Infectious disease outbreaks in residential care are complex to manage and difficult to control. Research in this setting that includes individuals who lack capacity must conform to national legislation. We report here on our study that is investigating outbreaks of scabies, an itchy skin infection, in the residential care setting in the southeast of England. There appears to be a gap in legislative advice regarding the inclusion of people who lack capacity in research that takes place during time-limited acute scenarios (...) such as outbreaks. We received inconsistent advice from experts regarding, in particular, the role of nominated consultees. There is a potential inequality for vulnerable populations who cannot themselves provide informed consent in terms of their access to participation in a range of health-related research. (shrink)
In responding to this debate, Ananth both surveys the existing literature, with special focus on the work of Christopher Boorse, and argues that a naturalistic ...
_Bringing Biology to Life _is a guided tour of the philosophy of biology, canvassing three broad areas: the early history of biology, from Aristotle to Darwin; traditional debates regarding species, function, and units of selection; and recent efforts to better understand the human condition in light of evolutionary biology. Topics are addressed using no more technical jargon than necessary, and without presupposing any advanced knowledge of biology or the philosophy of science on the part of the reader. Discussion questions are (...) also provided to encourage reader reflection. (shrink)
This paper defends the position that the supposed gap between biological altruism and psychological altruism is not nearly as wide as some scholars (e.g., Elliott Sober) insist. Crucial to this defense is the use of James Mark Baldwin's concepts of “organic selection”and “social heredity” to assist in revealing that the gap between biological and psychological altruism is more of a small lacuna. Specifically, this paper argues that ontogenetic behavioral adjustments, which are crucial to individual survival and reproduction, are also crucial (...) to species survival. In particular, it is argued that human psychological altruism is produced and maintained by various sorts of mimicry and self-reflection in the aid of both individual and species survival. The upshot of this analysis is that it is possible to offer an account of psychological altruism that is closelytethered to biological altruism without reducing entirely the former to thelatter. (shrink)
Jonathan Lear argues that the established purgation, purification, and cognitive stimulation interpretations of Aristotle’s concepts of catharsis and tragic pleasure are off the mark. In response, Lear defends an anti-cognitivist account, arguing that it is the pleasure associated with imaginatively “living life to the full” and yet hazarding nothing of importance that captures Aristotle’s understanding of catharsis and tragic pleasure. This analysis reveals that Aristotle’s account of imagination in conjunction with his understanding of both specific intellectual virtues and rational emotions (...) of an educated citizen not only tells against Lear’s anti-cognitivist construal, but also divulges an alternative cognitive stimulation reading. (shrink)
Theoretical and experimental studies on prey–predator systems where predator is supplied with alternate sources of food have received significant attention over the years due to their relevance in achieving biological conservation and biological control. Some of the outcomes of these studies suggest that with appropriate quality and quantity of additional food, the system can be steered towards any desired state eventually with time. One of the limitations of previous studies is that the desired state is reached asymptotically, which makes the (...) outcomes not easily applicable in practical scenarios. To overcome this limitation, in this work, we formulate and study optimal control problems to achieve the desired outcomes in minimum time. We consider two different models of additional food provided prey–predator systems involving Holling type IV functional response. In the first scenario, additional food is incorporated implicitly into the predator’s functional response with a possibility of achieving biological conservation through co-existence of species and biological control by maintaining prey at a level that is least harmful to the system. In the second, the effect of additional food is incorporated explicitly into the predator’s compartment with the goal of pest management by maintaining prey density at a very minimal damaging level. For both cases, appropriate optimal control strategies are derived and the theoretical findings are illustrated by numerical simulations. We also discuss the ecological significance of the theoretical findings for both models. (shrink)
Defenders of evolutionary medicine claim that medical professionals and public health officials would do well to consider the role of evolutionary biology with respect to the teaching, research, and judgments pertaining to medical theory and practice. An integral part of their argument is that the human body should be understood as a bundle of evolutionary compromises. Such an appreciation, which includes a proper understanding of biological function and physiological homeostasis, would provide a crucial perspective regarding the understanding and securing of (...) human health needs currently lacking in the medical arena. (shrink)
John Searle offers what he thinks to be a reasonable scientific approach to the understanding of consciousness. I argue that Searle is demanding nothing less than a Kuhnian-type revolution with respect to how scientists should study consciousness given his rejection of the subject-object distinction and affirmation of mental causation. As part of my analysis, I reveal that Searle embraces a version of emergentism that is in tension, not only with his own account, but also with some of the theoretical tenets (...) of science. I conclude that Searle has offered little to motivate scientists to adopt his proposal. (shrink)
Albert Jonsen and Stephen Toulmin have argued that the best way to resolve complex “moral” issues in clinical settings is to focus on the details of specific cases. This approach to medical decision-making, labeled ‘casuistry’, has met with much criticism in recent years. In response to this criticism, Carson Strong has attempted to salvage much of Jonsen’s and Toulmin’s version of casuistry. He concludes that much of their analysis, including Jonsen’s further elaboration about the casuistic methodology, is on the mark. (...) In this essay, the details of Jonsen’s and Toulmin’s version of casuistry and the major criticisms against their approach to clinical decision-making are explicated. Furthermore, it is argued that Strong’s salvage efforts fail to deflect these criticisms. The upshot of this analysis, which includes a few additional criticisms, is that Jonsen’s and Toulmin’s version of casuistry is not an appropriate framework from which to resolve complex “moral” issues in clinical settings. (shrink)
This is a book review/critical review of Jackson and Depew's _Darwinism, Democracy, and Race: American Anthropology and Evolutionary Biology in the Twentieth Century_.
