Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Go to John Cantwell’s response to the original paper from here › Go to Grazia Ietto-Gillies’ original paper from here ›.

The article reviews several books about philosophical isuuses including "Against Coherence: Truth, Probability, and Justification," by Olsson Erik J., "Fixing Frege," by Burgess John, "Events and Semantic Architecture," by Pietroski Paul M.

This innovative collection offers one of the first analyses of criminologies of the military from an interdisciplinary perspective. While some criminologists have examined the military in relation to the area of war crimes, this collection considers a range of other important but less explored aspects such as private military actors, insurgents, paramilitary groups and the role of military forces in tackling transnational crime. Drawing upon insights from criminology, this book's editors also consider the ways the military institution harbours criminal activity (...) within its ranks and deals with prisoners of war. The contributions, by leading experts in the field, have a broad reach and take a truly global approach to the subject. (shrink)

In this work, I attempt a four-part task: to explicate Heidegger's notion of the Fourfold, to show its necessary relation to technology, to think the limit that separates these, and to show how this constellation of the Fourfold and technology escapes from the "metaphysics of presence" with which Heidegger has been charged. ;1. The Fourfold is the belonging together of Earth, Sky, Mortals, and Divinities. Heidegger inherits the components from Holderlin, but transforms then in his thought. The gathering of these (...) four goes to make up the presencing of a singular and delimited entity . Such a thing exists as unique and irreplaceable. ;2. This singular mode of presence is only understandable against the background of limitless technological circulation. Influenced by Ernst Junger, Heidegger sees technology as setting into place a world of instantaneous replacement and sameness. The name for this manner of replaceable presence is "Bestand ." ;3. The unworld of technology is no simple "opposite" to the Fourfold, however. Rather the two modes of presence belong together. Heidegger repeatedly emphasizes how there can never be a complete loss of world in the enframing of technology. Conversely, the Fourfold is never free of the Bestand. A play of revelation and concealment is operative here and intimately related to Heidegger's new notion of essence. I examine this intricate and intimate co-belonging of technology and the Fourfold. ;4. This interpretation is used to counter the charge that Heidegger would think in terms of metaphysical presence, i.e., in terms of complete, self-present, and pure presence. Such a charge is leveled in the early work of Jacques Derrida. I show that Heidegger's thinking is already a thought of the trace. Since there is consequently no total presence or absence for Heidegger , there can be no simple overcoming of metaphysics either. Metaphysics cannot be so easily left behind, but must undergo a transformation . This is nothing more than a recognition of the trace and its place at the limit of singular, finite existence. ;The first chapter treats the circulation of technology, the remaining four address in series the elements of the Fourfold. (shrink)

John N Andrews; General Thinking Skills: are there such things?, Journal of Philosophy of Education, Volume 24, Issue 1, 30 May 2006, Pages 71–79, https://doi.o.

The modern slavery literature engages with history in an extremely limited fashion. Our paper demonstrates to the utility of historical research to modern slavery researchers by explaining the rise and fall of the ethics-driven market category of “free-grown sugar” in nineteenth-century Britain. In the first decades of the century, the market category of “free-grown sugar” enabled consumers who were opposed to slavery to pay a premium for a more ethical product. After circa 1840, this market category disappeared, even though considerable (...) quantities of slave-grown sugar continued to arrive into the UK. We explain the disappearance of the market category. Our paper contributes to the on-going debates about slavery in management by historicizing and thus problematizing the concept of “slavery”. The paper challenges those modern slavery scholars who argue that lack of consumer knowledge about product provenance is the main barrier to the elimination of slavery from today’s international supply chains. The historical research presented in this paper suggests that consumer indifference, rather than simply ignorance, may be the more fundamental problem. The paper challenges the optimistic historical metanarrative that pervades much of the research on ethical consumption. It highlights the fragility of ethics-driven market categories, offering lessons for researchers and practitioners seeking to tackle modern slavery. (shrink)

Published in 1918, _The View of Life_ is Georg Simmel’s final work. Famously deemed “the brightest man in Europe” by George Santayana, Simmel addressed a variety of topics across his essayistic writings, which have influenced scholars in aesthetics, ethics, epistemology, and sociology. Nevertheless, a set of core issues emerged over the course of his career, most centrally the genesis, structure, and transcendence of social and cultural forms and the nature and genesis of authentic individuality. Composed in the years before his (...) death, _The View of Life_ was, according to Simmel, his “testament,” a capstone work of profound metaphysical inquiry intended to formulate his conception of life in its entirety. Now Anglophone readers can at last read in full the work that shaped the argument of Heidegger’s _Being and Time_ and whose extraordinary impact on European intellectual life between the wars was extolled by Jürgen Habermas. Presented alongside these seminal essays are aphoristic fragments from Simmel’s last journal, providing a beguiling look into the mind of one of the twentieth century’s greatest thinkers. (shrink)

