Engineered microbes are of great potential utility in biotechnology and basic research. In principle, a cell can be built from scratch by assembling small molecule sets with auto‐catalytic properties. Alternatively, DNA can be isolated or directly synthesized and molded into a synthetic genome using existing genomic blueprints and molecular biology tools. Activating such a synthetic genome will yield a synthetic cell. Here we examine obstacles associated with this latter approach using a model system whereby a donor genome from H. influenzae (...) is fragmented, and the pieces are then modified and reassembled stepwise in an E. coli host cell. There are obstacles associated with this strategy related to DNA transfer, DNA replication, cross‐talk in gene regulation and compatibility of gene products between donor and host. Encouragingly, analysis of gene expression indicates widespread transcription of H. influenzae genes in E. coli, and analysis of gap locations in H. influenzae and other microbial genome assemblies reveals few genes routinely incompatible with E. coli. In conclusion, rebuilding and booting a genome remains a feasible and pragmatic approach to creating a synthetic microbial cell. BioEssays 29:580–590, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

A fragmentary red-figure cup, formerly in the collection of Henri Seyrig, has been connected with the myth of Danae and Perseus ever since Beazley first noted it in 1954. Although a number of iconographical discussions of this myth have appeared since, the vase has never been published and, therefore, its iconography never discussed. Today, the fragments are in the Louvre, inv. no. 980.0820. Thanks to the kindness of F. Villard and A. Pasquier, I am able to publish them here (...) for the first time. (shrink)

Historia, as both a type of critical inquiry and a source of information about nature and the human world, is a key category in Spinoza’s Tractatus theologico-politicus. In this work, the Latin word cannot be simply and invariably translated as “history,” not even if we add the proviso that its meaning wavers inevitably between “history” and “story,” for its semantic range is too broad and complex. At the two ends of the semantic spectrum we have the impartial report, on the (...) one hand, and the creations of sheer fantasy, on the other. Historia may therefore denote the detached observation of nature and the philological analysis of a text, but it can also refer to the free exercise of the imagination in a variety of narrative contexts. While Spinoza denies that the inquiry resulting from historia and its products may have true cognitive value, he acknowledges that historia plays a fundamental role in society and politics. The reason is that historia and the imagination are bound up together by a special relationship. This is apparent at all levels of the historical engagement with reality, but is particularly true in the case of religion, moral norms and belief systems, for in this variegated domain the link between imagination and historia functions as the connective tissue that keeps societies united and functioning. This specific nexus of imagination and historia is Spinoza’s original contribution to the early modern notion of “moral certainty.” More importantly, it is only at this level that Spinoza grants a modicum of intelligibility to the ‘historical’ productions of the imagination, be they signa, revelationes, or even nugae. The fact remains, though, that to a certain extent humans keep having a distorted grasp of reality, indeed hallucinate, even when their ‘historical’ accounts of reality are socially and politically productive. Here the key element is the notion of fictional continuity based on a socially constructed trust in narrative accounts of reality: the imagination turns reality into stories, but in so doing it keeps the otherwise constitutively hallucinatory nature of humans at bay and under control. Perceptibilitas, that is, the ability to provide acceptable cognitive solutions between intelligible knowledge and moral certainty, is ultimately what defines the contribution of the imagination to the human work of knowledge. (shrink)

Heiberg's Perseus represents a landmark in Golden Age culture.

