Terminally ill patients in 10 states plus Washington, D.C. have the right to take prescribed medications to end their lives (medical aid in dying). But otherwise-eligible patients with neuromuscular disabilities (ALS and other illnesses) are excluded if they are physically unable to “self-administer” the medications without assistance. This exclusion is incompatible with disability rights laws that mandate assistance to provide equal access to health care. This contradiction between aid-in-dying laws and disability rights laws can force patients and clinicians into violating (...) one or the other, potentially creating an underclass of patients denied medical care that is available to those with other (less physically disabling) terminal illnesses. The immediacy of this issue is demonstrated by a lawsuit in Federal court filed in August 2021, requesting assistance in self-administration for terminally ill patients with neuromuscular diseases. This paper discusses the background of this conflict, the ethical issues at the heart of the dilemma, and recommends potential remedies. (shrink)

IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD participants (...) with either normal cognition, mild cognitive impairment, or dementia. Ratios to Creatine resonance were obtained for glutamate, glutamine and glutamate combined, N-acetylaspartate, myoinositol, and total choline, and correlated with cognitive scores across multiple domains administered to the PD participants only.ResultsWhen individuals retain cognitive capabilities, the presence of Parkinson’s disease does not create metabolic disturbances in the PFC. However, when cognitive symptoms are present, PFC Glu/Cre ratios decrease with significant differences between the PD-NC and PPD groups. In addition, Glu/Cre ratios and memory scores were marginally associated, but not after Bonferroni correction.ConclusionThese preliminary findings indicate that fluctuations in prefrontal glutamate may constitute a biomarker for the progression of cognitive impairments in PD. We caution for larger MRS investigations of carefully defined PD groups. (shrink)

While eleven U.S. jurisdictions have authorized medical aid in dying (MAID), it remains inaccessible to terminally ill patients who have physical disabilities that make them unable to complete self...

In this interview, Ruth Klüger, writer and survivor of Auschwitz, speaks of the wound of who, once alive outside the lager, has felt a “feeling of rejection” by the world that she thought it would have accepted her – as if the fault of the executioners had contaminated the victims. A separation that the survivor will live for all her life, both because, as a matter of fact, she feels to have a “double citizenship” between the alive and the dead (...) – such that all in a sudden the normality breaks down and it gives way to the “old world” and the sensation that anything can be subtracted away – and because the witnesses, after having been rejected, they have turned into a generation of martyrs, object of a worship that can easily turn into nausea. However, the reflection on the human conditions cannot do away with the identification with what is acknowledged as similar, and for that reason a proximity is necessary. (shrink)

The hematopoietic system consists of more than ten differentiated cell types, all of which are derived from a single type of hematopoietic stem cell. The accessibility and interest of this system have made it a model for understanding normal and abnormal differentiation of mammalian cells. Newer techniques have generated a mass of data that requires integrative approaches for analysis and interpretation. The traditional view of the differentiation program holds that a small number of regulators are involved in each stage of (...) cell specification. However, this may not be the case. Recent analyses have shown that almost all substantial subsets of genes, including the set of broadly expressed transcription factors, are expressed in patterns that are unique for each lineage. Further, much of this difference between lineages can be captured in two‐dimensional graphs. Understanding the biologic significance, mechanisms and constraints underlying these differences is a challenge for experimentalists and computational biologists alike. BioEssays 26:1276–1287, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Berichte zur Wissenschaftsgeschichte, Volume 44, Issue 4, Page 391-413, December 2021.

In this paper we discuss the influence of war as a metaphor in the context of the COVID-19 pandemic. After an introduction on the traditional analysis of the war metaphor, we address the social consequences of using this metaphor, a topic that has been widely debated with regard to public communication in the context of COVID-19. We pay particular attention to a theory that many intellectuals have raised: the possibility that the use of the metaphor in this context is harmful (...) to a democratic society because it may lead citizens to accept limited civil liberties and authoritarian policies. After presenting the extensive literature on the use of the war metaphor before and during the COVID-19 pandemic, in the final section of the paper, we analyse experimental evidence of the effects of this metaphor. In the conclusion, we hint at open questions and suggest that the current evidence does not support claims of direct liberticidal influence. (shrink)

