Manipulationism holds that information about the results of interventions is of utmost importance for scientific practices such as causal assessment or explanation. Specifically, manipulation provides information about the stability, or invariance, of the relationship between X and Y: were we to wiggle the cause X, the effect Y would accordingly wiggle and, additionally, the relation between the two will not be disrupted. This sort of relationship between variables are called 'invariant empirical generalisations'. The paper focuses on questions about causal assessment (...) and analyses the status of manipulation. It is argued that manipulationism is trapped in a dilemma. If manipulationism is read as providing a conceptual analysis of causation, then it fails to provide a story about the methods for causal assessment. If, instead, manipulationism is read as providing a method for causal assessment, then it is at an impasse concerning causal assessment in areas where manipulations are not performed. Empirical generalisations are then reassessed, in such a way that manipulation is not taken as methodologically fundamental. The paper concludes that manipulation is the appropriate tool for some scientific contexts, but not for all. (shrink)

Questo libro suggerisce d'inserire il nome di Arthur Schopenhauer nella tradizione della filosofia come stile di vita. Sulla scia dei pioneristici lavori di Paul Rabbow, Michel Foucault e soprattutto Pierre Hadot, si argomenta come anche nei libri di Schopenhauer questa tradizione sia viva. In particolare, è negli "Aforismi sulla saggezza della vita", contenuti nei "Parerga e paralipomena", che è possibile trovare traccia di quelle pratiche che Hadot ha proposto di chiamare esercizi spirituali. Ciò che ne emerge è un "altro" Schopenhauer. (...) Non più, non tanto, non solo il grande campione del pessimismo, il negatore della volontà di vita, il filosofo del dolore e della noia. Ma un prezioso suggeritore su come sia possibile vivere una vita se non proprio più felice, certamente il meno infelice possibile. (shrink)

Ethical concerns about randomising persons to a no-treatment arm in the context of Ebola epidemic led to consideration of alternative designs. The stepped wedge design, in which participants or clusters are randomised to receive an intervention at different time points, gained popularity. Common arguments in favour of using this design are when an intervention is likely to do more good than harm, all participants should receive the experimental intervention at some time point during the study and the design might be (...) preferable for practical reasons. We examine these assumptions when considering Ebola vaccine research. First, based on the claim that a stepped wedge design is indicated when it is likely that the intervention will do more good than harm, we reviewed published and ongoing SW trials to explore previous use of this design to test experimental drugs or vaccines, and found that SW design has never been used for trials of experimental drugs or vaccines. Given that Ebola vaccines were all experimental with no prior efficacy data, the use of a stepped wedge design would have been unprecedented. Second, we show that it is rarely true that all participants receive the intervention in SW studies, but rather, depending on certain design features, all clusters receive the intervention. Third, we explore whether the SW design is appealing for feasibility reasons and point out that there is significant complexity. In the setting of the Ebola epidemic, spatiotemporal variation may have posed problematic challenges to a stepped wedge design for vaccine research. Finally, we propose a set of points to consider for scientific reviewers and ethics committees regarding proposals for SW designs. (shrink)

C’è prima la persona o prima la società? Per non cadere in una risposta dualistica, bisogna risalire alle radici antropologiche della vita sociale, che stanno alla base delle diverse forme che essa storicamente può assumere. Questo saggio esamina il rapporto tra le tendenze socializzanti innate e le virtù relazionali, alla luce di un’antropologia integrale, nella quale la persona umana è considerata nella sua globalità somatico-psichico-spirituale. Vengono qui esaminati il tessuto di legami in cui è inserita la nostra esistenza e la (...) responsabilità che compete a ognuno nei confronti del cosiddetto capitale sociale. (shrink)

Julián Marías (1914-2005) è un pensatore ancora poco conosciuto al lettore italiano, spesso oscurato dall’ombra del suo celebre maestro, José Ortega y Gasset. Filosofo indipendente e coraggioso, offre una proposta più coerente rispetto a Ortega sul tema essenziale comune a entrambi: il poter “dare ragione” della vita evitando gli opposti scogli del razionalismo e del vitalismo. “Dare ragione” della vita significa comprenderla nella sua “condizione morale” che trova espressione nel desiderio di felicità, nell’esigenza di amore e di amicizia, nei differenti (...) vissuti di ciascuna età. Significa riconoscerne la dimensione elettiva: vivere è preferire, saper fornire ragioni per l’opzione di qualcosa rispetto a qualcos’altro. Per questo motivo, più che alla categoria del bene, l’attenzione è rivolta a quella del meglio, fondamentale per comprendere il senso pieno delle proprie scelte e dell’intera trama della propria biografia. (shrink)

