Inflammatory mediators have an established role in inducing insulin resistance and promoting hyperglycemia. In turn, hyperglycemia has been argued to drive immune cell dysfunction as a result of mitochondrial dysfunction. Here, the authors review the evidence challenging this view. First, it is pointed out that inflammatory mediators are known to induce altered mitochondrial function. In this regard, critical care patients suffer both an elevated inflammatory tone as well as hyperglycemia, rendering it difficult to distinguish between the effects of inflammation and (...) hyperglycemia. Second, emerging evidence indicates that a decrease in mitochondrial respiration and an increase in reactive oxygen species (ROS) production are not necessarily manifestations of pathology, but adaptations taking shape as the mitochondria is abdicating its adenosine triphosphate (ATP)‐producing function (which is taken over by glycolysis) and instead becomes “retooled” for an immunological role. Collectively, these observations challenge the commonly held belief that acute hyperglycemia induces mitochondrial damage leading to immune cell dysfunction. (shrink)

This important new book by one of the world's leading political theorists boldly questions the moral justification for organizing our world as a territorial states-system and proposes major changes to states' sovereign powers.

This paper addresses whether, and to what extent, the African ethic of Ubuntu can contribute to ethical thinking in general and provide an alternative to stakeholder theory specifically. The conception of Ubuntu that is employed to further the analysis is Thaddeus Metz’s Ubuntu principle of right action, which focuses on promoting harmonious social relations premised on a shared identity and solidarity amongst people. This principle is used to develop an Ubuntu heuristic for organisational decision-making, which serves as the basis for (...) a relationholder theory. It is argued that this relationholder theory can overcome the weaknesses identified with a libertarian account of stakeholder theory, as well as serve as a profitable framework for determining both the purpose of the firm, and the responsibilities that management has towards those parties who affect, and who are affected by, the firm. (shrink)

Graphical AbstractThe finding that viruses with RNA and DNA genomes can recombine to produce chimeric entities provides valuable insights into the origin and evolution of viruses. It also substantiates the hypothesis that certain groups of DNA viruses could have emerged from plasmids via acquisition of capsid protein-coding genes from RNA viruses.

Wie verändern sich Mensch und Körper durch Technik? Und welches Menschenverständnis vertritt der Transhumanismus? Anna Puzio befasst sich in der ersten philosophischen Studie zur Anthropologie des Transhumanismus mit führenden Personen des Feldes, u. a. mit Nick Bostrom, David Pearce und Natasha Vita-More. Neben Körperoptimierung und Medizintechnologien beleuchtet sie auch Alltagstechnologien wie Wearables. Dabei entwickelt sie einen neuen Ansatz zur Technikanthropologie und ein neues inklusives Menschen- und Körperverständnis im Anschluss an Donna Haraway und den Kritischen Posthumanismus im amerikanischen Raum.

Abstract The role accorded to the public by scientists and philosophers of science has undergone an essential historical change in the last three centuries. Public participation in (witnessing of) scientific experiments was considered an important requirement for 17th century experimenters (e.g. for Boyle or Pascal). The cognitive role played by lay persons was later substantially downgraded; witnessing went out of fashion, while science became more and more esoteric and a matter for experts only. Part of this process was that all (...) scientific disciplines became intensively compartmentalized and in consequence a rather puzzling or even paradoxical situation appeared: that the scientists themselves were and are being reduced epistemically to the status of lay persons, outside of their proper field of expertise (as was pointed out by J. Hardwig). The paper deals with some cognitive aspects of this historical process. (shrink)

It is shown that in a linearly ordered MV-algebra A , the implication is unique if and only if the identity function is the unique De Morgan automorphism on A . Modulo categorical equivalence, our uniqueness criterion recalls Ohkuma's rigidness condition for totally ordered abelian groups. We also show that, if A is an Archimedean totally ordered MV-algebra, then each non-trivial De Morgan automorphism of the underlying involutive lattice of A yields a new implication on A , which is not (...) isomorphic to the original implication. (shrink)

Schoolgirls writing short stories have surrendered themselves to some rules of a game, which, according to Ricoeur and Gadamer, delimits a field where everything ’is played’, and thereby, ’shatters the seriousness’ of ’the self-presence of a subject’. This article proposes that this field has a serious side of its own that reveals something true about the everyday reality of being a girl. The proposed worlds in the girls’ short stories are places from which research on women’s lives should begin is (...) a central argument, along with the contention that for the researcher to be able to take the seriousness of this playful writing into account, she also has to assume the position of a playful figure. The article suggests that the empirical data of schoolgirl writing invited the researcher to think Ricoeur and feminist epistemology together. Further, a suggestion is that the roles of reading given by the texts have consequences for a ’new’ process-oriented writing pedagogy and the teacher of writing as well. (shrink)

