The use of transcranial Electrical Stimulation in the modulation of cognitive brain functions to improve neuropsychiatric conditions has extensively increased over the decades. tES techniques have also raised new challenges associated with study design, stimulation protocol, functional specificity, and dose-response relationship. In this paper, we addressed challenges through the emerging methodology to investigate the dose-response relationship of High Definition-transcranial Direct Current Stimulation, identifying the role of negative valence in tinnitus perception. In light of the neurofunctional testable framework and tES application, (...) hypotheses were formulated to measure clinical and surrogate endpoints. We posited that conscious pairing adequately pleasant stimuli with tinnitus perception results in correction of the loudness misperception and would be reinforced by concurrent active HD-tDCS on the left Dorsolateral Prefrontal Cortex. The dose-response relationship between HD-tDCS specificity and the loudness perception is also modeled. We conducted a double-blind, randomized crossover pilot study with six recruited tinnitus patients. Accrued data was utilized to design a well-controlled adaptive seamless Bayesian dose-response study. The sample size and optimum interims were anticipated for adaptive decision-making about efficacy, safety, and single session dose parameters. Furthermore, preliminary pilot study results were sufficient to show a significant difference within the longitudinally detected self-report tinnitus loudness between before and under positive emotion induction. This study demonstrated a research methodology used to improve emotion regulation in tinnitus patients. In the projected method, positive emotion induction is essential for promoting functional targeting under HD-tDCS anatomical specificity to indicate the efficacy and facilitate the dose-finding process. The continuous updating of prior knowledge about efficacy and dose during the exploratory stage adapts the anticipated dose-response model. Consequently, the effective dose range to make superiority neuromodulation in correcting loudness misperception of tinnitus will be redefined. Highly effective dose adapts the study to a standard randomized trial and transforms it into the confirmatory stage in which active HD-tDCS protocol is compared with a sham trial. Establishing the HD-tDCS intervention protocols relying on this novel method provides reliable evidence for regulatory agencies to approve or reject the efficacy and safety. Furthermore, this paper supports a technical report for designing multimodality data-driven complementary investigations in emotion regulation, including EEG-driven neuro markers, Stroop-driven attention biases, and neuroimaging-driven brain network dynamics. (shrink)

I provide a critical commentary regarding the attitude of the logician and the philosopher towards the physicist and physics. The commentary is intended to showcase how a general change in attitude towards making scientific inquiries can be beneficial for science as a whole. However, such a change can come at the cost of looking beyond the categories of the disciplines of logic, philosophy and physics. It is through self-inquiry that such a change is possible, along with the realization of the (...) essence of the middle that is otherwise excluded by choice. The logician, who generally holds a reverential attitude towards the physicist, can then actively contribute to the betterment of physics by improving the language through which the physicist expresses his experience. The philosopher, who otherwise chooses to follow the advancement of physics and gets stuck in the trap of sophistication of language, can then be of guidance to the physicist on intellectual grounds by having the physicist’s experience himself. In course of this commentary, I provide a glimpse of how a truthful conversion of verbal statements to physico-mathematical expressions unravels the hitherto unrealized connection between Heisenberg uncertainty relation and Cauchy’s definition of derivative that is used in physics. The commentary can be an essential reading if the reader is willing to look beyond the categories of logic, philosophy and physics by being ‘nobody’. (shrink)

