Our goal was to explore self‐care practices among men who have sex with men in the context of Mpox in Brazil. This study used qualitative research methods, including interviews and thematic analysis, to collect and analyze data from male participants across the Brazilian territory. The narratives unveil men's perspectives on self‐care, risk reduction, and health beliefs during the Mpox pandemic. Our findings highlight a multifaceted approach to self‐care among men, encompassing hygiene, physical contact management, mask usage, skin lesion vigilance, and (...) adherence to official guidelines. Men's attitudes toward sexual behaviors emphasize the importance of reducing sexual partners, practicing safe sex, and combating misinformation through accurate information dissemination. The development of these behaviors and self‐care practices can be facilitated by nurses guided by Dorothea Orem's Self‐Care Theory, supported by patient‐centered care, with strategies to address and confront the stigma associated with the disease and provide emotional support. Thus, the study underscores the pivotal role of self‐care in mitigating infection risks, especially in the context of emerging infectious diseases. It acknowledges the impact of socio‐cultural factors and healthcare policies on men's preventive measures. However, it also recognizes limitations, such as potential bias due to stigma concerns and a nonrepresentative sample. Ultimately, the research advocates for tailored education, promotion of gender equity, and healthcare empowerment to effectively manage health risks in such contexts. (shrink)

Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities. An artesunate suppository that can be given by minimally skilled persons might be of value when patients suddenly become too ill for oral treatment but are several hours from a facility that can give injectable treatment for severe disease. In such situations, by default, no treatment is (or can be) given until the patient (...) reaches a facility, making the placebo control design clinically relevant; alternative bioequivalence designs at the facility would misrepresent reality and risk incorrect conclusions. We describe the ethical issues underpinning a placebo-controlled trial in severe malaria. To protect patients and minimise risk, all patients were referred immediately to hospital so that each had a higher chance of prompt treatment through participation. There was no difference between artesunate and placebo in patients who reached clinic rapidly; among those who could not, a single artesunate suppository significantly reduced death or permanent disability, a finding of direct and indirect benefit to patients in participating villages and elsewhere. (shrink)

Neurosurgery for psychiatric disorders, also sometimes referred to as psychosurgery, is rapidly evolving, with new techniques and indications being investigated actively. Many within the field have suggested that some form of guidelines or regulations are needed to help ensure that a promising field develops safely. Multiple countries have enacted specific laws regulating NPD. This article reviews NPD-specific laws drawn from North and South America, Asia and Europe, in order to identify the typical form and contents of these laws and to (...) set the groundwork for the design of an optimal regulation for the field. Key challenges for this design that are revealed by the review are how to define the scope of the law, what types of regulations are required, and how to approach international harmonization given the potential migration of researchers and patients. (shrink)

Brian C. Ribeiro’s _Sextus, Montaigne, Hume: Pyrrhonizers_ invites us to view the Pyrrhonist tradition as involving all those who share a commitment to the activity of Pyrrhonizing and develops fresh, provocative readings of Sextus, Montaigne, and Hume as radical Pyrrhonizing skeptics.

Yoga is believed to have beneficial effects on cognition, attenuation of emotional intensity and stress reduction. Previous studies were mainly performed on eastern experienced practitioners or unhealthy subjects undergoing concomitant conventional therapies. Further investigation is needed on the effects of yoga per se, as well as its possible preventive benefits on healthy subjects. We investigated the effects of yoga on memory and psychophysiological parameters related to stress, comparing yoga practice and conventional physical exercises in healthy men . Memory tests, salivary (...) cortisol levels and stress, anxiety, and depression inventories were assessed before and after 6 months of practice. Yoga practitioners showed improvement of the memory performance, as well as improvements in psychophysiological parameters. The present results suggest that regular yoga practice can improve aspects of cognition and quality of life for healthy individuals. An indirect influence of emotional state on cognitive improvement promoted by yoga practice can be proposed. (shrink)

