Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities. An artesunate suppository that can be given by minimally skilled persons might be of value when patients suddenly become too ill for oral treatment but are several hours from a facility that can give injectable treatment for severe disease. In such situations, by default, no treatment is (or can be) given until the patient (...) reaches a facility, making the placebo control design clinically relevant; alternative bioequivalence designs at the facility would misrepresent reality and risk incorrect conclusions. We describe the ethical issues underpinning a placebo-controlled trial in severe malaria. To protect patients and minimise risk, all patients were referred immediately to hospital so that each had a higher chance of prompt treatment through participation. There was no difference between artesunate and placebo in patients who reached clinic rapidly; among those who could not, a single artesunate suppository significantly reduced death or permanent disability, a finding of direct and indirect benefit to patients in participating villages and elsewhere. (shrink)

Neurosurgery for psychiatric disorders, also sometimes referred to as psychosurgery, is rapidly evolving, with new techniques and indications being investigated actively. Many within the field have suggested that some form of guidelines or regulations are needed to help ensure that a promising field develops safely. Multiple countries have enacted specific laws regulating NPD. This article reviews NPD-specific laws drawn from North and South America, Asia and Europe, in order to identify the typical form and contents of these laws and to (...) set the groundwork for the design of an optimal regulation for the field. Key challenges for this design that are revealed by the review are how to define the scope of the law, what types of regulations are required, and how to approach international harmonization given the potential migration of researchers and patients. (shrink)

Yoga is believed to have beneficial effects on cognition, attenuation of emotional intensity and stress reduction. Previous studies were mainly performed on eastern experienced practitioners or unhealthy subjects undergoing concomitant conventional therapies. Further investigation is needed on the effects of yoga per se, as well as its possible preventive benefits on healthy subjects. We investigated the effects of yoga on memory and psychophysiological parameters related to stress, comparing yoga practice and conventional physical exercises in healthy men . Memory tests, salivary (...) cortisol levels and stress, anxiety, and depression inventories were assessed before and after 6 months of practice. Yoga practitioners showed improvement of the memory performance, as well as improvements in psychophysiological parameters. The present results suggest that regular yoga practice can improve aspects of cognition and quality of life for healthy individuals. An indirect influence of emotional state on cognitive improvement promoted by yoga practice can be proposed. (shrink)

Brian C. Ribeiro’s _Sextus, Montaigne, Hume: Pyrrhonizers_ invites us to view the Pyrrhonist tradition as involving all those who share a commitment to the activity of Pyrrhonizing and develops fresh, provocative readings of Sextus, Montaigne, and Hume as radical Pyrrhonizing skeptics.

This work highlights the faith of Jesus as a response to the affiliate relationship between the Father and the Son. This intimate union, characterized by the word Abba, reveals that the very existence of Jesus took place in the bosom of the Father and it was developed in the intimacy with Him. It is in thi.s loving bosom of the Father that, from the beginning, Jesus constitutes the consciousness of a God who is close, loving and able to hear the (...) cries of his people. The Lordship of God is crystallized in the actions of Jesus through the proclamation of the Kingdom. The force that makes Jesus embrace the plan of God is the Spirit, making Jesus desirous and able to carry out the will of the Father. (shrink)

A sociedade contemporânea tem como característica a imensa e diversificada variedade de culturas. Neste contexto a filosofia encontra um desafio profundo, a saber, buscar os invariantes conceituais que possibilitam interpretar a unidade no conceito. Neste artigo, abordaremos a problemática da interpretação filosófica da cultura numa tentativa de elucidar, filosoficamente, os invariantes conceituais presentes em todas as culturas, propriamente investigando o conceito de cultura na interpretação do jesuíta Henrique Cláudio de Lima Vaz, S.I.. Primeiramente, perguntando pelas características filosóficas da cultura e (...) sua composição em pluriversos culturais. Depois caminhando em direção a um questionamento sobre a ontologia, o lugar da filosofia e a constituição do ethos. Para finalmente apontar caminhos, que se configuram como desafios, a toda interpretação filosófica das culturas.: Contemporary society is characterized by the immense and diverse range of cultures. In this context the philosophy has a profound challenge, namely to seek conceptual invariants that allow the unit to interpret the concept. We will discuss the problem of philosophical interpretation of culture in an attempt to elucidate philosophically conceptual invariants present in all cultures, specifically investigating the concept of culture on the interpretation of the H. C. de Lima Vaz. First, by asking characteristics philosophical culture and its composition in cultural pluriversos. After walking towards a questioning of the ontology, the place of philosophy and ethos of the constitution. To finally pointing paths that constitute challenges to the entire philosophical interpretation of cultures. Key words: Culture, philosophy, ethos, Lima Vaz. (shrink)