Physical dimensions like “mass”, “length”, “charge”, represented by the symbols [M], [L], [Q], are not numbers, but used as numbers to perform dimensional analysis in particular, and to write the equations of physics in general, by the physicist. The law of excluded middle falls short of explaining the contradictory meanings of the same symbols. The statements like “m tends to 0”, “r tends to 0”, “q tends to 0”, used by the physicist, are inconsistent on dimensional grounds because “m”, “r”, (...) “q” represent quantities with physical dimensions of [M], [L], [Q] respectively and “0” represents just a number—devoid of physical dimension. Consequently, due to the involvement of the statement “q tends to 0'', where q is the test charge” in the definition of electric field leads to either circular reasoning or a contradiction regarding the experimental verification of the smallest charge in the Millikan–Fletcher oil drop experiment. Considering such issues as problematic, by choice, I make an inquiry regarding the basic language in terms of which physics is written, with an aim of exploring how truthfully the verbal statements can be converted to the corresponding physico-mathematical expressions, where “physico-mathematical” signifies the involvement of physical dimensions. Such investigation necessitates an explanation by demonstration of “self inquiry”, “middle way”, “dependent origination”, “emptiness/relational existence”, which are certain terms that signify the basic tenets of Buddhism. In light of such demonstration I explain my view of “definition”; the relations among quantity, physical dimension and number; meaninglessness of “zero quantity” and the associated logico-linguistic fallacy; difference between unit and unity. Considering the importance of the notion of electric field in physics, I present a critical analysis of the definitions of electric field due to Maxwell and Jackson, along with the physico-mathematical conversions of the verbal statements. The analysis of Jackson’s definition points towards an expression of the electric field as an infinite series due to the associated “limiting process” of the test charge. However, it brings out the necessity of a postulate regarding the existence of charges, which nevertheless follows from the definition of quantity. Consequently, I explain the notion of undecidable charges that act as the middle way to resolve the contradiction regarding the Millikan–Fletcher oil drop experiment. In passing, I provide a logico-linguistic analysis, in physico-mathematical terms, of two verbal statements of Maxwell in relation to his definition of electric field, which suggests Maxwell’s conception of dependent origination of distance and charge ) and that of emptiness in the context of relative vacuum. This work is an appeal for the dissociation of the categorical disciplines of logic and physics and on the large, a fruitful merger of Eastern philosophy and Western science. Nevertheless, it remains open to how the reader relates to this work, which is the essence of emptiness. (shrink)

The capacity to generate recursive sequences is a marker of rich, algorithmic cognition, and perhaps unique to humans. Yet, the precise processes driving recursive sequence generation remain mysterious. We investigated three potential cognitive mechanisms underlying recursive pattern processing: hierarchical reasoning, ordinal reasoning, and associative chaining. We developed a Bayesian mixture model to quantify the extent to which these three cognitive mechanisms contribute to adult humans’ performance in a sequence generation task. We further tested whether recursive rule discovery depends upon relational (...) information, either perceptual or semantic. We found that the presence of relational information facilitates hierarchical reasoning and drives the generation of recursive sequences across novel depths of center embedding. In the absence of relational information, the use of ordinal reasoning predominates. Our results suggest that hierarchical reasoning is an important cognitive mechanism underlying recursive pattern processing and can be deployed across embedding depths and relational domains. (shrink)

Epistemologies and research methods are not free of metaphysics. This is to say that they are both, supported by (or presumed by), and support (or presume) fundamental ontologies. A discussion of the epistemological foundations of "multimethod" research in the social sciences—in as much as such research claims to unearth "causal" relations—therefore cannot avoid the ontological presuppositions or implications of such a discussion. But though there isn’t necessarily a perfect correspondence between ontology, epistemology, and methodology, they do constrain each other. As (...) such it is possible to make methodological choices that are at odds with one’s (implicit) ontology or argue from an ontology that is inconsistent one’s choice of methods.Yet lack of recognition of this fact has hampered methodological discussions in political science, especially with respect to the discussion on the merits of multimethod research. The ontology implicitly accepted in such discussions is "reductionist" and "regularist," that is, one that respectively defines causes in terms of noncausal relations and states of affair and affirms that such noncausal relations are regularities in nature. This article will argue that any attempt to fit "multimethod" research (where "multimethod" signifies some combination of inferential statistics and case studies) within this narrow ontology is destined to fail since such a metaphysics logically cannot accord case studies a necessary or sufficient role in the in the establishment of causal relations. However, there are metaphysical positions within the ambit of an empiricist philosophy of science that can accommodate multiple methods without contradiction. The article discusses two such ontologies and suggests ways in which they might allow the establishment of a coherent epistemological foundation for multimethod research, however, within a decidedly empiricist philosophy of science. (shrink)

Articles chiefly on the Bratachāri Movement, founded and popularised by Gurusadaẏa Datta, 1882-1941; includes articles on nationalism with special reference to Bengal, India.

