The Pfizer-BioNTech coronavirus vaccine is 90 percent effective in protecting against COVID-19. It would not have been possible without the tireless effort of Professor Katalin Karikó, a scientific innovator fitting the mold of dynamic inventor ArthurDiamond presents in his book, Openness to Creative Destruction Sustaining Innovative Dynamism. Not only did Professor Karikó persist in her beliefs in the therapeutic potential of synthetic messenger RNA over the course of four decades, but she did so despite the criticisms of (...) other scientists and despite lack of financial backing for large parts of her career. Professor Karikó is a good example of the unconventional picture that Diamond paints of entrepreneurs in a specific version of market capitalism he terms, innovative dynamism. Specifically, she is an example of someone who does not hold prevailing academic theories in too high a regard and instead privileges her tacit knowledge (knowledge gained from years of working with mRNA in the lab) to persist believing in the potential of a therapy that now could quite literally save the world. Most surprisingly, she, like most of the entrepreneurs surveyed in the book, seem not primarily motivated by profit, though the money their projects eventually attract is integral to disseminating their creative ideas to the masses. -/- Are the many examples offered by Diamond that are similar to Professor Karikó’s story evidence against the long-standing suspicion that there is something morally damning in the self-interested motivations of innovative entrepreneurship? Is it the case that others would have inevitably pursued the cure that Karikó pursued, regardless of economic system? In light of COVID-19 and other high-pressure situations, ought we to care how we constrain the innovators who develop solutions? Diamond’s case for the economic system, innovative dynamism, seeks to answer these and other important questions concerning our political and cultural treatment of innovators and entrepreneurs. This review critically assesses his efforts. I make my case by first reviewing the major argumentative structure of the book, then I summarize and evaluate the three major themes Diamond presents in the book: (1) what is innovative dynamism and who are its competitors, (2) what are the major benefits of innovative dynamism, (3) who is the innovative entrepreneur and how do we support him or her? (shrink)
: The economic system of innovative dynamism is often accused of harming the environment. The opposite is true. As economies flourish through innovative dynamism, birth rates decline, new ways to extract old resources are invented, and previously useless materials are turned into useful new resources. Human and nonhuman animals are often adaptable and resilient in the […].
If all differences in behavior are explainable in terms of universal values pursued under variable constraints, then much ethical theorizing is pointless. A strong presumption in favor of universal values can be established by showing that differences in behavior that were previously thought to be explainable only in terms of differences in values, can in fact be explained in terms of differences in constraints. Eleven such cases are briefly discussed, including cases of differences among racial, religious and other groups in (...) crime, culinary practices and the acceptance of innovation. (shrink)
This book collects and focuses recent writings of Arthur Schlesinger on the themes of its title. In its short Foreword and seven concise essays, the book aims to explore, in some contrast with the genre of “instant history,” the relationship between President George W. Bush’s Iraq adventure and the national past. This aim and the present work are deserving of wide attention, both because of the contemporary need to deal with the extended war in Iraq and because Americans, in (...) particular, need to attend to their own history, if we are to avoid past mistakes and make the best use of our ongoing political traditions and institutions. In order to know better where we might go in the future, we need an adequate picture of where we have been in the past. Schlesinger invites us to debate the war, the Presidency, and their relation to the American past. (shrink)
Building on an earlier argument that isolationism may well be America's natural state, Schlesinger explains how the apparent rejection of isolationism during the long standoff with the Soviet Union during the Cold War was nothing more than a reaction to what was perceived as a direct and urgent threat to the security of the United States. In the wake of the Cold War's end, the incompatibility between collective international action and conceptions of national interest has highlighted the difficulties of democracies (...) in sending their armies to war, especially those that do not directly threaten national security. While much more can and should be done to enhance the effectiveness of global organizations already in place, what is needed, Schlesinger argues, is both a reexamination of the Wilsonian doctrine of collective security and a greater concentration on preventive diplomacy. (shrink)
Recent research has shown that a phase transformation of diamond to a different form of carbon is involved when diamonds are polished in the traditional fashion. The question as to how this phase transformation is activated and maintained to produce high wear rates is of great technological interest since it may radically change the way we view the processing of diamond. This paper describes the use of Raman spectroscopy to examine debris produced on the diamond polishing wheel, (...) both during its preparation and during polishing. In addition, polished diamond surfaces were examined for the possible existence of non-diamond surface layers in an attempt to identify material removal mechanisms. Raman spectroscopy proves ideal for these analyses because its relatively high spatial resolution is well suited to the analysis of small wear features and debris particles, and because of the wealth of information it reveals about chemical structure. This level of structural information has been lacking in previous analyses of diamond polishing debris. In addition to the non-diamond carbon found in the wear debris, significant quantities of two iron oxides, magnetite (Fe3O4) and haematite (α-Fe2O3), were also found. An interesting observation was that a transformation from magnetite to haematite could be induced either by using high power laser excitation or by frictional heating during polishing. It is suggested that some of the Raman peaks previously attributed to lonsdaleite might better be explained by the presence of these oxides. (shrink)
This is the first book to offer the best essays, articles, and speeches on ethics and intelligence that demonstrate the complex moral dilemmas in intelligence collection, analysis, and operations. Some are recently declassified and never before published, and all are written by authors whose backgrounds are as varied as their insights, including Robert M. Gates, former Director of the Central Intelligence Agency; John P. Langan, the Joseph Cardinal Bernardin Professor of Catholic Social Thought at the Kennedy Institute of Ethics, Georgetown (...) University; and Loch K. Johnson, Regents Professor of Political Science at the University of Georgia and recipient of the Owens Award for contributions to the understanding of U.S. intelligence activities. Creating the foundation for the study of ethics and intelligence by filling in the gap between warfare and philosophy, this is a valuable collection of literature for building an ethical code that is not dependent on any specific agency, department, or country. (shrink)
I address the commentators' calls for clarification of theoretical terms, discussion of similarities to other proposals, and extension of the ideas. In doing so, I keep the focus on the purpose of memory: enabling the organism to make sense of its environment so that it can take action appropriate to constraints resulting from the physical, personal, social, and cultural situations.
