The ability to convert human somatic cells into induced pluripotent stem cells (iPSCs) is allowing the production of custom‐tailored cells for drug discovery and for the study of disease phenotypes at the cellular and molecular level. IPSCs have been derived from patients suffering from a large variety of disorders with different severities. In many cases, disease related phenotypes have been observed in iPSCs or their lineage‐specific progeny. Several proof of concept studies have demonstrated that these phenotypes can be reversed in (...) vitro using approved drugs. However, several challenges must be overcome to take full advantage of this technology. Here, we highlight recent advances in the field and discuss the main challenges associated with this technology as it applies to disease modelling. (shrink)

I propose to consider the question, "Can machines think?" This should begin with definitions of the meaning of the terms "machine" and "think." The definitions might be framed so as to reflect so far as possible the normal use of the words, but this attitude is dangerous, If the meaning of the words "machine" and "think" are to be found by examining how they are commonly used it is difficult to escape the conclusion that the meaning and the answer to (...) the question, "Can machines think?" is to be sought in a statistical survey such as a Gallup poll. But this is absurd. Instead of attempting such a definition I shall replace the question by another, which is closely related to it and is expressed in relatively unambiguous words. The new form of the problem can be described in terms of a game which we call the 'imitation game." It is played with three people, a man (A), a woman (B), and an interrogator (C) who may be of either sex. The interrogator stays in a room apart front the other two. The object of the game for the interrogator is to determine which of the other two is the man and which is the woman. He knows them by labels X and Y, and at the end of the game he says either "X is A and Y is B" or "X is B and Y is A." The interrogator is allowed to put questions to A and B. We now ask the question, "What will happen when a machine takes the part of A in this game?" Will the interrogator decide wrongly as often when the game is played like this as he does when the game is played between a man and a woman? These questions replace our original, "Can machines think?". (shrink)

What is the basis for arguing that a volunteer army exploits citizens who lack civilian career opportunities? How do we determine that a doctor who has sex with his patients is exploiting them? In this book, Alan Wertheimer seeks to identify when a transaction or relationship can be properly regarded as exploitative--and not oppressive, manipulative, or morally deficient in some other way--and explores the moral weight of taking unfair advantage. Among the first political philosophers to examine this important topic (...) from a non-Marxist perspective, Wertheimer writes about ordinary experience in an accessible yet philosophically penetrating way. He considers whether it is seriously wrong for a party to exploit another if the transaction is consensual and mutually advantageous, whether society can justifiably prohibit people from entering into such a transaction, and whether it is wrong to allow oneself to be exploited. Wertheimer first considers several contexts commonly characterized as exploitive, including surrogate motherhood, unconscionable contracts, the exploitation of student athletes, and sexual exploitation in psychotherapy. In a section outlining his theory of exploitation, he sets forth the criteria for a fair transaction and the point at which we can properly say that a party has consented. Whereas many discussions of exploitation have dealt primarily with cases in which one party harms or coerces another, Wertheimer's book focuses on what makes a mutually advantageous and consensual transaction exploitive and analyzes the moral and legal implications of such exploitation. (shrink)

Quantum feminicity is a term that refers to the intersection of quantum theory, a technological branch of physics, with feminist theory, a social and political movement. Engaging the modal logics of this intersection, the article explores this intersection through one aspect of quantum literacy; that of the quantum splitting of the concept of the temporal narrative. The article examines what are the interdisciplinary convergences of feminist and physics’s respective philosophies. Focussing on the quantum modalities that are being practiced in relation (...) to the situated nature of technological platforms engaged, the article proposes that modelling a quantum feminicity can assist in disengaging modes of sexual difference that are used to gender all kinds of bodies through a countermanding the temporal. Experiences of bodies are considered as experimental modes that provide quantum vectors for feminist actions. (shrink)

The past fifty years have been a time of immense change in Ireland, as the country has moved from a traditional to a modern society. The introduction of electricity, the 'quiet revolution', was accompanied by changes in attitudes to Church, sex, relationships, property, emigration - to life in general. In that short time people have absorbed massive change, often enthusiastically, though perhaps with the occasional pang of regret for the 'old ways'. Here we see the faces, the landscapes and the (...) life of that recently disappeared Ireland - Jack Lynch, JFK, Grace Kelly, Dev, de Gaulle, the Troubles, folk traditions - alongside the new faces and the new styles of our modern society. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Introduction: Natural necessity, being, and becoming -- Accentuate the negative -- Diffracting dialectic -- Opening totality -- Constellating ethics -- Metacritique I : philosophy's primordial failing -- Metacritique II : dialectic and difference -- Conclusion: Natural necessity and the grounds of justice : natural necessity as material meshwork.