1. Premadharma o Rāsalīlā.-- 2. Bedānta o bijñāna ebaṃ Jagadgurura ābirbhāba.-- 3. Upanishad-brahmatattva ebaṃ yājñabalkyera advaitabāda.-- 4. Upanishad-jaṛa o jībatattva.-- 5. Karmabāda o janmāntara, abatāratattva ebaṃ prakr̥ta yoga ki? -- v. 6. Sāṃkhya paricaẏa, Buddhadebera 'nāstikatā' ebaṃ buddhi o bodhi. -- v. 7. Gītāẏa Īśvarabāda, Raṅgamatī, ebaṃ Meghadūta (mūla o padyānubāda).

Hierarchical cognitive mechanisms underlie sophisticated behaviors, including language, music, mathematics, tool-use, and theory of mind. The origins of hierarchical logical reasoning have long been, and continue to be, an important puzzle for cognitive science. Prior approaches to hierarchical logical reasoning have often failed to distinguish between observable hierarchical behavior and unobservable hierarchical cognitive mechanisms. Furthermore, past research has been largely methodologically restricted to passive recognition tasks as compared to active generation tasks that are stronger tests of hierarchical rules. We argue (...) that it is necessary to implement learning studies in humans, non-human species, and machines that are analyzed with formal models comparing the contribution of different cognitive mechanisms implicated in the generation of hierarchical behavior. These studies are critical to advance theories in the domains of recursion, rule-learning, symbolic reasoning, and the potentially uniquely human cognitive origins of hierarchical logical reasoning. (shrink)

Dennett (_Synthese,_ _53_(2), 159–180, 1982, 1991, _Journal of Consciousness Studies,_ _10_(9–10), 19–30, 2003, _Phenomenology and the Cognitive Sciences,_ _6_, 247–270, 2007 ) proposes and defends a method called _heterophenomenology_. Heterophenomenology is a method to study consciousness _from a third-person objective point of view_ as opposed to a first-person subjective point of view or (auto)-phenomenology. The method of heterophenomenology serves a necessary role in Dennett’s schema of bridging the gap between the manifest and the scientific image of the world. In this (...) paper, I attempt to present a limited critique of the method of heterophenomenology. The objection raised in this paper is limited to one of the steps involved in the method, i.e., the interpretation of the heterophenomenological text as analogous to novelist fiction. I attempt to show that the assumptions made by Dennett about the interpretation of fiction are contradictory in nature and therefore the same cannot be applied to the interpretation of a heterophenomenological text. The assumptions fail in justifying the interpretation of fiction itself and hence exporting them by analogy to interpret a heterophenomenological text is a mistake. (shrink)

Recent advances in genomic and imaging techniques have revealed the complex manner of organizing billions of base pairs of DNA necessary for maintaining their functionality and ensuring the proper expression of genetic information. The SMC proteins and cohesin complex primarily contribute to forming higher‐order chromatin structures, such as chromosomal territories, compartments, topologically associating domains (TADs) and chromatin loops anchored by CCCTC‐binding factor (CTCF) protein or other genome organizers. Cohesin plays a fundamental role in chromatin organization, gene expression and regulation. This (...) review aims to describe the current understanding of the dynamic nature of the cohesin‐DNA complex and its dependence on cohesin for genome maintenance. We discuss the current 3C technique and numerous bioinformatics pipelines used to comprehend structural genomics and epigenetics focusing on the analysis of Cohesin‐centred interactions. We also incorporate our present comprehension of Loop Extrusion (LE) and insights from stochastic modelling. (shrink)