Eutychus Or the Future of the Pulpit Winifred Holtby Originally published in 1928 "Few wittier or wiser books have appeared in this stimulating series." Spectator "…delicious fun." Guardian A dialogue between Archbishop Fénelon, who stands for the great ecclesiastical tradition of preaching, Anthony, who stands for the more superficial intellectual movements in England and Eutychus, the ordinary man, investigates the nature of the pulpit. 134pp Apella or the Future of the Jews A Quarterly Reviewer Originally published in 1925 "Cogent, because (...) of brevity and magnificent prose style…It should not be missed." Spectator "…his arguments are a provocation to fruitful thinking." Morning Post This volume attempts to foresee the future of the Jews across the world, in the light of their previous history, the situation in Russia and the modern developments of Zionism. Inter-marriage, Jewish nationalism, Jewish religion and reform movements are among the subjects discussed. 90pp Vicisti, Galilaee? Or Religion in England: A Survey and a Forecast Edward B Powley Originally published in 1929 "…a book to be read, thought over, and discussed by all Christians who are not afraid to take the shutters down." Guardian Who was Jesus? How did Christianity begin, become orthodox, receive recognition as the state religion of the Roman Empire? What has been the history of Christianity in England? This volume discusses these questions and surveys of state of English churches in the early 20 th century. 114pp Perseus, of Dragons H F Scott Stokes Originally published in 1924 "A diverting little book…both quaint and various." Morning Post This volume gives an account of the dragon in history: in ancient Greece, in early Christendom and in modern Europe and explains how the dragon-story originated from the myths and customs of pre-historic Egypt. The author then maintains that in twentieth century England the dragon is not dead, that the characteristics of respectability, bigotry and cant represent the modern day dragon. 70pp. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 7.1 (2002) 147-153 [Access article in PDF] Book Review Rattling the Cage: Toward Legal Rights for Animals Rattling the Cage: Toward Legal Rights for Animals Steven M. Wise. Foreward by Jane Goodall. Cambridge, Mass.: Perseus Books, 2000. pp. 384. US $17.50. ISBN 0-7382-0437-4 (Paperback) "Ancient philosophers claimed that all nonhuman animals had been designed and placed on this earth just for human beings. Ancient (...) jurists declared that law had been created just for human beings. Although philosophy and science have long since recanted, the law has not." Steven M. Wise, Rattling the Cage, p. 4. Readers of this journal are well-versed in the myriad ways in which nonhuman animals are harmfully exploited at the hands of human beings—from battery hens and veal calves to mass-produced pigs; from Pennsylvania pigeon shoots to canned hunts on Texas ranches; from rodeos to roadside zoos; from LD-50 toxicity tests on rats and Draize eye tests on rabbits to head trauma and infectious disease experimentation on primates. Despite other sticking points, it is by now uncontroversial among [End Page 147] nonanthropocentric theorists that, in utilitarian terms, the benefits to humans of the above practices fall far short of justifying the harms they cause to their nonhuman victims or, in deontological terms, that they violate the rights of creatures with inherent value. Indeed, these arguments are so well-rehearsed and so widely regarded as compelling that it no longer seems particularly bold to predict that if reason ever prevails over tradition and prejudice, the future will look back on this generation's treatment of our fellow creatures with the same kind of shame and condemnation with which European Americans regard our slaveholding past.More sobering but equally familiar is the observation that decisive arguments for the gross immorality of existing practices will bring about neither their elimination nor significant reform as long as the presumed legitimacy of human exploitation of nonhuman beings remains entrenched in both popular consciousness and economic, political, and legal institutions. In the interests of chipping away at popular apathy, academics should no doubt go on repeating the well-worn arguments against speciesism in classrooms, popular venues, and professional research. But in a world structured far more directly by the interests of a powerful few than by the values of the many, this consciousness-raising strategy properly plays at most a supporting role to the even more vital project of challenging and ultimately restructuring the institutions that sanction and carry out these injustices. In short, what nonhuman animals need from ethically sensitive intellectuals is not just rational argument, but effective legal and political action.One of the main institutional obstacles to progress in this area is undoubtedly the legal relegation of animals to property status—which is why Steve M. Wise's Rattling the Cage: Toward Legal Rights for Animals is such an important book. Wise teaches animal rights law at Harvard, Vermont, and John Marshall Law Schools and has spent more than twenty years fighting for animals in the legal system; his book displays the bittersweet fruit of that experience. The tenor throughout is a mixture of conviction in the justice of his cause—which cannot but sustain a vision of its eventual success—together with the frustration and determined patience borne from decades of butting up against an utterly implacable wall. An eloquent foreword by Jane Goodall, together with Wise's own harrowing first chapter, describe the nightmarish existences imposed on our nearest nonhuman relatives, the chimpanzees and bonobos, for the sake of science, entertainment, and profit—nightmares enabled by a legal system that [End Page 148] treats all nonhumans as mere things. An engaging storyteller with a synthetic conception of the history of ideas, Wise unearths the origins of this conception of animals in the Great Chain of Being, demonstrates its defeat by Darwinian science, and builds piece by piece a case—drawing heavily on research into animal consciousness—for extending legal rights at least to chimpanzees and bonobos.The substantive theses of this case are, first, that the denial of... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 7.1 (2002) 147-153 [Access article in PDF] Book Review Rattling the Cage: Toward Legal Rights for Animals Rattling the Cage: Toward Legal Rights for Animals Steven M. Wise. Foreward by Jane Goodall. Cambridge, Mass.: Perseus Books, 2000. pp. 384. US $17.50. ISBN 0-7382-0437-4 (Paperback) "Ancient philosophers claimed that all nonhuman animals had been designed and placed on this earth just for human beings. Ancient (...) jurists declared that law had been created just for human beings. Although philosophy and science have long since recanted, the law has not." Steven M. Wise, Rattling the Cage, p. 4. Readers of this journal are well-versed in the myriad ways in which nonhuman animals are harmfully exploited at the hands of human beings—from battery hens and veal calves to mass-produced pigs; from Pennsylvania pigeon shoots to canned hunts on Texas ranches; from rodeos to roadside zoos; from LD-50 toxicity tests on rats and Draize eye tests on rabbits to head trauma and infectious disease experimentation on primates. Despite other sticking points, it is by now uncontroversial among [End Page 147] nonanthropocentric theorists that, in utilitarian terms, the benefits to humans of the above practices fall far short of justifying the harms they cause to their nonhuman victims or, in deontological terms, that they violate the rights of creatures with inherent value. Indeed, these arguments are so well-rehearsed and so widely regarded as compelling that it no longer seems particularly bold to predict that if reason ever prevails over tradition and prejudice, the future will look back on this generation's treatment of our fellow creatures with the same kind of shame and condemnation with which European Americans regard our slaveholding past.More sobering but equally familiar is the observation that decisive arguments for the gross immorality of existing practices will bring about neither their elimination nor significant reform as long as the presumed legitimacy of human exploitation of nonhuman beings remains entrenched in both popular consciousness and economic, political, and legal institutions. In the interests of chipping away at popular apathy, academics should no doubt go on repeating the well-worn arguments against speciesism in classrooms, popular venues, and professional research. But in a world structured far more directly by the interests of a powerful few than by the values of the many, this consciousness-raising strategy properly plays at most a supporting role to the even more vital project of challenging and ultimately restructuring the institutions that sanction and carry out these injustices. In short, what nonhuman animals need from ethically sensitive intellectuals is not just rational argument, but effective legal and political action.One of the main institutional obstacles to progress in this area is undoubtedly the legal relegation of animals to property status—which is why Steve M. Wise's Rattling the Cage: Toward Legal Rights for Animals is such an important book. Wise teaches animal rights law at Harvard, Vermont, and John Marshall Law Schools and has spent more than twenty years fighting for animals in the legal system; his book displays the bittersweet fruit of that experience. The tenor throughout is a mixture of conviction in the justice of his cause—which cannot but sustain a vision of its eventual success—together with the frustration and determined patience borne from decades of butting up against an utterly implacable wall. An eloquent foreword by Jane Goodall, together with Wise's own harrowing first chapter, describe the nightmarish existences imposed on our nearest nonhuman relatives, the chimpanzees and bonobos, for the sake of science, entertainment, and profit—nightmares enabled by a legal system that [End Page 148] treats all nonhumans as mere things. An engaging storyteller with a synthetic conception of the history of ideas, Wise unearths the origins of this conception of animals in the Great Chain of Being, demonstrates its defeat by Darwinian science, and builds piece by piece a case—drawing heavily on research into animal consciousness—for extending legal rights at least to chimpanzees and bonobos.The substantive theses of this case are, first, that the denial of... (shrink)

