The temporal profile of dendritic branching in developing neurons is an interplay between the proliferating number of branching sites and the branching rates at these individual sites. The eventual metrical structure of dendritic arborizations is the outcome of joint processes of branching and elongation of outgrowing neurites. Dendritic growth models have shown to be powerful tools for quantitatively studying the rules of outgrowth, aiming at reproducing the shape characteristics in observed dendritic arborizations. Recent model studies, focusing on the branching (...) process, have predicted strongly decreasing branching rates during dendritic outgrowth. The implications of these findings for the metrical development of outgrowing dendrites will be discussed. (shrink)

The growth characteristics of the recently derived Trans-Gompertz function are compared to those of the Generalized Logistic function. Both functions are defined by one shaping parameter and one rate parameter. The functions are matched at a specified point on the growth curve by equating both the first and second derivatives. Analysis shows that the matched Trans-Gompertz function will have grown at a faster rate with a larger inflection point ratio.

We review here the data indicating a role for epidermal growth factor receptor (EGF receptor) signalling in early mouse development. Embryonic development of the metazoan embryo generally begins with the formation of a cystic structure and epithelial layers that subsequently form anlagen of the definitive body parts and organs. For the mammalian embryo, this cystic structure is a blastocyst whose wall consists of trophectoderm, the first epithelium to develop during mammalian embryogenesis. The onset of expression and function of (...) EGF receptors is coincident with the onset of trophectoderm development. Modulating EGF receptor expression and function modulates trophectoderm differentiation, leading to the hypothesis that functional EGF receptors participate in the induction of trophectoderm development and perhaps of other embryonic epithelial derivatives such as nervous tissues. (shrink)

Today we are in the midst of a far-reaching shift in scientific thought involving the recasting of many of our long-cherished ideas and preconceptions. To some this appears but the orderly evolution of scientific thought, while to others it portends a revolution in both the ideas and the methods of scientific inquiry.

Development requires not only the correct specification of organs and cell types in the right places (pattern), but also the control of their size and shape (growth). Many signaling pathways control both pattern and growth and how these two are distinguished has been something of a mystery. In the fly eye, a Pax6 homolog (eyeless) controls eye specification together with several other genes. Now Dominguez et al.1 show that Notch signaling controls eye growth through a second Pax6 (...) protein (Eyegone). In mice and humans the single Pax6 gene appears to encode both specification and growth controlling proteins through alternative mRNA splicing. BioEssays 26:600–603, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

A basic model of hierarchical structure, expressed by simple, linear differential equations, shows that the pattern of population growth is essentially determined by conditions of redundancy in the sub-structure of individuals. There does not exist any possible combination between growth rate and accident rate that could balance population numbers and/or the level of redundancy within the population; all possible combinations either lead to extinction or to positive population growth with a decline of the fraction of individuals with (...) redundant substructure. Declining populations, however, can be held fluctuating between certain limits by periodic phases of sub-unit repair. These results are particularly pertinent to the population dynamics of diploid (polyploid) organisms. (shrink)

Sigmoid functions have been applied in many areas to model self limited population growth. The most popular functions; General Logistic (GL), General von Bertalanffy (GV), and Gompertz (G), comprise a family of functions called Theta Logistic ( $$ \Uptheta $$ L ). Previously, we introduced a simple model of tumor cell population dynamics which provided a unifying foundation for these functions. In the model the total population ( N ) is divided into reproducing ( P ) and non-reproducing/quiescent ( (...) Q ) sub-populations. The modes of the rate of change of ratio P / N was shown to produce GL, GV or G growth. We now generalize the population dynamics model and extend the possible modes of the P / N rate of change. We produce a new family of sigmoid growth functions, Trans-General Logistic (TGL), Trans-General von Bertalanffy (TGV) and Trans-Gompertz (TG)), which as a group we have named Trans-Theta Logistic ( T $$ \Uptheta $$ L ) since they exist when the $$ \Uptheta $$ L are translated from a two parameter into a three parameter phase space. Additionally, the model produces a new trigonometric based sigmoid ( TS ). The $$ \Uptheta $$ L sigmoids have an inflection point size fixed by a single parameter and an inflection age fixed by both of the defining parameters. T $$ \Uptheta $$ L and TS sigmoids have an inflection point size defined by two parameters in bounding relationships and inflection point age defined by three parameters (two bounded). While the Theta Logistic sigmoids provided flexibility in defining the inflection point size, the Trans-Theta Logistic sigmoids provide flexibility in defining the inflection point size and age. By matching the slopes at the inflection points we compare the range of values of inflection point age for T $$ \Uptheta $$ L versus $$ \Uptheta $$ L for model growth curves. (shrink)

