exogenous historical-political changes. Moreover, each new period had a major impact on the organizational communication, language use and vocabulary of the secret services. This study seeks to interpret these historical transformations. (shrink)

We investigate Maxwell's attempt to justify the mathematical assumptions behind his 1860 Proposition IV according to which the velocity components of colliding particles follow the normal distribution. Contrary to the commonly held view we find that his molecular collision model plays a crucial role in reaching this conclusion, and that his model assumptions also permit inference to equalization of mean kinetic energies, which is what he intended to prove in his discredited and widely ignored Proposition VI. If we take a (...) charitable reading of his own proof of Proposition VI then it was Maxwell, and not Boltzmann, who gave the first proof of a tendency towards equilibrium, a sort of H-theorem. We also call attention to a potential conflation of notions of probabilistic and value independence in relevant prior works of his contemporaries and of his own, and argue that this conflation might have impacted his adoption of the suspect independence assumption of Proposition IV. (shrink)

In this article I offer an interpretation of the fundamental problem of phenomenology in terms of a philosophy of revelation proposing in this way the renewal of the last important development of Western philosophy both in terms of its metaphysical aspiration and scientific relevance. After the general introduction, I outline the philosophical problem of revelation. I show how this philosophy influenced early phenomenology. I explain the underlying subject matter in the history of phenomenology, i.e. the notion of disclosure. I also (...) outline what I term “apocalyptic phenomenology” in order to focus on the understanding of revelation. In this part I offer details of the notion of newness and the appropriate method applied here. Finally, I summarize the scientific relevance of my approach in the context of logic, methodology, disciplinarity with a special emphasis on the study of religion. (shrink)

Name der Zeitschrift: Zeitschrift für kritische Sozialtheorie und Philosophie Jahrgang: 5 Heft: 1 Seiten: 86-102.

When Istvan Hont died in 2013, the world lost a giant of intellectual history. A leader of the Cambridge School of Political Thought, Hont argued passionately for a global-historical approach to political ideas. To better understand the development of liberalism, he looked not only to the works of great thinkers but also to their reception and use amid revolution and interstate competition. His innovative program of study culminated in the landmark 2005 book Jealousy of Trade, which explores the birth of (...) economic nationalism and other social effects of expanding eighteenth-century markets. Markets, Morals, and Politics brings together a celebrated cast of Hont's contemporaries to assess his influence, ideas and methods. Richard Tuck, John Pocock, John Dunn, Raymond Geuss, Gareth Stedman Jones, Michael Sonenscher, John Robertson, Keith Tribe, Pasquale Pasquino, and Peter N. Miller contribute original essays on themes Hont treated with penetrating insight. (shrink)

In this study, we investigated whether control of the conflict between incongruent heuristic and analytical answer options in a reasoning task is modulated by the presence of conflict on previous trials. In two experiments, we found that the incongruency of the previous trial has a significant effect on the control exhibited on the current trial. Our data also showed that this adaptation effect is modulated by the incongruency of the previous series of trials. These results demonstrate the same control adaptation (...) effects for a reasoning task as observed for standard response interference tasks. Coinciding control effects in the two research areas suggest that cognitive control might be an important mechanism underlying performance on reasoning tasks. Based on these results we argue that the study of cognitive control in reasoning could potentially facilitate the refinement of empirical predictions and provide a new tool to explore the exertion of top-down control in human thinking. (shrink)

Jeffrey conditioning is said to provide a more general method of assimilating uncertain evidence than Bayesian conditioning. We show that Jeffrey learning is merely a particular type of Bayesian learning if we accept either of the following two observations: – Learning comprises both probability kinematics and proposition kinematics. – What can be updated is not the same as what can do the updating; the set of the latter is richer than the set of the former. We address the problem of (...) commutativity and isolate commutativity from invariance upon conditioning on conjunctions. We also present a disjunctive model of Bayesian learning which suggests that Jeffrey conditioning is better understood as providing a method for incorporating unspecified but certain evidence rather than providing a method for incorporating specific but uncertain evidence. The results also generalize over many other subjective probability update rules, such as those proposed by Field and Gallow. (shrink)

We call attention to different formulations of how physical laws relate to what is physically possible in the philosophical literature, and argue that it may be the case that determinism fails under one formulation but reigns under the other. Whether this is so depends on our view on the nature of laws, and may also depend on the inter-theoretical relationships among our best physical theories, or so shall we argue.

We argue that the truth of determinism is not an interpretation-free fact and we systematically overview relevant interpretational choices that are less known in the philosophical literature. After bypassing the well known interpretational problem that arises in quantum mechanics we identify three further questions about the representational role of the mathematical structures employed by physical theories. Finally we point out that even if we settle all representational issues the received view of physical possibility may also allow the truth of determinism (...) to depend on prior philosophical convictions, notably on one's philosophical account of the nature of laws. (shrink)

The volume offers the first-ever synthetic overview of the history of modern political thought in East Central Europe. Covering twenty national cultures and languages wedged between Russia, Turkey, Austria and Germany, it goes beyond the conventional nation-centered narrative and offers a novel vision of transnational intellectual history. The authors focus on the ways political thinkers outside of Western Europe sought to bridge the gap between an idealized Western modernity and their own societies. Mapping these discourses and debates from the Enlightenment (...) to the First World War, the volume helps rethinking some of our basic assumptions about the history of modern European culture and politics. (shrink)

The volume, stemming from the long-term cooperation of scholars working on East Central European intellectual history, discusses the patterns of patriotic and national identification in the light of the multiplicity of levels of ethnic, cultural and political allegiances characterizing this region in the early modern period.

The article traces the development of Hungarian intellectual history of the early modern period from the emergence of the national romantic constructions of literary history to the recent turn towards contextualist and conceptual history. One of its main findings is the ideological importance of this period for the formation of the national canon, as it became a central point of reference for the emerging local methodological tradition of intellectual history, even if it was often compartamentalized under other categories. From this (...) perspective, the article puts particular emphasis on ideological constructions seeking to define the nation and depict the emergence of modern national identity. This finding also offers a vantage point for analyzing the interplay between literary history and the socio-culturally focused approaches, which can be considered the main framework for the developments of the last two decades, when these local historiographical traditions entered into an interesting dialogue with the Western European and American schools of intellectual history. Along these lines, while pointing out the discursive continuities with the previous paradigms, which are shaping even the contemporary historiographical production, the article also ponders the ways in which the inherited (post-)romantic constructions can be successfully challenged. (shrink)

Biró, B. and I. Sain, Peano arithmetic as axiomatization of the time frame in logics of programs and in dynamic logics, Annals of Pure and Applied Logic 63 201-225. We show that one can prove the partial correctness of more programs using Peano's axioms for the time frames of three-sorted time models than using only Presburger's axioms, that is it is useful to allow multiplication of time points at program verification and in dynamic and temporal logics. We organized the paper (...) as follows: 1. Preliminaries, 2. The main result, 3. Peano arithmetic with bounded multiplication, 4. Connections with temporal logics and dynamic logics, Acknowledgements, References. (shrink)