With his fight against the sea monster Medusa, Perseus embodies for Warburg the “world-directed energy”. Warburg's “energetic aesthetics” could be interpreted then as nothing but another version of the hypertrophic, despotic subject Ferraris has often written about. We will show it that is not the case by considering the relationship that Warburg draws between Perseus and Hamlet.

In this brilliant essay, Jacques Derrida explores issues of vision, blindness, self-representation, and their relation to drawing, while offering detailed readings of an extraordinary collection of images. Selected by Derrida from the prints and drawings department of the Louvre, the works depict blindness—fictional, historical, and biblical. From Old and New Testament scenes to the myth of Perseus and the Gorgon and the blinding of Polyphemus, Derrida uncovers in these images rich, provocative layers of interpretation. For Derrida drawing is itself (...) blind; as an act rooted in memory and anticipation, drawing necessarily replaces one kind of seeing with another. Ultimately, he explains, the very lines which compose any drawing are themselves never fully visible to the viewer since they exist only in a tenuous state of multiple identities: as marks on a page, as indicators of a contour. Lacking a "pure" identity, the lines of a drawing summon the supplement of the word, of verbal discourse, and, in doing so, obscure the visual experience. Consequently, Derrida demonstrates, the very act of depicting a blind person undertakes multiple enactments and statements of blindness and sight. _Memoirs of the Blind_ is both a sophisticated philosophical argument and a series of detailed readings. Derrida provides compelling insights into famous and lesser known works, interweaving analyses of texts—including Diderot's _Lettres sur les aveugles_, the notion of mnemonic art in Baudelaire's _The Painter of Modern _ _Life_, and Merleau-Ponty's _The Visible and the _ _Invisible_. Along with engaging meditations on the history and philosophy of art, Derrida reveals the ways viewers approach philosophical ideas through art, and the ways art enriches philosophical reflection. An exploration of sight, representation, and art, _Memoirs of the Blind_ extends and deepens the meditation on vision and painting presented in _Truth and _ _Painting_. Readers of Derrida, both new and familiar, will profit from this powerful contribution to the study of the visual arts. (shrink)

