BackgroundAlthough patient advocates have developed templates for standard consent forms, evaluating patient preferences for first in human (FIH) and window of opportunity (Window) trial consent forms is critical due to their unique risks. FIH trials are the initial use of a novel compound in study participants. In contrast, Window trials give an investigational agent over a fixed duration to treatment naïve patients in the time between diagnosis and standard of care (SOC) surgery. Our goal was to determine the patient-preferred presentation (...) of important information in consent forms for these trials.MethodsThe study consisted of two phases: (1) analyses of oncology FIH and Window consents; (2) interviews of trial participants. FIH consent forms were analyzed for the location(s) of information stating that the study drug has not been tested in humans (FIH information); Window consents were analyzed for the location(s) of information stating the trial may delay SOC surgery (delay information). Participants were asked about their preferred placement of the information in their own trial’s consent form. The location of information in the consent forms was compared to the participants’ suggestions for placement. Results34 [17 FIH; 17 Window] of 42(81%) cancer patients approached participated. 25 consents [20 FIH; 5 Window] were analyzed. 19/20 FIH consent forms included FIH information, and 4/5 Window consent forms included delay information. 19/20(95%) FIH consent forms contained FIH information in the risks section 12/17(71%) patients preferred the same. Fourteen (82%) patients wanted FIH information in the purpose, but only 5(25%) consents mentioned it there. 9/17(53%) Window patients preferred delay information to be located early in the consent, before the “Risks” section. 3/5(60%) consents did this.ConclusionsDesigning consents that reflect patient preferences more accurately is essential for ethical informed consent; however, a one-size fits all approach will not accurately capture patient preferences. We found that preferences differed for FIH and Window trial consents, though for both, patients preferred key risk information early in the consent. Next steps include determining if FIH and Window consent templates improve understanding. (shrink)

Modern songs, films, novels and daily speech often use heart imagery to illustrate ‘inner self’ experiences, such as deeply felt emotions. Where do these ideas come from and what relevance do they have for medicine today? This article explores some of the key origins and periods of development of heart/‘inner self’ ideas before considering the significance of heart/‘inner self’ interactions in modern clinical practice: from Aristotelian anatomy and the translated Hebrew Scriptures; through Shakespeare, William Harvey and the Protestant Reformation; (...) to theories of emotion and modern-day cardiology. I conclude that heart/‘inner self’ interactions exist in clinically significant ways, but are poorly understood and under-recognised in healthcare settings. Greater integration of cardiovascular and psychosocial medicine would improve patient care. (shrink)

European Journal of Philosophy, EarlyView.

In this new book, David Harvey seeks to determine what is meant by the term in its different contexts and to identify how accurate and useful it is as a description of contemporary experience.

Is 'education' a thick epistemic concept? The answer depends, of course, on the viability of the 'thick/thin' distinction, as well as the degree to which education is an epistemic concept at all. I will concentrate mainly on the latter, and will argue that epistemological matters are central to education and our philosophical thinking about it; and that, insofar, education is indeed rightly thought of as an epistemic concept. In laying out education's epistemological dimensions, I hope to clarify the degree to (...) which it makes sense to regard the concept as 'thick'. I also discuss the relationship between philosophy of education and virtue epistemology and the sense in which being educated might itself be thought to be an epistemic virtue. Finally, I urge virtue epistemologists in particular and epistemologists generally to turn their attention to questions of education, to further both the philosophy of education and epistemology itself. (shrink)

A fascinating account of exemplarity in the context of deconstruction.