Observational discrepancies in galactic rotation curves and cluster dispersion data have been interpreted to imply the existence of dark matter. Numerous efforts at its detection, however, have failed to turn up any positive result. As a dynamical theory is always operative on the assumed mass distribution to predict kinematic observations, some scientists see the discrepancy as telling against General Relativity. Among the many theories that seek to modify gravity, those that are built on Modified Newtonian Dynamics (MOND), or yield MOND (...) behaviour at appropriate scales, achieve remarkable empirical success without assuming dark matter. The continued non-detection of dark matter and the empirical success of MOND supports the claim that the current evidential and theoretical context underdetermines General Relativity. In this article, I clarify the kind of underdetermination that can be said to threaten General Relativity. Specifically, I argue that the present evidential and theoretical context increase the possibility of an unconceived alternative to GR which would be just as well supported by the available evidence. (shrink)

There has been in recent decades very substantial work done on the concept of a nation, nationality and nationalism. In spite of the world coming together on many fronts—particularly, economy and a multicultural habitat formations especially in Europe and North America—these ideas remain politically volatile. In modern times, the idea of a nation has become powerfully associated with the idea of the state and the two notions are frequently used almost interchangeably. If among the emotional ties that form the basis (...) of the idea of a nation, we add a strong sense of belonging to a specific culture with its own history, traditions and the sharing of ethical and aesthetic values—it may quite naturally lead to the idea of one-nation, one-state and one culture. Such indeed has been a trend in the European concept of the idea of a nation of the 18th, 19th and partly of the twentieth century. However, same cannot be said about Indian nation. If we closely look at the growth of Indian nationalism in the backdrop of anti-colonial movement and formation of Indian state after gaining independence, we find lack of unanimity among thinkers. This paper explores the growth of Indian Nationalism and formation of Indian Nation through the eyes of one of the most seminal contemporary Indian thinkers Sri Aurobindo. (shrink)

The relationship between ethical ideology and job stress appears to be complex. This study is based on a model presented by Forsyth (Journal of Personality and Social Psychology 39:175, 1980), showing two dimensions (idealism and relativism) that play an important role in ethical evaluation and behavior. Based on a survey of 561 employees of hotel industry in India, ethical ideologies were found to be negatively associated with job stress. The data were analyzed using Pearson correlations and multiple regressions. The result (...) showed that relativism is negatively correlated with job stress. Further, it has been established that idealism and relativism interacted in such a way that there is a negative relationship between idealism and job stress when relativism is low and positive relationship when relativism is high. The findings imply that ethical ideology adversely influences the job stress in the organization. (shrink)

Transcript of speeches by a Hindu philosopher, chiefly on Hindu philosophy and Hinduism.

Durán et al argue in ‘Who is afraid of black box algorithms? On the epistemological and ethical basis of trust in medical AI’1 that traditionally proposed solutions to make black box machine learning models in medicine less opaque and more transparent are, though necessary, ultimately not sufficient to establish their overall trustworthiness. This is because transparency procedures currently employed, such as the use of an interpretable predictor,2 cannot fully overcome the opacity of such models. Computational reliabilism, an alternate approach to (...) adjudicating trustworthiness that goes beyond transparency solutions, is argued to be a more promising approach. CR can bring the benefits of traditional process reliabilism in epistemology to bear on this problem of model trustworthiness. Durán et al ’s explicitly reliabilist epistemology to assess the trustworthiness of black box models is a timely addition to current transparency-focused approaches in the literature. Their delineation of the epistemic from the ethical also serves the debate by clarifying the nature of the different problems. However, their overall account underestimates the epistemic value of certain transparency-enabling approaches by conflating different types of opacity and also oversimplifies transparency-advocating arguments in the literature. First, it is unclear why Durán et al consider transparency approaches as insufficient to overcome epistemic opacity, if heiraccount of opacity is the traditional one from the machine learning literature: opacity stemming from the mismatch between mathematical optimisation in high dimensionality that is characteristic of machine learning and the demands of human-scale reasoning and styles of semantic interpretation.3 …. (shrink)