'I will do as the Senate decrees.' These words from one of Rome's opponents encapsulate the authority Rome achieved by its subjugation of the Mediterranean. The Third Macedonian War, recounted in this volume, ended the kingdom created by Philip II and Alexander the Great and was a crucial step in Rome's eventual dominance. For Livy, the story is also a fascinating moral study of the vices and virtues that hampered and promoted Rome's efforts in the conflict. He presents the war (...) not so much as a battle against Perseus, Alexander's last and unworthy successor, than as a struggle within the Roman national character. Only traditional moral strength, embodied in Lucius Aemilius Paullus, the general who ultimately defeats Perseus, ensures the Roman victory. This edition also includes the Periochae, later summaries of Livy's entire original 142-book history of Rome from its founding to the age of Augustus. (shrink)

[Graeme Forbes] In I, I summarize the semantics for the relational/notional distinction for intensional transitives developed in Forbes. In II-V I pursue issues about logical consequence which were either unsatisfactorily dealt with in that paper or, more often, not raised at all. I argue that weakening inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a gorgon', are valid, but that disjunction inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a mortal (...) gorgon or an immortal gorgon', are invalid. Since 'a gorgon' and 'a mortal gorgon or an immortal gorgon' are extensionally and intensionally the same quantifier, it is not completely trivial to arrange the semantics of intensional transitives so that this classification of the inferences is obtained. ; the latter will be incorporated into a forthcoming monograph, Attitude Problems.) /// [Jennifer Saul] This paper discusses the question of which verbs are intensional transitives. In particular, I ask which verbs Forbes should take to be intensional transitives. I argue that it is very difficult to arrive at a clear and plausible understanding of what an intensional transitive is-making it difficult to answer these questions. I end by briefly raising some questions about the usefulness of the category of intensional transitives. (shrink)

[Graeme Forbes] In I, I summarize the semantics for the relational/notional distinction for intensional transitives developed in Forbes (2000b). In II-V I pursue issues about logical consequence which were either unsatisfactorily dealt with in that paper or, more often, not raised at all. I argue that weakening inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a gorgon', are valid, but that disjunction inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a (...) mortal gorgon or an immortal gorgon', are invalid. Since 'a gorgon' and 'a mortal gorgon or an immortal gorgon' are extensionally and intensionally the same quantifier, it is not completely trivial to arrange the semantics of intensional transitives so that this classification of the inferences is obtained. (This paper is an abridged version of Forbes (2001a); the latter will be incorporated into a forthcoming monograph, Attitude Problems.) /// [Jennifer Saul] This paper discusses the question of which verbs are intensional transitives. In particular, I ask which verbs Forbes should take to be intensional transitives. I argue that it is very difficult to arrive at a clear and plausible understanding of what an intensional transitive is-making it difficult to answer these questions. I end by briefly raising some questions about the usefulness of the category of intensional transitives. (shrink)

This study allows us to re-establish in the Sanctuary of Apollo a new limestone pillar that is very similar in conception to the one commonly known as "Paul-Emile's pillar". This monument was thus also probably dedicated on the initiative of the king Perseus when he returned to favour at Delphi. Since a letter from Adeimantos to Poliorcetes (302) was inscribed on it, it is suggested that this pillar may have functioned as a vehicle for the a posteriori transcription of (...) various bits of archives serving Macedonian propagande, which thus sought to courtter the defamatory campaign orchestrated by the Senate (cf. the famous "manifesto against Perseus"). The very recent discovery of another inscribed block confirme this hypothesis: we may well have here a reflection in monumental and epigraphical form of the power struggles that preceded the third Macedonian War, the last great political event to have had a close impact on the Sanctuary of Apollo and its Amphictiony. (shrink)

