Key Topics in Clinical Research aims to provide a short, clear, highlighted reference to guide trainees and trainers through research and audit projects, from first idea, through to data collection and statistical analysis, to presentation and publication. This book is also designed to assist trainees in preparing for their specialty examinations by providing comprehensive, concise, easily accessible and easily understandable information on all aspects of clinical research and audit.

We welcome Ballantyne & Schaefer’s discussion of the issues concerning consent and use of health data for research. In response to their acknowledgement of the need for public debate and discussion, we provide evidence from our own public consultation on this topic.

Lack of guidance and regulation for authorizing medical cannabis for conditions involving the health and neurodevelopment of children is ethically problematic as it promulgates access inequities, risk-benefit inconsistencies, and inadequate consent mechanisms. In two virtual sessions using participatory action research and consensus-building methods, we obtained perspectives of stakeholders on ethics and medical cannabis for children and youth. The sessions focused on the scientific and regulatory landscape of medical cannabis, surrogate decision-making and assent, and the social and political culture of medical (...) cannabis. We found that evidence-gathering and data dissemination, pressures on clinical relationships, and the lack of integration of culturally diverse perspectives and Indigenous knowledges were key areas of concern. Participants emphasized the importance of utilizing adaptive study designs, highlighted the importance of trust-building between clinicians, patients and caregivers, and discussed barriers including historical and ongoing stigmatization of medical cannabis. We conclude that continued public consultation and strength-based research that integrate diverse perspectives are critical steps forward. (shrink)

This text offers major re-evaluation of Wittgenstein's thinking. It is a collection of essays that presents a significantly different portrait of Wittgenstein. The essays clarify Wittgenstein's modes of philosophical criticism and shed light on the relation between his thought and different philosophical traditions and areas of human concern. With essays by Stanley Cavell, James Conant, Cora Diamond, Peter Winch and Hilary Putnam, we see the emergence of a new way of understanding Wittgenstein's thought. This is a controversial collection, with (...) essays by highly regarded Wittgenstein scholars that may change the way we look at Wittgenstein's body of work. (shrink)

In September 2000, the self-styled “anthropological journalist” Patrick Tierney began to make public his work claiming that the Yanomamö people of South America had been actively—indeed brutally—harmed by the sociobiological anthropologist Napoleon Chagnon and the geneticist-physician James Neel. Following a florid summary of Tierney’s claims by the anthropologists Terence Turner and Leslie Sponsel, the American Anthropological Association (AAA) saw fit to take Tierney’s claims seriously by conducting a major investigation into the matter. This paper focuses on the AAA’s problematic (...) actions in this case but also provides previously unpublished information on Tierney’s falsehoods. The work presented is based on a year of research by a historian of medicine and science. The author intends the work to function as a cautionary tale to scholarly associations, which have the challenging duty of protecting scholarship and scholars from baseless and sensationalistic charges in the era of the Internet and twenty-four-hour news cycles. (shrink)

Women in Rock, Women in Romanticism is the first book-length work to explore the interrelationships between contemporary female musicians and eighteenth- and nineteenth-century art, music, and literature by women and men. The music and videos of contemporary musicians including Erykah Badu, Beyoncé, The Carters, Hélène Cixous, Missy Elliot, the Indigo Girls, Janet Jackson, Janis Joplin (and Big Brother and the Holding Company), Natalie Merchant, Joni Mitchell, Janelle Monáe, Alanis Morrisette, Siouxsie Sioux, Patti Smith, St. Vincent (Annie Clark), and Alice (...) Walker are explored through the lenses of pastoral and Afropresentism, Gothic, female Gothic, and the literature of William Blake, Beethoven, Arthur Schopenhauer, Samuel Taylor Coleridge, Charlotte Dacre, Ralph Waldo Emerson, E.T.A. Hoffmann, Ann Radcliffe, William Shakespeare, Mary Shelley, her husband Percy Shelley, Henry David Thoreau, Horace Walpole, Jane Williams, Mary Wollstonecraft, and William Wordsworth to explore how each sheds light on the other, and how women have appropriated, responded to, and been inspired by the work of authors from previous centuries. (shrink)

The European Legacy, Volume 17, Issue 3, Page 406-407, June 2012.