Einsteinian gravity, of which Newtonian gravity is a part, is fraught with the problem of singularity that has been established as a theorem by Hawking and Penrose. The _hypothesis_ that founds the basis of both Einsteinian and Newtonian theories of gravity is that bodies with unequal magnitudes of masses fall with the same acceleration under the gravity of a source object. Since, the Einstein’s equations is one of the assumptions that underlies the proof of the singularity theorem, therefore, the above (...) hypothesis is implicitly one of the founding pillars of the same. In this work, I demonstrate how one can possibly write a non-singular theory of gravity which manifests that the above mentioned hypothesis is only valid in an approximate sense in the “large distance” scenario. To mention a specific instance, under the gravity of the earth, a 5 kg and a 500 kg fall with accelerations which differ by approximately \(113.148\times 10^{-32}\) meter/sec \(^2\) and the more massive object falls with less acceleration. Further, I demonstrate why the concept of gravitational field is not definable in the “small distance” regime which automatically justifies why the Einstein’s and Newton’s theories fail to provide any “small distance” analysis. In course of writing down this theory, I demonstrate why the continuum hypothesis as spelled out by Goedel, is undecidable. The theory has several aspects which provide the following realizations: (i) Descartes’ self-skepticism concerning exact representation of numbers by drawing lines (ii) Born’s wish of taking into account “natural uncertainty in all observations” while describing “a physical situation” by means of “real numbers” (iii) Klein’s vision of having “a fusion of arithmetic and geometry” where “a point is replaced by a small spot” (iv) Goedel’s assertion about “non-standard analysis, in some version” being “the analysis of the future”. (shrink)

The governments of China, India, and the United Kingdom are unanimous in their belief that bioinformatics should supply the link between basic life sciences research and its translation into health benefits for the population and the economy. Yet at the same time, as ambitious states vying for position in the future global bioeconomy they differ considerably in the strategies adopted in pursuit of this goal. At the heart of these differences lies the interaction between epistemic change within the scientific community (...) itself and the apparatus of the state. Drawing on desk-based research and thirty-two interviews with scientists and policy makers in the three countries, this article analyzes the politics that shape this interaction. From this analysis emerges an understanding of the variable capacities of different kinds of states and political systems to work with science in harnessing the potential of new epistemic territories in global life sciences innovation. (shrink)

SummaryExamining waiting time to birth among newlywed couples is likely to provide insights into the desire for spacing births among newlywed husbands and wives. Data from the Indian National Family Health Survey of 2005–06 are used to examine the desired waiting time to birth among newlywed couples. The dependent variable is spousal concordance on desired waiting times. Overall 65% of couples have concordant desired waiting times. Among discordant couples, wives were more likely to want to wait longer than their husbands. (...) Couples from richer wealth quintiles were more likely than couples from the poorest quintile to have concordant desired waiting times. Muslims were less likely than Hindus to have concordant desires. There is a need for spacing contraceptive methods among newlyweds in India. This may have implications for the Indian Family Planning Programme, which to date has largely focused on sterilization. Programmes need to include newlywed husbands to promote use of spacing methods. (shrink)

In response to Morningstar’s release of carbon risk (CR) scores in May 2018, (environmentally) sustainable mutual funds in the U.S. showed a greater reduction in their portfolio CR relative to conventional funds. The observed causal impact of this third-party disclosure is consistent with the funds’ primary investment objectives. Differences in fund names, potentially driven by marketing considerations, appear irrelevant to the behavior of sustainable funds. Conventional funds that are signatories to the UN’s Principles for Responsible Investment (PRI) or those with (...) secondary sustainability mandates behave more like other conventional funds rather than sustainable funds. These funds appear relatively insensitive to disclosures as their sustainability considerations are superseded by other primary investment criteria. Fiduciary and legal bonding influences fund managers’ response to sustainability disclosures. Sustainable funds lower their CR score by reducing exposure to fossil fuels, not by increasing exposure to renewables. (shrink)

