We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

This paper synthesises a collaborative review of social capital theory, with particular regard for its relevance to the changing educational landscape within Scotland. The review considers the common and distinctive elements of social capital, developed by the founding fathers-Putnam, Bourdieu and Coleman-and explores how these might help to understand the changing contexts and pursue opportunities for growth.

BackgroundThis study aimed to translate the negative and positive items of the Psychological Consequences Questionnaire into German, to adapt this version to the context of screening for cirrhosis and fibrosis of the liver, and to test its psychometric properties.Materials and methodsThe three subscales were translated into German using a forward-backward translation method. Furthermore, we adapted the wording to the context of liver diseases. In sum, the PCQ comprises twelve negative items and ten positive items. We tested the acceptability, distribution properties, (...) internal consistency, scale structure, and the convergent validity using an analysis sample of 443 patients who were screened for cirrhosis or fibrosis of the liver.ResultsWe found low non-response and non-unique answer rates on the PCQ items in general. However, positive items had higher non-response rates. All items showed strong floor effects. McDonald’s Omega was high for both the negative and the positive PCQ scale, as well as for the total PCQ scale. Confirmatory factor analysis could reproduce the three dimensions that the PCQ intends to measure. However, it suggests not summing up a total PCQ score and instead treat the subscales separately considering a higher order overall construct. Convergent validity with the short form of the Spielberger State-Trait Anxiety Inventory was acceptable.ConclusionOverall, our study results report a successful adaptation of the German PCQ with good performance in terms of acceptability, internal consistency, scale structure, and convergent validity. Floor-effects limit the content validity of the PCQ, which needs to be addressed in future research. However, the German version of the PCQ is a useful measurement for both negative and positive screening consequences - even in a non-cancer setting. (shrink)

Brains, it has recently been argued, are essentially prediction machines. They are bundles of cells that support perception and action by constantly attempting to match incoming sensory inputs with top-down expectations or predictions. This is achieved using a hierarchical generative model that aims to minimize prediction error within a bidirectional cascade of cortical processing. Such accounts offer a unifying model of perception and action, illuminate the functional role of attention, and may neatly capture the special contribution of cortical processing to (...) adaptive success. This target article critically examines this approach, concluding that it offers the best clue yet to the shape of a unified science of mind and action. Sections 1 and 2 lay out the key elements and implications of the approach. Section 3 explores a variety of pitfalls and challenges, spanning the evidential, the methodological, and the more properly conceptual. The paper ends (sections 4 and 5) by asking how such approaches might impact our more general vision of mind, experience, and agency. (shrink)

Mindware: An Introduction to the Philosophy of Cognitive Science invites readers to join in up-to-the-minute conceptual discussions of the fundamental issues, problems, and opportunities in cognitive science. Written by one of the most renowned scholars in the field, this vivid and engaging introductory text relates the story of the search for a cognitive scientific understanding of mind. This search is presented as a no-holds-barred journey from early work in artificial intelligence, through connectionist (artificial neural network) counter-visions, and on to neuroscience, (...) artificial life, dynamics, and robotics. The journey ends with some wide-ranging and provocative speculation about the complex coadaptive dance between mind, culture, and technology. Each chapter opens with a brief sketch of a major research tradition or perspective, followed by short yet substantial critical discussions dealing with key topics and problems. Ranging across both standard philosophical territory and the landscape of cutting-edge cognitive science, Clark highlights challenging issues in an effort to engage readers in active debate. Topics covered include mental causation; machine intelligence; the nature and status of folk psychology; the hardware/software distinction; emergence; relations between life and mind; the nature of perception, cognition, and action; and the continuity (or otherwise) of high-level human intelligence with other forms of adaptive response. Numerous illustrations, text boxes, and extensive suggestions for further reading enhance the text's utility. Helpful appendices provide background information on dualism, behaviorism, identity theory, consciousness, and more. An exceptional text for introductory and more advanced courses in cognitive science and the philosophy of mind, Mindware is also essential reading for anyone interested in these fascinating and ever-changing fields. (shrink)

