Twaalf studies over ethische en wijsgerige vraagstukken van de hoogleraar aan de Katholieke Hogeschool Tilburg (1919-1981).

Augustine of Hippo was regarded by sixteenth century Europe as one of the most contested religious and philosophical authorities. Through deep examination of the production, circulation and consumption of Augustine's works, Arnoud Visser reveals the wildly contrasting ways in which he was read and appropriated by publishers, humanist scholars, and individual readers.

O ye Gentlemen explores two permanent and vital strands in Arabic culture: the Greek tradition in science and philosophy and the literary tradition. More than thirty essays demonstrate that the strands freely interweave within the broader scope of Schrifttum.

A philosophical system that aims to explain the structure of nature from the perspective of the framework of human consciousness, and thus the foundations of mathematics and physics.

Background Informed consent procedures for large population-based cohort studies should be comprehensive and easy-to-use. This is particularly challenging when participants from different socio-economic groups and multicultural ethnic backgrounds are involved. Recently, more and more studies have tried to use multimedia in informed consent procedures. We describe the development and testing of a digital informed consent app and elaborate on whether this may contribute to a comprehensive and practical procedure to obtain informed consent for public health research. Methods In a sample (...) of parents with young children, we used a mixed method approach to study the user experience of an informed consent app and evaluate whether it can be used to adequately inform people and register their consent. Through semi-structured interviews we investigated participants’ experiences with and opinions about the app, with a special focus on comprehensibility of the content and the usability of the app. Information retention questions were asked to evaluate to what extent participants could recall key aspects of the provided study information. Results The 30 participants in this study used the app between 4 and 15 min to give their consent. Overall, they found the app well-designed, informative and easy to use. To learn more about the study for which informed consent is asked, most of the participants chose to watch the animated film, which was generally found to convey information in a clear manner. The identification process was met with mixed reactions, with some feeling it as a secure way to give consent, while for others it contradicted their view of using data anonymously. Information retention questions showed that while all participants remembered various aspects of the study, fewer than half answered all four questions satisfactorily. Conclusion Our study shows that a well-designed informed consent app can be an effective tool to inform eligible participants and to record consents. Still, some issues remain, including trust barriers towards the identification procedure and lack of information retention in some participants. When implementing consent procedures that incorporate digital formats, it may be beneficial to also invest in a complementary face-to-face recruitment approach. (shrink)

Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular actin cytoskeleton are primarily transmitted through integrin‐containing focal adhesions and cadherin‐containing adherens junctions. Crosstalk between these complexes is well established and modulates the mechanical landscape of the cell. However, integrins and cadherins constitute large families of adhesion receptors and form multiple complexes by interacting with different ligands, adaptor proteins, and cytoskeletal filaments. Recent findings indicate that integrin‐containing hemidesmosomes oppose force transduction and traction (...) force generation by focal adhesions. The cytolinker plectin mediates this crosstalk by coupling intermediate filaments to the actin cytoskeleton. Similarly, cadherins in desmosomes might modulate force generation by adherens junctions. Moreover, mechanotransduction can be influenced by podosomes, clathrin lattices, and tetraspanin‐enriched microdomains. This review discusses mechanotransduction by multiple integrin‐ and cadherin‐based cell adhesion complexes, which together with the associated cytoskeleton form an integrated network that allows cells to sense, process, and respond to their physical environment. (shrink)

In 1958 Arnould Bayart, 1911-1998, produced a semantics for first and second-order S5 modal logic, and in 1959 a completeness proof for first-order S5, and what he calls a 'quasi-completeness' proof for second-order S5. The 1959 paper is the first completeness proof for modal predicate logic based on the Henkin construction of maximal consistent sets, and indeed may be the easier application of the Henkin method even to propositional modal logic. The semantics is in terms of possible worlds, which, Bayart (...) notes, can be anything at all. The present paper provides an English translation of both these papers together with an historical introduction and a logical commentary. (shrink)

On May 14, 1940, Otto Neurath and Marie Reidemeister fled from the harbour of Scheveningen in The Hague to England. It was the last boat that could escape from Holland before the German occupiers took the city. Years earlier, in 1934, they had fled the same danger from Vienna to Holland. Otto Neurath can be seen as the godfather of today's infographics. In the Gesellschafts- und Wirtschaftsmuseum (Social & Economic Museum) that he founded in Vienna, developments in various areas of (...) society were shown by means of pictorial statistics to a broad audience - rich and poor, literate and illiterate. At the Museum, Otto Neurath acted as the scientific director and inspirer, Marie Reidemeister as the 'Transformer' of data into sketches, and Gerd Arntz as the head of the graphics department which designed pictograms and layouts. These three continued that work in Holland under the acronym Isotype (International System Of TYpographic Picture Education). After internment as 'enemy aliens' on the Isle of Man, Neurath & Reidemeister were able to continue their work in the UK. Through Wolfgang Foges and his book packaging firm Adprint, they were commissioned to design Isotype charts for books supported by the Ministry of Information during the war - what might be called 'soft propaganda'. From 1942, Isotypes were supplied for information about the embryonic welfare state (Beveridge Plan), for illustrated books about Britain's allies (USA and USSR), and on what British democracy should look like after the war. This book illustrates around 250 Isotypes from these publications and provides information about the producers, authors, editors, and designers, and not least about the working relationship between the Isotype Institute and Adprint. The examples presented show the remarkable quality of the graphics, produced under less than ideal circumstances during wartime. (shrink)