BackgroundObtaining informed consent for participation in genomic research in low-income settings presents specific ethical issues requiring attention. These include the challenges that arise when providing information about unfamiliar and technical research methods, the implications of complicated infrastructure and data sharing requirements, and the potential consequences of future research with samples and data. This study investigated researchers’ and participants’ parents’ experiences of a consent process and understandings of a genome-wide association study of malaria involving children aged five and under in Mali. (...) It aimed to inform best practices in recruiting participants into genomic research.MethodsA qualitative rapid ethical assessment was undertaken. Fifty-five semi-structured interviews were conducted with the parents of research participants. An additional nine semi-structured interviews were conducted with senior research scientists, research assistants and with a member of an ethics committee. A focus group with five parents of research participants and direct observations of four consent processes were also conducted. French and translated English transcripts were descriptively and thematically coded using OpenCode software.ResultsParticipants’ parents in the MalariaGEN study had differing understandings of the causes of malaria, the rationale for collecting blood samples, the purposes of the study and the kinds of information the study would generate. Genomic aspects of the research, including the gene/environment interaction underlying susceptibility or resistance to severe malaria, proved particularly challenging to explain and understand.ConclusionsThis study identifies a number of areas to be addressed in the design of consent processes for genomic research, some of which require careful ethical analysis. These include determining how much information should be provided about differing aspects of the research and how best to promote understandings of genomic research. We conclude that it is important to build capacity in the design and conduct of effective and appropriate consent processes for genomic research in low and middle-income settings. Additionally, consideration should be given to the role of review committees and community consultation activities in protecting the interests of participants in genomic research. (shrink)

Background: As actors with the key responsibility for the protection of human research participants, Research Ethics Committees (RECs) need to be competent and well-resourced in order to fulfil their roles. Despite recent programs designed to strengthen RECs in Africa, much more needs to be accomplished before these committees can function optimally.Objective: To assess training needs for biomedical research ethics evaluation among targeted countries.Methods: Members of RECs operating in three targeted African countries were surveyed between August and November 2007. Before implementing (...) the survey, ethical approvals were obtained from RECs in Switzerland, Cameroon, Mali and Tanzania. Data were collected using a semi-structured questionnaire in English and in French.Results: A total of 74 respondents participated in the study. The participation rate was 68%. Seventy one percent of respondents reported having received some training in research ethics evaluation. This training was given by national institutions (31%) and international institutions (69%). Researchers and REC members were ranked as the top target audiences to be trained. Of 32 topics, the top five training priorities were: basic ethical principles, coverage of applicable laws and regulations, how to conduct ethics review, evaluating informed consent processes and the role of the REC.Conclusion: Although the majority of REC members in the targeted African countries had received training in ethics, they expressed a need for additional training. The results of this survey have been used to design a training program in research ethics evaluation that meets this need. (shrink)

"C'est en 2010 que le doyen Alassane Ndaw me confia l'édition d'un recueil de ses textes incluant des articles déjà publiés ainsi que des inédits. Il me demanda expressément de rédiger, à cet effet, outre une introduction, une préface, et m'assura que j'avais toute liberté de conduire le travail éditorial. L'ouvrage, Penser l'Afrique noire, se présente donc comme un ensemble de quatorze textes déjà publiés ou inédits, auxquels s'ajoute un quinzième constituant l'épilogue qui fut à l'origine une magistrale préface (...) de Ndaw au beau livre d'art d'Olivier Föllimi, Hommage l'Afrique (Paris, Editions de la Martinière, 2010, 336 p.). Toute sa vie, Alassane Ndaw a poursuivi une seule idée, un seul objectif : établir une puissante synthèse entre tradition et modernité, entre pensée africaine et philosophie occidentale, en vue d'aboutir à la définition d'une personnalité culturelle capable, en surmontant tout déchirement, de se remembrer. Il cherchait moins une philosophie africaine qu'une forme africaine de la philosophie. L'élaboration de cette forme africaine de la philosophie lui apparaissait comme la tâche par excellence de l'herméneutique, qu'il fallait d'abord créer. Aussi bien s'était-il constamment attelé à deux activités majeures : expliciter et interpréter les traditions culturelles africaines, c'est-à-dire créer l'herméneutique africaine en la faisant. De la permanence de cette tâche, en même temps que de son actualité, témoigne cet ouvrage posthume de ce grand maître de la pensée africaine. " Djibril Samb. (shrink)