The true key to all the perplexities of the human condition, Rousseau boldly claims, is the “natural goodness of man.” It is also the key to his own notoriously contradictory writings, which, he insists, are actually the disassembled parts of a rigorous philosophical system rooted in that fundamental principle. What if this problematic claim—so often repeated, but as often dismissed—were resolutely followed and explored? Arthur M. Melzer adopts this approach in The Natural Goodness of Man. The first two parts (...) of the book restore the original, revolutionary significance of this now time-worn principle and examine the arguments Rousseau offers in proof of it. The final section unfolds and explains Rousseau’s programmatic thought, especially the Social Contract, as a precise solution to the human problem as redefined by the principle of natural goodness. The result is a systematic reconstruction of Rousseau’s philosophy that discloses with unparalleled clarity both the complex weave of his argument and the majestic unity of his vision. Melzer persuasively resolves one after another of the famous Rousseauian paradoxes–enlarging, in the process, our understanding of modern philosophy and politics. Engagingly and lucidly written, The Natural Goodness of Man will be of interest to general as well as scholarly readers. (shrink)
Two main goals of the emerging field of neurocognitive poetics are the use of more natural and ecologically valid stimuli, tasks and contexts and providing methods and models allowing to quantify distinctive features of verbal materials used in such tasks and contexts and their effects on readers responses. A natural key element of poetic language, metaphor, still is understudied insofar as relatively little empirical research looked at literary or poetic metaphors. An exception is Katz et al.’s corpus of 204 literary (...) metaphors by authors such as Shakespeare or Dylan Thomas, for which various rating data are available. We reanalyzed their corpus using a combination of quantitative narrative analysis, latent semantic analysis, and machine learning in order to identify relevant features of the metaphors that influenced the ratings. The combined application of computational tools sheds light on surface and affective-semantic features that co-determine the reception of poetic metaphors and successfully predicted the period of origin, authorship and goodness ratings of the metaphors. The present results can be used for generating quantitative hypotheses or selecting and matching verbal stimuli in empirical studies of literature and neurocognitive poetics. (shrink)
Language comprehension requires a simulation that uses neural systems involved in perception, action, and emotion. A review of recent literature as well as new experiments support five predictions derived from this framework. 1. Being in an emotional state congruent with sentence content facilitates sentence comprehension. 2. Because women are more reactive to sad events and men are more reactive to angry events, women understand sentences about sad events with greater facility than men, and men understand sentences about angry events with (...) greater facility than women. 3. Because it takes time to shift from one emotion to another, reading a sad sentence slows the reading of a happy sentence more for women than men, whereas reading an angry sentence slows the reading of a happy sentence more for men than for women. 4. Because sad states motivate affiliative actions and angry states motivate aggressive action, gender and emotional content of sentences interact with the response mode. 5. Because emotion simulation requires particular action systems, adapting those action systems will affect comprehension of sentences with emotional content congruent with the adapted action system. These results have implications for the study of language, emotion, and gender differences. (shrink)
Philosophy Between the Lines is the first comprehensive, book-length study of the history and theoretical basis of philosophical esotericism, and it provides a crucial guide to how many major writings—philosophical, but also theological, ...
ABSTRACTIn this article we investigate structural differences between “literary” metaphors created by renowned poets and “nonliterary” ones imagined by non-professional authors from Katz et al.’s 1988 corpus. We provide data from quantitative narrative analyses of the altogether 464 metaphors on over 70 variables, including surface features like metaphor length, phonological features like sonority score, or syntactic-semantic features like sentence similarity. In a first computational study using machine learning tools we show that Katz et al.’s literary metaphors can be successfully discriminated (...) from their nonliterary ones on the basis of response measures, in particular the ratings for familiarity, ease of interpretation, semantic relatedness, and comprehensibility. A second computational study then shows that the classifier can reliably detect and predict between-group differences on the basis of five QNA features generalizing from a... (shrink)
Modern socio?cultural studies of medicine demonstrate the symbolic character of much of medical reality. This symbolic reality can be appreciated as mediating the traditional division of medicine into biophysical and human sciences. Comparative studies of medical systems offer a general model for medicine as a human science. These studies document that medicine, from an historical and cross?cultural perspective, is constituted as a cultural system in which symbolic meanings take an active part in disease formation, the classification and cognitive management of (...) illness, and in therapy. Medicine's symbolic reality also forms a bridge between cultural and psychophysiological phenomena; the basis for psychosomatic and socioso?matic pathology and therapy. This in turn becomes a central problem for medical theory and for a philosophical reinvestigation of medicine. (shrink)