“There’s no disputing about taste.” That’s got a nice ring to it, but it’s not quite the ring of truth. While there’s definitely something right about the aphorism – there’s a reason why it is, after all, an aphorism, and why its utterance tends to produce so much nodding of heads and muttering of “just so” and “yes, quite” – it’s surprisingly difficult to put one’s finger on just what the truth in the neighborhood is, exactly. One thing that’s pretty (...) clear is that what’s right about the aphorism, that there’s no disputing about taste, isn’t that there’s no disputing about taste. There’s heaps of disputing about taste. People engage in disputes about which movies, music, paintings, literature, meals, furniture, architectural styles, etc. are good, beautiful, tasty, fun, elegant, ugly, disgusting, etc. all the time. This is obvious to anyone who has watched dueling-movie-critics shows, read theater reviews, or negotiated with a group or partner about which movie or restaurant to go to, or which sofa or painting to put in the living room. It takes great care and good aim to fling a brick without hitting somebody who’s engaged in a dispute about taste. (shrink)

Ranging across both standard philosophical territory and the landscape of cutting-edge cognitive science, Mindware: An Introduction to the Philosophy of Cognitive Science, Second Edition, is a vivid and engaging introduction to key issues, research, and opportunities in the field.Starting with the vision of mindware as software and debates between realists, instrumentalists, and eliminativists, Andy Clark takes students on a no-holds-barred journey through connectionism, dynamical systems, and real-world robotics before moving on to the frontiers of cognitive technologies, enactivism, predictive coding, (...) and the extended mind. Throughout, he highlights challenging issues in an effort to engage students in active debate. Each chapter opens with a brief sketch of a major research tradition or perspective, followed by concise critical discussions dealing with key topics and problems. (shrink)

This paper provides a general introduction to the use of causal models in the metaphysics of causation, specifically structural equation models and directed acyclic graphs. It reviews the formal framework, lays out a method of interpretation capable of representing different underlying metaphysical relations, and describes the use of these models in analyzing causation.

This paper addresses the question of what constitutes an apt interpreted model for the purpose of analyzing causation. I first collect universally adopted aptness principles into a basic account, flagging open questions and choice points along the way. I then explore various additional aptness principles that have been proposed in the literature but have not been widely adopted, the motivations behind their proposals, and the concerns with each that stand in the way of universal adoption. I conclude that the remaining (...) work of articulating aptness for a SEM analysis of causation is tied up with issue to do with modality, ontology, and mereology. Continuing this work is therefore likely to shed light on the relationship between these areas and causation more generally. (shrink)

The Handmaid’s Tale depicts a United States taken over by a fundamentalist dictatorship called Gilead that also resembles Plato’s ideal city. Attempts to explain Gilead’s debt to Plato face two challenges. First, aspects of Gilead that recall Plato also contain features that differ, at times dramatically, from the Platonic original. Second, Gilead invokes distorted versions of ideas from philosophies other than Plato’s. I explore two ways of making sense of Gilead’s distorted philosophical appropriations. The explanations differ over whether such distortions (...) are best explained by the nature of the philosophies they misrepresent, or by the nature of Gilead. The explanation that emphasizes Gilead’s own agency is ultimately best able to make sense of how illiberal regimes misappropriate philosophical concepts, both in the novel and in reality, in order to limit the political imagination of their subjects. (shrink)

This chapter examines Soren Kierkegaard's views and reception of romanticism. It suggests that Kierkegaard was ambivalent toward romanticism and explains that while he criticized the concept of irony, he also modeled some of his works on the writings of romanticists Friedrich Schleiermacher and Joseph Freiherr von Eichendorff. In addition, he was also engaged with romantic aesthetics, and analysed and transformed its key concepts. The chapter also explains that Kierkegaard's references to romanticism can be found in his early works, including The (...) Concept of Irony and Either/Or. (shrink)