In this paper, we examine the lawfulness of a proposal to provide elective ventilation to incompetent patients who are potential organ donors. Under the current legal framework, this depends on whether the best interests test could be satisfied. It might be argued that, because the Mental Capacity Act 2005 (UK) (and the common law) makes it clear that the best interests test is not confined to the patient's clinical interests, but extends to include the individual's own values, wishes and beliefs, (...) the proposal will be in the patient's best interests. We reject this claim. We argue that, as things currently stand, the proposal could not lawfully be justified as a blanket proposition by reference to the best interests test. Accordingly, a modification of the law would be necessary to render the proposal lawful. We conclude with a suggestion about how that could be achieved. (shrink)

What job should authorities give to review boards? We are grateful to Soren Holm, Rosamond Rhodes, Julian Savulescu and G Owen Schaefer for their thoughtful commentaries on our answer.1–4 Here we add to the discussion. Let us summarise the claims for which we argued.5 Relevant authorities can task boards with review for consistency with duly established code, thereby making code-consistent activities apt for approval and code-inconsistent activities apt for rejection. They can instead task boards with review for ethical acceptability, making (...) ethically acceptable activities apt for approval and ethically unacceptable activities apt for rejection. For every proposal a board might consider, these two different jobs establish different review bases, and their approvals and rejections also sometimes conflict. Some international and national statements require ECR, others instead require CCR, and others again seem either to require both or just to run the two together. Those responsible for these statements should make them clearer and better aligned here. For reasons of practicality, publicity and separation of powers, authorities do better to task boards with CCR and not ECR. These arguments also count against establishing any code with content that in effect collapses CCR into ECR. If our arguments withstand robust scrutiny, authorities should also remove ‘ethics’ and cognate terms from the names of these boards and their review activities and emphasise code expertise not ethics expertise in the required skill sets of boards. Our article noted that ‘ethical considerations informed the genesis of these boards and express their aspirations’. Rhodes similarly notes: ‘the authors and endorsers of research ethics codes, declarations and regulations … articulating the ethical standards for conducting human subject research’ and ‘This framework embeds the ethical parameters of human subject research into the moral missions of institutions’. Schaefer too …. (shrink)

This paper is a revalidation of Oliver Sacks's role in the development of medicine's narrative turn and, as such, a reinterpretation of the history of narrative in medicine. It suggests that, from the late 1960s, Sacks pioneered in his ‘Romantic Science’ a new medical mode that reunited the seemingly incommensurable art and science of medicine while also offering a way for medical humanities to shape clinical reasoning more effectively.

In this paper I expound and criticise the arguments of two leading exponents of critical ecological feminism. According to critical ecological feminism responsibility for the oppressions of the natural world and the oppressions of racism and sexism can be traced to a logic of domination that is based on suspect value dualities and presupposes an unacceptable ‘moral extensionism’. I argue firstly that critical ecological feminism's critique of value dualism presupposes the truth of the thesis that humans and non‐humans are morally (...) equal, a thesis for which it offers no persuasive arguments . Secondly I maintain that moral extensionism, contrary to the claims of critical ecological feminism, can support a genuine respect for the natural world. Finally I suggest that the arguments for one version of critical ecological feminism, in order to be made convincing, themselves require the truth of moral extensionism. (shrink)

In December 2013, the Nonhuman Rights Project (NhRP) filed a petition for a common law writ of habeas corpus in the New York State Supreme Court on behalf of Tommy, a chimpanzee living alone in a cage in a shed in rural New York (Barlow, 2017). Under animal welfare laws, Tommy’s owners, the Laverys, were doing nothing illegal by keeping him in those conditions. Nonetheless, the NhRP argued that given the cognitive, social, and emotional capacities of chimpanzees, Tommy’s confinement constituted (...) a profound wrong that demanded remedy by the courts. Soon thereafter, the NhRP filed habeas corpus petitions on behalf of Kiko, another chimpanzee housed alone in Niagara Falls, and Hercules and Leo, two chimpanzees held in research facilities at Stony Brook University. Thus began the legal struggle to move these chimpanzees from captivity to a sanctuary, an effort that has led the NhRP to argue in multiple courts before multiple judges. The central point of contention has been whether Tommy, Kiko, Hercules, and Leo have legal rights. To date, no judge has been willing to issue a writ of habeas corpus on their behalf. Such a ruling would mean that these chimpanzees have rights that confinement might violate. Instead, the judges have argued that chimpanzees cannot be bearers of legal rights because they are not, and cannot be persons. In this book we argue that chimpanzees are persons because they are autonomous. (shrink)

In this brief, we argue that there is a diversity of ways in which humans (Homo sapiens) are ‘persons’ and there are no non-arbitrary conceptions of ‘personhood’ that can include all humans and exclude all nonhuman animals. To do so we describe and assess the four most prominent conceptions of ‘personhood’ that can be found in the rulings concerning Kiko and Tommy, with particular focus on the most recent decision, Nonhuman Rights Project, Inc v Lavery.

