29 found
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  1. Detecting awareness in the conscious state.Adrian M. Owen, Martin R. Coleman, Melanie Boly, Matthew H. Davis, Steven Laureys, Dietsje Jolles & John D. Pickard - 2006 - Science 313:1402.
  2.  84
    Brain function in coma, vegetative state, and related disorders.Steven Laureys, Adrian M. Owen & Nicholas D. Schiff - 2004 - Lancet Neurology 3:537-546.
  3.  44
    Assessing Decision-Making Capacity in the Behaviorally Nonresponsive Patient With Residual Covert Awareness.Andrew Peterson, Lorina Naci, Charles Weijer, Damian Cruse, Davinia Fernández-Espejo, Mackenzie Graham & Adrian M. Owen - 2013 - American Journal of Bioethics Neuroscience 4 (4):3-14.
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  4.  23
    Alive inside.Andrew Peterson, Adrian M. Owen & Jason Karlawish - 2019 - Bioethics 34 (3):295-305.
    This article provides an ethical analysis of the U.S. practice guideline update on disorders of consciousness. Our analysis focuses on the guideline’s recommendations regarding the use of investigational neuroimaging methods to assess brain‐injured patients. Complex and multifaceted ethical issues have emerged because these methods alter the clinical understanding of consciousness. We address issues of false hope, patient suffering, and cost. We argue that, in spite of these concerns, there is significant benefit to using neuroimaging to assess brain‐injured patients in most (...)
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  5.  37
    An Ethics of Welfare for Patients Diagnosed as Vegetative With Covert Awareness.Mackenzie Graham, Charles Weijer, Damian Cruse, Davinia Fernandez-Espejo, Teneille Gofton, Laura E. Gonzalez-Lara, Andrea Lazosky, Lorina Naci, Loretta Norton, Andrew Peterson, Kathy N. Speechley, Bryan Young & Adrian M. Owen - 2015 - American Journal of Bioethics Neuroscience 6 (2):31-41.
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  6.  69
    Response to comments on "detecting awareness in the vegetative state".Adrian M. Owen, Martin R. Coleman, Melanie Boly, Matthew H. Davis, Steven Laureys, Dietsje Jolles & John D. Pickard - 2007 - Science 315 (5816).
  7.  43
    Acknowledging awareness: informing families of individual research results for patients in the vegetative state.Mackenzie Graham, Charles Weijer, Andrew Peterson, Lorina Naci, Damian Cruse, Davinia Fernández-Espejo, Laura Gonzalez-Lara & Adrian M. Owen - 2015 - Journal of Medical Ethics 41 (7):534-538.
  8.  20
    A Principled Argument, But Not a Practical One.Andrew Peterson, Lorina Naci, Charles Weijer & Adrian M. Owen - 2013 - American Journal of Bioethics Neuroscience 4 (1):52-53.
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  9. Using functional magnetic resonance imaging to detect Covert awareness in the vegetative state.Adrian M. Owen, Martin R. Coleman, Melanie Boly, Matthew H. Davis, Steven Laureys & John D. Pickard - 2007 - Archives of Neurology 64 (8):1098-1102.
  10.  57
    Ethics of neuroimaging after serious brain injury.Charles Weijer, Andrew Peterson, Fiona Webster, Mackenzie Graham, Damian Cruse, Davinia Fernández-Espejo, Teneille Gofton, Laura E. Gonzalez-Lara, Andrea Lazosky, Lorina Naci, Loretta Norton, Kathy Speechley, Bryan Young & Adrian M. Owen - 2014 - BMC Medical Ethics 15 (1):41.
    Patient outcome after serious brain injury is highly variable. Following a period of coma, some patients recover while others progress into a vegetative state (unresponsive wakefulness syndrome) or minimally conscious state. In both cases, assessment is difficult and misdiagnosis may be as high as 43%. Recent advances in neuroimaging suggest a solution. Both functional magnetic resonance imaging and electroencephalography have been used to detect residual cognitive function in vegetative and minimally conscious patients. Neuroimaging may improve diagnosis and prognostication. These techniques (...)
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  11.  30
    Using a hierarchical approach to investigate residual auditory cognition in persistent vegetative state.Adrian M. Owen, Martin R. Coleman, D. K. Menon, E. L. Berry, I. S. Johnsrude, J. M. Rodd, Matthew H. Davis & John D. Pickard - 2006 - In Steven Laureys (ed.), Boundaries of Consciousness. Elsevier.