Without trust there is no credible human health research (HHR). This article accepts this truism and addresses a crucial question that arises: how can trust continually be promoted in an ever-changing and uncertain HHR environment? The article analyses long-standing mechanisms that are designed to elicit trust—such as consent, anonymization, and transparency—and argues that these are best understood as trust represented by proxies of trustworthiness, i.e., regulatory attempts to convey the trustworthiness of the HHR system and/or its actors. Often, such proxies (...) are assumed to operate as markers that trust exists or, at least, has not been lost. But, since trust can neither be “built” nor “secured,” this is a precarious assumption. Worryingly, there is no existing theoretical account of how to understand and evaluate these proxies of trustworthiness as part of a trusted HHR ecosystem. To remedy this, the paper argues for a radical reimagining of trust and trustworthiness as performative acts that ought to be understood in relation to each other and by reference to the common values at stake. It is shown that proxies of trustworthiness are the operational tools used to perform trustworthiness. It advocates for a values-based approach to understanding the relationship between trust and trustworthiness. This establishes a strong basis for an evaluative framework for proxies of trustworthiness, i.e., to determine how to perform trustworthiness well. Five common proxies in HHR are scrutinized from a values perspective. The contribution is to provide a far-reaching normative and practical framework by which existing and future proxies of trustworthiness can be identified, assessed, maintained, or replaced in rapidly changing HHR regulatory ecosystems where trust itself is crucial to the success of the entire HHR enterprise. (shrink)

‘Argument’ has multiple meanings and referents in contemporary argumentation theory. Theorists are well aware of this but often fail to acknowledge it in their theories. In what follows, I distinguish several senses of ‘argument’ and argue that some highly visible theories are largely correct about some senses of the term but not others. In doing so, I hope to show that apparent theoretical rivals are better seen as collaborators or partners, rather than rivals, in the multi-disciplinary effort to understand ‘argument,’ (...) arguments, and argumentation in all their varieties. I argue as well for a pluralistic approach to argument evaluation and argumentative norms, since arguments and argumentation can be legitimately evaluated along several dimensions, but urge that epistemic norms enjoy conceptual priority. (shrink)

This important new book by one of the world's leading political theorists boldly questions the moral justification for organizing our world as a territorial states-system and proposes major changes to states' sovereign powers.

According to relationism, for Alice to believe that some rabbits can speak is for Alice to stand in a relation to a further entity, some rabbits can speak. But what could this further entity possibly be? Higher-order metaphysics seems to offer a simple, natural answer. On this view (roughly put), expressions in different syntactic categories (for instance: names, predicates, sentences) in general denote entities in correspondingly different ontological categories. Alice's belief can thus be understood to relate her to a sui (...) generis entity denoted by "some rabbits can speak", belonging to a different ontological category than Alice herself. This straightforward account of the attitudes has historically been deemed so attractive that it was seen as providing an important motivation for higher-order metaphysics itself (Prior [1971]). But I argue that it is not as straightforward as it might seem, and in fact that propositional attitudes present a foundational challenge for higher-order metaphysics. (shrink)

Philosophy in the Seraglio -- The wisdom of the East -- The New World and the noble savage -- The last frontiers -- The varieties of man -- An indelible stain -- The apotheosis of Europe.

Maimonides requires the multitude to observe many ceremonial commandments, while Spinoza makes no such demand. This chapter focuses on some of the main points of agreement between Maimonides and Spinoza on true religion, the religion of reason, or philosophic religion. True religion includes also piety, that is, moral conduct, which follows from the rational life. The piety of the philosopher and the non‐philosopher both consist in doing good to others. Maimonides’ approach to true religion adumbrates Spinoza's. Spinoza's concept of amor (...) Dei intellectualis echoes Maimonides’ concept of the passionate intellectual love of God. Spinoza's concept of piety is adumbrated in Maimonides. The Maimonidean thrust of Spinoza's concept of true religion is evident in his discussion of “the divine Law” or, more precisely, “the natural divine Law” and the summum bonum in TTP4. In Maimonides’ language, true religion is based on the intelligibilia and popular religion on generally accepted opinions. (shrink)