PurposeThis study aimed to examine the long-term association between social activity, physical function decline and cognitive function, as well as verify the long-term mediating effect of physical function decline on the relationship between social activity and cognitive function.MethodsData from the Korean Longitudinal Study of Aging that was collected over 10 years was analyzed. The sample included 10,240 adults aged 45–93 years. Multivariate latent growth modeling was applied to verify the long-term effect of social activity and (...) physical function on cognitive function.ResultsThe results revealed that social activity had a positive impact on cognitive function and negative impact on physical function decline after controlling for age and education level. Additionally, physical function decline negatively influenced cognitive function. Finally, social activity indirectly affected cognitive function through physical function decline.ConclusionThe contribution of this study was to test the long-term effect social activity on physical and cognitive function. (shrink)

Because the kidney (metanephros) starts to function before completing development, its patterning and morphogenesis need to be closely integrated with its growth. This is achieved by blast cells at the kidney periphery generating new nephrons that link up to the extending collecting‐duct arborisation, while earlier‐formed and more internal nephrons are maturing and beginning to filter serum. This pattern of development requires that cell division and apoptosis be co‐ordinated in the various kidney compartments (collecting‐ducts, blast cells, metanephric mesenchyme, nephrons (...) and vascular system). The underlying regulatory networks for cell proliferation are beginning to be unravelled, mainly through expression studies, mutation analysis and experimentation in vitro. This article summarises current knowledge of kidney growth and apoptosis, and analyses some of the 80 or so ligand–receptor pairings that seem to sustain development and growth. It also points to some unanswered questions, the most intriguing being what role does apoptosis play during normal kidney development? BioEssays 24:72–82, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

The growth activity of an organ (variable y) is defined simultaneously by the instantaneous absolute ratedy/dt and its variationd 2y/dt2. The use of these two descriptors allows a sigmoidal (i.e. continuous and non periodical, as observed for the logistic function) growth curve to be discretized into a series of 5 growth states or phases which are delimited by the following singular values: max, Vmax (=0), max, adult stage. The (V, ) plot, termedgrowth trajectory, visualizes, e.g. in (...) the case of Richards-Nelder's generalized logistics, the unequal duration of these phases and allows the dissymmetry property of the growth function to be characterized precisely.At a more integrated organization level, such anorganic series (e. g. the set of the leaves borne by a same branch), the above concepts allow two kinds of analyses to be carried out: (i) in thekinetic approach, the growth trajectory of the series can characterizes, under certain conditions, the emergence of a new property: theoccurrence of growth activity rhythms which are independent of meristem dormancy processes; (ii) thedemographic approach shows thegrowth structure of the phytomer population (a particular form of age structure) and the associated dimensional structure (plant partition into zones or regions in relation to the growth state of the various phytomers). (shrink)

Growth cones are the highly motile structures found at the tips of growing axons and dendrites (neurites), which extend from neurones, during the development of the nervous system. They function both as detectors and transducers of extrinsic guidance cues and as regions where the neurite cytoskeleton is assembled. Without concerted neurite assembly, advance cannot occur. Assembly of the neurite cytoskeleton in growing neurites chiefly involves microtubule assembly at the growth cone. Some of the factors that may influence (...) microtubule assembly in growth cones are becoming apparent and include posttranslational modification of tubulin itself and microtubule associated proteins, particularly tau and MAP1B. (shrink)

