Over the past few decades, there has been increasing attention focused on the ethics of health research, particularly in low- and middle-income countries. Despite the increasing focus on the literature addressing human protection, community engagement, appropriate consent procedures and ways to mitigate concerns around exploitation, there has been little discussion about how the duration of the research engagement may affect the ethical design and implementation of studies. In other words, what are the unique ethical challenges when researchers engage with host (...) communities for longer periods (10 years or more), and what special considerations does this time commitment generate when applying ethical principles to these kinds of studies? This article begins to outline key areas of ethical concern that arise during long-term, sustained research activities with communities in low-resource settings. Through a review of the literature and consultations with experts in health systems, we identified the following key themes: fair benefits and long-term beneficence; community autonomy, consultation and consent; impacts on local health systems; economic impacts of research participation; ethical review processes; and institutional processes and oversight within research organizations. We hope that this preliminary exploration will stimulate further dialogue and help inform ethical guidance around long-term research engagements in the developing world. (shrink)

The nature of quantum computation is discussed. It is argued that, in terms of the amount of information manipulated in a given time, quantum and classical computation are equally efficient. Quantum superposition does not permit quantum computers to ''perform many computations simultaneously'' except in a highly qualified and to some extent misleading sense. Quantum computation is therefore not well described by interpretations of quantum mechanics which invoke the concept of vast numbers of parallel universes. Rather, entanglement makes available types of (...) computation processes which, while not exponentially larger than classical ones, are unavailable to classical systems. The essence of quantum computation is that it uses entanglement to generate and manipulate a physical representation of the correlations between logical entities, without the need to completely represent the logical entities themselves. (shrink)

A bi-lingual edition of poems and a "free philosophical treatise" by a poet-logician who is now imprisoned somewhere in Russia. In this choppy and compressed treatise, written hours before he was arrested, the writer discusses some pseudo-problems of philosophy, argues against the principle of excluded middle, and states the real problem of philosophy as being the relationship between the subconscious and consciousness.--A. B. D.

Written for a popular audience, this book extols the virtues of individuality--A. R.

The major portion of this important work is the "Summary of the Republic." Coordinated with Grube’s translation, it proceeds book by book, first summarizing a chunk of text anywhere from a couple of Stephanus sections to several pages, then commenting in lettered notes of from two lines to four and a half pages. More technical material, aimed at advanced students and scholars, appears occasionally in smaller type. There is a fine bibliography. The format is successful: the book is easy to (...) use and attractive in appearance. (shrink)

This is a critical edition of the work published in 1681, two years after Hobbes' death. The dialogue contains mature reflections of Hobbes on the doctrine of sovereignty. It deals with the relation between law and reason, sovereign power, crimes, heresies and punishments. The editor's introduction sets forth arguments for regarding the text as a complete work, contrary to the views of L. Stephen, Tönnies, and Robertson. A critical analysis of the argument in the dialogue is also provided indicating the (...) relation of the dialogue to Hobbes' political philosophy. The dialogue is interesting in portraying the more "liberal" side of Hobbes. It is an invaluable aid to the study of Hobbes.--A. S. C. (shrink)

An attractive paperback reprint of Cohen's illuminating studies in the philosophy of logic.--A. C. P.

Background: The magnitude of bullying and harassment among psychiatrists is reportedly high, yet no peer-review published studies addressing this issue could be found. Therefore, it was decided to conduct a pilot study to assess the degree of the problem, the types of bullying/harassment and to provide some insights into the situation.Methods and Principal Findings: Following multiple focus group meetings, a yes/no response type questionnaire was developed to assess the degree and type of bullying and harassment experienced by psychiatrists. Over a (...) 3-month period the questionnaire was administered to a random sample of 60 psychiatrists. 57 out of the 60 psychiatrists reported harassment and bullying. Frequencies of the following response variables are presented in descending order: rumours 40% ; defamation 20% ; passing remarks 20% ; false accusations 15% ; threats 13.3% ; verbal abuse 13.3% ; unjustified complaints 13.3% ; promotion blocked 13.3% ; humiliation 13% ; bad reference given 10% ; credentials questioned 8.3% ; physical attacks 5% ; termination 5% ; derogatory remarks 1.7% and 1.7% were subjected to personal work. As a result of being subjected to harassment, 66.7% of the psychiatrists did not take any action, whereas 33.3% confronted the person they believed responsible. Asked whether the bullying and harassment caused distress, 18.3% of the psychiatrists did not report any effect, 30% reported mild distress, 40% moderate distress and severe distress was reported by 11.7%.Conclusions: It was concluded that the magnitude of bullying and harassment among psychiatrists may be quite high, as evidenced by this pilot study. There is a need for extensive systematic studies on this subject and to establish strategies to prevent and address this issue at a national and regulatory level. (shrink)