We comment on the last chapter of Henrich where the author offers a ‘key’ to Hegel’s Logic focusing on the problem of the passage from self-reference to determination in the beginning of the Logic. We argue that what he offers as a ‘key’ is actually a reduction of Hegel to the logic of understanding from the point of view of an autonomous Ego; consequently, he excludes dialectics. Contrarily, we present Hegel’s own solution, eliciting the remark where he shows that the (...) proposition “Being and Nothing are the same” negates itself insofar as it is uttered and reflected on the Other’s understanding. We conjecture that this remark offers a privileged point from which to consider the connection Hegel-Lacan, provided we recognize the Absolute in Hegel as the big Other in Lacan. We suggest that the dialectical identity of identity and difference is actually an operation in the Agora and that the Hegel-Marx-Lacan theory can be properly denominated dialectical materialism. We also offer an answer to Žižek’s question of how a “neutral medium of designation” can emerge within a “life-world practice” or out of a “universe of matter. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Reviewed by Sextus, Montaigne, Hume: Pyrrhonizers by Brian C. Ribeiro Donald C. Ainslie Brian C. Ribeiro. Sextus, Montaigne, Hume: Pyrrhonizers. Brill: Leiden, 2021. Pp. 165. Hardback, $154.00. Brian C. Ribeiro’s Sextus, Montaigne, Hume: Pyrrhonizers is a charming and quirky investigation of his three titular skeptics. It is perhaps best understood as a skeptical investigation of skepticism. By that I mean that, like a good Pyrrhonist, (...) Ribeiro explains how things appear to him without claiming to lay down a doctrine or dogma. His topic is how and why skepticism still matters (7). And he suggests that those who are moved by skeptical arguments can learn intellectual modesty from them and thereby achieve a degree of philosophical “calmness of soul” (141).Ribeiro approaches his three figures by taking the cogency of their skeptical arguments for granted. There is little investigation of why these philosophers call various beliefs into question, and his concern is rather what remains once the skeptical doubts are taken on board. Because what he calls “Pyrrhonizing” philosophers reveal that large swaths of our beliefs lack epistemic merit, they also show us how we are not fully rational creatures in our everyday lives. In the case of Sextus, Ribeiro’s focus is on the famous question of whether skeptics can live their skepticism once they have actually suspended all belief. With Sextus, as with Montaigne and Hume, Ribeiro opts for the more radical of the interpretive options; he is not persuaded by Michael Frede’s suggestion that Pyrrhonists restrict their suspension only to abstruse matters, not the everyday (51). But even if we follow the “four-fold way” (20–23) that Sextus offers us as guides for life—the directives of nature, feelings, custom, and expertise—Ribeiro still thinks we will inevitably fall back into belief. He concludes that the original Pyrrhonists should be read aspirationally: insofar as we develop our capacities [End Page 517] to argue on both sides of every question and thus are able to suspend judgment, to that extent we will achieve tranquility. In the case of Montaigne, Ribeiro focuses on his Christian fideism. Once he recognizes the incapacity of reason to resolve intellectual problems, he falls back on faith. And Ribeiro argues that the Catholic flavor of this faith is simply a reflection of Montaigne’s surroundings. In a different community, he could just as easily have embraced a different faith. The heart of the book concerns Hume, whom Ribeiro discusses in three chapters, as opposed to the one each devoted to Sextus and Montaigne. In keeping with his interpretive preferences, Ribeiro’s Hume is a radical skeptic, though he acknowledges the significant yet “utterly perplexing” (95n22) naturalist strains that are also present. Ribeiro takes the resulting tension to be insoluble (98), though I was not convinced. Consider that, in both the Treatise and the Enquiry, Hume uses causal reasoning to investigate causal reasoning. He learns that our ideas are caused by prior impressions; that repeated experience of conjoint events causes us to associate our ideas of similar events; and so on. In the Treatise, he concludes the argument that association is at the root of such causal reasoning by presenting a set of rules, a “logic,” for it. The argument is not as such skeptical, though when Hume “recasts” it in the first Enquiry, he does so in terms of “sceptical doubts” and a “sceptical solution.” In the Treatise, “total” and “extravagant” skepticism come into play only as “systems of philosophy” that Hume uses to shed light on his own core commitments. The problem, I think, is that Ribeiro tends to read Hume a little too literally, as if he is himself falling prey to the skeptical upheaval of the conclusion to the first book of the Treatise, or the final section of the first Enquiry. But I would suggest that Hume is rather deploying the rhetoric of skepticism in these discussions, using it for his ultimate philosophical ends (a point that is especially clear in Ribeiro’s favorite of Hume’s works, the Dialogues). He is showing his reader how his naturalistic philosophical project is itself rooted in human nature, and thus does not yield insight into the intrinsic structure of... (shrink)

