Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into (...) two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. (shrink)

ABSTRACT It has become standard to conceive of metalinguistic disagreement as motivated by a form of negotiation, aimed at reaching consensus because of the practical consequences of using a word with one content rather than another. This paper presents an alternative motive for expressing and pursuing metalinguistic disagreement. In using words with given criteria, we betray our location amongst social categories or groups. Because of this, metalinguistic disagreement can be used as a stage upon which to perform a social identity. (...) The ways in which metalinguistic disagreements motivated in this way diverge in character from metalinguistic negotiations are described, as are several consequences of the existence of metalinguistic disagreements motivated in this way. (shrink)

Ample sociological evidence demonstrates that binary gender ideologies are an intractable part of formal organizations and that transgender issues tend to be marginalized by a wide range of social institutions. Yet, in the last 15 years, more than 200 colleges and universities have attempted to ameliorate such realities by adopting gender-inclusive facilities in which students of any gender can share residential and restroom spaces. What cultural logics motivate these transformations? How can their emergence be reconciled with the difficulty of altering (...) the gender order? Using an original sample of 2,036 campus newspaper articles, I find that support for inclusive facilities frames such spaces as a resource through which an institution can claim improved standing in the field of higher education. This process of engendering reputation allows traditional gender separation in residential arrangements to be overcome, but it also situates institutional responsiveness to transgender issues as a means of enhancing a college or university’s public prestige. This, in turn, produces novel status systems in the field of higher education—albeit ones that perpetuate familiar forms of institutional and cultural exclusion. (shrink)

States are rapidly modifying law and policy to increase access to the opioid antidote naloxone, and the provision of naloxone rescue kits for use in the event of overdose is becoming increasingly common. As of late 2014 the majority of states had passed laws increasing naloxone access, and nearly as many have modified emergency responder scope of practice protocols to permit Emergency Medical Technicians and law enforcement officers to administer the medication. While the text of these laws is generally similar, (...) their implementation varies among states.This article outlines experiences and lessons learned from two diverse states, Massachusetts and North Carolina. In Massachusetts naloxone access initiatives were well underway before formal legislative action occurred, while in North Carolina the passage of a naloxone access law served as a catalyst for the creation of new programs and facilitated the scale-up of existing ones. In both states legislative action was necessary to permit the prescription and dispensing of naloxone to the friends and family members of people who use opioids, a key legal change. (shrink)

Biomedical and behavioral research is a complex, multidisciplinary, and highly varied enterprise with but a single goal: to produce and disseminate knowledge about the causes, effects, prevention, diagnosis, and treatment of human illnesses and impairments. Success requires public trust in the process. When that trust has been shaken (or worse), the response has been to establish offices to exercise oversight of the various actors and to require them to adhere to regulations that specify, with various levels of detail, what they (...) may or may not do.The two regulatory frameworks examined in this report by Barbara Bierer and Mark Barnes began separately, provoked by different scandals and abuses of public trust. (shrink)

A growing body of literature critical of ethics review boards has drawn attention to the processes used to determine the ethical merit of research. Citing criticism on the bureaucratic nature of ethics review processes, this literature provides a useful provocation for (re)considering how the ethics review might be enacted. Much of this criticism focuses on how ethics review boards _deliberate,_ with particular attention given to the lack of transparency and opportunities for researcher recourse that characterise ethics review processes. Centered specifically (...) on the conduct of ethics review boards convened within university settings, this paper draws on these inherent criticisms to consider the ways that ethics review boards might enact more communicative and deliberative practices. Outlining a set of principles against which ethics review boards might establish strategies for engaging with researchers and research communities, this paper draws attention to how _Deliberative communication_, _Engagement with researchers_ and the _Distribution of responsibility_ for the ethics review might be enacted in the day-to-day practice of the university human ethics review board. This paper develops these themes via a conceptual lens derived from Habermas’ (The theory of communicative action. Volume 1: Reason and the rationalization of society, 1984 ) articulation of ‘communicative action’ and Fraser’s (Social Text, 25(26), 56–80, 1990 ) consideration of ‘strong publics’ to cast consideration of the role that human ethics review boards might play in supporting university research cultures. _Deliberative communication_, _Engagement with researchers_ and the _Distribution of responsibility_ provide useful conceptual prompts for considering how ethics review boards might undertake their work. (shrink)

