Results for '��tienne Danchin'

66 found
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  1.  16
    The Delphic Boat. What Genomes Tell Us.Antoine Danchin - 2002 - Harvard University Press.
    Danchin argues that if scientists can reach a level of understanding of genomes, they will be able to resolve the major biological puzzle of the 21st century: the enigma of the living machine that creates the living machine.
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  2.  26
    "A Critical Note on the Use of the Term" Phenocopy.".Antoine Danchin - 1980 - In Massimo Piattelli-Palmarini (ed.), Language and Learning: The Debate Between Jean Piaget and Noam Chomsky. Harvard University Press.
    The discovery of the concrete basis for genes, and especially the clarification of mechanisms regulating gene expressions (in particular those that bear on the stepwise processing of hereditary information from the sequences of DNA nucleotides to the proteins) was to give flesh to the concept of a genetic program, for these regulations introduce relationships of order between the various elements of information contained in the genes. These order relations are then revealed during the time-dependent expression of the genetic program. They (...)
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  3.  8
    Order and Necessity.A. Danchin (ed.) - 1987 - Elsevier Sciences Publishers.
    Because this lecture was a tribute to the contribution of Monod to science it focused on his views, without discussing the work of others who contributed to his achievements. In particular, because Monod was implicitly a platonician/pythagorean (with his emphasis on the importance of beauty in things), he thought that symmetry had to be introduced in the concept of allostery. In fact this was an extra feature that was absent from the original work of Jean-Pierre Changeux on the enzyme threonine (...)
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  4.  20
    Archives or Palimpsests? Bacterial Genomes Unveil a Scenario for the Origin of Life.Antoine Danchin - 2007 - Biological Theory 2 (1):52-61.
    The three processes needed to create life, compartmentalization, metabolism, and information transfer (memory stored in nucleic acids and manipulation operated by proteins) are embedded in organized genome features. The core of life puts together growth and maintenance (which drives survival), while life in context explores and exploits specific niches. Analysis of gene persistence in a large number of genomes shows that the former constitutes the paleome, which recapitulates the three phases of the origin of life: metabolism of small molecules on (...)
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  5. Life’s Demons: Information and Order in Biology.Philippe M. Binder & Antoine Danchin - 2011 - EMBO Reports 12 (6):495-499.
    Two decades ago, Rolf Landauer (1991) argued that “information is physical” and ought to have a role in the scientific analysis of reality comparable to that of matter, energy, space and time. This would also help to bridge the gap between biology and mathematics and physics. Although it can be argued that we are living in the ‘golden age’ of biology, both because of the great challenges posed by medicine and the environment and the significant advances that have been made—especially (...)
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  6.  36
    Peirce's Early Semiotic Analysis of Representation.André De Tienne - 1988 - Semiotics:93-102.
  7.  20
    Confidence, Tolerance, and Allowance in Biological Engineering: The Nuts and Bolts of Living Things.Manuel Porcar, Antoine Danchin & Víctor de Lorenzo - 2015 - Bioessays 37 (1):95-102.
    The emphasis of systems and synthetic biology on quantitative understanding of biological objects and their eventual re-design has raised the question of whether description and construction standards that are commonplace in electric and mechanical engineering are applicable to live systems. The tuning of genetic devices to deliver a given activity is generally context-dependent, thereby undermining the re-usability of parts, and predictability of function, necessary for manufacturing new biological objects. Tolerance and allowance are key aspects of standardization that need to be (...)
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  8. No Wisdom in the Crowd: Genome Annotation at the Time of Big Data - Current Status and Future Prospects.Antoine Danchin - 2018 - Microbial Biotechnology 11 (4):588-605.
    Science and engineering rely on the accumulation and dissemination of knowledge to make discoveries and create new designs. Discovery-driven genome research rests on knowledge passed on via gene annotations. In response to the deluge of sequencing big data, standard annotation practice employs automated procedures that rely on majority rules. We argue this hinders progress through the generation and propagation of errors, leading investigators into blind alleys. More subtly, this inductive process discourages the discovery of novelty, which remains essential in biological (...)
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  9.  8
    Chronique Générale.Jacques & Deschepper Étienne - 1989 - Revue Philosophique De Louvain 87 (4):573-587.
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  10.  10
    Stabilisation fonctionnelle et épigenèse: une approche biologique de la genèse de l'identité individuelle.A. Danchin (ed.) - 1977 - Grasset.