This study provides a bibliometric analysis of the DESIDOC journal of library and information technology during 2012–2022. Research data for this study has been exported from the SCOPUS database. A total of 638 articles published during the study period were analyzed to determine the most cited articles, most prolific author, growth of publication, occurrence of keywords, citation pattern, and authorship pattern. To visualize the occurrence of keywords and the co-citation of the author network, Vosviewer software was used. This study also (...) reveals that bibliometric, scientometrics, e-resource, and citation analysis are the most prolific research areas. (shrink)

The paper discusses anumāna and its variety in general from the point of view of inferential cognition for the sake of oneself as well as for the sake of others; i.e. svārthānumāna and parārthānumāna as given in the Buddhist tradition of logic, especially with parārthānumāna, its nature and role. The paper argues that the Buddhist intent of division of anumāna into svārthānumāna and parārthānumāna was to bring Buddha-vacanas under the category of parārthānumāna and to save them from being classified under (...) śabda pramāṇa. It contends that such a division was not just an epistemological demand, but had a deeper philosophical significance in the Buddhist conceptual framework. Such a division is, therefore, intended to reject the role of śabda as an extra causal means or pramāṇa. The paper identifies the logical commitment in Buddhist tradition as hetu-centric commitment as it differs from the Nyāya tradition of vyāpti-centric one. (shrink)

This note establishes a new identification result for additive random utility discrete choice models. A decision-maker associates a random utility Uj+mj\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$U_{j}+m_{j}$$\end{document} to each alternative in a finite set j∈1,…,J\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$j\in \left\{ 1,\ldots,J\right\} $$\end{document}, where U=U1,…,UJ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathbf {U}=\left\{ U_{1},\ldots,U_{J}\right\} $$\end{document} is unobserved by the researcher and random with an unknown joint distribution, while the perturbation m=m1,…,mJ\documentclass[12pt]{minimal} \usepackage{amsmath} (...) \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathbf {m}=\left $$\end{document} is observed. The decision-maker chooses the alternative that yields the maximum random utility, which leads to a choice probability system m→Pr1|m,…,PrJ|m\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathbf { m\rightarrow }\left,\ldots,\Pr \left \right) $$\end{document}. Previous research has shown that the choice probability system is identified from the observation of the relationship m→Pr1|m\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \mathbf {m}\rightarrow \Pr \left $$\end{document}. We show that the complete choice probability system is identified from observation of a relationship m→∑j=1sPrj|m\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathbf {m}\rightarrow \sum _{j=1}^{s}\Pr \left $$\end{document}, for any sshrink)

Minichromosome maintenance (Mcm) proteins are well‐known for their functions in DNA replication. However, their roles in chromosome segregation are yet to be reviewed in detail. Following the discovery in 1984, a group of Mcm proteins, known as the ARS‐nonspecific group consisting of Mcm13, Mcm16‐19, and Mcm21‐22, were characterized as bonafide kinetochore proteins and were shown to play significant roles in the kinetochore assembly and high‐fidelity chromosome segregation. This review focuses on the structure, function, and evolution of this group of Mcm (...) proteins. Our in silico analysis of the physical interactors of these proteins reveals that they share non‐overlapping functions despite being copurified in biochemically stable complexes. We have discussed the contrasting results reported in the literature and experimental strategies to address them. Taken together, this review focuses on the structure‐function of the ARS‐nonspecific Mcm proteins and their evolutionary flexibility to maintain genome stability in various organisms. (shrink)