Although his subject matter is far from abstract and his arguments comparatively free from obscurity, Bernard Mandeville has generally been acknowledged a difficult philosopher. It is not hard to see why. First, Mandeville deliberately sets out to generate paradoxes. Secondly, he is not a systematic writer. His views are expounded and developed in a number of works of which The Fable of the Bees is only the best known. Thirdly, and most important, he is not solely a philosopher, but also (...) a satirist. His satire is intertwined with his purely philosophical theories and his style is often highly ironic. Any interpretation of Mandeville must consider his philosophical and his satirical intentions. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 10.1 (2003) 81-85 [Access article in PDF] "What's in the Box Then, Mum?"—Death, Disability, and Dogma Sheila Colman OVERHEARD IN AN EXCHANGE between a bereaved woman and her son outside the church just prior to a funeral service: "What's in the box, then?" "Daddy." The son is in his late 30s and has a learning disability. His mother had prepared him as well as (...) she could; his father had been ill for some time and was not expected to recover. Death, and the rituals surrounding it, had been explained and it was not the first family funeral he had attended.Trying to field such childlike questions is typical of living with a person with a learning disability; trying to find the right words is difficult enough without the added pressure of personal emotional distress.The generally accepted norm in life is that a child is parented within the home until adulthood and then independence is attained. Roles may well be reversed in later life in that the "child" may find responsibilities in caring for, and making decisions for, elderly parents. Few people can stop parenting when their offspring are fledged—even though it is at arms length and any advice may be ignored. Life with a child with a learning disability is unbalanced in this respect; as carers we do not lead lives considered to be normal because our children continue to be childlike for the rest of their, and our, lives. Some of us know that our sons and daughters do not have "apparently limitless potential... to develop skills and autonomy if only they are given the right help" (but try, as a parent or carer, saying that to a professional working in the field of learning disability!) and know that the best we can hope for is mature, rather than immature, dependence.No one tells parents of a learning disabled child—or any other, for that matter—what their responsibilities to that child are. Food, warmth, love, support, and so on are givens, but it takes a conscious effort to move a child toward adulthood when it involves changes in life, for example, moving away from the family home. The debate rages; is it letting go or getting rid of?We all delight in the pleasures our children experience in childhood; we know the magic has gone from the family Christmas once realisation dawns on the youngest child. If you consider that your son or daughter has been dealt a very poor hand in life, the temptation to prolong and promote that innocence is very tempting. It is much easier to prevaricate than to admit that life has its unpleasant sides; that failure and disappointment exist: my son was a great fan of Thomas the Tank engine videos until he was in his early teens, long after it was age appropriate. I passed them onto a younger child, having told him the videos were lost. The fall-out was spectacular [End Page 81] (but fortunately short lived!) and he eventually became very interested in Formula 1 motor racing. I had to push him to grow up.For all of us, the transition from childhood to adulthood is a process, not an event. Although I agree with the professionals that the child with a learning disability should be part of any discussions concerning his or her future, if that child does not have the intellectual capacity to make informed choices, someone else has to do it. That someone else is usually a parent, but is it a parent who is prepared to let go to help that person become an adult with his or her own life away from the family home, or is it a parent who has protected and coddled the child by promising they will never have to go?Lest you think I am a particularly hard, confrontational, and unfeeling mother, I would point out that I have almost 50 years of experience of living with learning disability in the immediate family; my son is 20 but my brother... (shrink)

It is well known that the medieval scholastics did not begin their philosophy systematically with an explicit theory of knowledge. Unfortunately many people have concluded from that fact that the very idea of an epistemology, and especially the idea of a critique of knowledge, was completely foreign to them. Within recent years authors such as Professor Van Steenberghen and Father Copleston have done a great deal to spread a correct understanding of St. Thomas’s views on this matter. Much evidence might (...) be adduced from the principal work of John Duns Scotus to show that he also took steps to justify man’s spontaneous conviction that some natural knowledge of truth with certainty can be attained. In this article we will consider some of these elements of Scotus’s philosophy as they are found in the volumes that have so far appeared in the critical edition of his works. (shrink)

Alan H. Goldman argues for the internalist or subjectivist view of practical reasons on the grounds that it is simpler, more unified, and more comprehensible ...