    Une approche biologique de la genèse de l'identité individuelle. Pour introduire notre discours biologique au niveau anthropologique, nous ferons le line entre un exposé purement ethnologique et un exposé d'analyse linguistique. Cette insertion est d'autant plus cruciale qu'il s'agit de présenter ici une approche de l'identité perpendiculaire à l'analyse structurale - comme le temps est orthogonal à l'espace. Plutôt donc que d'entrer immédiatement dans le vif du sujet, je vais user d'un langage qui peut paraître quelque peu paradoxal ou inadéquat, (...)
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  11.  38
    The Flow of Time and the Flow of Signs.André De Tienne - 2015 - American Journal of Semiotics 31 (1/2):29-53.
    Peirce nurtured a lifelong interest in the mathematics, metaphysics, and logic of time. For him, time was the primal form of continuum, and he studied it as such. That study is fundamentally connected to Peirce’s semiotic and metaphysical exploration of the continuum of consciousness. In this paper I will use two successive approaches to answer the question “To what extent does the flow of time regulate the flow of signs and the flow of signs influence or determine the flow of (...)
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  12. Antifragility and Tinkering in Biology (and in Business) Flexibility Provides an Efficient Epigenetic Way to Manage Risk.Antoine Danchin, Philippe M. Binder & Stanislas Noria - 2011 - Genes 2 (4):998-1016.
    The notion of antifragility, an attribute of systems that makes them thrive under variable conditions, has recently been proposed by Nassim Taleb in a business context. This idea requires the ability of such systems to ‘tinker’, i.e., to creatively respond to changes in their environment. A fairly obvious example of this is natural selection-driven evolution. In this ubiquitous process, an original entity, challenged by an ever-changing environment, creates variants that evolve into novel entities. Analyzing functions that are essential during stationary-state (...)
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  13. Information of the Chassis and Information of the Program in Synthetic Cells.Antoine Danchin - 2009 - Systems and Synthetic Biology 3:125-134.
    Synthetic biology aims at reconstructing life to put to the test the limits of our understanding. It is based on premises similar to those which permitted invention of computers, where a machine, which reproduces over time, runs a program, which replicates. The underlying heuristics explored here is that an authentic category of reality, information, must be coupled with the standard categories, matter, energy, space and time to account for what life is. The use of this still elusive category permits us (...)
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  14. The Logic of Metabolism and its Fuzzy Consequences.A. Danchin - 2014 - Environmental Microbiology 16 (1):19-28.
    Intermediary metabolism molecules are orchestrated into logical pathways stemming from history (L-amino acids, D-sugars) and dynamic constraints (hydrolysis of pyrophosphate or amide groups is the driving force of anabolism). Beside essential metabolites, numerous variants derive from programmed or accidental changes. Broken down, variants enter standard pathways, producing further variants. Macromolecule modification alters enzyme reactions specificity. Metabolism conform thermodynamic laws, precluding strict accuracy. Hence, for each regular pathway, a wealth of variants inputs and produces metabolites that are similar to but not (...)
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  15.  20
    Persistent Biases in the Amino Acid Composition of Prokaryotic Proteins.Géraldine Pascal, Claudine Médigue & Antoine Danchin - 2006 - Bioessays 28 (7):726-738.
    Correspondence analysis of 28 proteomes selected to span the entire realm of prokaryotes revealed universal biases in the proteins’ amino acid distribution. Integral Inner Membrane Proteins always form an individual cluster, which can then be used to predict protein localisation in unknown proteomes, independently of the organism’s biotope or kingdom. Orphan proteins are consistently rich in aromatic residues. Another bias is also ubiquitous: the amino acid composition is driven by the GþC content of the first codon position. An unexpected bias (...)
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  16.  80
    Is Non-Genetic Inheritance Just a Proximate Mechanism? A Corroboration of the Extended Evolutionary Synthesis.Alex Mesoudi, Simon Blanchet, Anne Charmantier, Étienne Danchin, Laurel Fogarty, Eva Jablonka, Kevin N. Laland, Thomas J. H. Morgan, Gerd B. Müller, F. John Odling-Smee & Benoît Pujol - 2013 - Biological Theory 7 (3):189-195.