The relationship between career counselling and widening participation is increasingly capturing the attention of educational researchers, especially those interested in its social justice implications. International research on first-in-family students demonstrates the continual class-based barriers they are faced with which influence their progression into and through higher education. Career counselling has an important role to play in both supporting first-in-family students to not only enter university but also set them on a career trajectory which allows them to fulfil their aspirations. However, (...) access to effective forms of career counselling remains fragmented and highly dependent on social class. This article explores how first-in-family students engage in what we call ‘DIY career counselling,’ where they draw on their informal networks and the internet to enhance their understanding of their future prospects and possible trajectories. Their efforts suggest a strong desire to learn more about what university can offer them and how they can position themselves advantageously in the job market; furthermore, their efforts also suggest a consumerist awareness that the career counselling on offer in their secondary schools was lacking. (shrink)

How do intelligent agents spawn and exploit integrated processing regimes spanning brain, body, and world? The answer may lie in the ability of the biological brain to select actions and policies in the light of counterfactual predictions – predictions about what kinds of futures will result if such-and-such actions are launched. Appeals to the minimization of ‘counterfactual prediction errors’ (the ones that would result under various scenarios) already play a leading role in attempts to apply the basic toolkit of the (...) neurocomputational theory known as ‘predictive processing’ to higher cognitive functions such as policy selection and planning. In this paper, I show that this also leads naturally to the discovery and use of extended processing regimes defined across heterogeneous mixtures of biological and non-biological resource. This solves a long-standing puzzle concerning the ‘recruitment’ of the right non-neural processing resources at the right time. It reveals how (and why) human brains spawn and maintain extended human minds. (shrink)

Are artists, designers and musicians inventors? Or does the invention originate from scientific discovery alone? Ecologies of Invention is the first collection of essays that brings together writers and scholars of international standing from the University of Sydney and beyond to examine assumptions underlying notions of inventiveness. The writers explain how inventiveness borne out of aesthetic ambitions is impacting on and changing our culture and society. Ecologies of Invention describes the articulation of inventive capacities across disciplines and across multiple scales, (...) from personal capacities to the social, spatial and network configurations that drive people to produce inventions. The book poses new questions for scholars, artists, architects, designers, historians, engineers, scientists, lawyers and economists about the nature, origins and processes of invention. 'This is a challenging book which confronts traditional thinking around creativity and inventiveness and raises issues that need serious debate'. Barry Jones AO. (shrink)

Introduction -- Creative actualization -- Modes of value -- Moral justification -- Creative actualization and the world -- Critical evaluation of metaphysical value theories -- Critical evaluation of subjective value theories -- Critical evaluation of relational value theories -- Conclusion : value hierarchies and value autonomy.

The philosopher and humanist Marsilio Ficino (1433-1499) has attracted scholarly attention as translator of Plato, the Corpus Hermeticum, Plotinus and other Neoplatonists, and for his complex synthesis of Platonism and Christianity. While most previous studies of Ficino's reception have focussed on Italy, France, England and Spain, this book presents a comprehensive study of his reception in Germany and neighbouring areas, examining how Northern writers between the fifteenth and eighteenth centuries remembered and reinvented Ficino's person and work. Focused chapters examine the (...) ways German authors adapted his theories of the Ancient Theology, melancholia, celestial influence and poetic inspiration, and used his writings in related fields such as alchemy and witchcraft. It also studies those who rejected Ficino's work, providing context for those who embraced his ideas. The most comprehensive bibliography of printed editions of Ficino's work since Kristeller forms the basis for a bibliometric analysis"--Back cover. (shrink)

The trilogy is viewed through the lens of myth and metaphor. A wide variety of philosophical and mythological themes are presented and expounded upon, drawing from a rich source of scholars, thinkers, writers, and poets from East and West alike. Heretical or not, the Star Wars prequels are a surprisingly rich source of insight into the whole saga.

