Paul Appelbaum and colleagues propose four models of informed consent to research that deploys whole genome sequencing and may generate incidental findings. They base their analysis on empirical data that suggests that research participants want to be offered incidental findings and on a normative consensus that researchers incur a duty to offer them. Their models will contribute to the heated policy debate about return of incidental findings. But in my view, they do not ask the foundational question, In the context (...) of genome sequencing, how much work can consent be asked to do? (shrink)

The cytokine interferon‐γ (IFN‐γ), initiates both cell cycle arrest and cell death in certain cell lines. Through a novel strategy of cell transfection with episomal vectors expressing antisense cDNAs, Deiss et al.(1.2) have demonstrated that it is possible to isolate genes that are required for the initiation of cell death by the cytokine IFN‐γ. This approach, referred to as TKO, for Technical Knock Out, has identified several genes whose activity appears to be essential for the induction of apoptosis by IFN‐γ (...) in HeLa cells. Interestingly, these genes appear to mediate IFN‐γ‐induced apoptosis in HeLa cells, but their inhibition by antisense does not ameliorate the anti‐proliferative effects of IFN‐γ in these cells. The clever strategy employed by these authors holds promise for others who wish to isolate genes required for other differentiative processes in cultured cell lines. (shrink)

Creativity and civil courage are major dimensions of an intellectual's authority and contribute towards the enrichment of democracy. This book develops a sociological account of civil courage and creative behaviour in order to enhance our understanding of the nature of intellectuals' involvement in society. Barbara A. Misztal employs both theoretical-analytic and empirical components to develop a typology of intellectuals who have shown civil courage and examines the biographies of twelve Nobel Peace Prize laureates, including Elie Wiesel, Andrei Sakharov and (...) Linus C. Pauling, to illustrate acts of courage which have embodied the values of civil society. She advances our understanding of the nature of intellectuals' public involvement and their contribution to social well-being. In the current climate of fear and insecurity, as governments are forced to deal with issues of increasing complexity, this is a pioneering sociological book with a highly original approach. (shrink)

Prologue: love of children lost and found for teacher educators -- The seed of play -- The seed of hope -- The seed of imaginative voice -- The seed of change -- The seed of unmasking -- The seed of inner awareness -- The seed of freedom -- The seed of love.

Der Vergleich einer modernen Rechts- und Gesellschaftstheorie anhand von Hayeks «Recht, Gesetz und Freiheit» mit einer postmodernen anhand Ladeurs «Der Staat gegen die Gesellschaft» fördert verblüffende Parallelen im Ausgangspunkt, der Argumentation und der Prognose respektive Diagnose einer institutionell bedingten postmodernen Krise von Staat und Gesellschaft zutage. Die Analyse der modernen Theorie ist zugleich eine umfassende und verständliche Einführung in von Hayeks Werk. Fundiert arbeitet die Schrift die Theorie als die in der Moderne gelegte Basis der postmodernen Gesellschaft heraus und gleicht (...) sie ab mit den Untersuchungen Ladeurs zur Postmoderne in dessen Streitschrift für die «Privatrechtsgesellschaft». Anknüpfend an den von beiden analog begründeten Weg in die Krise und die Wege zu ihrer Bewältigung zeigt die Autorin eine über diese Zeitspanne hinaus weisende kongruente liberale rechts-, staats- und gesellschaftspolitische Theorie auf. (shrink)

Humans appear to follow normative rules of inductive reasoning in "premise diversity tasks" that is, they know that dissimilar rather than similar evidence is better for generalising hypotheses. In three experiments, we use a "hypothesis limitation task" to compare a related inductive reasoning skill knowing how to limit hypotheses by using a negative test strategy. Participants are told that one category member has some property (e.g. Dogs have a merocrine gland) and are asked what evidence they would test to ensure (...) that either all (generalisation) or only (limitation) category members have that property (e.g. All/Only mammals have merocrine glands; tests: wolf, bull, crocodile). Despite participants' reluctance to use negative tests in the Wason 2-4-6 task and other reasoning tasks, participants do use normatively correct negative tests in the hypothesis limitation task as often as they use diverse positive tests in the premise diversity task. Moreover, when given a hypothesis limitation task before a rule evaluation task (similar to the 2-4-6 task), the use of negative tests increases. Thus, when testing hypotheses, people can and do use the right kind of test strategy for the task. (shrink)