    What role does non-genetic inheritance play in evolution? In recent work we have independently and collectively argued that the existence and scope of non-genetic inheritance systems, including epigenetic inheritance, niche construction/ecological inheritance, and cultural inheritance—alongside certain other theory revisions—necessitates an extension to the neo-Darwinian Modern Synthesis (MS) in the form of an Extended Evolutionary Synthesis (EES). However, this argument has been challenged on the grounds that non-genetic inheritance systems are exclusively proximate mechanisms that serve the ultimate function of calibrating organisms (...)
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  17.  1
    What is Happening to the Peirce Project?Michelle Bella, Giovanni Maddalena & André De Tienne - 2016 - European Journal of Pragmatism and American Philosophy 8 (2).
  18.  16
    Cells Need Safety Valves.Antoine Danchin - 2009 - Bioessays 31 (7):769-773.
    In Escherichia coli, the role of lacA, the third gene of the lactose operon, has remained an enigma. I suggest that its role is the consequence of the need for cells to have safety valves that protect them from the osmotic effect created by their permeases. Safety valves allow them to cope with the buildup of osmotic pressure under accidental transient conditions. Multidrug resistance (MDR) efflux, thus named because of our anthropocentrism, is ubiquitous. Yet, the formation of simple leaks would (...)
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  19. FRUSTRATION: PHYSICO-CHEMICAL PREREQUISITES FOR THE CONSTRUCTION OF A SYNTHETIC CELL.Antoine Danchin & Agnieszka Sekowska - 2008 - In Martin G. Hicks and Carsten Kettner (ed.), Proceedings of the International Beilstein Symposium on Systems Chemistry May 26th – 30th, 2008 Bozen, Italy. Beilstein Institute. pp. 1-19.
    To construct a synthetic cell we need to understand the rules that permit life. A central idea in modern biology is that in addition to the four entities making reality, matter, energy, space and time, a fifth one, information, plays a central role. As a consequence of this central importance of the management of information, the bacterial cell is organised as a Turing machine, where the machine, with its compartments defining an inside and an outside and its metabolism, reads and (...)
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  20. Les organismes vivants comme pièges à information.Antoine Danchin - 2008 - Ludus Vitalis 16 (30):211-212.
    Life can be defined as combining two entities that rest on completely different physico-chemical properties and on a particular way of handling information. The cell, first, is a « machine », that combines elements which are quite similar (although in a fairly fuzzy way) to those involved in a man-made factory. The machine combines two processes. First, it requires explicit compartmentalisation, including scaffolding structures similar to that of the châssis of engineered machines. In addition, cells define clearly an inside, the (...)
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  21. Motivated Research.Antoine Danchin - 2010 - EMBO Reports 11 (7):488.
    The dichotomy between the research to generate knowledge and the application of that knowledge to benefit mankind seems to be a recent development. In fact, more than 100 years ago Louis Pasteur avoided this debate altogether: one of his major, yet forgotten, contributions to science was the insight that research and its applications are not opposed, but orthogonal to each other (Stokes, 1997). If Niels Bohr ‘invented’ basic academic research—which was nevertheless the basis for many technological inventions and industrial applications—Pasteur (...)
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  22.  35
    Permanence and Change.Antoine Danchin & Carl R. Lovitt - 1983 - Substance 12 (3):61.
    Determinism/indeterminism, permanence /change, global/local — these have been the occasion for disputes that have persisted for ages. Combined in every conceivable fashion, these three pairs have given rise to theories of reality which, though incompatible, nevertheless possess some degree of adequacy. Accounting for the properties of the inorganic world, on invariably confronts several opposing attitudes, each of which questions the pertinence of the continuous/discontinuous pair, which underlies any discussion of the three pairs noted above. Thinkers of Antiquity sought to deal (...)
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  23. A Theory of the Epigenesis of Neuronal Networks by Selective Stabilization of Synapses.Jean Pierre Changeux, Philippe Courrège & Antoine Danchin - 1973 - Proceedings of the National Academy of Sciences Usa 70 (10):2974-8.
    A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of the (...)
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  24.  11
    Farouk Seif’s Hypostatic Semiotic Metaphysics.André De Tienne - 2020 - American Journal of Semiotics 36 (3):369-382.
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  25.  46
    Why Semiotics? A Question Requiring a Fundamental Answer for Peirce's Sake.André De Tienne - 2015 - American Journal of Semiotics 31 (3):167-181.