The Alice Books, full of illogical thoughts, words, and contradictions, were unrivaled entertainment until the publication of the medical literature promoting electronic fetal monitoring for every pregnancy. The modern-day EFM advocates acknowledge EFM’s decades long failure but simultaneously recommend EFM use for lawsuit protection and because the profession has used EFM for every pregnancy for fifty years, therefore, it must be efficacious. These self-indulgent, illogical rationalizations ignore the half century of evidence-based scientific research proving that EFM is a complete (...) failure as well as ignoring the fact that continued EFM use violates the fundamental principles of modern bioethics. This blind advocacy perpetuates four pernicious EFM harms occurring to mothers, babies, and the medical profession itself. This article sets out these four EFM harms with the goal of abolishing the misguided, illogical, contradictory, arguments used by the twenty-first century EFM Lewis Carroll mimics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Selected Letters by William, Henry JamesWilliam James EarleWilliam and Henry James. Selected Letters. Edited by Ignas K. Skrupskelis and Elizabeth M. Berkeley. Introduction by John J. McDermott. Charlottesville VA: University Press of Virginia, 1997. Pp. xxxi + 570. $ 39.95.Almost fifty years of letters to and from the very diversely brilliant James brothers: in this volume a generous, and probably ample, selection of 216 from (...) a total of 740 surviving letters or postcards, from an original total, according to the present editors, of twice as many. This volume of correspondence reflects the deep, unquestioned, unshakable familial (and virtually statutory) closeness of William and Henry who happened, as adults, to be seldom in the same place. There is, it must be said, very little explicit philosophy, narrowly or broadly defined, in these letters, but the philosophical reader will—or ought to—find much raw material for philosophical reflection. For example, a reasonable historicist thesis of how brotherhood, or family connection generally, plays itself out is supported by these documents. The nineteenth century is not the same as the twentieth. For example, here is William’s comment on the will of his sister, Alice, who left more to her companion and care-giver, Katherine Loring, a [End Page 479] women of extraordinary virtue and burden, than to her brother Robertson: “I can well sympathize with Alice’s desire to leave her something handsome; but I must say that her own consent (being apparently privy to the will) strikes me as tant soit peu lacking in delicacy. Surely no one of us would like to be in such a position in her family or any other” (271). This would be, in 1998, a rather unenlightened and ungenerous attitude, but is natural enough in 1892, even if not quite inevitable, not being shared by Alice herself. There is, incidentally, much discussion of wills and bequests, for the Jameses were of the genteel class, people with small family money and modest private incomes for whom the wherewithal to maintain homes with servants and to provide themselves with country houses and recuperative European vacations was always a faintly embarrassing, and occasionally a pressing, problem.It is probably also true that the much-discussed question of Henry’s homosexuality has, somehow, to be recast in historically relative terms. Here is an early report—1869—of Henry’s from Oxford: “As I walked along the river I saw hundreds of the mighty lads of England, clad in white flannel & blue, immense, fair-haired, magnificent in their youth, lounging down the stream in their punts or pulling in straining crews & rejoicing in their godlike strength” (41). This could not, the point is, be said by anyone, gay or straight, in 1998. Yet Henry is neither generally naive nor uncritically anglophile. He says of the Warwickshire scenery, which in a way he likes, that it is “too monotonously sweet & smooth—too comfortable, too ovine, too bovine, too English in a word.” And he adds, a little surprisingly: “It seems like a vast show region kept up at the expense of the poor” (41). This is only one of many appealing comments not sparsely scattered, but unpredictably, in letters of more ordinary news. Here’s one I liked occasioned by seeing theater in Paris: “We talk about it & write about it & criticize & dogmatize & analyse to the end of time: but those brave players stand forth & exemplify it & act—create—produce!” (66).Of course the “wit and wisdom” are not the monopoly of Henry. Here is William being wise: “We all learn sooner or later that we must gather ourselves up and more or less arbitrarily concentrate our interests, throw much overboard to save any” (55–56). Again: “It is a sweet world, in the interstices of its bedevilment & brutality” (321). And William being funny: “Boils are surely the most slowly evolving things in nature—Christian doctrine is nothing to them” (393). He is talking about his own boils and was subject, at every period, to ailments and infirmities: “Since writing to you, I have been swimming in deep seas of influenza, gout and Erysipelas of the face” (443). Or as he, in 1900, sums it up: “My... (shrink)