A very simple contextualist treatment of a sentence containing an epistemic modal, e.g. a might be F, is that it is true iff for all the contextually salient community knows, a is F. It is widely agreed that the simple theory will not work in some cases, but the counterexamples produced so far seem amenable to a more complicated contextualist theory. We argue, however, that no contextualist theory can capture the evaluations speakers naturally make of sentences containing epistemic modals. If (...) we want to respect these evaluations, our best option is a relativist theory of epistemic modals. On a relativist theory, an utterance of a might be F can be true relative to one context of evaluation and false relative to another. We argue that such a theory does better than any rival approach at capturing all the behaviour of epistemic modals. (shrink)

I think that there are good reasons to adopt a relativist semantics for epistemic modal claims such as ``the treasure might be under the palm tree'', according to which such utterances determine a truth value relative to something finer-grained than just a world (or a <world, time> pair). Anyone who is inclined to relativise truth to more than just worlds and times faces a problem about assertion. It's easy to be puzzled about just what purpose would be served by assertions (...) of this kind, and how to understand what we'd be up to in our use of sentences like ``the treasure might be under the palm tree'', if they have such peculiar truth conditions. After providing a very quick argument to motivate a relativist view of epistemic modals, I bring out and attempt to resolve this problem in making sense of the role of assertions with relativist truth conditions. Solving this problem should be helpful in two ways: first, it eliminates an apparently forceful objection to relativism, and second, spelling out the relativist account of assertion and communication will help to make clear just what the relativist position is, exactly, and why it's interesting. (shrink)

The notion of a global state of consciousness is an increasingly important construct in the science of consciousness. However, exactly what a global state of consciousness is remains poorly understood. In this paper I offer an account of global states of consciousness as consciousness-related capacity modulations. On this view global states are not themselves phenomenal states – they are not occurring experiences. Rather, they are states that specify which of a creature’s overall consciousness-related capacities are currently online. Given that the (...) search for the neural correlates of consciousness, as it is currently conceived, is the search for the neural basis of occurrent experiences, the NCC framework is incapable of revealing the neural basis of global states. As such, a mature science of consciousness will need to move beyond the search for NCCs, as that project is currently conceived. (shrink)

The moral status of animals is a subject of controversy both within and beyond academic philosophy, especially regarding the question of whether and when it is ethical to eat meat. A commitment to animal rights and related notions of animal protection is often thought to entail a plant-based diet, but recent philosophical work challenges this view by arguing that, even if animals warrant a high degree of moral standing, we are permitted - or even obliged - to eat meat. (...) class='Hi'>Andy Lamey provides critical analysis of past and present dialogues surrounding animal rights, discussing topics including plant agriculture, animal cognition, and in vitro meat. He documents the trend toward a new kind of omnivorism that justifies meat-eating within a framework of animal protection, and evaluates for the first time which forms of this new omnivorism can be ethically justified, providing crucial guidance for philosophers as well as researchers in culture and agriculture. (shrink)

Problems about the accidental properties of properties motivate us--force us, I think--not to identify properties with the sets of their instances. If we identify them instead with functions from worlds to extensions, we get a theory of properties that is neutral with respect to disputes over counterpart theory, and we avoid a problem for Lewis's theory of events. Similar problems about the temporary properties of properties motivate us--though this time they probably don't force us--to give up this theory as well, (...) and to identify properties with functions from world, time pairs to extensions. Again, the replacement theory is neutral with respect to a metaphysical dispute that the old theory (arguably) forces us to take a stand on--the dispute over whether objects have temporal parts. It also allows us to give a smoother semantics for predication, to better accommodate our intuitions about which objects temporary properties are properties of, and to make temporally self-locating beliefs genuinely self -locating. (shrink)

There is a lot that we don't know. That means that there are a lot of possibilities that are, epistemically speaking, open. For instance, we don't know whether it rained in Seattle yesterday. So, for us at least, there is an epistemic possibility where it rained in Seattle yesterday, and one where it did not. What are these epistemic possibilities? They do not match up with metaphysical possibilities - there are various cases where something is epistemically possible but not metaphysically (...) possible, and vice versa. How do we understand the semantics of statements of epistemic modality? The ten new essays in this volume explore various answers to these questions, including those offered by contextualism, relativism, and expressivism. (shrink)

Cognitive approaches contribute to our understanding of delusions by providing an explanatory framework that extends beyond the personal level to the sub personal level of information-processing systems. According to one influential cognitive approach, two factors are required to account for the content of a delusion, its initial adoption as a belief, and its persistence. This chapter reviews Bayesian developments of the two-factor framework.

