Evolutionary psychology and human sociobiology often reject the mere possibility of symbolic causality. Conversely, theories in which symbolic causality plays a central role tend to be both anti-nativist and anti-evolutionary. This article sketches how these apparent scientific rivals can be reconciled in the study of disgust. First, we argue that there are no good philosophical or evolutionary reasons to assume that symbolic causality is impossible. Then, we examine to what extent symbolic causality can be part of the theoretical toolbox of (...) the evolutionary social sciences. This examination leads to the conclusion that it is possible to make evolutionary sense of Mary Douglas’s theory of disgust, and that her view of symbolic causality can and should inform evolutionary theories of (sociocultural) disgust. (shrink)

Volume 19, Issue 12, December 2019, Page 51-54.

Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predomi- nantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase ‘paradigm shift’ in (...) his groundbreaking book The Structure of Scientific Revolutions. He argued that the arrival of the new and often incompatible idea forms the core of a new paradigm, the birth of an entirely new way of thinking. This article discusses whether Steiner and col- leagues truly brought about a paradigm shift in oncological surgery. By rejecting the principle of en block resection and by replacing it with the belief that not only is it oncologically safe to cut through the substance of the tumour but in doing so one can actually achieve better results, Steiner was able to truly revolutionise the man- agement of laryngeal cancer. Even though within this article the repercussions of his insight are limited to the upper aerodigestive tract oncological surgery, his willingness to question other peoples’ dogma makes his contribution truly a genuine paradigm shift. (shrink)

The explanatory gap . Consciousness is a mystery. No one has ever given an account, even a highly speculative, hypothetical, and incomplete account of how a physical thing could have phenomenal states. Suppose that consciousness is identical to a property of the brain, say activity in the pyramidal cells of layer 5 of the cortex involving reverberatory circuits from cortical layer 6 to the thalamus and back to layers 4 and 6,as Crick and Koch have suggested for visual consciousness. .) (...) Still, that identity itself calls out for explanation! Proponents of an explanatory gap disagree about whether the gap is permanent. Some say that we are like the scientifically naive person who is told that matter = energy, but does not have the concepts required to make sense of the idea. If we can acquire these concepts, the gap is closable. Others say the gap is uncloseable because of our cognitive limitations. Still others say that the gap is a consequence of the fundamental nature of consciousness. (shrink)

The crisis in donor organ and tissue supply is one of the most difficult challenges for transplant today. New policy initiatives, such as the driver's license option and requiredrequest, have been implemented in many states, with other initiatives, such as mandatedchoice and presumedconsent, proposed in the hopes of ameliorating this crisis. At the same time, traditional acquisition of organs from human cadavers has been augmented by living human donors, and nonheartbeating human donors, as well as experimental animal and artificial sources. (...) Despite these efforts, the crisis persists and is perhaps most tragic when it threatens the lives of children, driving parents to sometimes desperate measures. Herein, we address one very controversial step some parents have taken to obtain matching tissue or organs for their needy children—that is, having a child, in part, for the purpose of organ or tissue procurement. (shrink)

A milestone in Wittgenstein scholarship, this collection of essays ranges over a wide area of the philosopher's thought, presenting divergent interpretations of his fundamental ideas. Different chapters raise many of the central controversies that surround current understanding of the Tractatus, providing an interplay that will be particularly useful to students. Taken together, the essays present a broader and more comprehensive view of Wittgenstein's intellectual interests and his impact on philosophy than may be found elsewhere.The thirteen chapters treat topics from both (...) periods of Wittgenstein's work: More than half are devoted to his early thought, the Tractatus Logico-Philosophicus of 1921, reflecting a growing interest today among philosophers in reexamining this seminal book, while three chapters treat the Philosophical Investigations, published posthumously in 1953. The remaining chapters discuss such "nonstandard" topics as philosophy of religion, aesthetics, and anthropology.Contents: The Early Wittgenstein and the Middle Russell, Kenneth Blackwell; Frege and Wittgenstein, Michael Dummett; Wittgenstein and the Theory of Types, Hide Ishiguro; The So-called Realism of Wittgenstein's Tractatus, Brian McGuinness; The Logical Independence of Elementary Propositions, David Pears; The Rise and Fall of the Picture Theory, Peter Hacker; The Picture Theory and Wittgenstein's Later Attitude to It, Erik Stenius; Wittgenstein's Early Philosophy of Mind, Anthony Kenny; A Theory of Language?, G. E. M. Anscombe; Im Anfang war die Tat, Peter Winch; Wittgenstein's Full Stop, D. Z. Phillips; Quote: Judgments from Our Brain, Paul Ziff; Wittgenstein and the Fire Festivals, Frank Cioffi, Index.Irving Block is Associate Professor in the Philosophy Department at The University of Western Ontario. (shrink)