Prologue: autumn aroma -- What's left? -- Arts of noticing -- Contamination as collaboration -- Some problems with scale -- Interlude: smelling -- After progress : salvage accumulation -- Working the edge "freedom" -- Open ticket, Oregon -- War stories -- What happened to the state? : two kinds of Asian Americans in translation -- Between the dollar and the yen -- From gifts to commodities and back -- Salvage rhythms : business in disturbance -- Interlude: tracking -- Disturbed beginnings (...) : unintentional design -- The life of the forest : coming up among pines -- History -- Resurgence -- Serendipity -- Ruin in gaps and patches -- In science as translation -- Flying spores -- Interlude: dancing -- In the middle of things -- Matsutake crusaders -- Ordinary assets -- Anti-ending : some people I met along the way -- Spore trail: the further adventures of a mushroom -- Notes -- Index. (shrink)

Grounding theorists insist that grounding and explanation are intimately related. This claim could be understood as saying either that grounding ‘inherits’ its properties from explanation or it could be interpreted as saying that grounding plays an important—possibly an indispensable—role in metaphysical explanation. Or both. I argue that saying that grounding ‘inherits’ its properties from explanation can only be justified if grounding is explanatory by nature, but that this view is untenable. We ought therefore to be ‘separatists’ and view grounding and (...) explanation as distinct. As it turns out, though, once grounding has been in this sense distinguished from the explanation it backs, the view that the role grounding plays in explanation justifies its introduction ends up in serious trouble. I conclude that the role grounding plays in explanation does not justify attributing to grounding whatever nature we think it has, and it most likely does not give us any special reason to think grounding exists. (shrink)

One of David Rosenthal’s many important contributions to the philosophy of mind was his clear and unshirking account of introspection. Here we argue that while there is a kind of introspection (we call it “reflective introspection”) that Rosenthal’s account may be structurally fit to accommodate, there is also a second kind (“primitive introspection”) that his account cannot recover. We introduce Rosenthal’s account of introspection in §1, present the case for the psychological reality of primitive introspection in §2, and argue that (...) Rosenthal’s account lacks the resources to accommodate it in §3. (shrink)

The study aims at exposing Meinong's ideas that may be of interest to analytic philosophers. It contains all the basic information concerning Meinong's theory of objects with a special focus upon 'objectives', which are Meinong's propositions. Meinong's theory of meaning and his epistemological views are discussed in detail. An outline of his conception of truth, which is classified as firmly realistic, is followed by a review of the critical works touching upon Meinong's epistemological ideas. Finally, Meinong's theory of objects is (...) presented as inspiring the development of Meinongian logics, with his Aussersein as the prototype of an all-inclusive semantic domain. The issues considered include reference of terms and sentences as well as the general features of a Meinongian-style semantics. (shrink)

Modifying the descriptive and theoretical generalizations of Relativized Minimality, we argue that a significant subset of weak island violations arise when an extracted phrase should scope over some intervener but is unable to. Harmless interveners seem harmless because they can support an alternative reading. This paper focuses on why certain wh-phrases are poor wide scope takers, and offers an algebraic perspective on scope interaction. Each scopal element SE is associated with certain operations (e.g., not with complements). When a wh-phrase scopes (...) over some SE, the operations associated with that SE are performed in its denotation domain. The requisite operations may or may not be available in a domain, however. We present an empirical analysis of a variety of wh-phrases. It is argued that the wh-phrases that escape all weak islands (i.e., can scope over any intervener) are those that range over individuals, the reason being that all Boolean operations are defined for their domain. Collectives, manners, amounts, numbers, etc. all denote in domains with fewer operations and are thus selectively sensitive to scopal interveners—a “semantic relativized minimality effect”. (shrink)

Democratic innovations have been widely presented by both academics and practitioners as a potential remedy to the crisis of representative democracy. Many argue that deliberation should play a pivotal role in these innovations, fostering greater citizen participation and political influence. However, it remains unclear how digitalization affects the quality of deliberation—whether digital democratic innovations (DDIs) undermine or enhance deliberation. This paper takes an inductive approach in political theory to critically examine three features of online deliberation that matter for deliberative democracy: (...) scale, transparency, and the facilitation of equality. It argues that the enhancement of equality should be given special attention when designing and implementing deliberative DDIs. Equality is a basic democratic value that is crucial for the intrinsic quality of deliberation. One way of enhancing equality through digital deliberative practices is via AI facilitation, which can assist human facilitators and help mitigate power dynamics, often present in non-digital settings. (shrink)