The developing mammalian heart responds to a variety of conditions, including changes in nutrient availability, blood oxygenation, hemodynamics, or tissue homeostasis, with impressive growth plasticity. This ensures the formation of a functional and normal sized organ by birth. During embryonic and fetal development the heart is exposed to various physiological and potentially pathological changes in the intrauterine environment which dramatically impact on normal cardiac function, tissue composition, and morphology. This paper summarizes the mechanisms employed by the embryonic and (...) fetal heart to adapt to various intrauterine challenges to prevent or minimize postnatal consequences of impaired cardiac development. Future investigations of this growth plasticity might lead to new therapeutic strategies for the prevention of cardiac disease in postnatal life. (shrink)

Trees architectural study shows gradients in the meristematic activity. This activity is described by the number of internodes per growth unit, which is considered as the output of a dynamic random process. Several species were observed, which led us to propose and then estimate some mathematical models. Computing the functioning of a tree in a given environment therefore involves finding the probability function of the meristems and following the evolution of the parameters of this law along the botanical (...) gradients (order, trend, acrotony) within its architecture. (shrink)

Transforming growth factor‐β (TGF‐β) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF‐β function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF‐β action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF‐β signal transduction with respect to the regulation of gene expression, the (...) control of cell phenotype and the potential usage TGF‐β for the treatment of human diseases. (shrink)

We assume the existence of a specific G1 protein which is an initiator of DNA replication. This initiator is supposed to be synthesized according to Michaelis-Menten kinetics. In order to start DNA replication, it is assumed that this G1 specific protein must be produced in a required amount. Intra-cellular growth inhibitors and extra-cellular growth factors control the production of the initiator. This model allows to calculate the average G1 phase time as a function of the various chemical (...) concentrations of nutrients, enzymes, growth inhibitors and growth factors. This model is compared to cell kinetics experiments on a leukemic cell line responding to Interleukin 3 deprivation. The curves giving the experimental average G1 phase times with respect to Interleukin-3 concentrations are fitted by the mathematical model with a quite good agreement. (shrink)

In the past few years it has become apparent that the anterior/posterior (A/P) and dorsal/ventral (D/V) compartmant boundaries serve as the source of longrange signals that organize the A/P and D/V axes of the Drosophila wing. Recent work suggests that the vestigial gene may function as a nodal point through which the growth‐controlling activity of these two patterning systems is integrated(1).

In this paper, we analyse the simplest possible three-dimensional model of endogenous growth to account for the relationship between financial intermediation and economic growth. In our setting, households maximize an interim utility function and firms maximize profit. Households can save money only through banks which offer firms investment loans. We show that under very general assumptions, investments realized by firms depend not only on savings accumulated by banks but also on financial intermediation technology ϕ(θ). Using mathematical methods (...) of dynamical systems, we found stationary states of the system and study their stability. (shrink)

Embryonic development in a given species is orchestrated by genes regulating growth and differentiation in a stereotyped and conserved manner, resulting in embryos of consistent size and shape. Several signaling pathways, including that of Sonic Hedgehog (SHH), have been implicated in these processes. Recent experiments with Gas1 indicate that it may act as a growth-inducing gene, challenging its previous function as a gene specifically involved in growth arrest. Moreover, GAS1, a GPI-linked membrane protein, can bind SHH, (...) suggesting an interacting link between growth and patterning through SHH and GAS1.(1-4) BioEssays 24:22–26, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

Consumer-operated services organizations (COSOs) are independent, non-profit organizations that provide peer support and other non-clinical services to seriously mentally ill people. Mental health consumers provide many of these services and make up at least a majority of the organization’s leadership. Although the dominant conception of the COSO is as an adjunct to clinical care in the public mental health system, this paper reconceives the organization as a civic association and thereby a locus of citizenship. Drawing on empirical research on COSOs (...) in one state and the citizenship and civic democracy literatures, COSOs are analyzed here as membership organizations with democratic norms and strong ties to local communities. The suggestion is made that by embracing and enhancing their status as civic associations, COSOs may advance the goals of the social movement that spawned them and avoid predictable obstacles to further growth and development. (shrink)