Causal analysis in the social sciences takes advantage of a variety of methods and of a multi-fold source of information and evidence. This pluralistic methodology and source of information raises the question of whether we should accordingly have a pluralistic metaphysics and epistemology. This paper focuses on epistemology and argues that a pluralistic methodology and evidence don’t entail a pluralistic epistemology. It will be shown that causal models employ a single rationale of testing, based on the notion of variation. Further, (...) I shall argue that this monistic epistemology is also involved in alternative philosophical theories of causation. (shrink)

A partir da implantação da República, surgiu um movimento de intelectuais que procurou congregar e dinamizar num esforço comum os pensadores de várias áreas do conhecimento, através da revista A Águia, tendo em vista uma nova ordem moral e cívica dentro do ideal democrático. Procurámos dar a conhecer as linhas principais que consubstanciaram o espaço aberto pela revista, as influências recebidas e os debates que a animaram.

Medical practitioners have always been expected to abide by certain standards of conduct and uphold certain values, more or less throughout the world. In this book, besides discussing specific ethical issues, the author ponders questions such as the right to life and the integrity of the human person. Ethics in medicine takes account of the principles that underlie the best decisions, particularly in unusual circumstances – such as a pandemic. Many of these are enshrouded in the oaths most doctors take (...) – the Hippocratic Oath is perhaps the best known, and has influenced numerous others over the centuries. However, these principles and the resulting conduct have taken different directions at various moments in history and in different parts of the globe, though always primarily oriented to the protection of human health. The author compares some interesting similarities and differences, tracing the main social, legal and religious attitudes, in what has come to be known as "medical ethics", with all its benefits to Mankind. Alongside basic human dignity, four main values have been pivotal in medical ethics: Caring for sick people, putting their well-being at the center of concern, and doing good. Not causing harm: never making a patient take risks, and never prescribing a doubtful treatment. Fairness: treating all patients in accordance with their health needs, never favoring or neglecting anyone on the basis of background, occupation, etc. Self-determination: the patient can be informed about treatments and, when possible, should approve the prescriptions. The doctor must show empathy, respect for confidentiality, and responsibility. Briefly, this overview of the medical profession’s ethics focuses on experience, principles, aims, virtues and above all the basic rules which in various places through the centuries have governed the tortuous paths of Mankind. Written by an acclaimed expert in the field, this book is of value for all those working in healthcare, and people interested in its ethics. (shrink)

This book offers an up-to-date insight into the early philosophical debate on Einsteinian relativity. The essays explore the reception and interpretation of Einstein’s ideas by some of the most important philosophical schools of the time, such as logical positivism (Reichenbach), neo-Kantianism (Cassirer, Natorp), critical realism (Sellars), and radical empiricism (Mach). The book is aimed at physicists and historians of science researching the epistemological implications of the theory of relativity, as well as to scholars in philosophy interested in understanding how leading (...) philosophical figures of the early twentieth century reacted to the relativistic revolution. (shrink)

The book is devoted to the study of the sign-object relation in the semiotics of Charles Peirce. It puts this issue in the context of Peirce's philosophy of knowledge and of reality and individuates the final causality as the foundation of the semiotic relation, which gains its gnoseological reliableness from its underlying teleological tendencies.

In this article, I intend to propose an ethical model for digital solidarity. On the one hand, it emphasises the importance of adopting a solidarity model to escape the logic of surveillance capitalism and the race for profits typical of the digital giants’ business model. On the other, it is intended to point out that a model of solidarity embodied in the digital network may instead offer a more universalistic alternative to the types of solidarity that have often imposed themselves (...) in our contemporary political landscape, namely solidarity limited to groups in opposition to others. In order to show what economic and political characteristics this model should respect, two case studies will be examined, namely Wikipedia and Occupy Wall Street. (shrink)

The nature of the relationship between the two types of meiotic recombination outcomes, exchange (crossing‐over) and simple gene conversion, has been debated for years. I here propose that these two types of events are not necessarily causally related and hypothesize that the primary role of events detected as simple gene conversion is in the recognition of homology during synapsis.