The fourth volume of Professor Guthrie’s History, dealing with Plato’s life and with eighteen of his dialogues, is as welcome as its three predecessors. In keeping with the nature of a history of this sort, the picture of Plato’s life and thought presented here is judicious and non-controversial in its outlines. There are many helpful references both to the ancient and to the modern literature, and a vast amount of information is transmitted with surprising painlessness. For the facts of Plato’s (...) life, Guthrie relies on the traditional sources, especially on Epistle VII, the authenticity of which he accepts. His reconstruction is, therefore, itself quite traditional; little direct attention is given to Ryle’s attempt to undermine that view. The volume covers the following dialogues, listed here in the order of their presentation: Apology, Crito, Euthyphro, Laches, Lysis, Charmides, Hippias Major, Hippias Minor, Ion, Protagoras, Meno, Euthydemus, Gorgias, Menexenus, Phaedo, Symposium, Phaedrus, and Republic. No section is devoted in this volume to the first Alcibiades; Guthrie is noncommittal on its authenticity. The Cratylus and the Timaeus are also passed over because of difficulties in dating them. Somewhat questionable is the inclusion of the Phaedrus: Guthrie argues that it belongs among the middle dialogues, mainly on account of his view that the method of collection and division does not constitute a major discontinuity in Plato’s way of doing dialectic. On the question of Plato’s development, Guthrie follows most contemporary scholars in rejecting the unitarian view, according to which Plato held the theory of Forms, essentially unrevised, throughout his life. Rather, he leans towards the idea that the theory of Forms emerged out of Socrates’ concern with definition, bloomed in the middle dialogues, and came to be more critically examined in Plato’s later works. Guthrie deals with each dialogue separately: he examines each dialogue’s date, characters, and setting, presents a useful summary, and discusses a number of philosophically interesting questions. The section devoted to the Republic is a monograph in its own right and combines summary and discussion. The great virtues of this book are its level tone, its painstaking presentation of alternative views, and its scope. Though not always conclusive in its discussions of specific philosophical issues, it is a true labor of love, and unlikely to be superceded, as a reference work, in the near future.—A.N. (shrink)

An original contribution to fundamental metaphysics. It offers a theory of possible individuals and possible worlds. It endeavors to show how its theory of possibility is adequate to various philosophical demands, such as those of modal logic. It employs its theory of possibility to clarify and resolve issues concerning such topics as disposition concepts and counterfactual conditionals. And it deals fruitfully with related metaphysical problems, such as essentialism, the doctrine of internal relations, and so on. The theory of possibility, spelled (...) out formally and with considerable detail, is a development of the approach to possibility suggested by Rescher in his earlier book, Conceptual Idealism. (shrink)

Logical monism is the claim that there is a single correct logic, the 'one true logic' of our title. The view has evident appeal, as it reflects assumptions made in ordinary reasoning as well as in mathematics, the sciences, and the law. In all these spheres, we tend to believe that there aredeterminate facts about the validity of arguments. Despite its evident appeal, however, logical monism must meet two challenges. The first is the challenge from logical pluralism, according to which (...) there is more than one correct logic. The second challenge is to determine which form of logicalmonism is the correct one. One True Logic is the first monograph to explicitly articulate a version of logical monism and defend it against the first challenge. It provides a critical overview of the monism vs pluralism debate and argues for the former. It also responds to the second challenge by defending a particularmonism, based on a highly infinitary logic. It breaks new ground on a number of fronts and unifies disparate discussions in the philosophical and logical literature. In particular, it generalises the Tarski-Sher criterion of logicality, provides a novel defence of this generalisation, offers a clearnew argument for the logicality of infinitary logic and replies to recent pluralist arguments. (shrink)