In a discussion of rule-following inspired by Wittgenstein, Kripke asks us to consider the relation which holds between meaning plus by ‘+’ and answering questions like, ‘What is the sum of 68 and 57?’. A dispositional theory has it that if you mean plus by ‘+’ then you will probably answer, ‘125’. That is because, according to such a theory, to mean plus by ‘+’is, roughly speaking, to be disposed, by and large, and among other things, to answer such questions (...) with the correct sum. Kripke wants to emphasize, by contrast, that if you mean plus by ‘+’ then, faced with the question, ‘What is 68 + 57?’ yououghtto answer, ‘125’. One could sum up the assumption about meaning which appears to underpin this criticism of dispositional theories in terms of the slogan that meaning is normative. Allan Gibbard gives us a way of reading that slogan which is suggested by Kripke's brief remarks:The crux of the slogan that meaning is normative … might be another slogan: thatmeansimpliesought. To use roughly Kripke's example, from statements saying what I mean by the plus sign and other arithmetic terms and constructions, it will follow that Ioughtto answer ‘7’ when asked ‘What's 5 + 2?’. (shrink)

Four important arguments for probabilism—the Dutch Book, representation theorem, calibration, and gradational accuracy arguments—have a strikingly similar structure. Each begins with a mathematical theorem, a conditional with an existentially quantified consequent, of the general form: if your credences are not probabilities, then there is a way in which your rationality is impugned. Each argument concludes that rationality requires your credences to be probabilities. I contend that each argument is invalid as formulated. In each case there is a mirror-image theorem and (...) a corresponding argument of exactly equal strength that concludes that rationality requires your credences not to be probabilities. Some further consideration is needed to break this symmetry in favour of probabilism. (shrink)

Explores language and mysticism, Buddhism and Zen, Christianity, comparative religion, psychedelics, and psychology and psychotherapy. Gold Winner for Philosophy, 2017 Foreword INDIES Book of the Year Awards To commemorate the 2015 centenary of the birth of Alan Watts (1915–1973), Peter J. Columbus and Donadrian L. Rice have assembled a much-needed collection of Watts’s scholarly essays and lectures. Compiled from professional journals, monographs, scholarly books, conferences, and symposia proceedings, the volume sheds valuable light on the developmental arc of Watts’s thinking (...) about language and mysticism, Buddhism and Zen, Christianity, comparative religion, psychedelics, and psychology and psychotherapy. This definitive collection challenges Watts’s reputation as a “popularizer” or “philosophical entertainer,” revealing his concerns to be much more expansive and transdisciplinary than is suggested by the parochial “Zen Buddhist” label commonly affixed to his writings. The editors’ authoritative introduction elucidates contemporary perspectives on Watts’s life and work, and supports a bold rethinking of his contributions to psychology, philosophy, and religion. Peter J. Columbus is Administrator of the Shantigar Foundation in Rowe, Massachusetts. Donadrian L. Rice is Professor of Psychology at the University of West Georgia. Together they are the coeditors of Alan Watts—Here and Now: Contributions to Psychology, Philosophy, and Religion, also published by SUNY Press. (shrink)

This paper lays out the basic structure of any view involving coincident entities, in the light of the grounding problem. While the account is not novel, I highlight fundamental features, to which attention is not usually properly drawn. With this in place, I argue for a number of further claims: The basic differences between coincident objects are modal differences, and any other differences between them need to be explained in terms of these differences. More specifically, the basic difference is not (...) a difference in sort. A number of recent defenses of coincidence, which share the basic structure I outline, misidentify what, in their accounts, plays the basic role of addressing the grounding problem. More tentatively, I argue Coincident entities differ only in these modal properties, and properties they entail. In particular, they do not differ in properties like ‘being a tree,’ ‘being a statue,’ or aesthetic properties, and finally in light of how the account of coincidence offered addresses the grounding problem, the grounding problem provides no reason to prefer monism to pluralism. (shrink)