This chapter argues that human and animal minds indeed depend on a collection of domain-specific, task-specific, and encapsulated cognitive systems: on a set of cognitive ‘modules’ in Fodor's sense. It also argues that human and animal minds are endowed with domain-general, central systems that orchestrate the information delivered by core knowledge systems. The chapter begins by reviewing the literature on spatial reorientation in animals and in young children, arguing that spatial reorientation bears the hallmarks of core knowledge and of modularity. (...) It then considers studies of older children and adults, arguing that human spatial representations change qualitatively over development and show capacities not found in any other species. Finally, it presents two new experiments that investigate the role of emerging spatial language in uniquely human navigation performance. (shrink)

Artificial intelligence (AI), blockchain, virtual and augmented reality, (semi-)autonomous ve- hicles, autoregulatory weapon systems, enhancement, reproductive technologies and human- oid robotics – these technologies (and many others) are no longer speculative visions of the future; they have already found their way into our lives or are on the verge of a breakthrough. These rapid technological developments awaken a need for orientation: what distinguishes hu- man from machine and human intelligence from artificial intelligence, how far should the body be allowed to (...) be changed and what are the dangers and opportunities presented by these technologies? Many of these questions are also addressed to theology. For example, questions about the image of humanity, the understanding of creation, the ethics of technological body interventions or the moral status of robots. What does theology have to say about these technological developments? It is the right time for theology to scientifically explore tech- nologization and AI and to formulate answers. As technology changes the various areas of human life, society and the world around us, the places and topics of theology are also undergoing transformation. Puzio, Anna: Theology Meets AI: Examining Perspectives, Tasks, and Theses on the Intersection of Technology and Religion. In: Puzio, Anna/Kunkel, Nicole/Klinge, Hendrik (Hg.): Alexa, How Do You Feel About Religion? Theological Approaches to Technology and Artificial Intelligence (Theology and AI 1). Darmstadt: wbg 2023, S. 29–41. DOI: 10.53186/1030373. (shrink)

The treatise attempts to approach and deal with some of the most fundamental problems facing anyone who wishes to uphold some version of the so-called theory of tropes. Three assumptions serve as a basis for the investigation: tropes exist, only tropes exist, and a one-category trope-theory along these lines should be developed so that the tropes it postulates are able to serve as truth-makers for all kinds of atomic propositions. Provided that these assumptions are accepted, it is found that the (...) trope-theorist will have to deal with two important problems. First, some atomic propositions seem to require universal truth-makers. Second, some atomic propositions seem to require concrete truth-makers. As tropes are abstract particulars, it follows that the trope-theorist, in order to fulfil assumption, must provide an account of exactly how he or she could construct universality and concreteness from his or her basic stock of tropes. In the treatise such constructions are attempted and some basic problems with such constructions are revealed. Although these problems are serious enough it is argued that it is nevertheless possible to deal with these basic issues while staying squarely within the boundaries of a one-category trope-ontology. (shrink)

Ways of Scope Taking is concerned with syntactic, semantic and computational aspects of scope. Its starting point is the well-known but often neglected fact that different types of quantifiers interact differently with each other and other operators. The theoretical examination of significant bodies of data, both old and novel, leads to two central claims. (1) Scope is a by-product of a set of distinct Logical Form processes; each quantifier participates in those that suit its particular features. (2) Scope interaction is (...) further constrained by the semantics of the interacting operators. The arguments are developed using Minimalist syntax, Generalized Quantify theory, Discourse Representation Theory, and algebraic semantics. The contributors (Beghelli, Ben-Shalom, Doetjes, Farkas, Gutiérrez Rexach, Honcoop, Stabler, Stowell, Szabolcsi and Zwarts) make tightly related theoretical assumptions and focus on related empirical phenomena, which include the direct and inverse scope of quantifiers, distributivity, negation, modal and intensional contexts, weak islands, event-related readings, interrogatives, wh/quantifier interactions, and Hungarian syntax. An introduction to the formal semantics background is provided. Audience: Linguists, philosophers, computational and psycholinguists; advanced undergraduates, graduate students and researchers in these fields. (shrink)

Do the new sciences of well-being provide knowledge that respects the nature of well-being? This book written from the perspective of philosophy of science articulates how this field can speak to well-being proper and can do so in a way that respects the demands of objectivity and measurement.