Little is known about distance processing in patients with posterior brain damage. Although many investigators have claimed that distance estimates are normal or abnormal in some of these patients, many of these observations were made informally and the examiners often asked for relative, and not absolute, distance estimates. The present investigation served two purposes. First, we wanted to contrast the use of distance information in peripersonal space for perceptual report as opposed to visuomotor control in our visual form agnosic patient, (...) DF. Second, we wanted to see to what extent her abilities to process distance cues were dependent on binocular vision, in light of Milner et al.'s (1991) observations of preserved stereopsis in DF, and Dijkerman et al.'s (1996) and Marotta et al.'s (1997) observations that her visual guidance of grasping may be particularly dependent on binocular vision of the target. We hypothesized that DF's visuomotor responses would show normal sensitivity to target distance, while her perceptual estimates would not. In the first experiment, we required DF and two age- and sex-matched control subjects to reach out and grasp black cubes placed at varying distances, or to estimate the distance of the cubes from the hand starting position without making a reaching movement. In the second experiment, we required DF and two age-matched control subjects to point as rapidly and accurately as possible to small LED targets which differed in spatial location, under binocular and monocular conditions. The results showed that, relative to the control subjects, DF's grasping movements produced normal peak velocity-distance scaling-when she reached for blocks which varied in depth or pointed to LED targets which were presented at different distances in depth. In contrast, in the cube experiment, her verbal estimates of object distance were poorly scaled, although they improved slightly under the binocular conditions. The results are discussed in terms of current theories of processing streams in extrastriate visual cortex and the distinction between categorical and coordinate spatial processing. (shrink)

Previous research suggests that children can infer causal relations from patterns of events. However, what appear to be cases of causal inference may simply reduce to children recognizing relevant associations among events, and responding based on those associations. To examine this claim, in Experiments 1 and 2, children were introduced to a “blicket detector,” a machine that lit up and played music when certain objects were placed upon it. Children observed patterns of contingency between objects and the machine's activation that (...) required them to use indirect evidence to make causal inferences. Critically, associative models either made no predictions, or made incorrect predictions about these inferences. In general, children were able to make these inferences, but some developmental differences between 3- and 4-year-olds were found. We suggest that children's causal inferences are not based on recognizing associations, but rather that children develop a mechanism for Bayesian structure learning. Experiment 3 explicitly tests a prediction of this account. Children were asked to make an inference about ambiguous data based on the base rate of certain events occurring. Four-year-olds, but not 3-year-olds were able to make this inference. (shrink)

Context: The detection of objective reality, truth, and lies are still heated topics in epistemology. When discussing these topics, philosophers often resort to certain thought experiments, engaging an important concept that can be broadly identified as “the global observer.” It relates to Putnam’s God’s Eye, Davidson’s Omniscient Interpreter, and the ultimate observer in quantum physics, among others. Problem: The article explores the notion of the global observer as the guarantor of the determinability and configuration of events in the world. It (...) analyzes the consistency of the notion “global observer” from the standpoint of logic and philosophy, and discusses why application of this notion in some contexts poses challenges and appears to be paradoxical. Method: The paper uses conceptual methods of argumentation, such as logical and philosophical kinds of proof. Its key approach is the engagement of thought experiments. Results: The notion of a global observer is incoherent: “being global” and “being an observer” appear to be incompatible features. It is claimed that from the standpoint of global observation, there are no events occurring in the world. Furthermore, the indefiniteness of the world as a whole is asserted, which is related to the uninformedness of the global observer regarding the “true state of affairs.” “Global observation” turns out to be incompatible with the concept of the observer, blocking, as a result, the opportunity for a determinable configuration of events. It only makes sense to discuss local observations, which are limited to mutual observation or introspections, and not to assume the existence of some absolute truth, reality, or the state of affairs beyond the local observations. Constructivist content: The article emphasizes the role of the observer and observation. It opens up some problematic consequences of the core philosophical assumptions of globally observing existence. Referring to von Foerster’s and Luhmann’s idea that we can only speak reasonably about local observations, the paper argues that reality is neither external to nor independent of the observer. Implications: The paper could be productive for epistemic theories, theories of quantum physics, and theories of non-classical logic. (shrink)

As Part of the Omnibus Budget Reconciliation Act of 1990, the Patient Self Determination Act legislates new responsibilites for healthcare facilities. The authors served as members of the California Consortium on Patient Self-Determination, and the materials produced by this group offer healthcare facilities a valuable guide for implementing the PSDA. The ACt follows a historical trend led by doctrines of informed consent and increasing patient autonomy regarding rights to accept or refuse medical treatment and to execute advance directives. The requirements (...) of the Act will influence healthcare facilities and how they communicate with patients about advance directives. Although the Act seeks to increase awareness of advance directices among all participants in healthcare interactions, it could pose major stumbling blocks to providing sensitive and humane care if certain concerns are nor addressed adequatley. The benefits of the Act could be far reaching and substantial for patients and healthcare facilities alike. (shrink)

A close examination of Kim's argument in "Multiple Realization and the Metaphysics of Reduction" for the claim that if a kind is multiply realizable in a way that blocks identification with more fundamental properties it is also a kind unlikely to appear as an appropriate kind in a theory in the first place. Ultimately, I argue that there is one reasonably promising argument of this sort, but its success turns on explanatory questions the answers to which are far from obvious.