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This work highlights the faith of Jesus as a response to the affiliate relationship between the Father and the Son. This intimate union, characterized by the word Abba, reveals that the very existence of Jesus took place in the bosom of the Father and it was developed in the intimacy with Him. It is in thi.s loving bosom of the Father that, from the beginning, Jesus constitutes the consciousness of a God who is close, loving and able to hear the (...) cries of his people. The Lordship of God is crystallized in the actions of Jesus through the proclamation of the Kingdom. The force that makes Jesus embrace the plan of God is the Spirit, making Jesus desirous and able to carry out the will of the Father. (shrink)

Mucopolysaccharidosis type I (MPS I) is a rare lysosomal storage disorder treated with bone marrow transplantation or enzyme replacement therapy with laronidase, a high-cost orphan drug. Laronidase was approved by the US Food and Drug Administration and the European Medicines Agency in 2003 and by the Brazilian National Health Surveillance Agency in 2005. Many Brazilian MPS I patients have been receiving laronidase despite the absence of a governmental policy regulating access to the drug. Epidemiological and treatment data concerning MPS I (...) are scarce. This study aims to present a demographic profile of Brazilian patients with MPS I, describe the routes of access to laronidase in Brazil, and discuss associated ethical issues relating to public funding of orphan drugs. (shrink)

O tema do artigo é a análise retórica do Salmo 127 no contexto dos “Salmos das Subidas”. O objetivo consiste em analisar a relação retórica possível entre o sentido da composição e o desempenho processional dos peregrinos de Jerusalém. Especificamente, trata-se de perguntar pela relação entre o conteúdo do salmo e a peregrinação para Jerusalém, a que sua leitura estaria por hipótese destinada. A metodologia consiste a) em tradução do salmo, b) análise de sua posição relativa na estrutura quiástica da (...) coleção, c) diálogo crítico com autoridades do campo dos comentários aos Salmos d) e proposição de leitura alternativa em relação ao conjunto das leituras da literatura. Concluiu-se que o Salmo 127 pode ter sido composto como alerta ou ameaça quanto ao risco de adiar-se a peregrinação a Jerusalém por força de razões que poderiam resultar na contrariedade de Yahweh, aquele que, em última análise, se não estiver contrariado, é quem garante a eficiência daquelas atividades que ora se alegariam como razões para abster-se da peregrinação. (shrink)