This is a book that opens up an area of contemporary experience that rarely sees the light of day. I believe readers from all walks of life and different educational backgrounds will be as excited to read about these experiences as my subjects were delighted to talk about them. One measure of the public's interest in relevant oral history is the current popularity of Brandon Stanton's Humans of New York, Stories, found in museums and bookstores throughout the city. And the (...) fact that the recent Nobel went to Svetlana Alexievich, a writer whose work is grounded in oral history, will expand the market for such books, and is a sign that more and more readers are interested in what ordinary people, whose voices are usually muted, have to say about crucial aspects of modern life. The book's interdisciplinary appeal will attract faculty and students in cultural studies, English, sociology, and other departments and programs interested in aesthetics. The book will have considerable crossover appeal to a wide general audience that especially includes women (most of my subjects are women) and women of color (a third of my subjects are members of a minority). The book is, in fact, eminently "Oprah-ble" because of its undoubted appeal to her vast audience. The challenge for an academic press, of course, will be to gain this audience's attention, a task to which I will be more than happy to devote substantial time and effort. (shrink)

This important new work surveys the source and ramifications of the famed Nuremburg Code -- recognized around the world as one of the cornerstones of modern bioethics.

This volume is a tribute by his peers, and by younger scholars of the next generation, to Harvey M. Friedman, perhaps the most profound foundationalist since Kurt Godel. Friedman's researches, beginning precociously in his mid-teens, have fundamentally shaped our contemporary understanding of set theory, recursion theory, model theory, proof theory and metamathematics. His achievements in concept formation and theory formulation have also renewed the standard set by Godel and Alfred Tarski for the general intellectual interest and importance of technical (...) work in foundations. Friedman pioneered the now well-established and flourishing field of Reverse Mathematics, whose aim is to calibrate the intrinsic logico-mathematical consistency-strength of all the important theorems of mathematics. He has relentlessly pursued the full extent of the incompleteness phenomena into which Godel provided the first revealing glimpse. The Godel--Friedman program, as it is now deservingly called, seeks to find simple, natural and elegant mathematical statements of a combinatorial nature, that can be proved to be independent of set theory even when extended by powerful large-cardinal existence axioms. (shrink)

'..... And then there were none', is a collaborative book by four New Zealand photographers and a writer. Developed over the last two years with regular meetings indulgent in wine and homemade cheese as excuses for friendship and banter, '..... and then there were none' grew from conversations and arguments about mortality, our technologically mired existence and the degradation of the environment. Collaboration in a real sense, Harvey Benge, Jon Carapiet, Haru Sameshima, Stu Sontier, breaks out of conventional authorship (...) based story-telling, to play out their anxieties and doubts about the world they see, as one visual voice. The author Lloyd Jones adds his contribution of trenchant narrative texts of two scenes of slaughter and one execution. All addicted to travels, the project triggered its own version of flygskam [the feeling of climate guilt associated with airline travel] or the collaborators, conflicted by the international travel that made many of the photographs and the writing possible and tainted by knowing the greater price to be paid. Narratives included from such travels are drenched in sordid human histories that recall the myriad pathways that have led us to now, and to what comes next. The nod to mortality echoing through the book is rendered stark by the recent death of Benge, adding a sense of urgency to the title of the book - not just for the remaining collaborators, but for us all."--Publisher. (shrink)

Ostensibly a discussion about love, the debate in the Phaedrus also encompasses the art of rhetoric and how it should be practised. This new edition contains an introductory essay outlining the argument of the dialogue as a whole and Plato's arguments about rhetoric and eros in particular. The Introduction also considers Plato's style and offers an account of the reception of the dialogue from its composition to the twentieth century. A new Greek text of the dialogue is accompanied by a (...) select textual apparatus. The greater part of the book consists of a Commentary, which elucidates the text and makes clear how Plato achieves his philosophical and literary objectives. Primarily intended for advanced undergraduates and graduate students of ancient Greek literature and philosophy, it will also benefit scholars who want an up-to-date account of how to understand the text, argument, style and background of the work. (shrink)

The first full-length critical introduction in English to Nietzsche's lifelong obsession with Wagner, and why it matters for understanding Nietzsche's philosophy as a whole.