Pragmatism established a philosophical presence over a century ago through the work of Charles Peirce, William James and John Dewey, and has enjoyed an unprecedented revival in recent years owing to the pioneering efforts of Richard Rorty and Hilary Putnam. The essays in this volume explore the history and themes of classic pragmatism, discuss the revival of pragmatism and show how it engages with a range of areas of inquiry including politics, law, education, aesthetics, religion and feminism. Together they provide (...) readers with an overview of the richness and vitality of pragmatist thinking and the influence that it continues to exert both in philosophy and other disciplines. The volume will be of interest to students and scholars of pragmatism, American philosophy and political theory. (shrink)

There has been an upsurge of interest in Rorty's contribution to philosophy in recent years, and his extensive influence is now widely acknowledged. Clear division of RR's work to give people a way in to the study of this wide-ranging philosopher. Five parts dealing with: (1) Rorty's early work (2) key texts (3) Rorty's unique pragmatist approach to key philosophical themes (4) reactions to, and appropriations of, Rorty's work, and (5) a selection of essays dealing with the practical application of (...) Rorty's work to a selection of issues in culture, ethics, and politics. The clear presentation of Rorty's diverse work makes the volume ideal for advanced undergraduate and postgraduate-level courses in philosophy (with strong potential interest from those studying Law, Literature, Feminism and Aesthetics, to name a few). (shrink)

When does a woman give valid consent to sexual relations? When does her consent render it morally or legally permissible for a man to have sexual relations with her? Why is sexual consent generally regarded as an issue about female consent? And what is the moral significance of consent? These are some of the questions discussed in this important book, which will appeal to a wide readership in philosophy, law, and the social sciences. Alan Wertheimer develops a theory of (...) consent to sexual relations that applies to both law and morality in the light of the psychology of sexual relations, the psychology of perpetrators, and the psychology of the victims. He considers a wide variety of difficult cases such as coercion, fraud, retardation, and intoxication. We can all agree that 'no' means 'no'. This book suggests that the difficult question is whether 'yes' means 'yes'. (shrink)

Abstract This paper examines the treatment of thick ethical concepts in Williams's work in order to evaluate the consistency of his treatment of ethical and epistemic concepts and to assess whether the idea of a thick concept can be extended from ethics to epistemology. A virtue epistemology is described modeled on a cognitivist virtue ethics. Williams's genealogy of the virtues surrounding propositional knowledge (the virtues of ?truthfulness?) is critically evaluated. It is concluded that this genealogy is an important contribution to (...) the project of virtue epistemology. Thick concepts must not only feature in the account but will sustain more of the marks of objectivity than their ethical counterparts. This is so even on Williams's demanding assumptions. (shrink)

Sport categorization is often justified by benefits such as increased fairness or inclusion. Taking inspiration from John Rawls, Sigmund Loland’s fair equality of opportunity principle in sport (FEOPs) is a tool for determining whether the existence of an inequality ethically justifies the institution of a new category in any given sport. It is an elegant ethical normative framework, but since FEOPs does not account explicitly for athlete safety (i.e. athlete physical and mental wellbeing), we are left in an ethically dubious (...) situation where the risk of harm associated with a categorization regime might in fact prove to be greater than the risk of harm present within the sport before its introduction. To address this critical gap, I propose the ‘scales of ignorance’ ethical normative framework to weigh the relative risk of harm within a sport, crucially inserting athlete safety into the discourse surrounding ethical justification for categorization in sport. The current paper is the first explicit formulation of assessment and ethical justification of risk of harm in the familiar logic of FEOPs. The scales of ignorance framework can also be used independently of Loland’s approach. Two new concepts are also proposed: ‘insidious risk of harm’ and ‘pernicious risk of harm’. (shrink)

