The COVID-19 pandemic hit healthcare professionals (HCPs) hard, potentially leading to mental health deterioration. This longitudinal study investigated the 1-year evolution of psychological health of acute care HCPs during the COVID-19 pandemic and explored possible differences between high and low resilient HCPs. From April 2020 to April 2021, a convenience sample of 520 multinational HCPs completed an online survey every 3 months, up to five times. We used mixed linear models to examine the association between resilience and the variation of (...) COVID-19-related anxiety, depressiveness, perceived vulnerability, and psychological trauma symptomatology. We demonstrated “u-shaped” trajectories for all mental health symptoms. We also explored differences in the abovementioned variables between front-line and second-line acute care HCPs. In contrast to HCP.s with lower levels of resilience (-1SD), those with higher levels of resilience (+1SD) showed increased COVID-19 anxiety and perceived vulnerability over time. Front-line and second-line HCPs differed in their depressiveness and psychological trauma variation during the 1-year analysis. High and average resilient second-line HCPs showed steeper depressiveness increases with time than high and average resilient front-line HCPs. Acute care HCPs reported their most elevated clinical symptoms of depressiveness (5–7%) and psychological trauma symptomatology (26–46%) in April 2020. During the first year of the COVID-19 pandemic, second-line HCPs with more resilience showed a steeper worsening of their depressiveness than more resilient front-line HCPs. HCPs with low resilience may benefit from interventions at the beginning of a pandemic, whereas HCPs with high resilience might benefit from resilience-enhancing interventions at later phases.Trial RegistrationThe study protocol was pre-registered with the International Standard Randomised Controlled Trial Number (ISRCTN13694948) published (Fuchs et al., 2020). (shrink)

The Repugnant Conclusion served an important purpose in catalyzing and inspiring the pioneering stage of population ethics research. We believe, however, that the Repugnant Conclusion now receives too much focus. Avoiding the Repugnant Conclusion should no longer be the central goal driving population ethics research, despite its importance to the fundamental accomplishments of the existing literature.

Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Methods: Human patients undergoing Phase II invasive monitoring for (...) intractable epilepsy were implanted with depth electrodes capable of recording neurophysiological signals. Subjects performed a delayed-match-to-sample (DMS) memory task while hippocampal ensembles from CA1 and CA3 cell layers were recorded to estimate a multi-input, multi-output (MIMO) model of CA3-to-CA1 neural encoding and a memory decoding model (MDM) to decode memory information from CA3 and CA1 neuronal signals. After model estimation, subjects again performed the DMS task while either MIMO-based or MDM-based patterned stimulation was delivered to CA1 electrode sites during the encoding phase of the DMS trials. Each subject was sorted (post hoc) by prior experience of repeated and/or mild-to-moderate brain injury (RMBI), TBI, or no history (control) and scored for percentage successful delayed recognition (DR) recall on stimulated vs. non-stimulated DMS trials. The subject’s medical history was unknown to the experimenters until after individual subject memory retention results were scored. Results: When examined compared to control subjects, both TBI and RMBI subjects showed increased memory retention in response to both MIMO and MDM-based hippocampal stimulation. Furthermore, effects of stimulation were also greater in subjects who were evaluated as having pre-existing mild-to-moderate memory impairment. Conclusion: These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. (shrink)

Values and the scope of scientific inquiry, by M. Farber.--The phenomenology of epistemic claims: and its bearing on the essence of philosophy, by R. M. Zaner.--Problems of the Life-World, by A. Gurwitsch.--The Life-World and the particular sub-worlds, by W. Marx.--On the boundaries of the social world, by T. Luckmann.--Alfred Schutz on social reality and social science, by M. Natanson.--Homo oeconomicus and his class mates, by F. Machlup.--Toward a science of political economics, by A. Lowe.--Some notes on reality-orientation in contemporary societies, (...) by A. Brodersen.--The eclipse of reality, by E. Voegelin.--Alienation in Marx's Political economy and philosophy, by P. Merlan.--The problem of multiple realities: Alfred Schutz and Robert Musil, by P. L. Berger.--Phenomenology, history, myth, by F. Kersten.--The role of music in Leonardo's Paragone, by E. Winternitz.--Alfred Schutz bibliography (p. [297]-306). (shrink)

This is a rewarding book. In terms of area, it has one foot firmly planted in metaphysics and the other just as firmly set in the philosophy of science. Nature's Metaphysics is distinctive for its thorough and detailed defense of fundamental, natural properties as essentially dispositional and for its description of how these dispositional properties are thus suited to sustain the laws of nature as (metaphysically) necessary truths.

Introduction 1. Alexander in Modern Scholarship; The Present Translation The anti-Manichaean treatise of Alexander of Lycopolis has for a long time been ...

A lavishly decorated handbook of medicine was conceived for the lay public on topics such as human health, healing, medicine, and household management.