: As the twentieth century closes, marked by triumphal strides in medical advances, the American society has yet to ensure that each person has access to affordable health care. To correct this injustice, this article calls on the nation's political and corporate leaders, providers, and faith-based groups to join all Americans in a new national conversation on systemic health care reform. The Catholic faith tradition is one that compels both a proclamation to ministry values and a commitment to speak out (...) against the challenges or threats to what are essential to the well-being of individuals and society. The Catholic health ministry must therefore be both a voice for the voiceless and an agent of transformation. The nation's goal should be to "reposition" health care from its status as an important, but ultimately optional building block to one that is essential. (shrink)

Sensorimotor learning refers to improvements that occur through practice in the performance of sensory-guided motor behaviors. Leveraging novel technical capabilities of an immersive virtual environment, we probed the component kinematic processes that mediate sensorimotor learning. Twenty naïve subjects performed a simulated marksmanship task modeled after Olympic Trap Shooting standards. We measured movement kinematics and shooting performance as participants practiced 350 trials while receiving trial-by-trial feedback about shooting success. Spatiotemporal analysis of motion tracking elucidated the ballistic and refinement phases of hand (...) movements. We found systematic changes in movement kinematics that accompanied improvements in shot accuracy during training, though reaction and response times did not change over blocks. In particular, we observed longer, slower, and more precise ballistic movements that replaced effort spent on corrections and refinement. Collectively, these results leverage developments in immersive virtual reality technology to quantify and compare the kinematics of movement during early learning of full-body sensorimotor orienting. (shrink)

This book grew out of previously published papers of mine composed over a period of years; they have been reworked (sometimes beyond recognition) so as to form a reasonably coherent whole. Part One treats of informative inference. I argue (Chapter 2) that the traditional principle of induction in its clearest formulation (that laws are confirmed by their positive cases) is clearly false. Other formulations in terms of the 'uniformity of nature' or the 'resemblance of the future to the past' seem (...) to me hopelessly unclear. From a Bayesian point of view, 'learning from experience' goes by conditionalization (Bayes' rule). The traditional stum bling block for Bayesians has been to fmd objective probability inputs to conditionalize upon. Subjective Bayesians allow any probability inputs that do not violate the usual axioms of probability. Many subjectivists grant that this liberality seems prodigal but own themselves unable to think of additional constraints that might plausibly be imposed. To be sure, if we could agree on the correct probabilistic representation of 'ignorance' (or absence of pertinent data), then all probabilities obtained by applying Bayes' rule to an 'informationless' prior would be objective. But familiar contra dictions, like the Bertrand paradox, are thought to vitiate all attempts to objectify 'ignorance'. BuUding on the earlier work of Sir Harold Jeffreys, E. T. Jaynes, and the more recent work ofG. E. P. Box and G. E. Tiao, I have elected to bite this bullet. In Chapter 3, I develop and defend an objectivist Bayesian approach. (shrink)

The author aims to use Kuchipudi Indian classical Hindu dance to educate non-Hindus about Hinduism with postcolonialism in mind. This goal arises from her dance experiences and the historical era of imperialism. Colonization occurs when those in power believe there is a need to dominate in a manner that subjugates people. Colonizers created colonies as they moved into territory because they felt there was a need to “civilize” the so-called savages of the land. Postcolonialism is an intellectual discourse that confronts (...) the legacy of colonialism and attempts to de-colonize. With the legacy of colonialism and a postcolonial lens in mind, some research questions arise. How does she, as a Kuchipudi dancer, use Hindu dance to educate non-Hindus about the Eastern literature of Hinduism? For non-Hindus, she feels the power of the exoticizing gaze when she dances, which might very well block the educational intention of the dance. This exoticizing gaze prevents the understanding of the traditional nature of the dance and the introduction to Hinduism as a world religion. The author’s problem is moving the exotic gaze of non-Hindus to an educational gaze that seeks to learn about the ethics of Hinduism in a manner that takes into consideration the multiple perspectives of the complex society we live in today. (shrink)

What are the brain and cognitive systems that allow humans to play baseball, compute square roots, cook soufflés, or navigate the Tokyo subways? It may seem that studies of human infants and of non-human animals will tell us little about these abilities, because only educated, enculturated human adults engage in organized games, formal mathematics, gourmet cooking, or map-reading. In this chapter, we argue against this seemingly sensible conclusion. When human adults exhibit complex, uniquely human, culture-specific skills, they draw on a (...) set of psychological and neural mechanisms with two distinctive properties: they evolved before humanity and thus are shared with other animals, and they emerge early in human development and thus are common to infants, children, and adults. These core knowledge systems form the building blocks for uniquely human skills. Without them we wouldn’t be able to learn about different kinds of games, mathematics, cooking, or maps. To understand what is special about human intelligence, therefore, we must study both the core knowledge systems on which it rests and the mechanisms by which these systems are orchestrated to permit new kinds of concepts and cognitive processes. What is core knowledge? A wealth of research on non-human primates and on human infants suggests that a system of core knowledge is characterized by four properties (Hauser, 2000; Spelke, 2000). First, it is domain-specific: each system functions to represent particular kinds of entities such as conspecific agents, manipulable objects, places in the environmental layout, and numerosities. Second, it is task-specific: each system uses its representations to address specific questions about the world, such as “who is this?” [face recognition], “what does this do?” [categorization of artifacts], “where am I?” [spatial orientation], and “how many are here?” [enumeration]. Third, it is relatively encapsulated: each uses only a subset of the information delivered by an animal’s input systems and sends information only to a subset of the animal’s output systems. (shrink)