Caracterizar a demanda de atendimento psicológico e compreender a experiência dos profissionais que atuaram na pandemia do COVID-19, em uma plataforma de atendimento psicológico on-line. Realizou-se uma análise documental e entrevista semiestruturada com 20 psicólogos que atuaram no mínimo 6 meses na plataforma entre mar/2020 à dez/2022, em que foram atendidos um total 15.963 pacientes. Dentre as demandas, prevaleceram ideação suicida com planejamento, ansiedade e depressão. O perfil prevalente dos pacientes atendidos na pandemia corresponde à literatura, em períodos não pandêmicos, (...) bem como a prevalência de sintomas ansiosos e depressivos. Porém, destacou o surgimento do alto número de pacientes com ideação suicida, o que sugere um agravamento dos transtornos mentais, despertado pela pandemia, além de uma dificuldade comum aos entrevistados, relacionada a clareza dos critérios clínicos utilizados para determinação da gravidade dos casos. Os psicólogos apontaram dificuldades no manejo destes casos graves, intensificados pelo impacto emocional pandêmico também sentido por eles, junto ao despreparo para sua atuação online, as percebendo como limitações. Apesar do despreparo, a alta demanda incitou os profissionais aderirem as especificidades da modalidade. Estes relataram ter buscado aporte teórico e apoio emocional para manterem os recursos internos, cognitivos e emocionais, necessários ao setting terapêutico. Pode-se concluir que os resultados evidenciaram a importância de se refletir sobre os critérios de avaliação clínica utilizados para compreensão da severidade dos casos, sem deixar de considerar os recursos internos dos pacientes relativos à sua capacidade de sofrer, os quais podem ser identificados quando mantida a capacidade de rêverie do profissional. (shrink)

This collection of essays sheds new light on the relationship between two of the main drivers of intellectual discourse in ancient Greece: the epic tradition and the Sophists. The contributors show how throughout antiquity the epic tradition proved a flexible instrument to navigate new political, cultural, and philosophical contexts. The Sophists, both in the Classical and the Imperial age, continuously reconfigured the value of epic poetry according to the circumstances: using epic myths allowed the Sophists to present themselves as the (...) heirs of traditional education, but at the same time this tradition was reshaped to encapsulate new questions that were central to the Sophists' intellectual agenda. This volume is structured chronologically, encompassing the ancient world from the Classical Age through the first two centuries AD. The first chapters, on the First Sophistic, discuss pivotal works such as Gorgias' Encomium of Helen and Apology of Palamedes, Alcidamas' Odysseus or Against the Treachery of Palamedes, and Antisthenes' pair of speeches Ajax and Odysseus, as well as a range of passages from Plato and other authors. The volume then moves on to discuss some of the major works of literature from the Second Sophistic dealing with the epic tradition. These include Lucian's Judgement of the Goddesses and Dio Chrysostom's orations 11 and 20, as well as Philostratus' Heroicus and Imagines. (shrink)

The definition of metabolic syndrome has been, and still is, extremely controversial. My purpose is not to give a solution to the associated debate but to argue that the controversy is at least partially due to the different ‘causal content’ of the various definitions: their theoretical validity and practical utility can be evaluated by reconstructing or making explicit the underlying causal structure. I will therefore propose to distinguish the alternative definitions according to the kinds of causal content they carry: definitions (...) grounded on associations, definitions presupposing a causal model built upon statistical associations, and definitions grounded on underlying mechanisms. I suggest that analysing definitions according to their causal content can be helpful in evaluating alternative definitions of some diseases. I want to show how the controversy over MetS suggests a distinction among three kinds of definitions based on how explicitly they characterise the syndrome in causal terms, and on the type of causality involved. I will call ‘type 1 definitions’ those definitions that are purely associative; ‘type 2 definitions’ the definitions based on statistical associations, plus generic medical and causal knowledge; and ‘type 3 definitions’ the definitions based on mechanisms. These kinds of definitions, although different, can be related to each other. A definition with more specific causal content may be useful in the evaluation of definitions characterised by a lower degree of causal specificity. Moreover, the identification of the type of causality involved is of help to constitute a good criterion for choosing among different definitions of a pathological entity. In section I introduce the controversy about MetS, in section I propose some remarks about medical definitions and their ‘causal import’, and in section I suggest that the different attitudes towards the definition of MetS are relevant to evaluate their explicative power. (shrink)