The "Supplement" transmitted as the second book of "On the Soul" by Alexander of Aphrodisias is a collection of short texts on a wide range of topics from psychology, including the general hylomorphic account of soul and its faculties, and the theory of vision; questions in ethics ; and issues relating to responsibility, chance and fate. One of the texts in the collection, "On Intellect", had a major influence on medieval Arabic and Western thought, greater than that of (...) class='Hi'>Alexander's "On the Soul" itself. The treatises may all be by Alexander himself; certainly the majority of them are closely connected with his other works. Many of them, however, consist of collections of arguments on particular issues, collections which probably incorporate material from earlier in the history of the Peripatetic school. This translation is from a new edition of the Greek text based on a collation of all known manuscripts and comparison with medieval Arabic and Latin translations. (shrink)

This volume contains the Arabic translations of a lost treatise by Alexander of Aphrodisias "On the Principles of the Universe" with English translation, introduction and commentary. It also includes an Arabic and Syriac glossary. The introduction and commentary deal in detail with the manuscripts, the translators and the exegetical tendencies of the text, as well as with its reception in Arabic philosophy. The main theme of the work is the motion of the heavenly bodies and their influence on the (...) physical world. (shrink)

This paper discusses two passages from Alexander of Aphrodisias’s commentary on Aristotle’s _ Topics _ that are transmitted in Ps-Jābir’s _ Kitāb al-Nukhab _. It argues that the Arabic translation of Alexander’s commentary may have been made from a fuller version than what came down to us in Greek. Especially since the author(s) of the Jābir-corpus form a tradition different from the school of Ḥunayn b. Isḥāq (d. 873) and authors associated to the ‘Baghdad school’, whose earliest figure (...) is Abū Bishr Mattā b. Yūnus (d. 940), the Arabic fragments of Alexander’s commentary preserved in the _ Kitāb al-Nukhab _ promise to shed more light on the early reception of the _ Topics _ and the different contexts in which Aristotelian dialectic was studied in the Islamic world. (shrink)

This paper discusses two passages from Alexander of Aphrodisias’s commentary on Aristotle’s _ Topics _ that are transmitted in Ps-Jābir’s _ Kitāb al-Nukhab _. It argues that the Arabic translation of Alexander’s commentary may have been made from a fuller version than what came down to us in Greek. Especially since the author(s) of the Jābir-corpus form a tradition different from the school of Ḥunayn b. Isḥāq (d. 873) and authors associated to the ‘Baghdad school’, whose earliest figure (...) is Abū Bishr Mattā b. Yūnus (d. 940), the Arabic fragments of Alexander’s commentary preserved in the _ Kitāb al-Nukhab _ promise to shed more light on the early reception of the _ Topics _ and the different contexts in which Aristotelian dialectic was studied in the Islamic world. (shrink)

This book presents some of the most recent trends and developments in Presocratic scholarship. A wide range of topics are covered - from the metaphysical to the moral to the methodological - as well as a broad a range of authors: from recognized figures such as Heraclitus and Parmenides to Sophistic thinkers whose place has traditionally been marginalized, such as Gorgias and the author of the Dissoi Logoi. Several of the pieces are concerned with the later reception and influence of (...) the Presocratics on ancient philosophy, an area of study important both for the light it sheds on our evidence for Presocratic thought and for understanding the philosophical power of their ideas. Drawing together contributions from distinguished authorities and internationally acclaimed scholars of ancient philosophy, this book offers new challenges to traditional interpretations in some areas of Presocratic philosophy and finds new support for traditional interpretations in other areas. (shrink)

Die Untersuchung analysiert deswegen nach einem einleitenden Vorschlag zur Bestimmung des Verhältnisses von Logik und Metaphysik im Anschluss an Leibniz Baumgartens Erkenntnistheorie in ihrer charakteristischen Komplementarität von Ästhetik und Logik, die das gesamte Feld aller möglichen Gewissheit, d. h. des Bewusstseins der Wahrheit der verschiedensten Erkenntnisse, abdecken. Darüber hinaus erörtert sie auch deren mögliche Gegenstände, nämlich die Beschaffenheit der Dinge, wie sie das Wissen Gottes als eine ideale Metaphysik enthielte. Auf der Grundlage einer Ontologie teilweise unbestimmer aktualer Existenz kommt Baumgarten (...) zu einer kosmologischen Theorie monadischer Bewegtheit aller körperlichen Dinge. Sie führt zu einer Psychologie des Erkennens und Handelns, aus der ein indeterministischer Begriff menschlicher Willensfreiheit folgt, die auch von Gottes Allwissen nicht beschränkt wird. (shrink)

“Ex nihilo nihil fit,” goes the classic adage: nothing comes from nothing. Parmenides used the Principle of Sufficient Reason to argue that there was no such thing as change: If there was change, why did it happen when it happened rather than earlier or later? “Nothing happens in vain, but everything for a reason and under necessitation,” claimed Leucippus. Saint Thomas insisted in the.

Assuming S5, the main controversial premise in modal ontological arguments is the possibility premise, such as that possibly a maximally great being exists. I shall offer a new way of arguing that the possibility premise is probably true.

A recombinationist like the earlier Armstrong (1989) claims that logically possible worlds are recombinations of items found in the actual world, with some items reduplicated if need be and others deleted. An immediate consequence of this is that if an..

It is widely accepted that divine creation of human beings is compatible with evolutionary theory, except perhaps in regard of the human soul, and that neo-Darwinian evolutionary theory provides an explanation of speciation and of complex features of organisms that undercuts Paley-style teleological arguments, whether or not the evolutionary mechanisms are truly random or deterministic. I will argue that a plausible understanding of the doctrine of creation of human beings is either logically or rationally incompatible with full evolutionary theory, even (...) if one does not take souls into account. Consequently, a theist needs to move to a weaker version either of the creation doctrine or of evolutionary theory, or both. (shrink)

The production of a number of vaccines involves the use of cell-lines originally derived from fetuses directly aborted in the 1960s and 1970s. Such cell-lines, indeed sometimes the very same ones, are important to on-going research, including at Catholic institutions. The cells currently used are removed by a number of decades and by a significant number of cellular generations from the original cells. Moreover, the original cells extracted from the bodies of the aborted fetuses were transformed to produce the cell (...) lines, since otherwise they would be incapable of the kind of culturing that is required. (shrink)