The period following World War Two required a major reassessment of the very nature of political philosophy and political ideas and witnessed the emergence or reemerging of major concepts, such as political freedom, liberty and justice. In this clear and engaging introduction to recent political philosophy Alan Haworth explores the following topics: The philosophical nature of totalitarianism Hannah Arendt's explanation of totalitarianism in the context of Hitler and Stalin's regimes Karl Popper and the idea of the open society The (...) themes of authenticity, freedom and power in the work of Sartre and Foucault The Enlightenment and its relevance to liberalism in post-war political philosophy Rawls and the search for principles of justice Nozick's libertarianism and Sandel's communitarianism Persons, liberty and reason Global justice and the nation state Habermas and the continuation of the Enlightenment project. Haworth skillfully blends assessment of the ideas of important philosophers and political theorists with analysis of fundamental concepts in political philosophy such as freedom, justice and reason, making Political Philosophy After 1945 ideal reading for all students of political philosophy and political theory. (shrink)

Though less well known than his other work, Turings 1938 Princeton Thesis, this title which includes his notion of an oracle machine, has had a lasting influence on computer science and mathematics. It presents a facsimile of the original typescript of the thesis along with essays by Appel and Feferman that explain its still-unfolding significance.

Hegel and the Spirit explores the meaning of Hegel's grand philosophical category, the category of Geist, by way of what Alan Olson terms a pneumatological thesis. Hegel's philosophy of spirit, according to Olson, is a speculative pneumatology that completes what Adolf von Harnack once called the "orphan doctrine" in Christian theology--the doctrine of the Holy Spirit. Olson argues that Hegel's development of philosophy as pneumatology originates out of a deep appreciation of Luther's dialectical understanding of Spirit and that Hegel's (...) doctrine of Spirit is thus deeply interfused with the values of Würtemberg Pietism. Olson further maintains that Hegel's Enzyklopdie is the post-Enlightenment philosophical equivalent of a Trinitätslehre and that his Rechtsphilosophie is an ecclesiology. Thus Hegel and the Spirit demonstrates the truth of Karl Barth's observation that Hegel is the potential Aquinas of Protestantism. Exploring Hegel's philosophy of spirit in historical, cultural, and personal religious context, the book identifies Hegel's relationship with Hölderlin and his response to Hölderlin's madness as key elements in the philosopher's religious and philosophical development, especially with respect to the meaning of transcendence and dialectic. (shrink)

Part I. Philosophy of novels. 1. Introduction: philosophical content and literary value -- 2. Interpreting novels -- 3. The sun also rises: incompatible interpretations -- 4. The appeal of the mystery -- Part II. Philosophy in novels. 5. Moral development in Pride and prejudice -- 6. Huckleberry Finn and moral motivation -- 7. What we learn about rules from The cider house rules -- 8. Nostromo and the fragility of the self.

This chapter contains sections titled: From Liberalism to Republican Liberalism Cohen's Critique of Rawls A Liberal Republican Political Economy Liberal and Republican Approaches to Effective Political Agency The Republican Alternative Conclusion References.

Introduction : designing and turbulent Epicureans -- The proem to Book I : philosophy and the city -- The discovery of nature and the problem of the infinite and eternal -- Philosophic resignation : living beyond hope and fear -- O' mortal, o' fool, o' criminal, o' Memmius -- Gods of the philosophers and gods of the city -- Conclusion : the modern reversal.

Angela Ballantyne (2010) argues that international research is exploitative when the transactions between researchers and participants who lack basic goods do not provide participants with the maxi...

According to finite frequentism, the probability of an attribute A in a finite reference class B is the relative frequency of actual occurrences of A within B. I present fifteen arguments against this position.

This essay examines and compares two paradigms of technology, nature, and social life, and their associated environmental impacts. I explore moving from technocratic paradigms to the emerging ecological paradigms of planetary person ecosophies. The dominant technocratic philosophy's guiding policy and technological power is mechanistic. It conceptualizes nature as a resource to be controlled for human ends. Its global practices are drastically altering the integrity of the planet's ecosystems. In contrast, the organic, planetary person approaches respect the intrinsic values of all (...) beings. Deep ecology movement principles give priority to community and ecosystem integrity. These deep ecology movement principles guide the design and applications of technology by principles following from ecological understanding. I describe this shift in philosophical paradigms and how it affects our perceptions, values, and actions. (shrink)

The themes of the book—the value of knowledge and epistemic appraisal broadly conceived—are introduced in this chapter. The Meno problem is explained and related to the swamping problem as discussed by Jonathan Kvanvig. The stance of virtue epistemologists is outlined. This is followed by a brief discussion of the role of truth in epistemic appraisal. The remainder of the introduction summarises the contributions to the book.