Cet article examine le rôle joué par la notion d'intelligence dans la poésie de Xénophane et de Parménide. L'auteur soutient que ces deux philosophes, en modifiant les attributs traditionnels du noos humain et divin, répondent aux problèmes posés par le pessimisme gnoséologique de la tradition poétique archaïque, dans laquelle les mortels sont inéluctablement condamnés à l'ignorance. Comme le montre le cas d'Hésiode, même l'inspiration divine ne garantit pas d'acquérir la connaissance, parce que la divinité peut communiquer, à son gré, le (...) vrai ou le faux et que le poète est dépourvu de moyens pour établir la validité de la révélation. Chez Xénophane en revanche, la régularité de l'ordre naturel fondé sur l'immuable noos du dieu offre aux hommes la possibilité effective d'améliorer leur compréhension du monde, tandis que dans le poème de Parménide, la déduction des attributs de l'Être donne aux mortels l'accès à cette vérité qui était auparavant une prérogative exclusive des dieux. (shrink)

Philosophical works on actual causation make wide use of thought experiments. The principal aim of this paper is to show how thought experiments are used in the contemporary debate over actual causation and to discuss their role in relation to formal approaches in terms of causal models. I claim that a recourse to thought experiments is not something old fashioned or superseded by abstract models, but it is useful to interpret abstract models themselves and to use our intuitions to judge (...) the results of the model. Recent research on actual causation has stressed the importance of integrating formal models with some notion of normality; I suggest that thought experiments can be useful in eliciting intuitions where normality is not intended in a statistical sense. The first expository part gives a short presentation of the notion of actual causation, summarising some typical problems of counterfactual approaches and how they are treated in causal and structural models. The second part focuses on the problems of model isomorphism and criticises some radical ideas opposing the role of thought experiments, claiming that they may also be of use in evaluating formal models. (shrink)

Philosophical works on actual causation make wide use of thought experiments. The principal aim of this paper is to show how thought experiments are used in the contemporary debate over actual causation and to discuss their role in relation to formal approaches in terms of causal models. I claim that a recourse to thought experiments is not something old fashioned or superseded by abstract models, but it is useful to interpret abstract models themselves and to use our intuitions to judge (...) the results of the model. Recent research on actual causation has stressed the importance of integrating formal models with some notion of normality; I suggest that thought experiments can be useful in eliciting intuitions where normality is not intended in a statistical sense. The first expository part gives a short presentation of the notion of actual causation, summarising some typical problems of counterfactual approaches and how they are treated in causal and structural models. The second part focuses on the problems of model isomorphism and criticises some radical ideas opposing the role of thought experiments, claiming that they may also be of use in evaluating formal models. (shrink)

Philosophical works on actual causation make wide use of thought experiments. The principal aim of this paper is to show how thought experiments are used in the contemporary debate over actual causation and to discuss their role in relation to formal approaches in terms of causal models. I claim that a recourse to thought experiments is not something old fashioned or superseded by abstract models, but it is useful to interpret abstract models themselves and to use our intuitions to judge (...) the results of the model. Recent research on actual causation has stressed the importance of integrating formal models with some notion of normality; I suggest that thought experiments can be useful in eliciting intuitions where normality is not intended in a statistical sense. The first expository part gives a short presentation of the notion of actual causation, summarising some typical problems of counterfactual approaches and how they are treated in causal and structural models. The second part focuses on the problems of model isomorphism and criticises some radical ideas opposing the role of thought experiments, claiming that they may also be of use in evaluating formal models. (shrink)

In this paper, we will analyse the language used by a group of Tourism ESP students on WhatsApp. The data will be analysed from different perspectives: a) the grammatical mistakes made, and b) the students´ degree of adaptation to the most common linguistic features in text messages. The results indicate that these students continue to make some basic grammatical mistakes they should have already overcome. Moreover, many linguistic features of text messages were encountered in their interventions such as punctuation overuse (...) and deletion and overuse of sounds. Finally, they insert many emojis in their messages to express different meanings. (shrink)

Reflective function is defined as an individual’s ability to understand human behavior in terms of underlying mental states including thoughts, feelings, desires, beliefs, and intentions. More specifically, the capacity of parents to keep their child’s mental states in mind is referred to as parental RF. RF has been linked to adult mental health and parental RF to children’s mental health and development. The gold standard measure of RF is the interview-based Reflective Functioning Scale applied to the Parent Development Interview or (...) Adult Attachment Interview, which while well validated, is time-and labor-intensive to administer. Given the increasing need for reliable, valid, and rapid RF assessment in wide-ranging settings, two alternative measures were considered including the Reflective Function Questionnaire and Parental Reflective Function Questionnaire. We determined the convergent validity of these measures in comparison with the PDI-rated RFS. A sample of mothers and fathers was drawn from a sub-study of the ongoing Alberta Pregnancy Outcomes and Nutrition longitudinal cohort when their children were 42–60 months of age. Pearson correlations and multiple linear regression was conducted, followed by splitting the sample to compute Cohen’s kappas measures of agreement. Two subscales of the PRFQ correlated significantly with the gold standard PDI-rated RFS, providing evidence for convergent validity. As a brief multidimensional measure of parental RF, the PRFQ offers an alternative for measurement of RF in large-scale studies of parental development and child health. (shrink)