Immanuel Kant’s “Schema” and J. G. Fichte’s “Bild” are parallel figures of activity that serve as bridges. For both Kant and Fichte, it is not the image/schema taken as product that is primary, but the act of imaging. I show how Fichte leans on the Kantian argumentation of the schematism in order to attempt bridging the gulf critical philosophy leaves between theoretical and practical philosophy. My broader purpose is to indicate how two German Idealists emphasize activity as a way of (...) solving philosophical problems. (shrink)

This is not a critical review of Travis' book. It's an attempt to summarize the key thesis (occasion-sensitivity) in a way that makes the book accessible and distinguishes it from similar looking theses (such as relevance theory and truth-conditional pragmatics).

BackgroundThe U.S. Food and Drug Administration traditionally has kept confidential significant amounts of information relevant to the approval or non-approval of specific drugs, devices, and biologics and about the regulatory status of such medical products in FDA’s pipeline.ObjectiveTo develop practical recommendations for FDA to improve its transparency to the public that FDA could implement by rulemaking or other regulatory processes without further congressional authorization. These recommendations would build on the work of FDA’s Transparency Task Force in 2010.MethodsIn 2016-2017, we convened (...) a team of academic faculty from Harvard Medical School, Brigham and Women’s Hospital, Yale Medical School, Yale Law School, and Johns Hopkins Bloomberg School of Public Health to develop recommendations through an iterative process of reviewing FDA’s practices, considering the legal and policy constraints on FDA in expanding transparency, and obtaining insights from independent observers of FDA.ResultsThe team developed 18 specific recommendations for improving FDA’s transparency to the public. FDA could adopt all these recommendations without further congressional action.FundingThe development of the Blueprint for Transparency at the U.S. Food and Drug Administration was funded by the Laura and John Arnold Foundation. (shrink)

Perceptual learning involves an improvement in perceptual judgment with practice, which is often specific to stimulus or task factors. Perceptual learning has been shown on a range of visual tasks but very little research has explored chromatic perceptual learning. Here, we use two low level perceptual threshold tasks and a supra-threshold target detection task to assess chromatic perceptual learning and category effects. Experiment 1 investigates whether chromatic thresholds reduce as a result of training and at what level of analysis learning (...) effects occur. Experiment 2 explores the effect of category training on chromatic thresholds, whether training of this nature is category specific and whether it can induce categorical responding. Experiment 3 investigates the effect of category training on a higher level, lateralized target detection task, previously found to be sensitive to category effects. The findings indicate that performance on a perceptual threshold task improves following training but improvements do not transfer across retinal location or hue. Therefore, chromatic perceptual learning is category specific and can occur at relatively early stages of visual analysis. Additionally, category training does not induce category effects on a low level perceptual threshold task, as indicated by comparable discrimination thresholds at the newly learned hue boundary and adjacent test points. However, category training does induce category effects on a supra-threshold target detection task. Whilst chromatic perceptual learning is possible, learnt category effects appear to be a product of left hemisphere processing, and may require the input of higher level linguistic coding processes in order to manifest. (shrink)

Paul Davis explores the personal and cultural significances of translating as a distinctive mode of imaginative conduct for the five principal poet-translators of what was the golden age of the art in England: John Denham, Henry Vaughan, Abraham Cowley, John Dryden, and Alexander Pope.