Although C. D. Broad's notion of Becoming has received a fair amount of attention in the philosophy-of-time literature, there are no serious attempts to show how to replace the standard 'block' spacetime models by models that are more congenial to Broad's idea that the sum total of existence is continuously increased by Becoming or the coming into existence of events. In the Newtonian setting Broad-type models can be constructed in a cheating fashion by starting with a Newtonian block (...) model, carving chips off the block, and assembling the chips in an appropriately structured way. However, attempts to construct Broad-type models in a non-cheating fashion reveal a number of problematic aspects of Becoming that have not received adequate attention in the literature. The paper then turns to an assessment of the problem and prospects of adapting Becoming models to relativistic spacetimes. The results of the assessment differ in both minor and major ways from the ones in the extant literature. Finally, the paper describes how the causal set approach to quantum gravity promises to provide a mechanism for realizing Becoming, though the form of Becoming that emerges may not conform to any of the versions discussed in the philosophical literature. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Witness of the Body: The Past, Present, and Future of Christian Martyrdom ed. by Michael L. Budde and Karen ScottElizabeth Sweeny BlockWitness of the Body: The Past, Present, and Future of Christian Martyrdom Edited by Michael L. Budde and Karen Scott Grand Rapids, Mich.: Eerdmans, 2011. 238 pp. $22.00In Michael L. Budde’s introduction to this volume, he asserts its twofold purpose: to identify criteria for distinguishing authentic Christian (...) martyrdom from inauthentic and to return martyrdom to a more central place in Christian life. This collection of essays—some of which were presented as part of a lecture series at DePaul University during the 2006–7 academic year—aspires to reconsider and redefine martyrdom in order to remove both the “freak-show element” and the “heroic exceptionality” associated with martyrdom in modern culture (viii). The goal of the volume, which is part of the Eerdmans Ekklesia Series, is to resituate martyrdom within the everyday life of the church, and the majority of the essays argue for the ongoing significance of a revised martyrdom for this distinctive community. These eleven essays are as much about martyrs themselves as they are about how martyrdom is perceived, received, and remembered. The interdisciplinary volume [End Page 211] is successful in encouraging a broader understanding of martyrdom, one that may not necessarily include death, and in drawing attention to the ongoing need for memorializing Christian martyrs to inspire commitment and transformation.The volume is divided into four parts representing both chronological and substantive distinctions. Part 1, “Martyrdom as the Church’s Witness,” introduces the problem of isolating the requirements of martyrdom and defining who fits into this category, a challenge addressed throughout the volume. Part 2, “Martyrdom Builds the Church,” discusses positive elements of martyrdom, especially with respect to the value of women’s bodies, drawing on both the early female martyrs in general and Joan of Arc in particular. Part 3, “Martyrdom Destroys the Church,” recounts some of the most difficult aspects of modern martyrdom, calling for a more accurate history and recognition of the emergence of a new kind of martyrdom in which one’s loyalty is to country, not faith. Part 4, “Martyrdom and the Future Church,” calls attention to the need to continue celebrating the memory of martyrs and describes the contemporary Christian martyr as a peacemaker not seeking martyrdom in the traditional sense of the word.What stands out as a theme across a number of the essays, and what I judge to be a valuable contribution to Christian ethics, is an emphasis on the way martyrs live(d), suggesting that what can and should be emulated by Christians today is a commitment to action on behalf of conversion and transformation. Tripp York’s essay rightly argues that martyrdom need not be viewed as merely reactionary, as a way of life in opposition to something, but as transformative and “for the sake of the world” (37). Michael Budde makes a similar assertion that martyrdom is better defined as deep loyalty than as treason, thereby suggesting that this kind of loyalty to Christ ought not to be limited to the special calling of a few but seen as the commitment of all Christians. Stephen Fowl’s essay conveys the meaning of the title of this volume, identifying martyrdom as part of the larger practice of “believers’ witness of the body to God’s drama of salvation” (44). He argues that in life or death, one can magnify Christ, and one’s bodily actions and responses can reflect one’s character and commitments. Emmanuel Katongole provides powerful recognition of the ways in which Christian martyrs “keep the church from sleeping” (193) and “embody the mundane gestures and practice of peaceableness in their everyday living” (199). This volume succeeds in shifting the focus from martyrdom in the traditional sense—being put to death because of one’s faith—to the ways Christians today remember, respond to, and emulate the lives and actions of martyrs. [End Page 212]Elizabeth Sweeny BlockUniversity of ChicagoCopyright © 2013 Society of Christian Ethics... (shrink)

The bases of tenets of the World came from the East; Pythagoras learnt all there up the 26 years. At a home, the east ideas where took in no; then he bound the mathematics with the elements of matter. This was the best way to a blood feud of the all Humanity. The 17th age gave the bases of mathematics and the Greek atomism; this had led to the paranoia in all sciences. The LCE was brought in 19th age with (...) bases no; really it was the box of Pandora in the form of wrong sciences of the Nature. The wise revenge of Pythagoras was in the form of riddle for the best thinkers in the World in all times; us solved one in the 50th years. A base of the World is of the material space (MS) with praatoms (PAs) Ao; they are of the affinity to matter. A density of the MS is of ~ 5.10‐6 kg/m3 close to the Ears. PA Ao is of quant of matter and antimatter; they are of rotate in the different sides. All matter takes up Ao and to grow. In the giant stars to go the bursts giving Ao, or caloric. The matter of being in the World on base of the key law of conservation of heat (caloric) and matter by loss of energy; it is main. Leibniz offered to the conservation of mv2 in the World. But Newton knew that any move is damped, and it need in filled up. This the author proved by tests over the 300 years just. D.Bernoulli given to the model of gas. I. Kant proved that mv2 is the quantity of heat by stop of the body; it is no the energy! A key leitmotiv of thought is blocked the grasp of facts if ones not leaded to an accepted concept. P. Mayer had the blunder in base of the LCE; a work of gas expansion in Torricelli tube is equal nil strong! This is the gross blunder of a sick paranoiac! The 21 age gave up a new philosophy and a way to endless engine. The super skills from ideal quartz with moving jaws to respond to the all new philosophy and sciences. (shrink)