    This address begins with a few historical considerations regarding the foundation of the Semiotic Society of America and how the founders came to define the purpose of the Society as that of advancing the study of signs. The question of what it means to ask “Why semiotics?” is then taken up, introduced, and framed within a strictly Peircean framework. How would Peirce have answered it, he the paramount logician of signs? Taking inspiration from his 1902 essay “Why Study Logic?”, of (...)
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  26.  48
    Peirce's Early Method of Finding the Categories.André De Tienne - 1989 - Transactions of the Charles S. Peirce Society 25 (4):385-406.
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  27.  47
    Phenomenon Vs. Sign, Appearance Vs. Representation.André De Tienne - 1999 - Semiotics:419-431.
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  28.  44
    [Hypotheses of Space and Time: A Response to Kant] Appendix No. 2.Charles S. Peirce & André De Tienne - 1993 - Transactions of the Charles S. Peirce Society 29 (4):637-673.
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  29.  11
    Postprandial Peirce: A Final Talk: A Special Séance with Peirce: His Spirit Summoned for an Entertaining Interview.André De Tienne - 2020 - Transactions of the Charles S. Peirce Society 56 (2):279-290.
  30.  11
    Postprandial Peirce: A Final Talk.André De Tienne - 2020 - Transactions of the Charles S. Peirce Society 56 (2):279.
  31. The Cambridge School of Pragmatism.André de Tienne (ed.) - 2003 - Thoemmes.
  32.  8
    Prolegomenon to Horosemiotics: Semiotic Ramifications of a Peircean Borderline Distinction.André De Tienne - 2019 - Semiotics:1-14.
  33.  21
    Do Not Block the Way of Learning Peirce.André De Tienne - 2008 - Transactions of the Charles S. Peirce Society 44 (2):226-229.
  34.  11
    Peirce on the Power of Ideas: A Semioethical Argument with Metaphysical Ramifications.André De Tienne - 2018 - Semiotics 2018:1-13.
  35.  5
    Comment peut-on parler de l'automate cérébral aujourd'hui ?A. Danchin - 1980 - Revue Philosophique de la France Et de l'Etranger 170 (3):287 - 304.
    It is perhaps in the functioning of the brain that we can make contextual information most prominent. Indeed, while von Neumann and others invented computers with mimicking the brain in mind, the brain does not appear to behave as a Turing Machine. Neither is it a mechanical automaton. There is no “gost in the machine”. However, nobody would doubt that brain manages information, and in a very efficient way. To my view this is a strong indication that the information we (...)
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  36.  28
    Tributes Offered on Edward Madden, Hans Seigfried, and Christian J. W. Kloesel.André De Tienne - 2007 - Newsletter of the Society for the Advancement of American Philosophy 35 (106):6-9.
  37.  15
    O “Córrego Fluente” Que Carrega o Pragmatismo: James, Peirce, E Royce.André De Tienne - 2007 - Cognitio 8 (1):45-68.
  38. André De Tienne, L'analytique de La Représentation Chez Peirce. [REVIEW]Pierre Poirier - 1996 - Philosophy in Review 16:251-253.
     
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  39. André De Tienne, L'analytique de La Représentation Chez Peirce Reviewed By.Pierre Poirier - 1996 - Philosophy in Review 16 (4):251-253.
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  40.  3
    COVID-19 Adaptive Humoral Immunity Models: Weakly Neutralizing Versus Antibody-Disease Enhancement Scenarios.Ghozlane Yahiaoui, Gabriel Turinici, Oriane Pagani-Azizi & Antoine Danchin - 2022 - Acta Biotheoretica 70 (4):23.
    The interplay between the virus, infected cells and immune responses to SARS-CoV-2 is still under debate. By extending the basic model of viral dynamics, we propose here a formal approach to describe neutralisation versus weak neutralisation scenarios and compare them with the possible effects of antibody-dependent enhancement. The theoretical model is consistent with the data available in the literature; we show that both weakly neutralising antibodies and ADE can result in final viral clearance or disease progression, but that the immunodynamics (...)
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  41. d'Asie-Mineure Nr. 333, 398 und 461.Recueil des Inscriptions Grecques Chre'tiennes - 1924 - Byzantion 1:708.
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  42.  19
    Ni Dieu ni la religion, mais quelque chose qui en tienne lieu.François Ouellet - 2002 - Horizons Philosophiques 13 (1):55-62.