This chapter focuses on a set of arguments whose upshot is that, whatever tacit knowledge of the axiomatic base of a semantic theory is, it cannot be construed as a genuine propositional attitude or intentional state. It outlines three criticisms that Crispin Wright has raised against Evans's dispositionalist account of tacit knowledge of semantic axioms, and the responses that have been offered by Martin Davies on Evans's behalf. The chapter outlines Wright's alternative proposal, and argues that it presupposes, rather (...) than undercuts, the Evans‐Davies account which proceeds via the imposition of the mirror constraint. It attempts to defend the suggestion that the construction of theories of meaning should be subject to Davies's mirror constraint. The chapter concludes by considering whether the project of constructing semantic theories in accordance with the mirror constraint is in tension with Wittgenstein's reflections on rule‐following. (shrink)

I begin by asking what it is for a moving image to be animated, and thus, what it is for something to be an instance of animated cinema. I next distinguish different kinds of cinematic animation, and explore why, traditionally, so little philosophical attention has been paid to animated cinema per se, and why recent developments in cinematic technology have begun to remedy this deficiency. I comment here on the exchange between Stanley Cavell and Alexander Sesonske over the status (...) of animated movies. I then examine certain epistemological dimensions of animated cinema, and look at the conditions under which animated cinema can be art. I conclude by reflecting on the significance of the use of digital technology in the production of animated cinema. (shrink)

Whether causing flash crashes in financial markets, purchasing illegal drugs, or running over pedestrians, AI is increasingly engaging in activity that would be criminal for a natural person, or even an artificial person like a corporation. We argue that criminal law falls short in cases where an AI causes certain types of harm and there are no practically or legally identifiable upstream criminal actors. This Article explores potential solutions to this problem, focusing on holding AI directly criminally liable where it (...) is acting autonomously and irreducibly. Conventional wisdom holds that punishing AI is incongruous with basic criminal law principles such as the capacity for culpability and the requirement of a guilty mind. -/- Drawing on analogies to corporate and strict criminal liability, as well as familiar imputation principles, we show how a coherent theoretical case can be constructed for AI punishment. AI punishment could result in general deterrence and expressive benefits, and it need not run afoul of negative limitations such as punishing in excess of culpability. Ultimately, however, punishing AI is not justified, because it might entail significant costs and it would certainly require radical legal changes. Modest changes to existing criminal laws that target persons, together with potentially expanded civil liability, are a better solution to AI crime. (shrink)

Excerpt from Spinoza and Time The Arthur Davis Memorial Lecture was founded in 1917, under the auspices of the Jewish Historical Society of England, by his collaborators in the translation of "The Service of the Synagogue," with the object of fostering Hebraic thought and learning in honour of an unworldly scholar. The Lecture is to be given annually in the anniversary week of his death, and the lectureship is to be open to men or women of any race or creed, (...) who are to have absolute liberty in the treatment of their subject. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