Comment redonner aux élèves l'amour de la réflexion philosophique? Ce document tente de répondre à cette question : son objectif principal est d'inciter nos apprenants à lire et à écrire. Pour ce faire, on a voulu, par une série d'exercices schématisés et d'exemples simples, mettre à l'épreuve l'expression et la faculté d'argumentation des candidats au bac. Disserter, c'est avant tout faire valoir deux aptitudes : savoir lire et écrire. Savoir lire, parce que la dissertation exige un effort de décodage ou (...) de décryptage d'un message que véhicule une affirmation ou une question. Savoir écrire, parce qu'elle requiert l'argumentation, la conceptualisation, l'expression correcte et la présentation ordonnée des idées. Les candidats trouveront ici une propédeutique simple à la dissertation en participant à une réflexion ébauchée, mais inachevée portant sur des sujets afférents aux différents thèmes du programme. Commenter un texte philosophique, c'est avant tout dialoguer avec un auteur par-delà les barrières que sont l'espace et le temps. On ne peut s'initier à la philosophie qu'en apprenant à soutenir un débat contradictoire avec des auteurs. Si, comme dit Kant, on n'apprend guère la philosophie ; on ne peut qu'apprendre à philosopher, alors la voie royale du "philosopher" c'est la fréquentation assidue des textes philosophiques. Des textes, des schémas de commentaire ainsi que des exemples complets de commentaires proposés ici devraient aider le candidat à affiner sa capacité de communication et d'élaboration conceptuelle. (shrink)

The Rift Valley fever (RVF), which first appeared in Kenya in 1912, is an anthropozoonosis widespread in tropical areas. In Senegal, it is particularly felt in the Ferlo area where a strong presence of ponds shared by humans, cattle and vectors is noted. As part of the studies carried out on the environmental factors which favour its start and propagation, the focus of this paper is put on the decision making process to evaluate the impacts, the interactions and to make (...) RVF monitoring easier. The present paper proposes a model based on data mining techniques and dedicated to trade experts. This model integrates all the involved data and the results of the analyses made on the characteristics of the surrounding ponds. This approach presents some advantage in revealing the relationship between environmental factors and RVF transmission vectors for space–time epidemiology monitoring purpose. (shrink)

In this paper, we develop a 3D-individual-based model to understand effect of various small-scale mechanisms in phytoplankton cells, on the cellular aggregation process. These mechanisms are: spatial interactions between cells due to their chemosensory abilities, a molecular diffusion and a demographical process. The latter is considered as a branching process with a density-dependent death rate to take into account the local competition on resources. We implement the IBM and simulate various scenarios under real parameter values for phytoplankton cells. To quantify (...) the effects of the different processes quoted above on the spatial and temporal distribution of phytoplankton, we used two spatial statistics: the Clark–Evans index and the group belonging percentage. Our simulation study highlights the role of the branching process with a weak-to-medium competition in reinforcing the aggregating structure that forms from attraction mechanisms, and shows by contrast that aggregations cannot form when competition is high. (shrink)