In a recent commentary, Kim and colleagues argued that minimal-risk research should be deregulated so that such studies do not require review by an institutional review board. They claim that regulation of minimal-risk studies provides no adequate counterbalancing good and instead leads to a costly human subjects oversight system. We argue that the counterbalancing good of regulating minimal-risk studies is that oversight exists to ensure that respect for persons and justice requirements are satisfied when they otherwise might not be.
The contemporary debate on the concept of health is a tug-of-war between naturalists and normativists. Although health can be valued or disvalued, naturalists argue that the concept of health is value-free. In contrast, normativists argue that the concept of health is value-laden. This dissertation examines this controversy focusing on the naturalistic concept of health defended by Christopher Boorse. Boorse claims that health and disease are value-free concepts in the sense that diseased and healthy states can be gleaned from the facts (...) of nature without an appeal to value judgments. ;The dissertation first examines Boorse's critical assessment of both the naturalist and normativist concepts of health that he rejects. Then there is a critical examination of the concept of function, which is crucial to his concept of health. Subsequently, an exegesis of Boorse's concept of health is provided. This is followed by an evaluation of the many replies by his critics and Boorse's rejoinder to them. Finally, a modified version of Boorse's concept of health is proposed taking into account some of the intractable difficulties with his theory. ;There are six main findings regarding Boorse's theory: First, Boorse successfully rejects the main normative concepts of health. Second, he is partially successful against specific naturalistic concepts of health. Third, Boorse's contextualist concept of function is not entirely persuasive. Fourth, Boorse's concept of health is persuasive because he qualifies it to accommodate differences in age, gender, and species type. Fifth, with respect to his critics, Boorse is inconsistent in his reliance on evolution and does not give a proper place to the environment in his account. Sixth, a modified version of Boorse's concept of health, which includes an evolutionary sense of function, homeostasis, and acknowledges environmental factors , is a more appropriate way to understand health. ;This dissertation arrives at three major conclusions: First, Boorse's concept of health is mainly successful in response to the normativists, but he should concede that epistemic norms are part of his concept of health. Second, an evolutionary concept of function is superior to Boorse's part-functionalist account. Third, a prominent place should be given to both homeostasis and environmental factors, along with the factors of age, sex, and species mentioned by Boorse. A modification of Boorse's account reflecting these conclusions will be a more defensible naturalistic concept of health. (shrink)
We examine managers’ earnings forecasts for evidence of incentive alignment or subversion characteristics. We find that forecasts by managers compensated via relative performance goals are more likely to be pessimistic and less accurate than those by managers compensated via absolute performance goals. For firms not issuing earnings forecasts, disclosures in Form 10-Ks are more pessimistic for RP firms than for AP firms. Furthermore, we find that RP firms perform worse than AP firms in terms of future stock returns. Overall, our (...) evidence is consistent with a proposition that, contrary to sound ethical business practices, RP managers make self-serving earnings disclosures to subvert the efforts of their peers to meet performance targets more easily. (shrink)
Migrant farmworkers dominate the horticultural workforce in many parts of the Minority World. The ‘manual’ work that they do—picking and packing fruits and vegetables, and pruning vines and trees—is widely designated unskilled. In policy, media, academic, activist and everyday discourses, hired farm work is framed as something anybody can do. We interrogate this notion with empirical evidence from the Sunraysia horticultural region of Australia. The region’s grape and almond farms depend heavily on migrant workers. By-and-large, the farmers and farmworkers we (...) spoke to pushed back against the unskilled tag. They asserted that farmworkers acquire knowledge and skills over time and that experienced farmworkers are valuable—their value being brought into sharp relief against accounts of inexperienced farmworkers’ errors. Our interviewees provided rich insights into farmworkers’ engagements with crops and the intricacies of picking and pruning well. Far from being bereft of knowledge and skills, they recognised that experienced farmworkers bring benefits. They improve productivity, product quality and ultimately profits. This is especially so when open communication channels exist across the farm hierarchy, when experienced farmworkers’ insights are taken seriously by their employers. Our research is informed by organisational studies literature and scholarship on craft/making. Like factory floor workers and artisans, experienced farmworkers bring accumulated knowledge and skills to their work, gained through repeat performance. They reflect on and adjust their activities in dialogue with their materials and the environment. Experienced farmworkers demonstrate care, dexterity and judgement. They are not unskilled, and they are more than labouring bodies. (shrink)
The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. (...) Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection. (shrink)