Biographer Richardson has written a moving portrait of James--pivotal member of the Metaphysical Club and author of The Varieties of Religious Experience. The biography, ten years in the making, draws on unpublished letters, journals, and family records. Richardson paints extraordinary scenes from what James himself called the "buzzing blooming confusion" of his life, beginning with childhood, as he struggled to achieve amid the domestic chaos and intellectual brilliance of Father, brother Henry, and sister Alice. James was (...) a beloved teacher who taught courage and risk-taking, and served as mentor to W.E.B. Du Bois, Gertrude Stein, and many other Harvard outsiders. Richardson also illuminates James's hugely influential works. One of the great figures in mysticism here brought richly to life, James is a man "whose leading ideas are still so fresh and challenging that they are not yet fully assimilated by the modern world they helped to bring about."--From publisher description. (shrink)

Tamen's essay is one of a group of responses to Émilie Hache and Bruno Latour's article “Morality or Moralism?” which advocates our “sensitization” to nonhuman things. Tamen examines the picture of universal reciprocation that Hache and Latour propose, according to which, when I “bow at” (acknowledge) things, some things bow back at me, and I must treat whatever bows back as if it were like me. Unlike James Lovelock, a passage from whose work they discuss, Hache and Latour understand (...) this picture in a sense that is essentially “honorary.” The picture or premise they propose sets up, they admit, “a promising misunderstanding.” Tamen offers two arguments in response: one against as-if locutions and another against the very notion of setting up a misunderstanding. But it is good news, Tamen concludes, that sensitization cannot be set up. To what extent we would want a “revival of scruple” to succeed is a serious question, the answer dependent on how much scruple about which things and for what reasons. However pleasing the Hache/Latour or Lovelock picture, it is easy to imagine an intemperate degree of scruple, requiring agonies of continual debate and calculation of the minutest consequences of our acts and the most unlivable alternatives. (shrink)

이 글의 시발점은 해러웨이에게 ‘사이보그 페미니즘’의 상상력을 제공했던, 70년대 페미니스트 SF에 대한 관심이었다. ‘소년들의 과학적 오락물’이라는 게토에서 출발한 SF가 페미니스트 문학의 대안적 서사 전략, 새로운 페미니스트 정치학의 단초가 되기까지, 여성작가들은 장르적 관습에 부응하여 글을 쓰고 또 그것을 변형하면서 활용해 왔다. 이 글은 70년대 그가 사실은 앨리스 셸던(Alice B. Sheldon)이라는 중년여성이었다는 사실이 밝혀지기 전까지, ‘남성적 스타일’로 사랑받았던 ‘제임스 팁트리 주니어(James Tiptree, Jr.)’를 읽어 보려고 한다. 팁트리 주니어는 지금 페미니스트 SF의 대표작가 중 하나다.BR ‘남성적 스타일’과 ‘페미니스트 SF’라는 평가 사이에 놓인 (...) 팁트리 주니어의 SF를 읽으면서, 먼저 장르적 글쓰기와 젠더의 관계에 대해, 글을 쓰는 몸의 성(sex)과 쓰여진 텍스트 스타일에 대한 젠더적 평가 사이의 관계에 대해 생각해 보려고 한다. 이것은 팁트리의 글쓰기 양식(style)에 대한 분석이자, 그의 SF가 보여준 세계관과 페미니스트 상상력에 대한 분석이기도 하다. 또한 조금 뒤늦게 앨리스 셸던의 또 다른 분신으로 등장한 라쿠나 셸던(Raccoona Sheldon)의 SF를 팁트리 주니어의 것과 비교하면서, 젠더 정체성의 경계에 대해, 그리고 글쓰기를 통한 ‘젠더하기(performing gender)’에 대해 살펴 볼 것이다. 이를 통해, 팁트리의 SF는 해러웨이가 주장하는 ‘사이보그 글쓰기’의 한 사례가 될 수 있다는 사실이 드러날 것이다. 해러웨이에게 SF는 정치적 의미와 지향을 담은 글쓰기로, 미래를 향하지만 지금을 성찰하는 도구로 이해된다. 그녀는 페미니스트 SF를 위계적 이분법을 교란하고 정체성의 경계를 문제 삼는 새로운 페미니스트 정치학의 ‘사이보그 테크놀로지’로 받아들인다. 팁트리의 글쓰기는 자연과 문화의 관계를 재설정하고 ‘자연의 재발명’을 상상한다는 점에서, 그리고 또 주체와 타자 사이의 경계를 물으며 이분법적 질서를 교란한다는 점에서, 해러웨이가 말하는 사이보그 글쓰기의 실천으로 읽을 수 있다. (shrink)