The paper studies Livy's account in Book 45 of the aftermath of Aemilius Paullus' conquest of Macedon employing two interpretative methods, both common in recent studies of historians. The first is “metahistory,” in other words interpreting events within a historical narrative as commenting covertly on the genre of history and on the work as an example of that genre. The second is seeing how internal audiences provide a guide for the reader's interpretation. These, though theoretically independent, are in practice often (...) related, with internal audiences being used as a trigger for wider reflections on the text and the genre. Four linked passages from Livy 45 are discussed in detail. One invites a systematic metahistorical reading without the use of an internal audience, partly to endorse Livy's own manner of “secondary” history, partly to promote a moral reading of the text. The other three employ internal audiences to similar effect: first, Aemilius' meeting with the defeated Perseus, and the lesson which he draws about the mutability of fortune; second, the spectacular games he organizes at Amphipolis; and third, his eventual triumph in Rome, along with the speech that Servilius gives in its support. The understanding of the genre of history that Livy promotes through these passages is, however, astonishingly narrow and didactic, ignoring even central aspects of his own work which do not conform to that understanding. The paper concludes by considering why Livy would wish to present himself and his genre as single-mindedly moralistic when neither he nor it actually was. (shrink)

Dans beaucoup de textes magiques , on retrouve des triangles, des carrés et des cercles créés par des mots magiques arrangés selon ces for­mes. Une série de gemmes et de papyri avait recours à des héros de la mythologie grecque pour la guérison de certaines maladies. On s’adressait à Tantale, Lycurgue ou Persée pour contrôler des organes du corps humain, et les formules qui les nommaient étaient écrites en forme de triangles. On a l’habitude d’expliquer ces formations triangulaires de mots (...) comme une soustraction progressive de lettres qui faisait décroître la maladie et les autres maux. Cette explication est valable dans certains cas, mais non dans d’autres. Souvent des triangles du même type ajoutent chaque partie du mot au mot lui-même, comme dans le cas de noms de divinités, dont la force était multipliée par cette opération graphique. La Tetraktys pythagoricienne est le cas le plus ancien de ce type d’additions. Les formations carrées de mots multipliaient un mot par lui-même et représentaient d’autres formes d’exaltation d’un nom divin ou d’une formule magique. Ces spéculations se fondaient sur la pensée mathématique et géométrique des pythagoriciens. Les mots magiques palindromiques étaient souvent écrits sous forme circulaire, laquelle pouvait entourer et contrôler le nom d’une personne ou des symboles du mal.Geometric formations of words in the ancient magic arts. In many magical texts triangles, squares and circles often occur, which are created by magical words arranged in these forms. A series of gems and papyri look to the heroes of Greek mythology for the treatment of specific diseases. In fact, it is known that spells invoking Tantalos, Lycourgos or Perseus were created in order to control the organs of the human body and that triangular word formations were used to write these spells. The usual explanation of triangular word formations maintains that the progressive elimination of letters compels sickness and other evil to diminish. This is true, but this explanation cannot be applied to every triangle or wing formation. Similar triangles often add each part of the word to the others, as in the case of divine names, whose force is magnified by such a graphic operation. The pythagoric Tetraktys is the most ancient example of such sums. The square formations multiplied one word by itself and represented other ways of extolling a divine name or the might of a magical spell. These speculations were based on the mathematics and geometry of the Pythagoric tradition. Palindromic magical words were often written in circular formations, which could cluster round and control the name of a person or symbols of something evil. (shrink)

[Graeme Forbes] In I, I summarize the semantics for the relational/notional distinction for intensional transitives developed in Forbes. In II-V I pursue issues about logical consequence which were either unsatisfactorily dealt with in that paper or, more often, not raised at all. I argue that weakening inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a gorgon', are valid, but that disjunction inferences, such as 'Perseus seeks a mortal gorgon, therefore Perseus seeks a mortal (...) gorgon or an immortal gorgon', are invalid. Since 'a gorgon' and 'a mortal gorgon or an immortal gorgon' are extensionally and intensionally the same quantifier, it is not completely trivial to arrange the semantics of intensional transitives so that this classification of the inferences is obtained. ; the latter will be incorporated into a forthcoming monograph, Attitude Problems.) /// [Jennifer Saul ] This paper discusses the question of which verbs are intensional transitives. In particular, I ask which verbs Forbes should take to be intensional transitives. I argue that it is very difficult to arrive at a clear and plausible understanding of what an intensional transitive is-making it difficult to answer these questions. I end by briefly raising some questions about the usefulness of the category of intensional transitives. (shrink)