From mass murder to genocide, slavery to colonial suppression, acts of atrocity have lives that extend far beyond the horrific moment. They engender trauma that echoes for generations, in the experiences of those on both sides of the act. Gabriele Schwab reads these legacies in a number of narratives, primarily through the writing of postwar Germans and the descendents of Holocaust survivors. She connects their work to earlier histories of slavery and colonialism and to more recent events, such as South (...) African Apartheid, the practice of torture after 9/11, and the "disappearances" that occurred during South American dictatorships. Schwab's texts include memoirs, such as Ruth Kluger's _Still Alive_ and Marguerite Duras's _La Douleur_; second-generation accounts by the children of Holocaust survivors, such as Georges Perec's _W_, Art Spiegelman's _Maus_, and Philippe Grimbert's _Secret_; and second-generation recollections by Germans, such as W. G. Sebald's _Austerlitz_, Sabine Reichel's _What Did You Do in the War, Daddy?_, and Ursula Duba's _Tales from a Child of the Enemy_. She also incorporates her own reminiscences of growing up in postwar Germany, mapping interlaced memories and histories as they interact in psychic life and cultural memory. Schwab concludes with a bracing look at issues of responsibility, reparation, and forgiveness across the victim/perpetrator divide. (shrink)

In this book, Camila Loew analyzes four women’s testimonial literary writings on the Holocaust to examine and question some of the tenets of the fields of Holocaust studies, gender studies, and testimony. Through a close reading of the works of Charlotte Delbo, Margarete Buber-Neumann, Ruth Klüger, and Marguerite Duras, Loew foregrounds these authors’ search for a written form to engage with their experiences of the extreme. Although each chapter contains its individual focus and features, the book possesses a unity in (...) intention, concerns, and consequences. In the theoretical introduction that unites the four chapters, Loew eschews essentialism and revises the emergence of the field of Women and Holocaust studies from the early 1980s on, and signals some of its shortcomings. In response, and in accordance with a recent turn in various disciplines of the Humanities, Loew highlights the ethical dimension of testimony and its responsible commitment to the other. In dealing with the texts as literary testimonies—a complex genre, between literature and history—, testimony is freed from the obligation to respond to the requirements of factual truth, and becomes a privileged form to voice the traumatic event, and to symbolically explore the role of excess. (shrink)

La dimension artistique du mémorial de Peter Eisenmann a été peu considérée. A la croisée de l'architecture et de la sculpture, il convient d'étudier sa dimension urbaine et de relever son identité comme monument in situ. Les réflexions du philosophe Derrida sur le déconstructivisme architectural, notamment de Libeskind, sont capitales. Comme le dit Habermas, son défenseur majeur, le monument s'adresse aux descendants allemands des bourreaux. Notre essai propose une lecture adornienne du mémorial qui dépend de l'art abstrait et de sa (...) métexis aux ténèbres. Le mutisme du mémorial implique une réflexion sur les questions de l'infigurable et de l'ineffable concernant la Shoah. Si le sens de l'oeuvre semble être absent, cela peut s'expliquer par la déclaration de Ruth Klüger, selon laquelle l'extermination des juifs par les nazis est un non-sens absolu. Le monument invite à ouvrir le champ de la mémoire et contient un avertissement : l'autodestruction de l'espèce humaine. (shrink)