Background: Increasing collaboration between industrialised and developing countries in human research studies has led to concerns regarding the potential exploitation of resource deprived countries. This study, commissioned by the former National Bioethics Advisory Commission of the United States, surveyed developing country researchers about their concerns and opinions regarding ethical review processes and the performance of developing country and US international review boards .Methods: Contact lists from four international organisations were used to identify and survey 670 health researchers in developing countries. (...) A questionnaire with 169 questions explored issues of IRB review, informed consent, and recommendations.Results: The majority of the developing country researchers were middle aged males who were physicians and were employed by educational institutions, carrying out research on part time basis. Forty four percent of the respondents reported that their studies were not reviewed by a developing country IRB or Ministry of Health and one third of these studies were funded by the US. During the review process issues such as the need for local language consent forms and letters for approval, and confidentiality protection of participants were raised by US IRBs in significantly higher proportions than by host country IRBs.Conclusion: This survey indicates the need for the ethical review of collaborative research in both US and host countries. It also reflects a desire for focused capacity development in supporting ethical review of research. (shrink)

Da Costa and French explore the consequences of adopting a 'pragmatic' notion of truth in the philosophy of science. Their framework sheds new light on issues to do with belief, theory acceptance, and the realism-antirealism debate, as well as the nature of scientific models and their heuristic development.

Like other epistemic activities, inquiry seems to be governed by norms. Some have argued that one such norm forbids us from believing the answer to a question and inquiring into it at the same time. But another, hither-to neglected norm seems to permit just this sort of cognitive arrangement when we seek to confirm what we currently believe. In this paper, I suggest that both norms are plausible and that the conflict between them constitutes a puzzle. Drawing on the felicity (...) conditions of confirmation requests and the biased interrogatives used to perform them, I argue that the puzzle is genuine. I conclude by considering a response to the puzzle that has implications for the debate regarding the relationship between credences and beliefs. (shrink)

A. H. Louie's More Than Life Itself is an exploratory journey in relational biology, a study of life in terms of the organization of entailment relations in living systems. This book represents a synergy of the mathematical theories of categories, lattices, and modelling, and the result is a synthetic biology that provides a characterization of life. Biology extends physics. Life is not a specialization of mechanism, but an expansive generalization of it. Organisms and machines share some common features, but organisms (...) are not machines. Life is defined by a relational closure that places it beyond the reach of physicochemical and mechanistic dogma, outside the reductionistic universe, and into the realm of impredicativity. Function dictates structure. Complexity brings forth living beings. (shrink)

In Sons of Anarchy, the male members of the MC are only one part of the story, as the Charming women play equally pivotal roles in the action. This chapter takes a look at the women to see how they wield their power, what they do with it, and how it is limited by the world in which they operate. The stories told on Sons of Anarchy are familiar to us. The character's lives ebb and flow with hopes and fears, (...) gains and losses, friendship and enmity, love and resentments, and regrets and triumphs that we can identify with. We ride alongside the characters as they strive for the ideals that make life worth living, such as friendship, love, and happiness, though none of the characters seems to have achieved these ideals perfectly in their lives. (shrink)

We use a neutrosophic set, instead of an intuitionistic fuzzy because the neutrosophic set is more general, and it allows for independent and partial independent components, while in an intuitionistic fuzzy set, all components are totally dependent. In this article, we present and demonstrate the concept of neutrosophic invariant subgroups. We delve into the exploration of this notion to establish and study the neutrosophic quotient group. Further, we give the concept of a neutrosophic normal subgroup as a novel concept.