As previous pandemics, the coronavirus disease 2019 (COVID-19) has direct and indirect effects on mental health and well-being. The purpose of the current study was to examine whether meaning in life mediated the association between coronavirus suffering and satisfaction with life and whether stress-related growth moderated the mediating effect of meaning in life on the association between these variables. Stress-Related Growth Measure (SGM) was also conducted for the purpose of this study. The participants were 402 (66% women) young (...) adults who completed the Suffering Measure During COVID-19, Meaningful Living Measure, Satisfaction With Life Scale, and SGM. The results indicated that the SGM has adequate psychometric properties with unidimensional structure of stress-related growth in the face of adversity. Moderated mediation analysis revealed that coronavirus suffering directly influenced satisfaction with life as well as indirectly by its effect on meaning in life. Additionally, stress-related growth was found as a moderator in the relationship between coronavirus suffering–meaning in life and coronavirus suffering–satisfaction with life. These results suggest that meaning in life mitigates the effect of coronavirus suffering on satisfaction with life, and this mediating effect is moderated by stress-related growth in young adults. While meaning in life helps explain the relationship between coronavirus suffering and satisfaction with life, the stress-related growth functions as a protective factor against the adverse effect of coronavirus experiences. (shrink)

Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial morphogen and also has antiproliferative effects in some cancer cell lines. The membrane receptor for hepatocyte growth factor/scatter factor has been identified as the c‐met proto‐oncogene product.

Trees architectural study shows gradients in the meristematic activity. This activity is described by the number of internodes per growth unit, which is considered as the output of a dynamic random process. Several species were observed, which led us to propose and then estimate some mathematical models. Computing the functioning of a tree in a given environment therefore involves finding the probability function of the meristems and following the evolution of the parameters of this law along the botanical (...) gradients within its architecture. (shrink)

In 2011, Hibbard suggested an intelligence measure for agents who compete in an adversarial sequence prediction game. We argue that Hibbard’s idea should actually be considered as two separate ideas: first, that the intelligence of such agents can be measured based on the growth rates of the runtimes of the competitors that they defeat; and second, one specific (somewhat arbitrary) method for measuring said growth rates. Whereas Hibbard’s intelligence measure is based on the latter growth-rate-measuring method, we (...) survey other methods for measuring function growth rates, and exhibit the resulting Hibbard-like intelligence measures and taxonomies. Of particular interest, we obtain intelligence taxonomies based on Big-O and Big-Theta notation systems, which taxonomies are novel in that they challenge conventional notions of what an intelligence measure should look like. We discuss how intelligence measurement of sequence predictors can indirectly serve as intelligence measurement for agents with Artificial General Intelligence (AGIs). (shrink)

Cluster growth models are utilized for a wide range of scientific and engineering applications, including modeling epidemics and the dynamics of liquid propagation in porous media. Invasion percolation is a stochastic branching process in which a network of sites is getting occupied that leads to the formation of clusters. The occupation of sites is governed by their resistance distribution; the invasion annexes the sites with the least resistance. An iterative cluster growth model is considered for computing the expected (...) size and perimeter of the growing cluster. A necessary ingredient of the model is the description of the mean perimeter as the function of the cluster size. We propose such a relationship for the site square lattice. The proposed model exhibits the expected phase transition of percolation models, i.e., it diverges at the percolation threshold p c. We describe an application for the porosimetry percolation model. The calculations of the cluster growth model compare well with simulation results. (shrink)

Peter Munz, a former student of both Popper and Wittgenstein, begins his comparison of the two great twentieth-century philosophers, by explaining that since the demise of positivism there have emerged, broadly speaking, two philosophical options: Wittgenstein, with the absolute relativism of his theory that meaning is a function of language games and that social configurations are determinants of knowledge; and Popper’s evolutionary epistemology – conscious knowledge is a special case of the relationship which exists between all living beings and (...) their environments. Professor Munz examines and rejects the Wittgensteinian position. Instead, Our Knowledge of the Growth of Knowledge , first published in 1985, elaborates the potentially fruitful link between Popper’s critical rationalism and Neo-Darwinism. Read in the light of the latter, Popper’s philosophy leads to the transformation of Kant’s Transcendental Idealism into ‘Hypothetical Realism’, whilst the emphasis on the biological orientation of Popper’s thought helps to illumine some difficulties in Popper’s ‘falsificationism’. (shrink)