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. The Supreme Court, Bronx County, declined to grant habeas corpus relief and order Happy’s transfer to an elephant sanctuary, relying, in part, on previous decisions that denied habeas relief for the NhRP’s chimpanzee clients, Kiko and Tommy. Those decisions use incompatible conceptions of ‘person’ which, when properly understood, are either philosophically inadequate or, in fact, compatible with Happy’s personhood.

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. We reject arbitrary distinctions that deny adequate protections to other animals who share with protected humans relevantly similar vulnerabilities to harms and relevantly similar interests in avoiding such harms. We strongly urge this Court, in keeping with the best philosophical standards of rational judgment and ethical standards of justice, to recognize that, as a nonhuman person, Happy should be (...) released from her current confinement and transferred to an appropriate elephant sanctuary, pursuant to habeas corpus. (shrink)

Abstractabstract:John B. Cobb, Jr., is one of the most influential Christian theologians of the past fifty years. Having written from an interdisciplinary lens, engaging economics, education, biology, and beyond, Cobb is not the typical theologian. One of Cobb's earliest concerns is the environmental crisis, having written the first single-author book on the subject in 1972. Cobb recognized early on that the environmental crisis was systemic, pervading modernity in both thought and culture, and sought to approach the problem as such. (...) This paper explores Cobb's religious and philosophical arguments regarding the environmental crisis. The first section identifies theological (anthropocentrism) and philosophical (substance-based thinking) assumptions that impede serious awareness of the environmental crisis. Here, Cobb's alternatives are presented in the quest for a more responsive worldview. Second, because environmental issues are pervasive in our modes of thinking, reconsidering education becomes a promising avenue in forming an ecological civilization. This section explores Cobb's detestation of the current education system in the West that idolizes isolated, fragmented disciplines. Instead, Cobb suggests the creation of a holistic, post-disciplinary approach. Finally, Cobb's legacy for the common good concludes this paper by supplying examples of his impact on the creation of an ecological civilization. (shrink)

Go to Grazia Ietto-Gillies’ paper here ›.

A globally expressivist analysis of the indicative conditional based on the Ramsey Test is presented. The analysis is a form of ‘global’ expressivism in that it supplies acceptance and rejection conditions for all the sentence forming connectives of propositional logic (negation, disjunction, etc.) and so allows the conditional to embed in arbitrarily complex sentences (thus avoiding the Frege–Geach problem). The expressivist framework is semantically characterized in a restrictor semantics due to Vann McGee, and is completely axiomatized in a logic dubbed (...) ICL (‘Indicative Conditional Logic’). The expressivist framework extends the AGM (after Alchourron, Gärdenfors, Makinson) framework for belief revision and so provides a categorical (‘yes’–‘no’) epistemology for conditionals that complements McGee’s probabilistic framework while drawing on the same semantics. The result is an account of the semantics and acceptability conditions of the indicative conditional that fits well with the linguistic data (as pooled by linguists and from psychological experiments) while integrating both expressivist and semanticist perspectives. (shrink)

The view that decision methods can only be justified by appeal to pragmatic considerations is defended. Pragmatic considerations are viewed as providing the underlying subject matter (“semantics”) of decision theories. It is argued that other approaches (e.g. justifying principles by appeal to obviousness, common usage, etc.) fail to provide grounds for a normative decision theory.It is argued that preferences that can lead to pragmatically adverse outcomes in a relevantly similar possible decision situation are pragmatically unsound, even if the decision situation (...) never arises. This rebuts several standard objections to money-pump and Dutch book arguments. However, because one can only appeal to relevantly similar decision situations in pragmatic arguments, these will have a less general scope than is often imagined. A conclusion is that pragmatic arguments for strong unconditional principles such as ‘always maximise expected utility!’ do not work. Pragmatic considerations can however be used to argue for conditional principles of the form ‘if conditions X, Y and Z are satisfied, then one ought to satisfy W’, where W need not follow logically from X, Y and Z.The notion of a sound pragmatic argument is defined in terms of particular notion of coherence, it is shown how this can be applied and how it handles problematic cases such as van Fraassen’s Dutch book for the principle of Reflection. (shrink)