  12.  13
    Unlocking the Voices of Patients with Severe Brain Injury.Andrew Peterson, Kevin Mintz & Adrian M. Owen - 2022 - Neuroethics 15 (1):1-15.
    This paper critically examines whether patients with severe brain injury, who can only communicate through assistive neuroimaging technologies, may permissibly participate in medical decisions. We examine this issue in the context of a unique case study from the Brain and Mind Institute at the University of Western Ontario. First, we describe how the standard approach to medical decision making might problematically exclude patients with communication impairments secondary to severe brain injury. Second, we present a modified approach to medical decision making. (...)
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  13.  23
    Informed consent for functional MRI research on comatose patients following severe brain injury: balancing the social benefits of research against patient autonomy.Tommaso Bruni, Mackenzie Graham, Loretta Norton, Teneille Gofton, Adrian M. Owen & Charles Weijer - 2019 - Journal of Medical Ethics 45 (5):299-303.
    Functional MRI shows promise as a candidate prognostication method in acutely comatose patients following severe brain injury. However, further research is needed before this technique becomes appropriate for clinical practice. Drawing on a clinical case, we investigate the process of obtaining informed consent for this kind of research and identify four ethical issues. After describing each issue, we propose potential solutions which would make a patient’s participation in research compatible with her rights and interests. First, we defend the need for (...)
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  14.  39
    Toward a Science of Brain Death.Andrew Peterson, Loretta Norton, Lorina Naci, Adrian M. Owen & Charles Weijer - 2014 - American Journal of Bioethics 14 (8):29-31.
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  15.  25
    Ethical and Clinical Considerations at the Intersection of Functional Neuroimaging and Disorders of Consciousness.Adrian C. Byram, Grace Lee, Adrian M. Owen, Urs Ribary, A. Jon Stoessl, Andrea Townson & Judy Illes - 2016 - Cambridge Quarterly of Healthcare Ethics 25 (4):613-622.
    :Recent neuroimaging research on disorders of consciousness provides direct evidence of covert consciousness otherwise not detected clinically in a subset of severely brain-injured patients. These findings have motivated strategic development of binary communication paradigms, from which researchers interpret voluntary modulations in brain activity to glean information about patients’ residual cognitive functions and emotions. The discovery of such responsiveness raises ethical and legal issues concerning the exercise of autonomy and capacity for decisionmaking on matters such as healthcare, involvement in research, and (...)
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  16.  8
    Caregiver reactions to neuroimaging evidence of covert consciousness in patients with severe brain injury: a qualitative interview study.Charles Weijer, Adrian M. Owen, Sarah Munce, Laura Elizabeth Gonzalez-Lara, Fiona Webster & Andrew Peterson - 2021 - BMC Medical Ethics 22 (1):1-13.
    BackgroundSevere brain injury is a leading cause of death and disability. Diagnosis and prognostication are difficult, and errors occur often. Novel neuroimaging methods can improve diagnostic and prognostic accuracy, especially in patients with prolonged disorders of consciousness (PDoC). Yet it is currently unknown how family caregivers understand this information, raising ethical concerns that disclosure of neuroimaging results could result in therapeutic misconception or false hope.MethodsTo examine these ethical concerns, we conducted semi-structured interviews with caregivers of patients with PDoC who were (...)
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  17.  10
    A Novel Approach to Dream Content Analysis Reveals Links Between Learning-Related Dream Incorporation and Cognitive Abilities.Stuart M. Fogel, Laura B. Ray, Valya Sergeeva, Joseph De Koninck & Adrian M. Owen - 2018 - Frontiers in Psychology 9.
  18.  18
    The dissociation between command following and communication in disorders of consciousness: an fMRI study in healthy subjects.Natalie R. Osborne, Adrian M. Owen & Davinia Fernández-Espejo - 2015 - Frontiers in Human Neuroscience 9.
  19. Ethical considerations in functional magnetic resonance imaging research in acutely comatose patients.Charles Weijer, Tommaso Bruni, Teneille Gofton, G. Bryan Young, Loretta Norton, Andrew Peterson & Adrian M. Owen - 2015 - Brain:0-0.
    After severe brain injury, one of the key challenges for medical doctors is to determine the patient’s prognosis. Who will do well? Who will not do well? Physicians need to know this, and families need to do this too, to address choices regarding the continuation of life supporting therapies. However, current prognostication methods are insufficient to provide a reliable prognosis. -/- Functional Magnetic Resonance Imaging (MRI) holds considerable promise for improving the accuracy of prognosis in acute brain injury patients. Nonetheless, (...)