Many philosophers (myself included) have been converted to causal decision theory by something like the following line of argument: Evidential decision theory endorses irrational courses of action in a range of examples, and endorses “an irrational policy of managing the news”. These are fatal problems for evidential decision theory. Causal decision theory delivers the right results in the troublesome examples, and does not endorse this kind of irrational news-managing. So we should give up evidential decision theory, and be causal decision (...) theorists instead. Unfortunately, causal decision theory has its own family of problematic examples for which it endorses irrational courses of action, and its own irrational policy that it is committed to endorsing. These are, I think, fatal problems for causal decision theory. I wish that I had another theory to offer in its place. (shrink)

Unconscious Thought Theory posits that a period of distraction after information acquisition leads to unconscious processing which enhances decision making relative to conscious deliberation or immediate choice . Support thus far has been mixed. In the present study, artificial grammar learning was used in order to produce measurable amounts of conscious and unconscious knowledge. Intermediate phases were introduced between training and testing. Participants engaged in conscious deliberation of grammar rules, were distracted for the same period of time, or progressed immediately (...) from training to testing. No differences in accuracy were found between intermediate phase groups acting on decisions made with meta-cognitive awareness . However, the accuracy of guess responses was significantly higher after distraction relative to immediate progression or conscious deliberation. The results suggest any beneficial effects of ‘unconscious thought’ may not always transfer to conscious awareness. (shrink)

Where does the mind stop and the rest of the world begin? The question invites two standard replies. Some accept the demarcations of skin and skull, and say that what is outside the body is outside the mind. Others are impressed by arguments suggesting that the meaning of our words "just ain't in the head", and hold that this externalism about meaning carries over into an externalism about mind. We propose to pursue a third position. We advocate a very different (...) sort of externalism: an _active externalism_, based on the active role of the environment in driving cognitive processes. (shrink)

On many of the idealized models of human cognition and behavior in use by philosophers, agents are represented as having a single corpus of beliefs which (a) is consistent and deductively closed, and (b) guides all of their (rational, deliberate, intentional) actions all the time. In graded-belief frameworks, agents are represented as having a single, coherent distribution of credences, which guides all of their (rational, deliberate, intentional) actions all of the time. It's clear that actual human beings don't live up (...) to this idealization. The systems of belief that we in fact have are fragmented. Rather than having a single system of beliefs that guides all of our behavior all of the time, we have a number of distinct, compartmentalized systems of belief, different ones of which drive different aspects of our behavior in different contexts. It's tempting to think that, while of course people are fragmented, it would be better (from the perspective of rationality) if they weren't, and the only reason why our fragmentation is excusable is that we have limited cognitive resources, which prevents us from holding too much information before our minds at a time. Give us enough additional processing capacity, and there'd be no justification for any continued fragmentation. I argue that this is not so. There are good reasons to be fragmented rather than unified, independent of the limitations on our available processing power. In particular, there are ways our belief-forming mechanisms—including our perceptual systems—could be constructed that would make it better to be fragmented than to be unified. And there are reasons to think that some of our belief-forming mechanisms really are constructed that way. (shrink)

Very often, different people, with different constitutions and comic sensibilities, will make divergent, conflicting judgments about the comic properties of a given person, object, or event, on account of those differences in their constitutions and comic sensibilities. And in many such cases, while we are inclined to say that their comic judgments are in conflict, we are not inclined to say that anybody is in error. The comic looks like a poster domain for the phenomenon of faultless disagreement. I argue (...) that the kind of theory that does the best job of accounting for the appearance of faultless disagreement is a de se version of a response-dependence account, according to which thinking that x is funny is self-attributing a property of the type, being disposed to have R to x in C. (shrink)

This paper investigates the time it takes unconscious vs. conscious knowledge to form by using an improved “no-loss gambling” method to measure awareness of knowing. Subjects could either bet on a transparently random process or on their grammaticality judgment in an artificial grammar learning task. A conflict in the literature is resolved concerning whether unconscious rather than conscious knowledge is especially fast or slow to form. When guessing , accuracy was above chance and RTs were longer than when feeling confident (...) . In a second experiment, short response deadlines only interfered with the quality of confident decisions . When people are unaware of their knowledge, externally enforced decisions can be made rapidly with little decline in quality; but if given ample time, they await a metacognitive process to complete. The dissociation validates no-loss gambling as a measure of conscious awareness. (shrink)