Historically left to the margins, the topics of imagination and creativity have gained prominence in philosophy of science, challenging the once dominant distinction between ‘context of discovery’ and ‘context of justification’. The aim of this chapter is to explore imagination and creativity starting from issues within contemporary philosophy of science, making connections to these topics in other domains along the way. It discusses the recent literature on the role of imagination in models and thought experiments, and their comparison with fictions. (...) It then turns to the importance of constraints on imaginings in the scientific domain, as well as whether constraints can hinder creativity. The second part of the paper focuses on the social dimensions of science. It considers imagination and creativity of scientific communities, asks whether the institution of science promotes creativity (and whether we want it to) or if it encourages conservativeness, and ends with a reflection on the politics of imagination and creativity in science. (shrink)

Bred to provide human companionship, dogs eclipse all other species when it comes to reading the body language of people. Dog owners hunger for a complete rapport with their pets; in the dog the fantasy of empathetic resonance finds its ideal. But cross-species communication is never easy. Dog love can be a precious but melancholy thing. An attempt to understand human attachment to the _canis familiaris_ in terms of reciprocity and empathy, _Melancholia’s_ _Dog_ tackles such difficult concepts as intimacy and (...) kinship with dogs, the shame associated with identification with their suffering, and the reasons for the profound mourning over their deaths. In addition to philosophy and psychoanalysis, Alice A. Kuzniar turns to the insights and images offered by the literary and visual arts—the short stories of Ivan Turgenev and Franz Kafka, the novels of J. M. Coetzee and Rebecca Brown, the photography of Sally Mann and William Wegman, and the artwork of David Hockney and Sue Coe. Without falling into sentimentality or anthropomorphization, Kuzniar honors and learns from our canine companions, above all attending to the silences and sadness brought on by the effort to represent the dog as perfectly and faithfully as it is said to love. (shrink)

For too long the questions of how we treat animals and how we treat our fellow human beings have been considered separately. But the contours of the current animal crisis make it clear – the harms we are inflicting on the nonhuman world have devastating impacts on humans: zoonotic diseases caused by habitat destruction and animal exploitation have brought human life to a standstill; mass production of animals for food is poisoning the ground and contributing to catastrophic climate change. Animal (...) Crisis responds to this fractured relationship between human beings and animals by exploring the complex social and political contexts in which animals are harmed, revealing the connections between our callous and cruel attitudes to the animal world and those same attitudes towards vulnerable human groups. Marking a stark contrast to traditional theories in animal ethics, Alice Crary and Lori Gruen argue that there can be no animal liberation without human emancipation. Borrowing from critical social theory and ecofeminism, they build a framework for understanding and combatting the structural forces that shape and enable the diminishment of some for the advantage of a few, isolating critical resources that are crucial for animal and human emancipatory struggles alike. (shrink)