We talk as if there are natural kinds and in particular we quantify over them. We can count the number of elements discovered by Sir Humphrey Davy, or the number of kinds of particle in the standard model. Consequently, it looks at first sight at least, that natural kinds are entities of a sort. In the light of this we may ask certain questions: is the apparent existence of natural kinds real or an illusion? And if real, what sort of (...) entity are natural kinds? Are they sui generis? Or can they be identified with or reduced to some other kind of entity? In this essay I shall look at possible reasons for asserting that either kinds are no sort of entity, or, if they are entities, their existence is equivalent to some fact not involving kinds. Richard Boyd seems to take the view that the apparent existence of natural kinds is an illusion. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Hegel on Pseudo-Philosophy: Reading the Preface to the Phenomenology of Spirit by Andrew Alexander DavisPaul T. WilfordDAVIS, Andrew Alexander. Hegel on Pseudo-Philosophy: Reading the Preface to the Phenomenology of Spirit. London: Bloomsbury, 2023. ix + 214 pp. Cloth, $125In Hegel on Pseudo-Philosophy, Andrew Davis makes a convincing argument that just as the problem of how to distinguish sophistry from philosophy is a recurrent theme of Plato's (...) dialogues, so too is the problem of sophistry or "pseudo-philosophy" central to the preface to Hegel's Phenomenology of Spirit. Indeed, the problem of how to recognize and guard against pseudo-philosophy is the common theme linking the prefaces to the Phenomenology of Spirit, the Science of Logic, the Encyclopedia, and the Philosophy of Right, each of which endeavors "to reveal something about the essence of philosophy... by highlighting the ways pseudo-philosophy fails to do justice to philosophical content." Such an undertaking is especially important to Hegel's Phenomenology of Spirit, however, because the subject matter [End Page 543] of the work is nothing but the logos of the appearances of spirit. To arrive at knowledge of spirit requires attending to all the various ways in which spirit (or Geist) can appear, but, as Davis remarks, "like life, Geist may be thought as a source of appearances, but not as an appearance itself. It is always 'behind' what appears." As a result, the Phenomenology is an exercise in trying "to grasp what does not appear through appearances alone." Thus, just as the Phenomenology approaches the truth of spirit by considering spirit's partial, abstract, and one-sided modes of appearing, so too does the preface to the Phenomenology approach the truth of philosophy by investigating forms of pseudo-philosophy.As Hegel himself states, there are two principal tasks pursued in the preface: (1) to offer a preliminary sketch of what it would mean for "the cognition of absolute actuality to become perfectly lucid about its own nature;" and (2) to eliminate some "habitually accepted forms of thought" that prove obstacles to philosophic cognition. While most commentators take their bearings from the former, Davis's approach to the preface is unique (to my knowledge) in foregrounding the latter. Yet, as his book unfolds, it becomes clear that the latter is the route into the former. Indeed, one of the central lessons of the book is that, although the elimination of erroneous habits of thought may seem to be merely negative and therefore principally propaedeutic to the positive task of leading the reader toward "absolute knowing," the examination of error is an integral component of grasping the true. If the Phenomenology as a whole is a "highway of despair"—a comprehensive refutation of natural consciousness's pretensions to knowledge that is simultaneously a dialectical ascent to conceptually comprehending knowing (begreifende Wissen)—the preface initiates the reader into the via negativa that philosophic cognition must travel to attain self-knowledge.Davis's book is structured around seven forms of pseudo-philosophy, each of which is treated as a discrete, distinguishable problem in its own right and also as emblematic of the common failure to recognize that the form of philosophy is inseparable from the content of philosophy. As Davis argues, this failure lies at the root of the attempt (common to much of modern philosophy since Descartes) to establish a priori a universal method for thinking (what Leibniz called a mathesis universalis) that will secure certain and indubitable knowledge. But this effort proves self-undermining, always ultimately engendering the very skepticism it seeks to master. Through observing the aporiai generated by forms of pseudo-philosophy, we learn that "the method of philosophy is inseparable from the subject matter of philosophy. Method cannot be isolated and discussed on its own. Philosophy is thinking (form) about thinking (content)."Davis thus gradually discloses Hegel's positive answer to the question "what is philosophy?" through a series of determinate negations of philosophy's imitations. We learn that philosophy is the recollective, self-comprehending, self-moving thinking of thinking by attending to a set of tendencies that impede philosophy: "a tendency to explain rather than [End Page 544] present (chapter 1), a... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 25.2 (2001) 371-373 [Access article in PDF] Book Review French Fiction in the Mitterrand Years: Memory, Narrative, Desire French Fiction in the Mitterrand Years: Memory, Narrative, Desire, by Colin Davis & Elizabeth Fallaize; 160pp. Oxford: Oxford University Press, 2000, $24.95. Like the Mitterrand era itself, Davis and Fallaize's French Fiction in the Mitterrand Years is somewhat uneven. The election of François Mitterrand in 1981 as the (...) President of the Fifth Republic was a milestone in modern French history. After the conservative politics of the 1960s and 70s, the election of a socialist president and legislature seemed to offer the possibility of a new political and intellectual atmosphere. Indeed, the first two years of Mitterrand's presidency brought sweeping reforms. However, several scandals, continued economic problems and later "cohabitation" with a right-wing legislative majority muted the original verve. Mired in partisan politics, the government often appeared ineffectual.As with the political arena, French fiction of the 1980s was produced under the shadow of another long-standing French institution--the nouveau roman. Again we find a new direction, a turning-away from the past during the 1980s. Yet there was no outright refusal. There were no manifestos or polemical articles written by budding novelists, no claim to Literature. As Annie Ernaux describes her work Une Femme (1987): "Mon projet est de nature littéraire [...]. Mais je souhaite rester, d'une certaine façon, au-dessous de la littérature" (My project is of a literary nature [...]. But I wish to remain, in a certain way, beneath literature (p. 144).This lack of pretension is important, for it helps us better understand the writing of the period. As Davis and Fallaize point out, in the fiction of the Mitterrand years we find a return to history, to the subject, and to storytelling, three areas disdained by the new novelists of the 1950s and 60s (pp. 12-15). But at the same time, there is not an elegiac return to the conventions of the past. There are no didactic tales of Lucien de Rubempré's lost illusions. A good example of this is Patrick Roegiers's Beau Regard (1990), the account of a dinner during which hardly anyone speaks, told by a narrator who knows no one else at the table. Davis and Fallaize note: "In these novels the event is merely an incident, the story no more than an anecdote, and the anecdote merely a fait divers" (p. 147). Although not inconsequential, argue Davis and Fallaize, there is an unquestionable modesty to these texts.In the introduction to their work Davis and Fallaize write: "The aim of the current book is to analyze some of the most important and interesting directions in French fiction through detailed discussions of a selection of texts, all published during François Mitterrand's period as President of the Fifth Republic (1981-95)" (p. 1). This is exactly what they accomplish, selecting six novels--Duras's L'Amant (The Lover, 1984), Pennac's Au bonheur des ogres (The Scapegoat, 1985), Semprun's La Montagne blanche (1986), Echenoz's Lac (Lake, 1989), Guilbert's A l'ami qui ne m'a pas sauvé la vie (To the Friend Who Did Not Save [End Page 371] my Life, 1990), and Ernaux's Passion simple (Simple Passion, 1991)--and spending one chapter on each. They also discuss some of the important features of the era's fiction including memory, especially of World War II, contemporary culture and postmodernism, and autofiction.However, the book's limited goal also leads to some of its problems. As a whole, the work lacks cohesion. Chapters often read like individual essays. Moreover, although some chapters are well-grounded critically and contextually, others are not. Finally, the conclusion is too brief to synthesize aptly the various topics discussed in the previous chapters. The reader does not have a solid grasp of the fictional landscape of the Mitterrand years, but rather, as the introduction indicated, knowledge of "some of the [...] interesting directions in French fiction."One of the most illuminating chapters considers Daniel... (shrink)