Background: Informed consent in the modern era is a common and important topic both for the well-informed patient and to prevent unnecessary litigation. However, the effectiveness of informed consent in trauma patients is an under-researched area. This paper aims to assess the differences in patient recall of the consent process and desire for information by performing a comparative analysis between orthopaedic trauma and elective patients. Methods: Information from 41 consecutive elective operations and 40 consecutive trauma operations was collected on the (...) first post-operative day. Results: 100% of elective patients and 90% of trauma patients knew what operation they had received (p = 0.06). Overall recall of complications was poor, but was significantly lower in trauma patients compared with elective patients (62% vs 22%, p<0.001). 30% of trauma patients desired more information about their operation compared to 12% of elective patients (p = 0.049), although only 35% of trauma patients wanted written as well as verbal explanations, compared to 85% of elective patients p<0.001). Overall 100% of elective and 90% of trauma patients were happy with the consent process (p = 0.06). Subset analysis of neck of femur compared to other trauma patients showed that the above factors were not significantly different between the two groups. Conclusions: Recall of complications in the trauma patients is significantly lower than in elective patients, although both groups scored poorly overall. Repeated verbal explanations should be reinforced with the option of additional information leaflets for trauma operations. Further research into the usefulness of DVDs for commonly performed operations is warranted, although official internet resources may be more cost-effective. (shrink)

This paper articulates the commitments, contours and justifications for a pluralist but non-eclectic critical, realist, reflexive social science with emancipatory aims. In it, we stress that social science can and should be used to guide the conceptualization of desirable and viable forms of social organization and their conditions of realization. In this regard, we advocate explanatory theorizing as an ethical duty of social scientists and as a moral good in itself as well as being an inherent epistemological component of scientific (...) practice. This entails that we take seriously the research strategies apposite to our disciplinary, intertextual and interdiscursive locations to make a serious theoretical case and practical case for the kind of social science here advocated. In our view, such a social science must acknowledge the path-breaking work of Roy Bhaskar, but must also recognize that the arguments deployed in texts as a resource in intellectual work can never be treated as the axiomatic grounds for further thought, but must be interrogated thoroughly and in each case what is to be retained must be defensible. No position has a monopoly of relevant insights and the development of science often involves syntheses. Syntheses must not be syncretic but reflexively interrogated to assess epistemological, ontological and conceptual coherence to avoid eclecticism. Development in critical realist philosophy will, we believe, continue to confront and offer plausible resolutions to a range of battles within and pertinent to philosophy and social-scientific metatheory. However, realists must recognize the continuing importance and discursive effects of a variety of critical and realist work in being able to defend, sustain and develop rigorous social-scientific research with emancipatory commitments. (shrink)

Many targets of the Wnt/β-catenin signaling pathway are regulated by TCF transcription factors, which play important roles in animal development, stem cell biology, and oncogenesis. TCFs can regulate Wnt targets through a “transcriptional switch,” repressing gene expression in unstimulated cells and promoting transcription upon Wnt signaling. However, it is not clear whether this switch mechanism is a general feature of Wnt gene regulation or limited to a subset of Wnt targets. Co-repressors of the TLE family are known to contribute to (...) the repression of Wnt targets in the absence of signaling, but how they are inactivated or displaced by Wnt signaling is poorly understood. In this mini-review, we discuss several recent reports that address the prevalence and molecular mechanisms of the Wnt transcription switch, including the finding of Wnt-dependent ubiquitination/inactivation of TLEs. Together, these findings highlight the growing complexity of the regulation of gene expression by the Wnt pathway. Wnt targets are regulated by a “switch” where TLE co-repressors are displaced from TCFs by β-catenin, leading to activation of transcription. Recent reports challenge this view and suggest that additional processes, including exchange of specific TCF proteins and Wnt-dependent ubiquitination of TLEs, play important roles in the Wnt transcriptional switch. (shrink)

Study on Upanishads and commentaries of Śaṅkarācārya, Hindu philosopher, on it.