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  20.  8
    When thoughts become actions : neuroimaging in non-responsive patients.Adrian M. Owen - 2012 - In Sarah Richmond, Geraint Rees & Sarah J. L. Edwards (eds.), I Know What You're Thinking: Brain Imaging and Mental Privacy. Oxford University Press. pp. 73.
  21.  16
    Functional magnetic resonance imaging, Covert awareness, and brain iniury.Adrian M. Owen - 2011 - In Judy Illes & Barbara J. Sahakian (eds.), Oxford Handbook of Neuroethics. Oxford University Press. pp. 135.
    Rapid technological advances have produced a variety of novel techniques that allow a comprehensive assessment of brain function to be combined with detailed information about brain structure and connectivity. Any assessment that is based on exhibited behavior after brain injury will be prone to error for a number of reasons. These questions are explored in the context of recent studies in both healthy populations and brain injured patients that have sought to investigate covert awareness through the use of functional neuroimaging. (...)
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  22.  15
    Modulation of cognitive flexibility by hunger and desire.Richard M. Piech, Adam Hampshire, Adrian M. Owen & John A. Parkinson - 2009 - Cognition and Emotion 23 (3):528-540.
  23.  16
    Expert and crowd-sourced validation of an individualized sleep spindle detection method employing complex demodulation and individualized normalization.Laura B. Ray, Stéphane Sockeel, Melissa Soon, Arnaud Bore, Ayako Myhr, Bobby Stojanoski, Rhodri Cusack, Adrian M. Owen, Julien Doyon & Stuart M. Fogel - 2015 - Frontiers in Human Neuroscience 9.
  24.  7
    The Potential Role of fNIRS in Evaluating Levels of Consciousness.Androu Abdalmalak, Daniel Milej, Loretta Norton, Derek B. Debicki, Adrian M. Owen & Keith St Lawrence - 2021 - Frontiers in Human Neuroscience 15.
    Over the last few decades, neuroimaging techniques have transformed our understanding of the brain and the effect of neurological conditions on brain function. More recently, light-based modalities such as functional near-infrared spectroscopy have gained popularity as tools to study brain function at the bedside. A recent application is to assess residual awareness in patients with disorders of consciousness, as some patients retain awareness albeit lacking all behavioural response to commands. Functional near-infrared spectroscopy can play a vital role in identifying these (...)
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  25.  7
    Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness.Carlo Cavaliere, Marco Aiello, Carol Di Perri, Davinia Fernandez-Espejo, Adrian M. Owen & Andrea Soddu - 2014 - Frontiers in Human Neuroscience 8.
  26.  2
    Protocol for the Prognostication of Consciousness Recovery Following a Brain Injury.Catherine Duclos, Loretta Norton, Geoffrey Laforge, Allison Frantz, Charlotte Maschke, Mohamed Badawy, Justin Letourneau, Marat Slessarev, Teneille Gofton, Derek Debicki, Adrian M. Owen & Stefanie Blain-Moraes - 2020 - Frontiers in Human Neuroscience 14.
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  27.  4
    While you were sleeping: Evidence for high-level executive processing of an auditory narrative during sleep.Stuart Fogel, Laura Ray, Zhuo Fang, Max Silverbrook, Lorina Naci & Adrian M. Owen - 2022 - Consciousness and Cognition 100:103306.
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  28.  2
    UPDATE-Comment-Response: Cortical function in the persistent vegetative state.D. Menon, Adrian M. Owen & John D. Pickard - 1999 - Trends in Cognitive Sciences 3 (2):44-45.
  29.  13
    The role of executive processes in working memory deficits in Parkinson’s Disease.Adrian M. Owen, Edward Necka, Roger R. Barker, Daniel Bor & Aleksandra Gruszka - 2016 - Polish Psychological Bulletin 47 (1):123-130.
    Idiopathic Parkinson’s disease impairs working memory, but the exact nature of this deficit in terms of the underlying cognitive mechanisms is not well understood. In this study patients with mild clinical symptoms of PD were compared with matched healthy control subjects on a computerized battery of tests designed to assess spatial working memory and verbal working memory. In the spatial working memory task, subjects were required to recall a sequence of four locations. The verbal working memory task was methodologically identical (...)
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