There is significant controversy over whether patients have a ‘right not to know’ information relevant to their health. Some arguments for limiting such a right appeal to potential burdens on others that a patient’s avoidable ignorance might generate. This paper develops this argument by extending it to cases where refusal of relevant information may generate greater demands on a publicly funded healthcare system. In such cases, patients may have an ‘obligation to know’. However, we cannot infer from the fact that (...) a patient has an obligation to know that she does not also have a right not to know. The right not to know is held against medical professionals at a formal institutional level. We have reason to protect patients’ control over the information that they receive, even if in individual instances patients exercise this control in ways that violate obligations. (shrink)

The subject of this book is the work of Scottish-born Sir William Mitchell, the Hughes Professor of Philosophy and Vice Chancellor at the University of Adelaide, and the first major philosopher who lived in South Australia. Mitchell worked at Adelaide University during the years 1895-1940 and died in 1962. Mitchell is a major, yet long forgotten, historical figure and intellectual, and an important figure in the history of Scottish and Australian philosophy. He was a part of Scottish schools of thought (...) that influenced early Australian intellectual and cultural life. (The same influence is behind the work of the more famous figure, John Anderson, former Professor of Philosophy at Sydney University.) Anderson’s work recently underwent a revival due to the publication of a recent biography (A Passion to Oppose: John Anderson, Philosopher, by Brian Kennedy, Melbourne University Press, 1995). However, there has never been a serious scholarly appraisal of the work of William Mitchell. At the time of preparation of this book there was no recent published material on Mitchell’s life, work or influence. -/- This book fills this need. I argue that Mitchell’s work is surprisingly relevant to current concerns among cognitive scientists and philosophers of mind. He wrote on issues that are only today being discussed by philosophers and psychologists under the auspices of ‘cognitive science’. His major work: Structure and Growth of the Mind (MacMillan, 1907) is a major treatise on philosophical psychology. The topics that concerned Mitchell are only now being revisited in the form of contemporary debates. -/- The specific aims of the book are as follows: • To assess the impact of late nineteenth/early twentieth century science (especially neurology, psychology and physics) on Mitchell’s philosophical work and trends in philosophical psychology during that period. • To demonstrate the importance of Mitchell’s philosophical work in the context of contemporary theories of mind and content, cognitive science, and the philosophy of science and perception. • To make clear the extent of Mitchell’s philosophical influence on others at the time • To locate Mitchell’s work in relation to other influences on philosophy in Australia. (shrink)