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  43. De la phénoménologie descriptive à la phénoménologie spéculative. Apports de la phénoménologie à la théologie chrétienne.S. J. Gilbert - 2020 - Isidorianum 28 (56):165-185.
    El artículo estudia cómo la fenomenología puede contribuir al quehacer teológico. A tal fin, el prof. Gilbert comienza por identificar los inicios de la fenomenología. Seguidamente, presenta lo que él denomina fenomenología “descriptiva”, marcada por las ciencias humanas, que sirvió para reconocer las características esenciales de la religión. Pero la fenomenología puede dar un paso más, ya estrictamente filosófico, para elaborar un modo de fenomenología “especulativa”. Finalmente, el artículo indica las aportaciones de esta esta fenomenológica al desarrollo de la teología, (...)
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  44.  16
    John R. Shook and André De Tienne , The Cambridge School of Pragmatism. [REVIEW]Henrik Rydenfelt - 2007 - Transactions of the Charles S. Peirce Society 43 (3):586-592.
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  45.  13
    “Je N'ai Jamais Vu Une Sensibilité Comme la Tienne, Jamais Une Tête Si Délicieuse!”: Rousseau, Sade, and Embodied Epistemology.Henry Martyn Lloyd - 2015 - Intellectual History Review 25 (3):327-342.
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  46. On Peirce's Notion of Information: Remarks on De Tienne's Paper "Information in Formation": Sobre a Noção Peirceana de Informação: Observações Sobre o Artigo "Informação Em Formação" de De Tienne.João Queiroz & Charbel Niño El-Hani - 2007 - Cognitio 8 (2).
     
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  47. Omnipresent Maxwell’s Demons Orchestrate Information Management in Living Cells.Antoine Danchin Gregory Boel, Olivier Danot, Victor de Lorenzo & Antoine Danchin - 2019 - Microbial Biotechnology 12 (2):210-242.
    The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell. Besides coding for ubiquitous structures, minimal genomes encode a wealth of functions that dissipate energy in an unanticipated way. Analysis of these functions shows that they are meant to manage information under conditions when discrimination of substrates in a noisy background is preferred over a simple recognition process. We show here that many of these functions, including transporters and (...)
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  48.  31
    Proof and Understanding in Mathematical Practice.Danielle Macbeth - 2012 - Philosophia Scientiae 16 (1):29-54.
    Prouver des théorèmes est une pratique mathématique qui semble clairement améliorer notre compréhension mathématique. Ainsi, prouver et reprouver des théorèmes en mathématiques, vise à apporter une meilleure compréhension. Cependant, comme il est bien connu, les preuves mathématiques totalement formalisées sont habituellement inintelligibles et, à ce titre, ne contribuent pas à notre compréhension mathématique. Comment, alors, comprendre la relation entre prouver des théorèmes et améliorer notre compréhension mathématique. J'avance ici que nous avons d'abord besoin d'une notion différente de preuve , qui (...)
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  49. L’Analytique de la Représentation Chez Peirce. La Genèse de la Théorie des Catégories. [REVIEW]Emmanuel Bourdieu - 1998 - Dialogue 37 (1):175-178.
    Ce travail de systématisation de la table kantienne aboutit, successivement, à deux systèmes combinatoires, chacun s’articulant autour d’un sous-système de trois «protocatégories» qui sont, dans le premier cas, les trois personnes grammaticales, JE, IL, TU, et, dans le second, trois «stades», simplicité, positivité et perfection. Dans les deux cas, la primauté de l’étude des «protocatégories» formelles s’affirme face à celle des catégories matérielles de la table kantienne. Que dire de la relation entre les deux triades? André de Tienne estime qu’il (...)
     
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  50. Le Concept D'Idéologie.Nestor Capdevila - 2004 - Presses Universitaires de France.
    Depuis son invention par Destutt de Tracy et sa réinvention par Marx et Engels, le concept d'idéologie n'a cessé de faire problème. Passé dans le langage courant, largement utilisé par les sciences humaines, bien qu'en des significations souvent exclusives les unes des autres, il hante la philosophie comme une sorte de mauvais génie perturbateur qui lui rappellerait l'impureté de ses origines et de ses usages, et qu'il lui faudrait toujours s'employer à réduire ou à sublimer. Encore faudrait-il en produire une (...)
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