We comment on the last chapter of Henrich where the author offers a ‘key’ to Hegel’s Logic focusing on the problem of the passage from self-reference to determination in the beginning of the Logic. We argue that what he offers as a ‘key’ is actually a reduction of Hegel to the logic of understanding from the point of view of an autonomous Ego; consequently, he excludes dialectics. Contrarily, we present Hegel’s own solution, eliciting the remark where he shows that the (...) proposition “Being and Nothing are the same” negates itself insofar as it is uttered and reflected on the Other’s understanding. We conjecture that this remark offers a privileged point from which to consider the connection Hegel-Lacan, provided we recognize the Absolute in Hegel as the big Other in Lacan. We suggest that the dialectical identity of identity and difference is actually an operation in the Agora and that the Hegel-Marx-Lacan theory can be properly denominated dialectical materialism. We also offer an answer to Žižek’s question of how a “neutral medium of designation” can emerge within a “life-world practice” or out of a “universe of matter. (shrink)

As proposições condicionais receberam atenção teórica concentrada, embora intermitente, desde a Antiguidade. A atenção durante últimos quarenta anos tem sido intensa. Nesse artigo, apresentaremos os principais desenvolvimentos da análise lógica acerca das proposições condicionais e discutiremos como elas desempenham papel central em muitas teorias filosóficas. Na primeira parte dessas observações introdutórias, mostraremos como os antigos, principalmente as escolas megárica e estoica, envolveram-se com a questão dos condicionais e quão importante isso foi para os posteriores desenvolvimentos da análise lógica dos condicionais (...) no medievo e na Idade Moderna. Por fim, apresentaremos, já na contemporaneidade, C. I. Lewis expondo sua teoria da implicação estrita em franca oposição à doutrina da implicação que ele julgava errada. Espera-se que este trabalho sirva como a apresentação panorâmica de um campo que em lógica ainda é muito frutífero e fecundo para aprofundamentos e novas ideias. (shrink)

Mucopolysaccharidosis type I (MPS I) is a rare lysosomal storage disorder treated with bone marrow transplantation or enzyme replacement therapy with laronidase, a high-cost orphan drug. Laronidase was approved by the US Food and Drug Administration and the European Medicines Agency in 2003 and by the Brazilian National Health Surveillance Agency in 2005. Many Brazilian MPS I patients have been receiving laronidase despite the absence of a governmental policy regulating access to the drug. Epidemiological and treatment data concerning MPS I (...) are scarce. This study aims to present a demographic profile of Brazilian patients with MPS I, describe the routes of access to laronidase in Brazil, and discuss associated ethical issues relating to public funding of orphan drugs. (shrink)

O tema do artigo é a análise retórica do Salmo 127 no contexto dos “Salmos das Subidas”. O objetivo consiste em analisar a relação retórica possível entre o sentido da composição e o desempenho processional dos peregrinos de Jerusalém. Especificamente, trata-se de perguntar pela relação entre o conteúdo do salmo e a peregrinação para Jerusalém, a que sua leitura estaria por hipótese destinada. A metodologia consiste a) em tradução do salmo, b) análise de sua posição relativa na estrutura quiástica da (...) coleção, c) diálogo crítico com autoridades do campo dos comentários aos Salmos d) e proposição de leitura alternativa em relação ao conjunto das leituras da literatura. Concluiu-se que o Salmo 127 pode ter sido composto como alerta ou ameaça quanto ao risco de adiar-se a peregrinação a Jerusalém por força de razões que poderiam resultar na contrariedade de Yahweh, aquele que, em última análise, se não estiver contrariado, é quem garante a eficiência daquelas atividades que ora se alegariam como razões para abster-se da peregrinação. (shrink)

