Motivated by weaknesses with traditional accounts of logical epistemology, considerable attention has been paid recently to the view, known as anti-exceptionalism about logic, that the subject matter and epistemology of logic may not be so different from that of the recognised sciences. One of the most prevalent claims made by advocates of AEL is that theory choice within logic is significantly similar to that within the sciences. This connection with scientific methodology highlights a considerable challenge for the anti-exceptionalist, as two (...) uncontentious claims about scientific theories are that they attempt to explain a target phenomenon and prove their worth through successful predictions. Thus, if this methodological AEL is to be viable, the anti-exceptionalist will need a reasonable account of what phenomena logics are attempting to explain, how they can explain, and in what sense they can be said to issue predictions. This paper makes sense of the anti-exceptionalist proposal with a new account of logical theory choice, logical predictivism, according to which logics are engaged in both a process of prediction and explanation. (shrink)

Given the plethora of competing logical theories of validity available, it’s understandable that there has been a marked increase in interest in logical epistemology within the literature. If we are to choose between these logical theories, we require a good understanding of the suitable criteria we ought to judge according to. However, so far there’s been a lack of appreciation of how logical practice could support an epistemology of logic. This paper aims to correct that error, by arguing for a (...) practice-based approach to logical epistemology. By looking at the types of evidence logicians actually appeal to in attempting to support their theories, we can provide a more detailed and realistic picture of logical epistemology. To demonstrate the fruitfulness of a practice-based approach, we look to a particular case of logical argumentation—the dialetheist’s arguments based upon the self-referential paradoxes—and show that the evidence appealed to support a particular theory of logical epistemology, logical abductivism. (shrink)

While anti-exceptionalism about logic is now a popular topic within the philosophy of logic, there’s still a lack of clarity over what the proposal amounts to. currently, it is most common to conceive of AEL as the proposal that logic is continuous with the sciences. Yet, as we show here, this conception of AEL is unhelpful due to both its lack of precision, and its distortion of the current debates. Rather, AEL is better understood as the rejection of certain traditional (...) properties of logic. The picture that results is not of one singular position, but rather a cluster of often connected positions with distinct motivations, understood in terms of their rejection of clusters of the various traditional properties. In order to show the fruitfulness of this new conception of AEL, we distinguish between two prominent versions of the position, metaphysical and epistemological AEL, and show how the two positions need not stand or fall together. (shrink)

Considerable attention recently has been paid to anti-exceptionalism about logic, the thesis that logic is more similar to the sciences in important respects than traditionally thought. One of AEL’s prominent claims is that logic’s methodology is similar to that of the recognised sciences, with part of this proposal being that logics provide explanations in some sense. However, insufficient attention has been given to what this proposal amounts to, and the challenges that arise in providing an account of explanations in logic. (...) This paper clarifies these challenges, and shows how the practice-based approach is best placed to meet them. (shrink)

Metaphilosophy, Volume 53, Issue 2-3, Page 267-283, April 2022.

According to Fogelin’s account of deep disagreements, disputes caused by a clash in framework propositions are necessarily rationally irresolvable. Fogelin’s thesis is a claim about real-life, and not purely hypothetical, arguments: there are such disagreements, and they are incapable of rational resolution. Surprisingly then, few attempts have been made to find such disputes in order to test Fogelin’s thesis. This paper aims to rectify that failure. Firstly, it clarifies Fogelin’s concept of deep disagreement and shows there are several different breeds (...) of such disagreements. Thus, to fully assess Fogelin’s thesis, it will be necessary to seek out cases of each breed to evaluate their rational irresolvability. Secondly, it begins this task by looking at a significant debate within the logical literature over the truth of contradictions. We demonstrate that, while the debate exemplifies a breed of deep disagreement, the parties involved can supply one another with rationally compelling reasons. (shrink)

This paper first offers a standard modal extension of dialetheic logics that respect the normal semantics for negation and conjunction, in an attempt to adequately model absolutism, the thesis that there are true contradictions at metaphysically possible worlds. It is shown, however, that the modal extension has unsavoury consequences for both absolutism and dialetheism. While the logic commits the absolutist to dialetheism, it commits the dialetheist to the impossibility of the actual world. A new modal logic AV is then proposed (...) which avoids these unsavoury consequences by invalidating the interdefinability rules for the modal operators with the use of two valuation relations. However, while using AV carries no significant cost for the absolutist, the same isn't true for the dialetheist. Although using AV allows her to avoid the consequence that the actual world is an impossible world, it does so only on the condition that the dialetheist admits that she cannot give a dialetheic solution to all self-refe.. (shrink)

According to Fogelin’s account of deep disagreements, disputes caused by a clash in framework propositions are necessarily rationally irresolvable. Fogelin’s thesis is a claim about real-life, and not purely hypothetical, arguments: there are such disagreements, and they are incapable of rational resolution. Surprisingly then, few attempts have been made to find such disputes in order to test Fogelin’s thesis. This paper aims to rectify that failure. Firstly, it clarifies Fogelin’s concept of deep disagreement and shows there are several different breeds (...) of such disagreements. Thus, to fully assess Fogelin’s thesis, it will be necessary to seek out cases of each breed to evaluate their rational irresolvability. Secondly, it begins this task by looking at a significant debate within the logical literature over the truth of contradictions. We demonstrate that, while the debate exemplifies a breed of deep disagreement, the parties involved can supply one another with rationally compelling reasons. (shrink)