With the continuous enrichment of material life and the increasing improvement of spiritual life, the quality of life of people in the new era has improved comprehensively. After achieving technological advancements, further improving people's living standards will become the first priority, and indicators concerning quality of life will become more important, including spiritual needs, environmental conditions and social order. In particular, the degree of spiritual and cultural satisfaction is a prominent indicator for consideration. The current research investigates how new-age art (...) is changing and how it may affect society dynamics in the future. It explores how new-age art, as a phenomenon in culture, adjusts to shifting environments, emphasizing the social roles, realization of values, and influencing elements of the art. With a focus on spiritual and cultural fulfillment, the study highlights the value of art in improving people's quality of life while taking into account elements such as social order, environmental influences, and spiritual demands. The primary goal is to comprehend the ways in which new age art raises living standards and general well-being. The results demonstrate the lasting contributions that new-age art makes to enjoyment, cultural transmission, and education, thereby reaffirming its important position in society. The paper emphasizes how crucial the socialist culture sector with Chinese characteristics will become to the future economic framework. This study found that new-age art continuously produces excellent literary and artistic works in addition to preserving traditional Chinese culture and fostering cultural self-confidence through its support for the improvement of living standards and industrial growth. This illustrates its practical importance in upholding economic supremacy and promoting cultural advancement. (shrink)

We prove that a function definable with parameters in an o-minimal structure is bounded away from ∞ as its argument goes to ∞ by a function definable without parameters, and that this new function can be chosen independently of the parameters in the original function. This generalizes a result in [1]. Moreover, this remains true if the argument is taken to approach any element of the structure , and the function has limit any element of (...) the structure. (shrink)

Peter Munz, a former student of both Popper and Wittgenstein, begins his comparison of the two great twentieth-century philosophers, by explaining that since the demise of positivism there have emerged, broadly speaking, two philosophical options: Wittgenstein, with the absolute relativism of his theory that meaning is a function of language games and that social configurations are determinants of knowledge; and Popper’s evolutionary epistemology – conscious knowledge is a special case of the relationship which exists between all living beings and (...) their environments. Professor Munz examines and rejects the Wittgensteinian position. Instead, _Our Knowledge of the Growth of Knowledge_, first published in 1985, elaborates the potentially fruitful link between Popper’s critical rationalism and Neo-Darwinism. Read in the light of the latter, Popper’s philosophy leads to the transformation of Kant’s Transcendental Idealism into ‘Hypothetical Realism’, whilst the emphasis on the biological orientation of Popper’s thought helps to illumine some difficulties in Popper’s ‘falsificationism’. (shrink)

Assembly of minimal genomes revealed many genes encoding unknown functions. Three overlooked functional categories account for some of them. Cells are prone to make errors and age. As a first key function, discrimination between proper and changed entities is indispensable. Discrimination requires management of information, an authentic, yet abstract, cur- rency of reality. For example proteins age, sometimes very fast. The cell must identify, then get rid of old proteins without destroying young ones. Implementing discrimination in cells leads to (...) the second set of functions, usually ignored. Being abstract, information must nevertheless be embodied into material entities, with unavoidable idiosyncratic properties. This brings about novel unmet needs. Hence, the buildup of cells elicits specific but awkward material implementations, ‘kludges’ that become essential under particular settings, while difficult to identify. Finally, a third functional category char- acterizes the need for growth, with metabolic implementations allowing the cell to put together the growth of its cytoplasm, membranes, and genome, spanning different spatial dimensions. Solving this metabolic quandary, critical for engineering novel synthetic biology chassis, uncovered an unexpected role for CTP synthetase as the coordinator of nonhomothetic growth. Because a significant number of SynBio constructs aim at creating cell factories we expect that they will be attacked by viruses (it is not by chance that the function of the CRISPR system was identified in industrial settings). Substantiating the role of CTP, natural selection has dealt with this hurdle via synthesis of the antimetabolite 30-deoxy-30,40-didehydro- CTP, recruited for antiviral immunity in all domains of life. (shrink)