This paper seeks to build on the extensive connections that have arisen between automata theory, combinatorics on words, fractal geometry, and model theory. Results in this paper establish a characterization for the behavior of the fractal geometry of “k-automatic” sets, subsets of $[0,1]^d$ that are recognized by Büchi automata. The primary tools for building this characterization include the entropy of a regular language and the digraph structure of an automaton. Via an analysis of the strongly connected components of such a (...) structure, we give an algorithmic description of the box-counting dimension, Hausdorff dimension, and Hausdorff measure of the corresponding subset of the unit box. Applications to definability in model-theoretic expansions of the real additive group are laid out as well. (shrink)

The keystone of the system, this volume deals with the central mystery of Christianity, viz., the doctrine of Christ. The book is carefully, even beautifully written. To some, Tillich's existentializing will prove a stumbling block; to others it may make the heart of Christianity acceptable for the first time.--D. R.

Apoptotic pathways have always been regarded as a key‐player in preserving tissue and organ homeostasis. Excessive activation or resistance to activation of cell death signaling may indeed be responsible for several mechanisms of disease, including malignancy and chronic degenerative diseases. Therefore, targeting apoptotic factors gained more and more attention in the scientific community and novel strategies emerged aimed at selectively blocking or stimulating cell death signaling. This is also the case for the TMEM219 death receptor, which is activated by a (...) circulating ligand, the Insulin‐like growth factor binding protein 3 (IGFBP3) and induces a caspase‐8‐dependent apoptosis of the target cells. Interestingly, stimulation of the IGFBP3/TMEM219 axis exerts an anti‐proliferative effect, while blockade of the TMEM219 deleterious signal protects TMEM219‐expressing cells of the endocrine pancreas, lung, and intestine from damage and death. Here, we summarize the most updated reports on the role of the IGFBP3/TMEM219 apoptotic axis in disease conditions, including intestinal disorders and diabetes, and we describe the advancements in designing and testing novel TMEM219‐based targeting approaches in emerging potential clinical applications. (shrink)

Megastable chaotic systems are somehow the newest in the family of special chaotic systems. In this paper, a new megastable two-dimensional system is proposed. In this system, coexisting attractors are in some islands, interestingly covered by megalimit cycles. The introduced two-dimensional system has no defined equilibrium point. However, it seems that the origin plays the role of an unstable equilibrium point. Therefore, the attractors are determined as hidden attractors. Adding a forcing term to the system, we can obtain chaotic solutions (...) and coexisting strange attractors. Moreover, the effect of three different values of the forcing term’s amplitude is studied. The dynamical properties of the designed system are investigated using attractor plots, bifurcation diagrams, and Lyapunov Exponents diagram. Phase portraits of the novel megastable oscillator are presented by FPGA design. Xilinx system generator block diagrams of the proposed system and trigonometric functions are also presented. (shrink)

The decline in the interest in ethical theory is first outlined, as a background to the author’s discussion of principlism. The author’s own stance, that of a communitarian philosopher, is then described, before the subject of principlism itself is addressed. Two problems stand in the way of the author’s embracing principlism: its individualistic bias and its capacity to block substantive ethical inquiry. The more serious problem the author finds to be its blocking function. Discussing the four scenarios the author (...) finds that the utility of principlism is shown in the two scenarios about Jehovah’s Witnesses but that when it comes to selling kidneys for transplantation and germline enhancement, principlism is of little help. (shrink)

As a comparatively recent development, the adventure-sports coach struggles for a clear and distinct identity. The generic term ‘instructor’ no longer characterizes the role and function of this subgroup of outdoor professionals. Indeed, although the fields of adventure/outdoor education and leadership are comparatively well researched, the arrival of this ‘new kid on the block’ appears to challenge both the adventure-sports old guard and traditional views of sports coaching. In an attempt to offer clarity and stimulate debate, this paper attempts (...) to conceptualize the adventure-sports coach in the context of the existing roles in the field and current motivations for activity in the outdoors. We identify issues that are specific to the adventure-sports coach while also recognizing those skills and competencies shared with other professionals, both in the adventure sports profession and traditional sports coaching fields. Based on this review, we offer a conceptual model which may be used to focus debate, stimulate research and, at a possible later stage, to underpin accreditation, training and professional development. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