The concept of “health”, in Nietzsche’s philosophy, is not opposed to that of disease but incorporates it within itself. The paper aims to show how being in “good health” has, according to Nietzsche, a physiological significance that is intimately connected to aesthetics. Richard Wagner’s music is the iconic example of how rhythm from medicine can become poison and lead a body to décadence. Even in some patients with neurological diseases, musical rhythm can function as medicine, which does not work equally (...) for everyone but according to individual, embodied laws. (shrink)

Structural realism is considered by many realists and antirealists alike as the most defensible form of scientific realism. There are now many forms of structural realism and an extensive literature about them. There are interesting connections with debates in metaphysics, philosophy of physics and philosophy of mathematics. This entry is intended to be a comprehensive survey of the field.

The Enneagram is like a mirror, reflecting dimensions of ourselves that are sometimes hard to see. In this helpful guide, spiritual director and Enneagram teacher Alice Fryling offers an introduction to each number of the Enneagram, with questions and meditations to lead you into deeper self-awareness and reveal how you can experience God's love more abundantly.

Moral philosophy is the study of what morality is and what it requires of us. As Socrates said, it's about "how we ought to live"-and why. It would be helpful if we could begin with a simple, uncontroversial definition of what morality is. Unfortunately, we cannot. There are many rival theories, each expounding a different conception of what it means to live morally, and any definition that goes beyond Socrates's simple formula-tion is bound to offend at least one of them. (...) This should make us cautious, but it need not paralyze us. In this chapter, I will describe the "minimum conception" of morality. (shrink)

This paper explores contemporary debates about the meaning and value of realism in political theory. I seek to move beyond the widespread observation that realism encompasses a diverse set of critiques and commitments, by urging that we recognize two key strands in recent realist thought. Detachment realists claim that political theory is excessively abstract and infeasible and thereby fails adequately to inform actual political decision-making. Displacement critics, on the other hand, suggest that political theory threatens or disrespects real politics. Not (...) only are these visions of realism very different, there are also important tensions between them. I focus, in particular, on clarifying and evaluating the more complex charge that political theory displaces politics. (shrink)

Ausgehend von Freuds Begriff des unbewussten Agierens spannt Alice Pechriggl ein semantisches Feld auf, in dem das Begriffspaar »Freiheit zu Handeln - Zwang zu Agieren« mit dem überkreuz gelegten Begriffspaar »freies Agieren - Handlungszwang/ Zwangshandlung« verknüpft wird. In sieben Anläufen entwirft sie unterschiedliche Szenarien dieses Spannungsfeldes und betrachtet dabei Denkakte zwischen Agieren und Deliberatio, Psyche und Körper als Handlungsschauplätze sowie Demokratie als die Regierungsform des deliberativen Handelns. Menschliches Handeln wird im breiteren Kontext unbewussten Agierens sowohl aus philosophischer als auch (...) aus gruppen-/psychoanalytischer Perspektive erhellt. (shrink)

For this 1897 publication, the American philosopher William James brought together ten essays, some of which were originally talks given to Ivy League societies. Accessible to a broader audience, these non-technical essays illustrate the author's pragmatic approach to belief and morality, arguing for faith and action in spite of uncertainty. James thought his audiences suffered 'paralysis of their native capacity for faith' while awaiting scientific grounds for belief. His response consisted in an attitude of 'radical empiricism', which deals (...) practically rather than ideologically with real-world phenomena. When facing a 'momentous' decision about belief, he says, we both can and must choose the best hypothesis. The first four essays apply this principle to religious faith, and the rest explore the pragmatic approach to such topics as determinism, ethics and individual achievement. James developed his ideas further in The Varieties of Religious Experience and Pragmatism, both of which are reissued in this series. (shrink)

Argues that love plays an essential—if often implicit—role in Hegel's mature theory of moral subjectivity and political community.