Skepticism, Relativism, and Religious Knowledge shows where responses to skepticism and relativism by Karl Barth and Reformed epistemology have led to impasses, and reconstructs their insights in a more robust response that does not depend on making excessive claims about our epistemic capacities. This response is based on a more nuanced conception of the relationship between trust, doubt, faith, and reason, and a Kierkegaardian perspective on religious knowledge that stresses the role of the will and the intellectual and theological virtues.

Thought-provoking explorations of the relationship between psychoanalysis and Judaism.

‘Argument’ has multiple meanings and referents in contemporary argumentation theory. Theorists are well aware of this but often fail to acknowledge it in their theories. In what follows, I distinguish several senses of ‘argument’ and argue that some highly visible theories are largely correct about some senses of the term but not others. In doing so, I hope to show that apparent theoretical rivals are better seen as collaborators or partners, rather than rivals, in the multi-disciplinary effort to understand ‘argument,’ (...) arguments, and argumentation in all their varieties. I argue as well for a pluralistic approach to argument evaluation and argumentative norms, since arguments and argumentation can be legitimately evaluated along several dimensions, but urge that epistemic norms enjoy conceptual priority. (shrink)

Wie verändern sich Mensch und Körper durch Technik? Und welches Menschenverständnis vertritt der Transhumanismus? Anna Puzio befasst sich in der ersten philosophischen Studie zur Anthropologie des Transhumanismus mit führenden Personen des Feldes, u. a. mit Nick Bostrom, David Pearce und Natasha Vita-More. Neben Körperoptimierung und Medizintechnologien beleuchtet sie auch Alltagstechnologien wie Wearables. Dabei entwickelt sie einen neuen Ansatz zur Technikanthropologie und ein neues inklusives Menschen- und Körperverständnis im Anschluss an Donna Haraway und den Kritischen Posthumanismus im amerikanischen Raum.

This book surveys research in quantification starting with the foundational work in the 1970s. It paints a vivid picture of generalized quantifiers and Boolean semantics. It explains how the discovery of diverse scope behavior in the 1990s transformed the view of quantification, and how the study of the internal composition of quantifiers has become central in recent years. It presents different approaches to the same problems, and links modern logic and formal semantics to advances in generative syntax. A unique feature (...) of the book is that it systematically brings cross-linguistic data to bear on the theoretical issues, discussing French, German, Dutch, Hungarian, Russian, Japanese, Telugu (Dravidian), and Shupamem (Grassfield Bantu), and pointing to formal semantic literature involving quantification in around thirty languages. -- -/- 1. What this book is about and how to use it; 2. Generalized quantifiers and their elements: operators and their scopes; 3. Generalized quantifiers in non-nominal domains; 4. Some empirically significant properties of quantifiers and determiners; 5. Potential challenges for generalized quantifiers; 6. Scope is not uniform and not a primitive; 7. Existential scope versus distributive scope; 8. Distributivity and scope; 9. Bare numeral indefinites; 10. Modified numerals; 11. Clause-internal scopal diversity; 12. Towards a compositional semantics of quantifier words. (shrink)

(1) Is the rational person _eo ipso_ intellectually virtuous? (2) Is the intellectually virtuous person _eo ipso_ rational? In what follows I answer both questions in the negative.

Some people commonly know a proposition just in case they all know it, they all know that they all know it, they all know that they all know that they all know it, and so on. They commonly believe a proposition just in case they all believe it, they all believe that they all believe it, they all believe that they all believe that they all believe it, and so on. A long tradition in economic theory, theoretical computer science, linguistics (...) and philosophy has held that people have some approximation of common knowledge or common belief in a range of circumstances, for example, when they are looking at an object together, or when they have just discussed something explicitly in conversation. In this paper, I argue that people do not have any approximation of common knowledge or common belief in these circumstances. The argument suggests that people never have any approximation of common knowledge or common belief. (shrink)

(1) Is the rational person _eo ipso_ intellectually virtuous? (2) Is the intellectually virtuous person _eo ipso_ rational? In what follows I answer both questions in the negative.