The view that decision methods can only be justified by appeal to pragmatic considerations is defended. Pragmatic considerations are viewed as providing the underlying subject matter (“semantics”) of decision theories. It is argued that other approaches (e.g. justifying principles by appeal to obviousness, common usage, etc.) fail to provide grounds for a normative decision theory.It is argued that preferences that can lead to pragmatically adverse outcomes in a relevantly similar possible decision situation are pragmatically unsound, even if the decision situation (...) never arises. This rebuts several standard objections to money-pump and Dutch book arguments. However, because one can only appeal to relevantly similar decision situations in pragmatic arguments, these will have a less general scope than is often imagined. A conclusion is that pragmatic arguments for strong unconditional principles such as ‘always maximise expected utility!’ do not work. Pragmatic considerations can however be used to argue for conditional principles of the form ‘if conditions X, Y and Z are satisfied, then one ought to satisfy W’, where W need not follow logically from X, Y and Z.The notion of a sound pragmatic argument is defined in terms of particular notion of coherence, it is shown how this can be applied and how it handles problematic cases such as van Fraassen’s Dutch book for the principle of Reflection. (shrink)

Five types of constructions are introduced for non-prioritized belief revision, i.e., belief revision in which the input sentence is not always accepted. These constructions include generalizations of entrenchment-based and sphere-based revision. Axiomatic characterizations are provided, and close interconnections are shown to hold between the different constructions.

Ever since [4], systems of spheres have been considered to give an intuitive and elegant way to give a semantics for logics of theory- or belief- change. Several authors [5, 11] have considered giving up the rather strong assumption that systems of spheres be linearly ordered by inclusion. These more general structures are called hypertheories after [8]. It is shown that none of the proposed logics induced by these weaker structures are compact and thus cannot be given a strongly complete (...) axiomatization in a finitary logic. Complete infinitary axiomatizations are given for several intuitive logics based on hypertheories that are not linearly ordered by inclusion. (shrink)

It is argued that the "inner" negation $\mathord{\sim}$ familiar from 3-valued logic can be interpreted as a form of "conditional" negation: $\mathord{\sim}$ is read '$A$ is false if it has a truth value'. It is argued that this reading squares well with a particular 3-valued interpretation of a conditional that in the literature has been seen as a serious candidate for capturing the truth conditions of the natural language indicative conditional (e.g., "If Jim went to the party he had a (...) good time"). It is shown that the logic induced by the semantics shares many familiar properties with classical negation, but is orthogonal to both intuitionistic and classical negation: it differs from both in validating the inference from $A \rightarrow \nega B$ to $\nega(A\rightarrow B)$ to. (shrink)

Conditional constructions – constructs of the form If A, then B – have for over a century been subject to intense study in a wide variety of philosophical areas, as well as outside of philosophy. One important reason is that such constructs allow one to encode connections and dependencies, be they causal, epistemic, conceptual, or metaphysical. This chapter briefly outlines some of the main formal models that have been employed to analyze such constructs, as well as their philosophical motivation.

It is argued that indicative conditionals are best viewed as having truth conditions (and so they are in part factual) but that these truth conditions are ‘gappy’ which leaves an explanatory gap that can only be filled by epistemic considerations (and so indicative conditionals are in part epistemic). This dual nature of indicative conditionals gives reason to rethink the relationship between logic viewed as a descriptive discipline (focusing on semantics) and logic viewed as a discipline with a normative import (focusing (...) on epistemic notions such as ‘reasoning’, ‘beliefs’ and ‘assumptions’). In particular, it is argued that the development of formal models for epistemic states can serve as a starting point for exploring logic when viewed as a normative discipline. (shrink)

An alleged counterexample to causal decision theory, put forward by Andy Egan, is studied in some detail. It is argued that Egan rejects the evaluation of causal decision theory on the basis of a description of the decision situation that is different from—indeed inconsistent with—the description on which causal decision theory makes its evaluation. So the example is not a counterexample to causal decision theory. Nevertheless, the example shows that causal decision theory can recommend unratifiable acts which presents a problem (...) in the dynamics of intentions. It is argued that we can defuse this problem if we hold that decision theory is a theory of rational decision making rather than a theory of rational acts. It is shown how decisions can have epistemic side-effects that are not mediated by the act and that there are cases where one can only bring oneself to perform the best act by updating by imaging rather than by conditioning. This provides a pragmatic argument for updating by imaging rather than by conditioning in these cases. (shrink)

Conditionals that contain a modality in the consequent give rise to a particular semantic phenomenon whereby the antecedent of the conditional blocks possibilities when interpreting the modality in the consequent. This explains the puzzling logical behaviour of constructions like "If you don't buy a lottery ticket, you can't win", "If you eat that poison, it is unlikely that you will survive the day" and "If you kill Harry, you ought to kill him gently". In this paper it is argued that (...) a semantic version of the Ramsey Test provides a key in the analysis of such constructions. The logic for this semantics is axiomatized and some examples are studied, among them a well-known puzzle for contrary-to-duty obligations. (shrink)