Children deserve optimal medical care. Although prescription drugs play a prominent and essential role in pediatric health care delivery, health care providers often must make prescribing decisions for their young patients based on imperfect or absent safety and efficacy data for pediatric populations. Until relatively recently, the Food and Drug Administration made surprisingly little effort to improve the quality or quantity of clinical research data for this patient group. Despite recent agency efforts to improve the situation, only one-third of drugs (...) prescribed to children currently have been studied for safety and efficacy in pediatric populations. Moreover, recent agency initiatives to encourage pediatric drug research have generated mixed results and unintended consequences. The complex of issues surrounding the testing and prescribing of prescription drugs used for children will require that pharmaceutical companies, the FDA, and health care providers examine current practices, acknowledge their shortcomings, and consider cooperative, creative solutions. (shrink)

The purpose of this paper is to examine the various guidelines presented in the literature for instituting an ethics curriculum and to empirically study their effectiveness. Three questions are addressed concerning the trainability of ethics material and the proper integration and implementation of an ethics curriculum. An empirical study then tested the effect of ethics training on moral awareness and reasoning. The sample consisted of two business classes, one exposed to additional ethics curriculum (experimental), and one not exposed (control). For (...) the experimental group, ethics exercises and discussion relevant to each topic were completed. Findings suggested gender differences such that, relative to other groups, women in the experimental group showed significantly improved moral awareness and decision-making processes. An explanation of the underlying cognitive processes is presented to explain the gender effect. (shrink)

In this paper, the concept of political culture is considered in reference to the notions of G.A. Almond, S. Verba and J. Rawls. It is defined as a specific educational project, which is linked to the idea of a fair, democratic and constitutional system. The author also points to potential contemporary obstacles to implementation of this project. Deepening inequalities arising from personal culture are the first threat to liberal civic education. The second threat is associated with the development of new (...) media and the related changes in the public sphere, including various forms of political and civic activity. (shrink)

The pessimistic conclusion that people have relatively poor insight into the weighting schemes they use when they make holistic judgements has been generally accepted among judgement researchers. The empirical research that supported this generalisation rested on indices of self-insight that were produced directly by the subjects. It was often the case that subjects were unable to correctly name even the single most important factor influencing their decisions, as indicated by a mathematical model of their judgement schemes. Using an alternate method (...) of assessing self-insight, however, Reilly and Doherty found that subjects have far better self-insight than previously believed possible. The present paper employed the same methodology to investigate insight into the policy of another person as well as into oneself, and examined the relation of self-insight and other-insight to interpersonal conflict. Subjects were 50 dyads of university students. The results showed that: subjects exhibited the expected high levels of self-insight via the recognition procedure; subjects were able to identify the statistically generated policy of their roommate, thus exhibiting other-insight; the ability to identify one's own policy is somewhat related to the ability to articulate one's own policy that is, roommates with insight via recognition had higher indices of self-insight as measured by the traditional correlation method; subjects who were able to identify their own policy were more likely to identify their roommate's policy and individuals who possess self- and other-insight had less conflict in their roommate relationships. (shrink)

This article explores risk in professional nursing practice. Professional risk refers to the threat of professional discipline if it is found that a registered nurse has violated professional nursing practice standards. We argue professional risk is socially constructed and understood differently by nurse regulatory bodies, unions, professional associations and frontline nurses. Regulatory bodies emphasize professional accountability of nurses; professional associations focus on system problems in health‐care; unions undertake protecting nurses' right to health and safety; and frontline nurses experience fear and (...) uncertainty in their attempt to interpret practice standards to avoid professional discipline. Perspectives of professional risk are investigated by analyzing three professional nursing bodies' views of professional codes governing the right of nurses to refuse unsafe work assignments. The workplace dynamics surrounding work refusal experienced by frontline nurses are illustrated primarily through the lens of the 2003 SARS influenza outbreak in Ontario, Canada. We conclude that frontline nurses in Ontario are required to manage risk by following professional protocols prioritizing patient care and professional accountability which disregard the systemic, unpredictable and hazardous circumstances in their everyday practice. Moreover, we argue professional protocols cannot anticipate every eventuality in clinical practice creating the fear of professional discipline for nurses. (shrink)

We critique the distinction Byrne makes between strong causes and enabling conditions, and its implications, on both theoretical and empirical grounds. First, we believe that the difference is psychological, not logical. Second, we disagree that there is a strict Third, we disagree that it is easier for people to generate causes than counterfactuals.

