Despite abundant evidence associating CD38 overexpression and CD4 T cell depletion in HIV infection, no causal relation has been investigated. To address this issue, a series of mechanisms are proposed, supported by evidence from different fields, by which CD38 overexpression can facilitate CD4 T cell depletion in HIV infection. According to this model, increased catalytic activity of CD38 may reduce CD4 T cells’ cytoplasmic nicotin‐amide adenine dinucleotide (NAD), leading to a chronic Warburg effect. This will reduce mitochondrial function. Simultaneously, CD38's (...) catalytic products ADPR and cADPR may be transported to the cytoplasm, where they can activate calcium channels and increase cytoplasmic Ca2+ concentrations, further altering mitochondrial integrity. These mechanisms will decrease the viability and regenerative capacity of CD4 T cells. These hypotheses can be tested experimentally, and might reveal novel therapeutic targets. (shrink)

This article argues that thinking about entrepreneurship as a potential instrument for relief from endemic poverty and disadvantage, especially among the Indigenous, has all too often been captive to a concept of entrepreneurship that is built out of constrained economic and cultural assumptions. The authors develop this argument from a critical discussion of contributions by Karl Polanyi and Robert Heilbroner. The result is that approaches to venture have been encouraged that are sometimes a poor fit for the circumstances of those (...) they are meant to benefit, and other forms that could have considerable promise have gone unexplored. This article outlines some features of Indigenous culture and build on the analysis of David Harper to construct an improved notion of entrepreneurship that allows for these distinctive features. The article concludes that research and policy making concerning entrepreneurship as an instrument of development among the Indigenous need to be undertaken with this reconstructed understanding of entrepreneurship that is a better fit for the realities of Indigenous culture. (shrink)

We introduce the papers in this special issue by providing an overarching perspective on the variety in kinds of commons and the ethical issues stemming from their diversity. Despite a long history of local commons management, recent decades have witnessed a surge of scholarly interest in the concept of “the commons,” including a growing management literature. This swell was impelled especially by Garrett Hardin’s paper of 1968, and the body of work generated by Elinor Ostrom and her colleagues. However, the (...) term itself has come to be used in a variety of ways. To contextualize its ethical dimensions, we map a number of commons-related concepts such as common-pool resources, common property regime, excludability and subtractability, common-pool resource types and commons or “commoning” as a source of production. Following a brief summary of papers in this special issue, the essay concludes with an identification of implications for research, practice and policy. (shrink)

The concept of a ‘just weight and measure’ within the Bible is one that has insightful value for Christian ethics and economic transactions. Considering that in many situations law and judicial systems within Western society are not capable of completely constraining unethical economic transactions, what society requires are alternative motivations to enact ethical economic transactions. This article is focused on proposing a possible motivation for Christians considering the ever-growing complexities within the marketplace. It draws on insights on the concept of (...) a ‘just weight and measure’ in Deuteronomy and its conceptual use within the books of the eighth-century prophets. A primary insight that is highlighted is the relationship between the unethical economic transactions in eighth-century Israel and God's rejection of their cultic services. When applied analogically to contemporary contexts, lessons can be gleaned from the concept of a ‘just weight and measure’ for Christian ethical economic transactions. (shrink)

An analysis of the level of emotional and dependency according to sociodemographic characteristic factors in university students in a period of confinement due to COVID-19. 689 female students of the city of Arequipa were included; we used a measurement instrument with 23 items that allowed us to understand the influence of the current situation on the psychological state of the university. The results indicate that there is a low level of emotional dependence, in relation to the variable of the emotional (...) situation being one of the main reasons why single students are less likely to have this dependence as they do not have any type of romantic relationship, since they focus more on their personal goals through their university studies, which shows that they are more independent when taking on challenges and objectives consistent with their academic training, compared to those who maintain a relationship. (shrink)

José María Bozo -- Manuel Ignacio Salvatierra -- Manuel María Caballero -- Manuel Antonio Paniagua -- José Peredo Antelo.