PREFACEProf. Göran Sundholm of Leiden University inspired the group of Logic at Lille and Valparaíso to start a fundamental review of the dialogical conception of logic by linking it to constructive type logic. One of Sundholm's insights was that inference can be seen as involving an implicit interlocutor. This led to several investigations aimed at exploring the consequences of joining winning strategies to the proof-theoretical conception of meaning. The leading idea is, roughly, that while introduction rules lay down the conditions (...) under which a winning strategy for the Proponent may be built, the elimination rules lay down those elements of the Opponent's assertions that the Proponent has the right to use for building winning strategy. It is the pragmatic and ethical features of obligations and rights that naturally lead to the dialogical interpretation of natural deduction.During the Visiting Professorship of Prof. Sundholm at Lille in (2012) the group of Lille started delving into the ways of implementing Per Martin-Löf's Constructive Type Theory with the dialogical perspective. In particular, Aarne Ranta's (1988) paper, the first publication on the subject, was read and discussed during Sundholm’s seminar. The discussions strongly suggested that the game-theoretical conception of quantifiers as deploying interdependent moves provide a natural link between CTT and dialogical logic. This idea triggered several publications by the group of Lille in collaboration with Nicolas Clerbout and Juan Redmond at the University of Valparaíso, including the publication of the book (2015) by Clerbout / Rahman that provides a systematic development of this way of linking CTT and the dialogical conception of logic. However the Clerbout / Rahman book was written from the CTT perspective on dialogical logic, rather than the other way round. The present book should provide the perspective from the other side of the dialogue between the Dialogical Framework and Constructive Type Theory. The main idea of our present study is that Sundholm's (1997) notion of epistemic assumption is closely linked to the Copy-Cat Rule or Socratic Rule that distinguishes the dialogical framework from other game-theoretical approaches. One way to read the present book is as a further development of Sundholm’s extension of Austin's (1946, p. 171) remark on acts of assertion to inference. Indeed, Sundholm (2013, p. 17) gave the following forceful formulation: When I say therefore, I give others my authority for asserting the conclusion, given theirs for asserting the premisses.Per Martin-Löf, in recent lectures, have utilized the dialogical perspective on epistemic assumptions to get out of a certain circle that threatens the explanation of the notions of inference and demonstration. A demonstration may be explained as a chain of (immediate) inferences starting from no premisses. That an inference J1... Jn—————Jis valid means that the conclusion J can be made evident on the assumption that J1, …, Jn are known. The notion of epistemic assumption thus enters in the explanation of valid inference. We cannot, however, in this explanation understand 'known' in the sense of demonstrated, for then we are explaining the notion of inference in terms of demonstration, whereas demonstration has been explained in terms of inference. Martin-Löf suggests that we here understand 'known' in the sense of asserted, so that epistemic assumptions are judgements others have made, judgements for which others have taken the responsibility; that the inference is valid then means that, given that others have taken responsbility for the premisses, I can take responsibility for the conclusion:The circularity problem is this: if you define a demonstration to be a chain of immediate inferences, then you are defining demonstration in terms of inference. Now we are considering an immediate inference and we are trying to give a proper explanation of that; but, if that begins by saying: Assume that J1, …, Jn have been demonstrated – then you are clearly in trouble, because you are about to explain demonstration in terms of the notion of immediate inference, hence when you are giving an account of the notion of immediate inference, the notion of demonstration is not yet at your disposal. So, to say: Assume that J1, …, Jn have already been demonstrated, makes you accusable of trying to explain things in a circle. The solution to this circularity problem, it seems to me now, comes naturally out of this dialogical analysis. […]The solution is that the premisses here should not be assumed to be known in the qualified sense, that is, to be demonstrated, but we should simply assume that they have been asserted, which is to say that others have taken responsibility for them, and then the question for me is whether I can take responsibility for the conclusion. So, the assumption is merely that they have been asserted, not that they have been demonstrated. That seems to me to be the appropriate definition of epistemic assumption in Sundholm's sense. One of the main tenets of the present study is that the further move of relating the Socratic Rule rule with judgemental equality provides both a simpler and more direct way to implement the constructive type theoretical approach within the dialogical framework. Such a reconsideration of the Socratic Rule, roughly speaking, amounts to the following. 1.A move from P that brings-forward a play-object in order to defend an elementary proposition A can be challenged by O. 2.The answer to such a challenge, involves P bringing forward a definitional equality that expresses the fact that the play-object chosen by P copies the one O has chosen while positing A. For short, the equality expresses at the object-languaje level that the defence of P relies on the authority given to O to be able to produce the play-objects she brings forward. More generally, according to this view, a definitional equality established by P and brought forward while defending the proposition A, expresses the equality between a play-object (introduced by O) and the instruction for building a play-object deployed by O while affirming A. So it can be read as a computation rule that indicates how to compute O's instructions. Let us recall that from the strategic point of view, O's moves correspond to elimination rules of demonstrations. Thus, the dialogical rules that prescribe how to introduce a definitional equality – correspond – at the strategic level – to the definitional equality rules for CTT as applied to the selector-functions involved in the elimination rules. So, what we are doing here is extending the dialogical interpretation of Sundholm's epistemic assumption to the rules that set up the definitional equality of a type.The present work is structured in the following way:•In the Introduction we state the main tenets that guide our book•Chapter II contains a brief overview of Constructive Type Theory penned by Ansten Klev with exercises and their solutions. •Chapter III offers a novel presentation of the dialogical conception of logic. In fact, the first two sections of the chapter provide an overview of standard dialogical logic – including solved exercises, slightly adapted to the content of the present volume. The rest of the sections develop a new dialogical approach to Constructive Type Theory. •Chapters IV and V contain the main body of our study, namely the relation between the Socratic Rule, epistemic assumptions, and equality. The chapter provides the reader with thoroughly worked out examples with comments. •After the Final Remarks the book containsa.An appendix containing a an overview of all the rules for the new formulation of dialogical approach to constructive type theory developed in the book; b.a brief outline of Per Martin-Löf's informal presentation of the demonstration of the axiom of choice.c.two examples of a tree-shaped graph of an extensive strategy. Acknowledgments: Many thanks to Mark van Atten (Paris1), Giuliano Bacigalupo (Zürich), Charles Zacharie Bowao (Univ. Ma Ngouabi de Brazzaville, Congo), Christian Berner (Lille3), Michel Crubellier (Lille3), Pierre Cardascia (Lille3), Oumar Dia (Dakar), Marcel Nguimbi ((Univ. Marien Ngouabi de Brazzaville, Congo), Adjoua Bernadette Dango (Lille3 / Alassane Ouattara de Bouaké, Côte d'Ivoire), Steephen Rossy Eckoubili (Lille3), Johan Georg Granström (Zürich), Gerhard Heinzmann (Nancy2), Muhammad Iqbal (Lille3), Matthieu Fontaine (Lille3), Radmila Jovanovic (Belgrad), Hanna Karpenko (Lille3), Laurent Keiff (Lille3), Sébastien Magnier (Saint Dennis, Réunion), Clément Lion (Lille3), Gildas Nzokou (Libreville), Fachrur Rozie (Lille3), Helge Rückert (Mannheim), Mohammad Shafiei (Paris1), and Hassan Tahiri (Lisbon), for rich interchanges, suggestions on the main claims of the present study and proof-reading of specific sections of the text. Special thanks to Gildas Nzokou (Libreville), Steephen Rossy Eckoubili (Lille3) and Clément Lion (Lille3), with whom a Pre-Graduate Textbook in French on dialogical logic and CTT is in the process of being worked out – during the visiting-professorship in 2016 of the former. Eckoubili is the author of the sections on exercises for dialogical logic, Nzokou cared of those involving the development of CTT-demonstrations out of winning-strategies. Special thanks also to Ansten Klev (Prague) for helping with technical details and conceptual issues on CTT, particularly so as author of the chapter introducing CTT. (shrink)