Trata das possibilidades de uma teologia ecumênica das religiões tendo como eixo articulador a preocupação pela paz, pela justiça e pela integridade da criação. O objetivo é analisar temas de destaque para o cenário das análises sociais e teológicas como: a) O valor do humano e da ética social para o diálogo interreligioso, b) As possibilidades de uma unidade aberta, convidativa e integradora no âmbito das religiões; c) A importância pública das religiões; d) As religiões como códigos de comunicação; e) (...) O poder do império e o poder do diálogo das religiões. Para isso, vamos contar com as contribuições de Hans Küng, Jürgen Moltmann, Julio de Santa Ana, Xavier Pikaza e José Comblin respectivamente. A proposição é que a perspectiva ecumênica, uma vez articulada com as dimensões sociais, políticas, econômicas e culturais, dentro dos variados contextos históricos, pode oferecer densidade e amplitude para a reflexão teológica. Os esforços que valorizam a capacidade de diálogo e de sensibilidade ecumênica e aqueles que destacam a importância pública das religiões partem da concepção de que a perspectiva ecumênica, tanto em nível prático quanto em nível teórico-metodológico, requer e possibilita uma compreensão mais apurada da realidade, um aperfeiçoamento de visões dialógicas e o cultivo de maior sensibilidade para a valorização da vida e para a promoção da paz e da justiça. Palavras-chave: Teologia das religiões. Ecoteologia. Paz e justiça. Ecumenismo.This paper focus on the possibilities of an ecumenical theology of religions, having as a its principal concern peace, justice and integrity of creation. It aims to analyze some central issues for the social and theological scenario, such as: a) humanity and social ethics for interreligious dialogue; b) the possibilities for an open, engaging and inviting interreligious unity; c) the public relevance of religions; d) religions as communicating codes; e) the imperial powers and the power of religious dialogue. We will take into account the contributions of Hans Küng, Jürgen Moltmann, Julio de Santa Ana, Xavier Pikaza and José Comblin. The study affirms that the ecumenical perspective, once articulated to social, political, economic and cultural dimensions, within the various theological contexts, can offer density and extension for the theological reflection. Efforts that value the capacity for dialogue and ecumenical sensibility and those that highlight the public importance of religions start from the conception that the ecumenical perspective, both in the practical and in the theoretical-methodological levels, requests and makes it possible for a deeper comprehension of the reality, an improvement of dialogic visions and the cultivation of more expressions of sensibility for the valorization of life and for the promotion of peace and justice. Key-words: Theology of religions. Ecotheology. Peace and justice. (shrink)

This six volume backlist collection brings together an assortment of seminal works by highly influential British philosopher A. C. Ewing. This comprehensive and diverse collection encompasses a fantastic selection of his work in the field of moral philosophy and the history of philosophy; ranging from the definition of good, through to his views on punishment and a study on the work of Emmanuel Kant. Spanning more than 30 years in Professor Ewing’s distinguished career, the reissued volumes in this collection, originally (...) published between 1924 and 1959, offer a thorough and engaging insight into Professor Ewing’s work. (shrink)

AC Grayling is Britain’s leading popular philosopher. A professor at Birkbeck College, University of London, he has written over 20 books, ranging from academic monographs such as Truth, Meaning and Realism to more accessible works such as What is Good? and The Mystery of Things. His most recent books are Towards The Light and The Choice of Hercules.

AC Grayling is Britain’s leading popular philosopher. A professor at Birkbeck College, University of London, he has written over 20 books, ranging from academic monographs such as Truth, Meaning and Realism to more accessible works such as What is Good? and The Mystery of Things. His most recent books are Towards The Light and The Choice of Hercules.

INTRODUCTION This volume of essays is meant as a tribute to Alistair Crombie by some of those who have studied with him. The occasion of its publication is ...

I do not think that the existence of God can be proved or even that the main justification for the belief can be found in argument in the ordinary sense of that term, but I think two of the three which have, since Kant at least, been classified as the traditional arguments of natural theology have some force and are worthy of serious consideration. This consideration I shall now proceed to give. I cannot say this of the remaining one of (...) the arguments, the ‘ontological proof’, which I shall therefore not discuss here. (shrink)

A little while ago I thought the ontological argument dead and buried beyond any possible hope of resurrection and no philosophical event has caused me much greater surprise than its revival by a member of the very linguistic school to whose line of thinking it seemed most alien and who were held to have given it its quietus once for all. I am tempted to welcome any relapse into metaphysics by a member of this school as being some sign of (...) grace, but on this issue I must for once take sides with the prevailing tradition against at least this kind of metaphysics. Let me make clear, however, what it is I am combating. The term ‘ontological argument’ has been used for arguments which its original supporters would certainly not have recognised as theirs. It has been used for instance to stand for the claim that it is an essential presupposition of thought that what we must think is true of the real, a claim which could not be used to prove the existence of God unless we had available another proof that we really must think that God exists. It has been used for kinds of ‘idealist’ arguments which I do not want to discuss here. It has been used for the argument that the idea of a perfect being cannot be explained as derived from any other idea and must therefore be explained as produced in us by a being who really is perfect, an argument which appears in Descartes side by side with the ontological argument but which he carefully distinguishes from it. (shrink)

In the first and shorter part of this essay I comment on Wittgenstein's general influence on the practice of philosophy since his time. In the second and much longer part I discuss aspects of his work which have had a more particular influence, chiefly on debates about meaning and mind. The aspects in question are Wittgenstein's views about rule-following and private language. This second part is more technical than the first.