The burden of proof (BOP) fallacy is an informal fallacy involving the failure to recognize or properly assign the BOP in a persuasive reasoned dialogue, that is, an interchange between two or more parties whose aim is to prove or defend a position and, in doing so, persuade the other side of its truth or plausibility. In some such dialogues, the amount or strength of evidence required in order to accomplish this goal reasonably may differ for one of the parties (...) involved. The BOP fallacy can occur in two ways. The first is when one side of the dialogue fails to recognize that its opponent incurs the BOP. The second way the BOP fallacy can occur is when one side of the dialogue assigns the BOP incorrectly. There are still some factors that play a role in determining which side of a dialogue incurs the BOP and this chapter discusses these factors. (shrink)

Sentido ontológico de la paz. -- Sé lo que eres. -- Univresidad, humanidades, humanismo. -- Luces de Heráclito el oscuro. -- Bergson : psicología, moral, religión. -- Tolstoi, un hombre humanizado. -- Porras : el hombre venicó al ministro.

"Results presented in two international seminars held in Palermo and Milan in 2012"--Page 1.

Recently, an increasing number of researchers in different parts of the world have been studying childhood from a point of view that highlights children who are considered “peripheral” – far from the ideal model associated with Western countries. We began with the intention of getting to know African children in Angola, informed by the belief that the preservation of languages is important in maintaining social knowledge and traditions. This text describes a preliminary study carried out in a culturally rich location (...) with strong traditions, but which is also marked by processes of cultural denial and devaluation. According to Ndombele and Timbane (2020), most Angolan children learn Portuguese at age seven, when they start school, especially in rural areas. This fact hinders the literacy learning process, and presents the risk of the disappearance of some native languages. Many schools teach children only in Portuguese. When visiting a school in Ganda, a rural area of Benguela, we found a group of children who, primarily through the games they played, keep the Umbundu language alive, and with that the identity and culture of their ancestors. Building on this, these children and their teachers created a syllable association game based on the music sung as they played. The game had two modalities - in the Umbundu language and in the Portuguese language – and functioned as a bilingual pedagogical tool. In the initial moment of offering the game for testing with the children, it was discovered that by singing the song of the game and discussing the possible solutions by themselves, they were able to make correct associations of the syllables in Umbundu, which they then translated into Portuguese. Thus, a resource was created together with the teachers, which, in addition to valuing the native language of the population, allowed the use of children's knowledge to create a didactic resource. In addition, it was possible to encounter the concept of childhood in the current world, deconstructing the idea of a single and ideal model, especially in light of those children who bring habits from home that do not always harmonize with the school routine, and often clash with Euro/Western model, which is based on age separation of classes as a requirement to guarantee learning, and tend to devalue other exchanges that help children learn. (shrink)

THEODOR GOMPERZ AND JOHN STUART MILL The subject of this essay is the little known episode of an unusual friendship. To the writer its fascination lies as ...

The processing of sensitive information in the health field is subject to rigorous standards that guarantee the protection of information confidentiality. Recently, the Italian Data Protection Authority (Garante per la Protezione dei Dati Personali) stated their formal opinion on a standard procedure in dental offices involving the submission of a questionnaire that includes the patient's health status. HIV infection status is included on the form. The Authority has stated that all health data collection must be in accordance with the current (...) Italian normative framework for personal data protection and respect the patient's freedom. This freedom allows the patient to decide, in a conscious and responsible way, whether to share health information with health personnel without experiencing any prejudice in the provision of healthcare requested. Moreover, data collection must be relevant and cannot exceed the principles of treatment goals with reference to the specific care of the concerned person. However, the need for recording information regarding HIV infection at the first appointment, regardless of the clinical intervention or therapeutic plan that needs to be conducted, should not alter the standard protection measures of the healthcare staff. In fact, these measures are adopted for every patient. (shrink)