The idea of using responsibility in the allocation of healthcare resources has been criticized for, among other things, too readily abandoning people who are responsible for being very badly off. One response to this problem is that while responsibility can play a role in resource allocation, it cannot do so if it will leave those who are responsible below a “sufficiency” threshold. This paper considers first whether a view can be both distinctively sufficientarian and allow responsibility to play a role (...) even for those who will be left with very poor health. It then draws several further distinctions that may affect the application of responsibility at this level. We conclude that a more plausible version of the sufficientarian view is to allow a role for responsibility where failure to do so will leave someone else who is not responsible below the sufficiency threshold. However, we suggest that individuals must exhibit “sufficient responsibility” in order for this to apply, involving both a sufficient level of control and an avoidable failure to respond adequately to reasons for action. (shrink)

The research ethics committee is a key element of university administration and has gained increasing importance as a review mechanism for those institutions that wish to conduct responsible...

Hun Chung argues for a theory of distributive justice – ‘prospect utilitarianism’ – that overcomes two central problems purportedly faced by sufficientarianism: giving implausible answers in ‘lifeboat cases’, where we can save the lives of some but not all of a group, and failing to respect the axiom of continuity. Chung claims that prospect utilitarianism overcomes these problems, and receives empirical support from work in economics on prospect theory. This article responds to Chung's criticisms of sufficientarianism, showing that they are (...) misplaced. It then shows that prospect utilitarianism faces independent problems, since it too requires a threshold, which Chung bases on the idea of ‘adequate functioning’. The article shows that there are problems with this as a threshold, and that it is not empirically supported by prospect theory. (shrink)

Martin Davies draws parallels between Herz's personal life and Prussian politics and culture to make sense of the end of the eighteenth century when Enlightenment tradition and Romantic thought coincided.

Shaking the respect for history? -- Imprisoned by history -- The historical unconscious -- History: a self-centred science -- History: deception as cultural practice.

Anthony Kenny concludes The God of the Philosophers by saying that ‘If the argument of the previous chapters has been correct then there is no such being as the God of traditional natural theology … There cannot, if our argument has been sound, be a timeless, immutable, omniscient, omnipotent all-good being’ . According to Kenny.

Mindfulness and the Birth Sphere draws together and critically appraises a raft of emerging research around mindfulness in healthcare, looking especially at its relevance to pregnancy and childbirth. This is an essential read for all those interested in mindfulness in connection to pregnancy and childbirth, including midwives, doulas, doctors and birth activists, whether involved in practice, research or education.

This chapter contains sections titled: * 1 The Universe Is Weirdly Fine-Tuned for Life * 2 The Cosmic Code * 3 The Concept of Laws * 4 Are the Laws Real? * 5 Does a Multiverse Explain the Goldilocks Enigma? * 6 Many Scientists Hate the Multiverse Idea * 7 Who Designed the Multiverse? * 8 If There Were a Unique Final Theory, God Would Be Redundant * 9 What Exists and What Doesn’t: Who or What Gets to Decide? * (...) 10 The Origin of the Rule That Separates What Exists From What Doesn’t * 11 Why Mind Matters * 12 The Universe as a Finite Computer Exposes the Fiction of Idealized Laws * 13 Quantum Mechanics Could Permit the Feedback Loop Between Mind and the Laws Of Physics * Notes. (shrink)