According to a common misconception, Kant rejects rhetoric as worthy of no respect and neglects popularity as a dispensable accessory. Two recent publications on the communicative dimension of Kant’s conception and practice of philosophy represent a very solid rebuttal of such criticism. The books in question are Kant’s Philosophy of Communication by G. L. Ercolini and A linguagem em Kant. A linguagem de Kant edited by Monique Hulshof and Ubirajara Rancan de Azevedo Marques, especially in light of the long chapter (...) “Kant e a Questão da Popularidade e da Linguagem da Filosofia” by Leonel Ribeiro dos Santos (pp. 17- 69). What Ercolini’s monograph and Santos’ chapter have in common, is that they both argue that Kant does indeed value and practice both rhetoric and popularity. However, they differ from each other in that Ercolini lets Kant’s reflection on popularity derive from occasional factors, while Santos locates its origin at the heart of Kant’s critical project. In order fully to appreciate their novelty, these two contributions call for an overview of the state of research on the subject of Kant’s conception of rhetoric. Thus, before closely examining them, I will briefly outline the relevant scholarship by dividing it into the three classes of those who interpret Kant (a) as a skillful rhetorician, (b) as dismissive of rhetoric, and finally (c) as according rhetoric a moral function. (shrink)

An attractive paperback reprint of Cohen's illuminating studies in the philosophy of logic.--A. C. P.

Scholars of epistemology have identified two conceptions of epistemic injustice: discriminatory epistemic injustice and distributive epistemic injustice. The former refers to wrongs to one’s capacity as a knower that are the result of identity prejudice. The latter refers to violations of one’s right to know what one is entitled to know. This essay advances a third conception, formative epistemic injustice, which refers to wrongs to one’s capacity as a knower that are the result of or result in malformation—the undue restriction (...) of one’s formative capacities. The author argues that formative epistemic injustice is a distinctly educational wrong and that it brings to light important epistemic injustices that standard accounts of epistemic injustice either downplay or are unable to capture. This third conception of epistemic injustice is an important analytic tool for theorizing both epistemic injustice and educational justice. (shrink)

Ludwig Wittgenstein (1889-1951) was an extraordinarily original thinker, whose influence on twentieth-century thinking far outside the bounds of philosophy alone. In this engaging Introduction, A.C. Grayling makes Wittgenstein's thought accessible to the general reader by explaining the nature and impact of Wittgenstein's views. He describes both his early and later philosophy, the differences and connections between them, and gives a fresh assessment of Wittgenstein's continuing influence on contemporary thought.

A rather popular mixture of biography, philosophy, and theology, for the Catholic layman. Scotus' role in the defense of the doctrine of the Immaculate Conception receives special emphasis. --A. C. P.

In this benchmark five-volume study, originally published between 1922 and 1955, Surendranath Dasgupta examines the principal schools of thought that define Indian philosophy. A unifying force greater than art, literature, religion, or science, Professor Dasgupta describes philosophy as the most important achievement of Indian thought, arguing that an understanding of its history is necessary to appreciate the significance and potentialities of India's complex culture. Volume I offers an examination of the Vedas and the Brahmanas, the earlier Upanisads, and the six (...) systems of Indian philosophy. (shrink)

The point of formalisation is to model various aspects of natural language. Perhaps the main use to which formalisation is put is to model and explain inferential relations between different sentences. Judged solely by this objective, a formalisation is successful in modelling the inferential network of natural language sentences to the extent that it mirrors this network. There is surprisingly little literature on the criteria of good formalisation, and even less on the question of what it is for a formalisation (...) to mirror the inferential network of a natural language or some fragment of it. This paper takes some exploratory steps towards a quantitative account of the main ingredient in the goodness of a formalisation. We introduce and critically examine a mathematical model of how well a formalisation mirrors natural-language inferential relations. (shrink)