The idea of the present Issue originated in a workshop held at the University of Urbino, Italy, in June 2014, and subsequently developed into an independent editorial project by including contributions that were not initially presented at the workshop. The eight essays that follow authored by young and emerging philosophers as well as fully accomplished ones—touch upon various aspects of the most recent debate surrounding TEs, closely engaging with many influential proposals that have been put forward over the last few (...) years. They can be organised around three main areas of concern. The first group deals with general issues raised by the use of TEs, such as the possibility of drawing a principled distinction between scientific and philosophical TEs (Marco Buzzoni), the role played by intuitions within philosophical TEs (Julia Langkau), and the different ways in which the intended conclusion of a TE can be resisted (Roy Sorensen). The second group focuses on the logical form of philosophical TEs (Sören Häggqvist; Daniele Sgaravatti), and on the kind of access to modal knowledge they are standardly taken to provide (Vittorio Morato). The third and last group explores the virtues and limits of TEs used in two specific philosophical areas, namely the philosophy of science (Margherita Benzi), and the philosophy of mind (Elizabeth Schier). (shrink)

Beim Wort 'Aufklarung' denken wir zunachst und zumeist an Immanuel Kant und sein beruhmtes Diktum vom 'Ausgang des Menschen aus seiner selbstverschuldeten Unmundigkeit'. Doch die europaische Aufklarungsbewegung war vieldimensional und bewegte sich nicht nur in einer Richtung. Der bohmische Philosoph Bernard Bolzano (1781-1848) steht fur einen ganz anderen Pfad in der Geschichte der Aufklarung. Er war ein Philosoph der mitteleuropaischen Denkstromung, der eine Welt jenseits des Kapitalismus und der Ausbeutung des Planeten dachte. Er sah in der Aufklarung einen konkreten Auftrag (...) an jeden einzelnen Menschen, 'stets kluger, (moralisch) besser und damit glucklicher zu werden': Nicht die Welt zu beherrschen, sondern sie zu verstehen, das sei der Auftrag auf diesem Weg zum allgemeinen Gluck. Die Monographie stellt Leben und Werk dieses zu Unrecht vergessenen katholischen Denkers umfassend und quellengesattigt vor. (shrink)

Die Meisterwerke der Moralistik haben Millionen von Menschen als philosophische Lebensbegleiter gedient. Doch worum geht es in der Moralistik eigentlich? 0Die Moralistik befasst sich mit der Natur des Menschen und mit Möglichkeiten kluger, individueller Selbstbehauptung. Sie führt die antiken Ansätze einer philosophischen Klugheitslehre fort und besetzt damit einen in der neuzeitlichen Ethik vernachlässigten Teil der praktischen Philosophie. Ihre Meisterwerke vermitteln uns Menschenkenntnis und soziale Orientierung und stehen uns auf dem Weg eines gelingenden Lebens beratend zur Seite. In ihnen liegt (...) der Ursprung der modernen Philosophie der Lebenskunst. Das Buch stellt sowohl die Entwicklung der Moralistik als auch ihr philosophisches Anliegen anschaulich und gut lesbar dar. (shrink)

Die Erfahrung eines Konflikts zwischen Forderungen der Moral und kluger Verfolgung des Eigeninteresses ist elementar. In Gefangenen-Dilemma-Situationen hat es für die Beteiligten katastrophale Konsequenzen, wenn alle klug ihr Eigeninteresse verfolgen. Hingegen kann in solchen Situationen jeder unter dem Gesichtspunkt seines Eigeninteresses besser gestellt werden, wenn sich jeder von Forderungen der Moral leiten läßt. Eine Funktion der Moral kann daher sein, die Individuen gerade vor den Fallen der Klugheit zu schützen.

Die Erfahrung eines Konflikts zwischen Forderungen der Moral und kluger Verfolgung des Eigeninteresses ist elementar. In Gefangenen-Dilemma-Situationen hat es für die Beteiligten katastrophale Konsequenzen, wenn alle klug ihr Eigeninteresse verfolgen. Hingegen kann in solchen Situationen jeder unter dem Gesichtspunkt seines Eigeninteresses besser gestellt werden, wenn sich jeder von Forderungen der Moral leiten läßt. Eine Funktion der Moral kann daher sein, die Individuen gerade vor den Fallen der Klugheit zu schützen.

Den Begriff, unter den Sokrates in dem Satz „Sokrates ist ein Kluger“ gebracht wird, sollte man nicht als „Klugheit“ fassen, sondern als den Klugen als solchen. Der Kluge wird also von Sokrates ausgesagt. Der Kluge als solcher ist ein abstraktes Ding, keine Eigenschaft. So gesehen ist ohne weiteres klar, dass der Begriff des Klugen (= der Kluge als solcher) selbst klug ist, und zwar ebenso buchstäblich, wie Sokrates klug ist.

This chapter contains sections titled: Vaccine Hunting Horrible Harry Into the Lab Necessary Questions.