Dual-track assessment directs research ethics committees to assess the risks of research interventions based on the unclear distinction between therapeutic and non-therapeutic interventions. The net risks test, in contrast, relies on the clinically familiar method of assessing the risks and benefits of interventions in comparison to the available alternatives and also focuses attention of the RECs on the central challenge of protecting research participants.Research guidelines around the world recognise that clinical research is ethical only when the risks to participants are (...) reasonable.1 Appropriate implementation of this requirement is vital to protecting research participants and allowing research to proceed when it poses acceptable risks. Unfortunately, as the US National Bioethics Advisory Commission notes: “current regulations do not further elaborate how risks and potential benefits are to be assessed, and little additional guidance is available to IRBs.”1The NBAC, as well as numerous commentators, recommend that research ethics committees , ethics review committees and institutional review boards should adopt what may be called dual-track risk assessment.2–5 Yet, dual-track assessment unnecessarily divides research interventions into two different categories before assessing their risks and relies on the unclear distinction between therapeutic and non-therapeutic interventions. As a result, dual-track assessment provides RECs with confusing guidance and has the potential to block valuable research that poses acceptable risks. This paper describes one alternative, the net risks test, and argues that this approach offers a better method for assessing research risks, one that puts RECs in a position to protect participants without blocking appropriate research studies.BACKGROUNDClinical research exposes participants to interventions and procedures to gather systematic data that may be used to improve overall health and well-being. To ensure that research is ethical, RECs must ensure that the risks and burdens to participants are not excessive and that …. (shrink)

We present asecond-personalaccount of corporate moral agency. This approach is in contrast to thefirst-personalapproach adopted in much of the existing literature, which concentrates on the corporation’s ability to identify moral reasons for itself. Our account treats relationships and communications as the fundamental building blocks of moral agency. The second-personal account rests on a framework developed by Darwall. Its central requirement is that corporations be capable of recognizing the authority relations that they have with other moral agents. We discuss the relevance (...) of corporate affect, corporate communications, and corporate culture to the second-personal account. The second-personal account yields a new way to specify first-personal criteria for moral agency, and it generates fresh insights into the reasons those criteria matter. In addition, a second-personal analysis implies that moral agency is partly a matter of policy, and it provides a fresh perspective on corporate punishment. (shrink)

In this paper I respond to Robert Taylor's argument that a Rawlsian framework does not support strong affirmative action programs. The paper makes three main arguments. The first disputes Taylor's claim that strong AA would not be needed in ideal conditions. Private racial discrimination, I suggest, might still exist in such conditions, so strong AA might be needed there. The second challenges Taylor's claims that pure procedural justice constrains Rawlsian nonideal theory. I argue that this rests on a fetishizing of (...) pure procedural justice that is absent from Rawls's work. I also show that a revised formulation of Taylor's concern here also fails. My third argument makes a positive Rawlsian case for strong AA in nonideal conditions that builds on a Taylor concession. Taylor suggests that the goal of nonideal theory is to create a world in which ideal theory can be applied. My argument begins by showing that another permissible goal of Rawlsian nonideal theory is to ameliorate injustice. I then argue that Rawls's contractualist framework supports the strongest forms of AA when category 3 interventions are blocked. (shrink)

Native and to some extent non-native speakers have shown processing advantages for idioms compared to novel literal phrases, and there is limited evidence that this advantage also extends to memory in L1 children. This study investigated whether these advantages generalize to recognition memory in adults. It employed a learning paradigm to test whether there is a recognition memory advantage for idioms compared to literal phrases in adult L1 and L2 learners considering both form and meaning recognition. Additionally, we asked whether (...) the presence of unfamiliar vocabulary interferes with phrasal learning by looking at recall of such unfamiliar words. When encountering new idioms, L2 learners often must cope with both figurative meaning and unfamiliar vocabulary. While single word meaning need not interfere with idiomatic meaning, it is a building block for the meaning of literal phrases. In Experiment 1, L2 learners showed equal recall for the form and meaning of literal and idiomatic phrases in which either all words were highly familiar, or one word was unfamiliar. However, unfamiliar words decreased overall recognition and were also remembered significantly better in literal compared to idiomatic phrases. In Experiment 2, L1 speakers also showed no recall differences between phrase types, but they displayed a trending increase in recognition in the presence of unfamiliar words. We conclude that there is no inherent recognition memory advantage for idioms based on figurativeness alone, and word- and phrasal meaning interact differently in learner groups. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

Since the origins of the notion of emergence in attempts to recover the content of vitalistic anti-reductionism without its questionable metaphysics, emergence has been treated in terms of logical properties. This approach was doomed to failure, because logical properties are either sui generis or they are constructions from other logical properties. If the former, they do not explain on their own and are inevitably somewhat arbitrary (the problem with the related concept of supervenience, Collier, 1988a), but if the latter, reducibility (...) is assured because logical constructs are reducible, by definition, to their logical components. A satisfactory account of emergence must recognise that it is a dynamical, not a logical property of property of natural systems, and that its basis is dynamical rather than logical composition. Collier (1988a) introduced the concept of cohesion as the closure of the causal relations among the dynamical parts of a dynamical particular that determine its resistance to external and internal fluctuations that might disrupt its integrity. Cohesion is an equivalence relation that partitions a set of dynamical particulars into unified and distinct entities, providing the identity conditions for such particulars. Cohesion blocks reduction of dynamical particulars, and is necessary for dynamical emergence. We will give reasons for thinking that cohesion might be sufficient for emergence as well. (shrink)