We seem, or so it seems to some theorists, to experience a rich stream of highly detailed information concerning an extensive part of our current visual surroundings. But this appearance, it has been suggested, is in some way illusory. Our brains do not command richly detailed internal models of the current scene. Our seeings, it seems, are not all that they seem. This, then, is the Grand Illusion. We think we see much more than we actually do. In this paper (...) I shall (briefly) rehearse the empirical evidence for this rather startling claim, and then critically examine a variety of responses. One especially interesting response is a development of the so-called ‘skill theory’, according to which there is no illusion after all. Instead, so the theory goes, we establish the required visual contact with our world by an ongoing process of active exploration, in which the world acts as a kind of reliable, interrogable, external memory (Noe, Pessoa and. (shrink)

This book offers an overview of theories of the Concept, drawing on the philosopher Hegel and the Soviet psychologist Lev Vygotsky. Concepts are shown to be both units of the mind and units of a cultural formation.

This chapter examines the state of the art of physical enhancement, demonstrating how the problem of regulating excellence is becoming more difficult as technology advances. Modifications are grouped into the following categories, building on Ellul's seminal discussions on philosophy and technology: technique, equipment, and biology. Technical enhancements are those that involve knowledge‐based innovations, leading to improved performance. Such examples encompass modifications arising from scientific insights, such as better understanding about the effect of nutrition. An emerging technology is the “Glove,” developed (...) by Heller and Grahn. This innovative cooling device has been utilized by the San Francisco 49ers and it demonstrates the blurred boundary between therapeutic use and enhancement. The “glove” leads us to forms of enhancement that arise from innovations in equipment design, though even this concept has expanded in remarkable ways recently. The chapter also offers insight into some of the major, emerging biotechnological enhancements that affect physical capabilities. (shrink)

This chapter focuses on one of the common fallacies in Western philosophy called the inflation of conflict (IC). A form of IC is a type of hasty generalization. A wider view of how things stand outside the courtroom may reveal little real disagreement among experts. Conventions in the popular press that promote “both sides of the story” or constant debate formats seem to encourage this type of IC. Another form of IC correctly points to disagreement in a field but incorrectly (...) implies that, as a result, little can be known. Noting disagreement among authorities can be the basis of a good argument. When there is widespread disagreement on the core aspects of a topic and the participants are bona fide authorities, then there is a good reason for a non‐expert to suspend judgment on the issue. (shrink)

This chapter focuses on one of the common fallacies in Western philosophy, 'kettle logic' (KL). KL is a fallacy in which multiple contradictory premises are presented to support a point. As such, it is logically impossible for all of the premises to be true. Formally, KL arguments are valid arguments, for it is impossible for contradictory premises to be true and the conclusion false. Sigmund Freud believes KL is employed in dreams quite often. Contradictory beliefs are commonly offered, which give (...) notice that one is in a dream. Freud's presentation of the tea kettle argument makes it clear that the man presents all of the premises as true. In real life and even in dreams, determining whether the arguer intends for all the considerations to be true, or whether additional information is missing, is much more difficult, but necessary in order to avoid the fallacy. (shrink)

Andy Blunden's Hegel Marx & Vygotsky, Essays in Social Philosophy presents his novel approach to social theory in a series of essays. Blunden aims to use the cultural psychology of Lev Vygotsky and the Soviet Activity Theorists to renew Hegelian Marxism as an interdisciplinary science. This allows psychologists and social theorists to share their insights through concepts equally valid in either domain. The work includes critical reviews of the works of central figures in Soviet psychology and other writers offering (...) fruitful insights. Essays on topics as diverse as vaccine scepticism and the origins of language test out the interdisciplinary power of the theory, as well as key texts on historical analysis, methodology and the nature of the present conjuncture. (shrink)