Trope theory is the view that the world is a world of abstract particular qualities. But if all there is are tropes, how do we account for the truth of propositions ostensibly made true by some concrete particular? A common answer is that concrete particulars are nothing but tropes in compresence. This answer seems vulnerable to an argument (first presented by F. H. Bradley) according to which any attempt to account for the nature of relations will end up either in (...) contradiction, nonsense, or will lead to a vicious infinite regress. I investigate Bradley’s argument and claim that it fails to prove what it sets out to. It fails, I argue, because it does not take all the different ways in which relation and relata may depend on one another into account. If relations are entities that are distinct from yet essentially dependent upon their relata, the Bradleyan problem is solved. We are then free to say that tropes in compresence are what make true propositions ostensibly made true by concrete particulars. (shrink)

Section 1 provides a brief summary of the pair-list literature singling out some points that are particularly relevant for the coming discussion. -/- Section 2 shows that the dilemma of quantifi cation versus domain restriction arises only in extensional complement interrogatives. In matrix questions and in intensional complements only universals support pairlist readings, whence the simplest domain restriction treatment suffices. Related data including conjunction, disjunction, and cumulative readings are discussed -/- Section 3 argues that in the case of extensional complements (...) the domain restriction treatment is inadequate for at least two independent reasons. One has to do with the fact that not only upward monotonic quantifi ers support pairlist readings, and the other with the derivation of apparent scope out readings. The reasoning is supplemented with some discussion of the semantic properties of layered quantifi ers.  The above will establish the need for quantifi cation, so the question arises how the objections explicitly enlisted in the literature against quantifi cation can be answered. Section 4 considers the de dicto reading of the quantifi er s restriction, quanti cational variability, and the absence of pairlist readings with whether questions, and argues that they need not militate against the quanti ficational analysis. -/- Section 5 summarizes the emergent proposal -/- Finally, section 6 discusses the signifi cance of the above findings for the behavior of weak islands. (shrink)

Extensively investigated in the field of psychology, psychiatry, education, and social policy, self-esteem has been comparatively under-researched in philosophy. However, a number of theories and notions relevant to the understanding of self-esteem and related experiences have been put forward in both classical and contemporary phenomenology of emotion. Drawing upon this body of research, in this chapter I will present a phenomenological account of self-esteem. First, I will suggest that this is best understood as a particular kind of background affective orientation, (...) and, more specifically, as a narratively shaped “existential feeling”. I will then move to explore the relevance of such an account for the philosophical understanding of pride, embarrassment, and shyness, thus providing an example of the influence exerted by self-esteem on other self-related affects and traits. (shrink)

Kann der christliche Glaube an Gott in einer der Freiheit verpflichteten Moderne bedeutsam sein? Wie kann man von Gott sprechen unter dem Anspruch der Autonomie der Vernunft? Die Studie gibt darauf eine Antwort mittels einer Analyse der genealogischen Rekonstruktionen von Moderne, wie sie die Philosophen Hermann Krings und Herbert Schnädelbach vorgelegt haben. Dabei zeigt sich, dass es innertheologische Momente waren, die am Ende des Spätmittelalters die Moderne freigesetzt haben. So lässt sich die Moderne als eine Epoche begreifen, in der der (...) Glaube nochmals radikalisiert hermeneutisch erschlossen werden kann." --provided by publisher, back cover. (shrink)

Plotinus (204/5-270 C.E.) is a central figure in the history of Western philosophy. However, during the Middle Ages he was almost unknown. None of the treatises constituting his Enneads were translated, and ancient translations were lost. Although scholars had indirect access to his philosophy through the works of Proclus, St. Augustine, and Macrobius, among others, it was not until 1492 with the publication of the first Latin translation of the Enneads by the humanist philosopher Marsilio Ficino (1433-1499) that Plotinus was (...) reborn to the Western world. Ficino's translation was accompanied by a long commentary in which he examined the close relationship between metaphysics and anthropology that informed Plotinus's philosophy. Focusing on Ficino's interpretation of Plotinus's view of the soul and of human nature, this book excavates a fundamental chapter in the history of Platonic scholarship, one which was to inform later readings of the Enneads up until the nineteenth century. It will appeal to scholars and students interested in the history of Western philosophy, intellectual history, and book history. (shrink)

Whatever societies accept as "knowledge" is embedded in specific epistemological, political and economic power relations. How is knowledge produced and functionalized? What is the difference between knowledge and the sciences? Can there be science without universal truth claims? Questions like these, all of them highly relevant, are discussed in twelve essays from the perspective of Sociology, Law, Cultural Studies and the Humanities.