Prawitz has recently developed a theory of epistemic grounding that differs in many respects from his earlier semantics of arguments and proofs. An innovative approach to inferences yields a new conception of the intertwinement of the notions of valid inference and proof. We aim at singling out three reasons that may have led Prawitz to the ground-theoretic turn, i.e.: a better order in the explanation of the relation between valid inferences and proofs; a notion of valid inference based on which (...) valid inferences and proofs are recognisable as such; a reconstruction of the deductive activity that makes inferences capable of yielding justification per se. These topics are discussed by Prawitz with reference to a very general and ancient question: why and how correct deduction has the epistemic power to compel us to accept its conclusions, provided its premises are justified? We conclude by remarking that, in spite of some improvements, the ground-theoretic approach shares with the previous one a problem of vacuous validity which, as Prawitz himself points out, blocks in both cases a satisfactory explanation of epistemic compulsion. (shrink)

As seen by Professor Capek, Bergson’s views about the nature of matter were either misunderstood or ignored in the decades following their publication at the turn of the century. The explanation for this attitude of both Bergson’s opponents and his disciples lies in the fact that, at that time, although there were rumblings under the foundations of classical physics, "hardly anybody could then guess even remotely the extent of the coming scientific revolution." One of the main stumbling blocks for Bergson’s (...) readers was the non-pictorial character of his ‘model’ of matter, which was conceived as consisting of imageless events. In Bergson and Modern Physics, Capek attempts to remove this stumbling block and to evaluate the relation between Bergson’s thought and modern physics as it stands today. The book consists of three parts: Bergson’s biological theory of knowledge, his theory of duration, and his theory of the physical world and its relations to contemporary physics. Three appendices deal with Russell’s complex relation to Bergson, with the much discussed relation of microphysical indeterminancy to freedom, and with Bergson’s views on entropy and modern cosmogony, respectively. The book is indexed and carries extensive references to the scientific and philosophical literature. With this book Capek provides a competent exposition and historical perspective of Bergson’s philosophy and its relation to modern physics.—D. R. P. (shrink)

The correct locus (or loci) of binding theory has been a matter of much discussion. Theories can be seen as varying along at least two dimensions. The rst is whether binding theory is con gurationally determined (that is, the theory exploits the geometry of a phrase marker, appealing to such purely structural notions as c-command and government) or whether the theory depends rather on examining the relations between items selected by a predicate (where by selection I am intending to cover (...) everything from semantic dependencies to syntactic subcategorization). The second is the level of grammar on which binding is de ned. Attempting to roughly equate levels across di erent theories, suggestions have included the semantics/lexical conceptual structure (Jackendo 1992), thematic structure (Jackendo 1972, Wilkins 1988), argument structure/D-structure/initial grammatical relations (Manning 1994, Belletti and Rizzi 1988, Perlmutter 1984), surface syntax/grammatical relations, logical form, linear order, pragmatics (Levinson 1991), and discourse (Iida 1992). The data is su ciently varied and complex that many theories end up as mixtures, variously employing a combination of elements along both dimensions (for instance, Chomsky (1986) relies purely on con gurational notions for the relationship between an anaphor and its antecedent, but uses concepts from selection in the de nition of the binding domain of an anaphor). LFG has always rejected a con gurational account of binding. For instancError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMape, Simpson (1991) argues that a con gurational theory of binding in Warlpiri cannot be maintained, among other reasons because nite clauses lack a VP.. (shrink)

The main objective o f this descriptive paper is to present the general notion of translation between logical systems as studied by the GTAL research group, as well as its main results, questions, problems and indagations. Logical systems here are defined in the most general sense, as sets endowed with consequence relations; translations between logical systems are characterized as maps which preserve consequence relations (that is, as continuous functions between those sets). In this sense, logics together with translations form a (...) bicomplete category of which topological spaces with topological continuous functions constitute a full subcategory. We also describe other uses of translations in providing new semantics for non-classical logics and in investigating duality between them. An important subclass of translations, the conservative translations, which strongly preserve consequence relations, is introduced and studied. Some specific new examples of translations involving modal logics, many-valued logics, para- consistent logics, intuitionistic and classical logics are also described. (shrink)

In this paper I scrutinize the so-called China Brain thought experiment famously articulated by Ned Block to see whether it refutes functionalism as a theory of consciousness. I argue that it does not. Block’s case rests on a single premise, P, in the following argument: a creature with a China Brain would lack qualitative experience, despite its being a functional replica of you or me, and working under the assumption that we have rich mental life complete with qualia. (...) Yet if a China Brain-creature were truly and completely R, and yet P were true as the thought experiment purports to show, functionalism would have to be false. Since I want to reject that conclusion, I must do one of the following: deny that Mr. Li is truly R in the first place; grant that Mr. Li is truly R and grant that P, but deny that we have M; or grant that Mr. Li is truly R and grant that we have M, but deny that P. I opt for the third option. First, I paint a picture according to which Mr. Li's having M would not seem as implausible as it does at first. That is, I try to make the premise P seem less intuitive. But in case I am unpersuasive in this first approach, I employ a second tactic as well. This one is to suggest that we cannot know, even in principle whether P, so it is an irrelevant intuition upon which to base the China Brain attack. In any case, the China Brain fails to provide a true counterexample to functionalism. (shrink)

Some would argue that the more promising areas of business ethics research are "sensitive." In such areas, it would be expected that subjects, if inclined to respond at all, would be guarded in their responses, or respond inaccurately. We provide an introduction to an empirical approach -- the unmatched block count (UCT) -- for collecting these potentially sensitive data which provides absolute anonymity and confidentiality to subjects and "legal immunity" to the researcher. Interestingly, under UCT protocol researchers could not (...) divulge subjects' responses even if they were inclined to do so. Beyond that, UCTs provide complete disclosure to subjects and there is no deception. (shrink)

Block's distinction between phenomenal and access consciousness is accepted, and it is agreed that one may be found without the other, but his account of the distinction is challenged. Phenomenal consciousness is perceptual consciousness, and it is a matter of gaining information of a detailed, nonverbal sort about the subject's body and environment. Access consciousness is good, old-fashioned introspection.