Contemporary capitalism is caught in a dual crisis of economy and ecology. Central to both dimensions of this crisis is the issue of growth. On the one hand, capitalist economies must exhibit perpetual growth in order to function properly. On the other hand, the expansion of capitalist production and consumption ultimately interferes with the processes of natural growth that we find within the domain of ecology. Parallax of Growth explores the ideas of economy and ecology (...) and the factors that have put them on a collision course. Among other things, the book aims to explain why our current mode of economic organization seems to be inherently committed to perpetual growth. A key answer, argues Bjerg, is that contemporary capitalism is characterized by an inherent ′debt drive′, whereby the creation of money through the issuance of commercial bank credit has locked our economy in a vicious circle of forced growth and increasing debt. Parallax of Growth is not a catalogue of solutions to the ecological or the economic crisis. The book aims to shift the inquiry from ‘what shall we do?’ to ‘why have we not already done it?’ In order to address the challenges of our contemporary times of crisis, it is not enough to point out all the different reasons why perpetual economic growth is impossible and unsustainable. We need to understand how the idea of growth is deeply ingrained in the ideology as well as the organization of our society. The book aims to open the space for philosophical thinking about this important issue. (shrink)

Background: We define compassion as an enduring disposition that centers upon empathetic concern for another person's suffering and the motivation to act to alleviate it. The contribution of specific candidate genes to the development of dispositional compassion for others is currently unknown. We examine candidate genes in the oxytocin and dopamine signaling pathways.Methods: In a 32-year follow-up of the Young Finns Study, we examined with multiple indicators latent growth curve modeling the molecular genetic underpinnings of dispositional compassion for others (...) across the life span. We selected five single nucleotide polymorphisms whose functions are known in humans: rs2268498, rs3796863, rs1800497, rs4680, and rs1611115. Compassion was measured with Cloninger's Temperament and Character Inventory on three repeated observations spanning 15 years. Differences between gender were tested.Results: We did not find an effect of the five SNPs in oxytocin and dopamine pathway genes on the initial levels of dispositional compassion for others. Individuals who carry one or two copies of the T-allele of DBH rs1611115, however, tend to increase faster in compassion over time than those homozygotes for the C-allele, b = 0.063. This effect was largely driven by male participants, 0.206, and was not significant in female participants when analyzed separately.Conclusions: Men who are known to have, on average, lower compassion than women seem to reduce this difference over time if they carry the T-allele of DBH rs1611115. The direction of the association indicates that dopamine signaling activity rather than overall dopamine levels might drive the development of compassion. (shrink)

The relationship between a biological process and a behavioral trait indicates a proximate mechanism by which natural selection can act. In that context, examining an aspect of infant health is one method of investigating the adaptive significance of infant-directed speech (ID speech), and it could help to explain the widespread use of this communication style. The correlation between infant growth and infant-directed speech is positive and significant, and provides a vehicle for testing evolutionary history hypotheses.

Human neoplasms develop following the progressive accumulation of genetic and epigenetic alterations to oncogenes and tumor suppressor genes. These alterations confer a growth advantage to the cancer cell, leading to its clonal proliferation, invasion into surrounding tissues, and spread to distant organs. Genes that are altered in neoplasia affect three major biologic pathways that normally regulate cell growth and tissue homeostasis: the cell cycle, apoptosis, and differentiation. While each of these pathways can be defined by a unique set (...) of molecular events, they are not biologically separate. Rather, they function more as an integrated molecular network, and perturbations in one pathway can have profound consequences on another. Insights into what distinguishes the regulation of growth and differentiation in a normal cell versus a cancer cell have led to the development of novel anticancer therapies. BioEssays 24:83–90, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

There is increasing evidence to suggest that cytoplasmic tyrosine kinases of the Src family have a pivotal role in the regulation of a number of cellular processes. Members of this family have been implicated in cellular responses to a variety of extracellular signals, such as those arising from growth factors and cell‐cell interactions, as well as in differentiative and developmental processes in both vertebrates and invertebrates. A better understanding of the regulation and of the structure‐function relationships of these (...) enzymes might aid in the development of specific ways to interfere with their action, as well as serving as a paradigm for regulation of other protein tyrosine kinases that have SH2 and SH3 domains. In this review we will first discuss the regulation of Src family protein tyrosine kinases, with particular emphasis on their SH2 and SH3 domains. We will then briefly review other non‐receptor protein tyrosine kinases that have SH2 and SH3 domains. (shrink)