A global health archive consisting of podoconiosis tissue slides and blocks, was donated to Brighton & Sussex Medical School in 2014. There is little guidance on the socioethical and legal issues surrounding the retrospective use of archived or ‘abandoned’ tissue samples, which poses a number of questions relating to the ethical standing of the archive. There is a great deal of interpretation in the guidelines that are currently in existence; however, modern ethical principles cannot be applied as it is not (...) feasible to either reconsent or retrospectively seek approval. Our research team believed that it was unethical to leave the archive in storage, as this option favours neither researcher nor subjects. Permission was obtained from the Human Tissue Authority and a local ethics board for the tissues to be utilized in on-going research on podoconiosis aetiology. There is a delicate balance between the benefits gained by society relating to the development and progress of scientific research and the risks to the donor regarding the reuse of their tissues. Clearer guidelines should be made available to ensure that researchers are able to reuse tissue archives in contemporary research. (shrink)

Forgiveness is a highly personal act. Only a moral agent can forgive and the only proper object of forgiveness is a moral agent. One trait that is particularly characteristic of moral agents is selfevaluation. It is precisely this activity that is involved in a genuine act of forgiveness. According to Bishop Butler and several other contemporary philosophers, forgiveness involves foreswearing one’s resentment towards another person. Successful forgiveness, for these accounts, essentially involves overcoming oneself. An important part of this self-overcoming involves (...) dissolving resentment. I argue that disowning resentment is a key step along the way towards successful forgiveness. In order to dissolve resentment, an individual must engage in self-reflection and selfevaluation. Frankfurt’s hierarchical theory of intentional agency provides a helpful conceptual apparatus for analyzing the act of forgiveness. (shrink)