The aim of this article is to bring to social theorists’ attention the growing visibility of the notion of dignity within human rights legislation, bioethics and public discourse generally, as well as to evaluate this term’s potential to enhance our capacities to respond to old and new challenges. The article starts with a short presentation of the career of the concept and discussion of the various impasses and conceptual tensions connected with the notion of human dignity. It is followed by (...) an exploration of how the idea of human dignity has become one of the main achievements of modern times. The question of how respect for human dignity has turned out to be the fundamental feature of democratic society is addressed with help from both Waldron’s perspective on human dignity as the ground of human rights and Habermas’s approach that stresses the moral content of human rights. The final part of the article examines the value of the notion of dignity for social theorizing by looking at ways the employment of the concept may contribute to sociological thought and enquiry. (shrink)

This study documents and characterizes a phenomenon in naturally‐occurring conversation which I have termed interactional reconstruction. Interactional reconstruction involves retroactive reinterpretation of an earlier utterance (or set of utterances) on the basis of a more recent utterance (or set of utterances). This work is meant to serve two functions: first, to enrich our theories of human communication; and second, to explore directions and implications for theories of meaning and discourse modeling within cognitive science.

SummaryCross-sectional studies in Australia and the Philippines and a longitudinal prospective study in a selected Australian sample of breast-feeding mothers have shown that basal serum prolactin concentrations are elevated during 15–21 months of lactational amenorrhoea.A predictive model of serum PRL levels and return of cyclic ovarian activity during full breast-feeding, partial breast-feeding and weaning has been developed from the results of breast-feeding behaviour and serum PRL, gonadotrophin and oestradiol measurements in 34 mothers breast-feeding on demand for a mean of 67 (...) weeks.Breast-feeding patterns influence serum PRL levels. Important factors during full breast-feeding are the age of the baby, the longest interval between feeds at night and total 24-hr suckling time, and following the introduction of supplements, the mean interval between feeds, together with the total 24-hr suckling time and the number of solid supplements per day.The precise mechanisms whereby breast-feeding regulates cyclic ovarian activity remain unknown. Gonadotrophin secretion appears to be quantitatively normal, but qualitative changes, secondary to altered hypothalamic activity, may be the most important factor. A direct inhibitory effect of PRL on ovarian follicular development and steroidogenesis remains possible.Ovulation with a normal luteal phase is probable for 30% of breast-feeding mothers before the first menses, but is unlikely before 6 months, provided breast-feeding is frequent day and night.Measurement of serum PRL is a sensitive index of the return of menstruation and fertility during lactation in the population studied. (shrink)

To understand public discourse in the United States on genetic causation of behavioral disorders, we analyzed media representations of genetic research on addiction published between 1990 and 2010. We conclude first that the media simplistically represent biological bases of addiction and willpower as being mutually exclusive: behaviors are either genetically determined, or they are a choice. Second, most articles provide only cursory or no treatment of the environmental contribution. A media focus on genetics directs attention away from environmental factors. Rhetorically, (...) media neglect the complexity underlying the etiology the addiction and direct focus back toward individual causation and responsibility. (shrink)

On the fiftieth anniversary of Philosophy and Rhetoric I hope a future for the journal that not only continues to publish scholarship that reflects seriously on the productive possibilities of putting the unique understandings of the human condition delivered by philosophy into contact with the singular insights into the power and perils of speech, writing, and gesture offered up by rhetoric. I also wish for it printed pages on which scholars engage thoughtfully the challenges posed by worlds and loss of (...) worlds. Never before in my lifetime has this task seemed so urgent and so necessary. This article is delivered in that spirit.On 13 July 2013 a jury of six women in Sanford, Florida, returned a verdict of not... (shrink)

The two target articles in this issue bring into focus the struggle for governance over biomedical interventions that may offer some families more agency—the capacity to act—in the context of many...