The historical consensus is that logical evidence is special. Whereas empirical evidence is used to support theories within both the natural and social sciences, logic answers solely to a priori evidence. Further, unlike other areas of research that rely upon a priori evidence, such as mathematics, logical evidence is basic. While we can assume the validity of certain inferences in order to establish truths within mathematics and test scientifi c theories, logicians cannot use results from mathematics or the empirical sciences (...) without seemingly begging the question. Appeals to rational intuition and analyticity in order to account for logical knowledge are symptomatic of these commitments to the apriority and basicness of logical evidence. This chapter argues that these historically prevalent accounts of logical evidence are mistaken, and that if we take logical practice seriously we fi nd that logical evidence is rather unexceptional, sharing many similarities to the types of evidence appealed to within other research areas. (shrink)

Protein turnover (PT) has been formally defined only in equilibrium conditions, which is ill‐suited to quantify PT during dynamic processes that occur during embryogenesis or (extra) cellular signaling. In this Hypothesis, we propose a definition of PT in an out‐of‐equilibrium regime that allows the quantification of PT in virtually any biological context. We propose a simple mathematical and conceptual framework applicable to a broad range of available data, such as RNA sequencing coupled with pulsed‐SILAC datasets. We apply our framework to (...) a published dataset and show that stimulation of mouse dendritic cells with LPS leads to a proteome‐wide change in PT. This is the first quantification of PT out‐of‐equilibrium, paving the way for the analysis of biological systems in other contexts. (shrink)

Rejectivism is one of the most influential embodiments of pragmatism within contemporary philosophy of logic, advancing an explanation of the meaning of a logical notion, negation, in terms of the speech act of denial. This paper offers a challenge to rejectivism by proposing that in virtue of explaining negation in terms of denial, the rejectivist ought to be able to explain the concept of contradiction partially in terms of denial. It is argued that any failure to achieve this constitutes an (...) explanatory failure on the part of rejectivism, and reasons are then provided to doubt that the challenge can be successfully met. (shrink)

This essay seeks to show the divergence of real and virtual communication codes by means of analyzing Charlie Brooker’s dystopian series Black Mirror, in respect of the influence of new communication technologies and gadgets in the form of bodily extensions. It draws on both recent sociopolitical phenomena and sociological findings to undermine why and how the speculative fiction of Black Mirror displays the characters’ engagement in their environs as inherently obscene, and at same time mirrors the recent developments that are (...) looming ahead in the future which makes the series prophetical rather than merely dystopian in its outlook. (shrink)

Co‐expression of two or more genes at the single‐cell level is usually associated with functional co‐regulation. While mRNA co‐expression—measured as the correlation in mRNA levels—can be influenced by both transcriptional and post‐transcriptional events, transcriptional regulation is typically considered dominant. We review and connect the literature describing transcriptional and post‐transcriptional regulation of co‐expression. To enhance our understanding, we integrate four datasets spanning single‐cell gene expression data, single‐cell promoter activity data and individual transcript half‐lives. Confirming expectations, we find that positive co‐expression necessitates (...) promoter coordination and similar mRNA half‐lives. Surprisingly, negative co‐expression is favored by differences in mRNA half‐lives, contrary to initial predictions from stochastic simulations. Notably, this association manifests specifically within clusters of genes. We further observe a striking compensation between promoter coordination and mRNA half‐lives, which additional stochastic simulations suggest might give rise to the observed co‐expression patterns. These findings raise intriguing questions about the functional advantages conferred by this compensation between distal kinetic steps. (shrink)

The view that contradictions cannot be true has been part of accepted philosophical theory since at least the time of Aristotle. In this regard, it is almost unique in the history of philosophy. Only in the last forty years has the view been systematically challenged with the advent of dialetheism. Since Graham Priest introduced dialetheism as a solution to certain self-referential paradoxes, the possibility of true contradictions has been a live issue in the philosophy of logic. Yet, despite the arguments (...) advanced by dialetheists, many logicians and philosophers still hold the opinion that contradictions cannot be true. -/- Rather than advocating the truth of certain contradictions, this thesis offers a different challenge to the classical logician. By showing that it can be philosophically coherent to propose that true contradictions are metaphysically possible, the thesis suggests that the classical logician must do more than she currently has to justify her confidence in the impossibility of true contradictions. Simply fighting off the dialetheist’s putative examples of true contradictions at the actual world isn’t enough to justify the classical logician’s conclusion that true contradictions are impossible. -/- To aid the thesis dialectically, we introduce a new position, absolutism, which hypothesises that it’s metaphysically possible for at least one contradiction to be true, contrasting with the dialetheic hypothesis that some contradictions are true in the actual world. We demonstrate that absolutism can be given a philosophically coherent interpretation, an appropriate logic, and that certain criticisms are completely toothless against absolutism. The challenge put to the classical logician is then: On what logical or philosophical grounds can we rule out the metaphysical possibility of true contradictions? (shrink)

Caring for hospitalized patients with COVID-19 raises ethical dilemmas in which clinicians must weigh the unknown value of an intervention against the unknown risk of viral transmission. Current guidelines for delivering high-value care in the time of the COVID-19 pandemic do not directly address ethical dilemmas that arise from the unique concerns of individual patients. We propose an “ethical pause” in which clinicians address ethical dilemmas by taking time to ask three questions that invoke the major bioethical principles of beneficence, (...) nonmaleficence, and distributive justice: will this intervention help my patient? Could this intervention harm my patient? Could this intervention harm or help others? Using two exemplar cases, we demonstrate how the process of deliberately asking and answering structured ethical questions is a mindful problem-solving strategy that facilitates delivery of high-value care. (shrink)