As proposições condicionais receberam atenção teórica concentrada, embora intermitente, desde a Antiguidade. A atenção durante últimos quarenta anos tem sido intensa. Nesse artigo, apresentaremos os principais desenvolvimentos da análise lógica acerca das proposições condicionais e discutiremos como elas desempenham papel central em muitas teorias filosóficas. Na primeira parte dessas observações introdutórias, mostraremos como os antigos, principalmente as escolas megárica e estoica, envolveram-se com a questão dos condicionais e quão importante isso foi para os posteriores desenvolvimentos da análise lógica dos condicionais (...) no medievo e na Idade Moderna. Por fim, apresentaremos, já na contemporaneidade, C. I. Lewis expondo sua teoria da implicação estrita em franca oposição à doutrina da implicação que ele julgava errada. Espera-se que este trabalho sirva como a apresentação panorâmica de um campo que em lógica ainda é muito frutífero e fecundo para aprofundamentos e novas ideias. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Sextus, Montaigne, Hume: Pyrrhonizers by Brian C. RibeiroJerry GreenRIBEIRO, Brian C. Sextus, Montaigne, Hume: Pyrrhonizers. Leiden: Brill, 2021. ix + 165 pp. Cloth, $145.00; eBook, $149.00As the title suggests, this short, engaging work explores a continuity between three major thinkers in the Western skeptical tradition. The label "Pyrrhonizers" is well chosen: What draws Sextus Empiricus, Montaigne, and Hume together is a set of attitudes about the limits of (...) reason and the value of constant inquiry. These thinkers are united not by commitment to a set of propositions that would group them together in some kind of static philosophical school but, rather, by a kind of pessimism about rationality's power. Ribeiro uses these figures to prompt a thought-provoking inversion of a traditional challenge to skepticism: Not only is it possible for a skeptic to live his skepticism, it is also unexpectedly easy to do so, because rationality has a surprisingly weak hold on us. This means that we can continue to be skeptics even when we cannot bring ourselves to believe or reject dogmatic claims, so long as we continue to pyrrhonize.Chapter 1 is a defense of the psychological reality of epistemic akrasia, a phenomenon by which an epistemic agent fails to form beliefs governed by the evidence she takes herself to have (analogous to the more familiar weakness of will in moral psychology). In particular, Ribeiro focuses on skeptical cases where one takes oneself to have sufficient reason to suspend judgment regarding p but nevertheless persists in believing that p. This chapter engages with contemporary literature in epistemology that [End Page 158] denies the possibility of epistemic akrasia; Ribeiro points to real cases of the phenomenon to show that it is an actual occurrence in human psychology.Chapter 2 surveys the three eponymous subjects of the book, arguing that Sextus, Montaigne, and Hume are engaged in a single, historically continuous project regarding epistemic agency and human reason-responsiveness. Whatever differences these three figures may have, each is interested in probing the boundaries of belief, looking for the borders of rationality where our beliefs persist even in the face of evidence or arguments against them.Chapter 3 looks more closely at the version of Pyrrhonian skepticism found in Sextus Empiricus. Ribeiro argues that Sextus saw global suspension of belief as an ethical ideal conducive to tranquility and hence eudaimonia. Comparable to the Stoic moral sage, this ideal may not be fully realizable in actual life, but one can nevertheless make progress toward this ideal. Crucially, this progress is compatible with intractable beliefs about which suspension of judgment is difficult or fleeting: Even if one cannot globally suspend judgment about all matters at once, one can still become increasingly more tranquil as one develops the ability to suspend judgment more successfully over time.Chapter 4 transitions to Montaigne's Essays. Ribeiro devotes the bulk of the chapter to showing that Montaigne was explicitly influenced by ancient Pyrrhonian skepticism (via both Sextus and Cicero). The most important point, however, is that Montaigne exemplifies the Pyrrhonian project in his constant revisions to his Essays throughout his life, modeling the zetetic approach of perpetual investigation. Montaigne's chief contribution to this project is to redirect it away from the dogmatic disputes over unclear matters that we see among the ancient skeptics, and toward continual autobiographical self-reflection.Chapter 5 pauses the historical focus of the previous chapters, to return to the topic of human rationality. This chapter uses a Humean observation of the power of custom or habit compared to reason to argue that human rational self-control is surprisingly weak. Similar to the worry about epistemic akrasia discussed in chapter 1, here Ribeiro uses the plausibility of certain skeptical arguments to suggest that we may lack the ability to form beliefs even when we take the arguments supporting those beliefs to be persuasive.Chapters 6 and 7 return to a historical focus, this time concentrating on Hume. Drawing on the work of Karánn Durland, chapter 6 argues that there is an irresolvable tension across Hume's works: In some places Hume endorses naturalism, in others skepticism. Ribeiro takes this to be further evidence for... (shrink)