Difficulty is often treated as blame-mitigating, and even exculpating. But on some occasions difficulty seems to have little or no bearing on our assessments of moral responsibility, and can even exacerbate it. In this paper, I argue that the relevance (and irrelevance) of difficulty with regard to assessments of moral responsibility is best understood via Quality of Will accounts. I look at various ways of characterising difficulty – including via sacrifice, effort, skill and ‘trying’ – and set out to demonstrate (...) that these factors are only blame-mitigating where, and to the extent that, they complicate ascriptions of insufficient concern. Matters become more complex, however, when we turn to difficult circumstances that seem to generate such objectionable attitudes. This is arguably the case with epistemic difficulty and certain instances of moral ignorance. Here I argue that certain difficult circumstances diminish the sense in which false moral beliefs are genuinely revelatory of the agents who hold them. In particular, I draw on the distinction between difficulty that generates objectionable attitudes, and objectionable attitudes that generate difficulty. I argue that the former, but not the latter, can plausibly be viewed as blame mitigating, and that this would apply to (limited) cases of moral ignorance. (shrink)

Prologue: autumn aroma -- What's left? -- Arts of noticing -- Contamination as collaboration -- Some problems with scale -- Interlude: smelling -- After progress : salvage accumulation -- Working the edge "freedom" -- Open ticket, Oregon -- War stories -- What happened to the state? : two kinds of Asian Americans in translation -- Between the dollar and the yen -- From gifts to commodities and back -- Salvage rhythms : business in disturbance -- Interlude: tracking -- Disturbed beginnings (...) : unintentional design -- The life of the forest : coming up among pines -- History -- Resurgence -- Serendipity -- Ruin in gaps and patches -- In science as translation -- Flying spores -- Interlude: dancing -- In the middle of things -- Matsutake crusaders -- Ordinary assets -- Anti-ending : some people I met along the way -- Spore trail: the further adventures of a mushroom -- Notes -- Index. (shrink)

Grounding theorists insist that grounding and explanation are intimately related. This claim could be understood as saying either that grounding ‘inherits’ its properties from explanation or it could be interpreted as saying that grounding plays an important—possibly an indispensable—role in metaphysical explanation. Or both. I argue that saying that grounding ‘inherits’ its properties from explanation can only be justified if grounding is explanatory by nature, but that this view is untenable. We ought therefore to be ‘separatists’ and view grounding and (...) explanation as distinct. As it turns out, though, once grounding has been in this sense distinguished from the explanation it backs, the view that the role grounding plays in explanation justifies its introduction ends up in serious trouble. I conclude that the role grounding plays in explanation does not justify attributing to grounding whatever nature we think it has, and it most likely does not give us any special reason to think grounding exists. (shrink)

One of David Rosenthal’s many important contributions to the philosophy of mind was his clear and unshirking account of introspection. Here we argue that while there is a kind of introspection (we call it “reflective introspection”) that Rosenthal’s account may be structurally fit to accommodate, there is also a second kind (“primitive introspection”) that his account cannot recover. We introduce Rosenthal’s account of introspection in §1, present the case for the psychological reality of primitive introspection in §2, and argue that (...) Rosenthal’s account lacks the resources to accommodate it in §3. (shrink)

Domain extension in mathematics occurs whenever a given mathematical domain is augmented so as to include new elements. Manders argues that the advantages of important cases of domain extension are captured by the model-theoretic notions of existential closure and model completion. In the specific case of domain extension via ideal elements, I argue, Manders’s proposed explanation does not suffice. I then develop and formalize a different approach to domain extension based on Dedekind’s Habilitationsrede, to which Manders’s account is compared. I (...) conclude with an examination of three possible stances towards extensions via ideal elements. (shrink)