HEIDEGGER COULD NEVER RESIST A GOOD STORY. He could never resist giving what he had discovered about alëtheia and the oblivion of Being a narrative form. In Being and Time we were promised a story--which was to be written backwards--of the "destruction of the history of ontology." Beginning at the end, with Kant, it was to feel its way back through the tradition in a deconstructive gesture, looking for what had all along been blocking the discovery of the temporal meaning (...) of Being which had at last begun to emerge in Kant. In the later works this story is considerably recast. Again, the vantage point is the end, but now the end is the age of the Gestell, the enframing, the "end of philosophy," which holds us all in its grip. The end is not conceived as a modern breakthrough but as an eschaton, a dead end into which the West has run. The task of thought is to make its way back into the primordial "Beginning" in order to recapture that fleeting moment which will make it possible for us today to begin anew, to make the present into an "authentic" end, which means a transition to another beginning. (shrink)

This chapter provides a quick primer on the volumes of the comic titles Captain America and Avengers. It talks about the beginnings and endings of which usually coincide with major events in the Marvel Universe. The story starts with the first volume of Avengers, since it was in the classic issue #4 of that title that Captain America was found in a block of ice and revived. These long‐running volumes of Captain America and Avengers lasted until 1996. Both series (...) ended when the Avengers were apparently killed in a battle with the villainous Onslaught. After the Avengers vs. X‐Men event, Marvel Comics relaunched many of its books and introduced new ones. The Watcher only knows what volume Captain America and the various Avengers titles are on, but Cap will live in on comics, movies, and TV long after this book has changed the course of American history. (shrink)

Religion and the Philosophy of Life considers how religion as the source of civilization transforms the fundamental bio-sociology of humans through language and the somatic exploration of religious ritual and prayer. Gavin Flood offers an integrative account of the nature of the human, based on what contemporary scientists tell us, especially evolutionary science and social neuroscience, as well as through the history of civilizations. Part one contemplates fundamental questions and assumptions: what the current state of knowledge is concerning life itself; (...) what the philosophical issues are in that understanding; and how we can explain religion as the driving force of civilizations in the context of human development within an evolutionary perspective. It also addresses the question of the emergence of religion and presents a related study of sacrifice as fundamental to religions' views about life and its transformation. Part two offers a reading of religions in three civilizational blocks-India, China, and Europe/the Middle East-particularly as they came to formation in the medieval period. It traces the history of how these civilizations have thematised the idea of life itself. Part three then takes up the idea of a life force in part three and traces the theme of the philosophy of life through to modern times. On the one hand, the book presents a narrative account of life itself through the history of civilizations, and on the other presents an explanation of that narrative in terms of life.". (shrink)

It is taken for granted that the explanation of the Universe’s space-time dimension belongs to the host of the arguments that exhibit the superiority of modern (inflationary) cosmology over the standard model. In the present paper some doubts are expressed . They are based upon the fact superstring theory is too formal to represent genuine unification of general relativity and quantum field theory. Neveretheless, the fact cannot exclude the opportunity that in future the superstring theory can become more physical. Hence (...) this paper does not aim to query neither string cosmology, nor superstring theory; it asks for “tolerance in the matters cosmological”. It advices the researchers not to dwell on the common way of unification and to take into consideration the other ways as well. (shrink)

The term “euthanasia” is used in conflicting ways in the bioethical literature, as is the term “assisted suicide,” resulting in definitional confusion, ambiguities, and biases which are counterproductive to ethical and legal discourse. I aim to rectify this problem in two parts. Firstly, I explore a range of conflicting definitions and identify six disputed definitional factors, based on distinctions between (1) killing versus letting die, (2) fully intended versus partially intended versus merely foreseen deaths, (3) voluntary versus nonvoluntary versus involuntary (...) decisions, (4) terminally ill versus non-terminally ill patients, (5) patients who are fully conscious versus those in permanent comas or persistent vegetative states, and (6) patients who are suffering versus those who are not. Secondly, I distil these factors into six “building blocks” and combine them to develop an unambiguous, value-neutral taxonomy of “end-of-life practices.” I hope that this taxonomy provides much-needed clarification and a solid foundation for future ethical and legal discourse. (shrink)

Phillips argues that Block faces a “serious internal challenge” in defending the claim that unconscious perception is of the same fundamental kind as conscious perception. This challenge is said to result from Block’s commitment to phenomenal overflow. However, in this paper, I demonstrate that Phillips’ rejection of overflow likewise renders his view on unconscious perception “internally challenged” and therefore equally problematic.