Despite growing consumerism and skepticism about authority in the culture as a whole, most patients continue to be pliant. If there is a serious threat to physician autonomy, it is more likely to come from third‐party payers and new forms of medical practice, particularly the rise of for‐profit hospital chains, than from patients. Though physicians are restless, they will learn to adapt to the new conditions of practice.

With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, characterizing the (...) experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species. (shrink)

For many old and new mechanists, Mechanism is both a metaphysical position and a thesis about scientific methodology. In this paper we discuss the relation between the metaphysics of mechanisms and the role of mechanical explanation in the practice of science, by presenting and comparing the key tenets of Old and New Mechanism. First, by focusing on the case of gravity, we show how the metaphysics of Old Mechanism constrained scientific explanation, and discuss Newton’s critique of Old Mechanism. Second, we (...) examine the current mechanistic metaphysics, arguing that it is not warranted by the use of the concept of mechanism in scientific practice, and motivate a thin conception of mechanism (the truly minimal view), according to which mechanisms are causal pathways for a certain effect or phenomenon. Finally, we draw analogies between Newton’s critique of Old Mechanism and our thesis that the metaphysical commitments of New Mechanism are not necessary in order to illuminate scientific practice. (shrink)

Presents a guide to the basics of quantum mechanics and measurement.

The present paper shows how one might model Everettian quantum mechanics using hyperfinitely many worlds. A hyperfinite model allows one to consider idealized measurements of observables with continuous-valued spectra where different outcomes are associated with possibly infinitesimal probabilities. One can also prove hyperfinite formulations of Everett’s limiting relative-frequency and randomness properties, theorems he considered central to his formulation of quantum mechanics. Finally, this model provides an intuitive framework in which to consider no-collapse formulations of quantum mechanics more (...) generally. (shrink)

The present paper shows how one might model Everettian quantum mechanics using hyperfinitely many worlds. A hyperfinite model allows one to consider idealized measurements of observables with continuous-valued spectra where different outcomes are associated with possibly infinitesimal probabilities. One can also prove hyperfinite formulations of Everett’s limiting relative-frequency and randomness properties, theorems he considered central to his formulation of quantum mechanics. Finally, this model provides an intuitive framework in which to consider no-collapse formulations of quantum mechanics more (...) generally. (shrink)

This chapter will review selected aspects of the terrain of discussions about probabilities in statistical mechanics (with no pretensions to exhaustiveness, though the major issues will be touched upon), and will argue for a number of claims. None of the claims to be defended is entirely original, but all deserve emphasis. The first, and least controversial, is that probabilistic notions are needed to make sense of statistical mechanics. The reason for this is the same reason that convinced Maxwell, (...) Gibbs, and Boltzmann that probabilities would be needed, namely, that the second law of thermodynamics, which in its original formulation says that certain processes are impossible, must, on the kinetic theory, be replaced by a weaker formulation according to which what the original version deems impossible is merely improbable. Second is that we ought not take the standard measures invoked in equilibrium statistical mechanics as giving, in any sense, the correct probabilities about microstates of the system. We can settle for a much weaker claim: that the probabilities for outcomes of experiments yielded by the standard distributions are effectively the same as those yielded by any distribution that we should take as a representing probabilities over microstates. Lastly, (and most controversially): in asking about the status of probabilities in statistical mechanics, the familiar dichotomy between epistemic probabilities (credences, or degrees of belief) and ontic (physical) probabilities is insufficient; the concept of probability that is best suited to the needs of statistical mechanics is one that combines epistemic and physical considerations. (shrink)

In the most inclusive sense, psychological mechanisms offer a type of causal explanation of mental states and behavior, often with reference to underlying processes, systems, activities, or entities. By postulating and investigating such mechanisms, researchers have sought explanations of a wide range of psychological phenomena. However, the concept has been deployed in dramatically different ways, with very different meanings, depending upon the particular school or tradition of psychology (and specific research program therein). In fact, usage has been so diverse as (...) to defy easy categorization or definition. But a historical perspective, even if rather selective, can trace the broad outlines of the significance of psychological mechanisms for the study of the mind. Perhaps most notable is the role they have played in the psychoanalytic tradition; research efforts within behaviorism and cognitive science have also made liberal use of versions of the concept in their explanatory frameworks (for discussion of evolutionary psychology, see the entry “evolved psychological mechanisms”). Cutting across all of these traditions are several key themes relating to psychological mechanisms, including questions concerning the scope of the relevant causal claims, debates about causal determinism and regularity, and the unresolved relation between mind and body. (shrink)

The terms “perspectivism” and “perspectivalism” have been the focus of an intense philosophical discussion with important repercussions for the debate about the role of mechanisms in scientific explanations. However, leading exponents of the new mechanistic philosophy have conceded more than was necessary to the radically subjectivistic perspectivalism, and fell into the opposite error, by retaining not negligible residues of objectivistic views about mechanisms. In order to remove this vacillation between the subjective-cultural and the objective-natural sides of mechanisms, we shall raise (...) the question about theory-ladenness over again and interpret it in its connection with the technical–experimental nature of scientific knowledge, as affirming the perspectival character of scientific knowledge: It is because of the character at once theory-laden and practice-laden, i.e. technique-laden, of our putting questions to nature that empirical reality must be investigated from particular perspectives: nature can be known scientifically only from a potentially infinite number of perspectives or theoretical points of view, concretely exemplified by mechanisms or experimental ‘machines’ that allow specific access to specific aspects of sensible reality. (shrink)

In this essay, we draw on John Haugeland’s work in order to argue that Burge is wrong to think that exercises of perceptual constancy mechanisms suffice for perceptual representation. Although Haugeland did not live to read or respond to Burge’s Origins of Objectivity, we think that his work contains resources that can be developed into a critique of the very foundation of Burge’s approach. Specifically, we identify two related problems for Burge. First, if (what Burge calls) mere sensory responses are (...) not representational, then neither are exercises of constancy mechanisms, since the differences between them do not suffice to imply that one is representational and the other is not. Second, taken by themselves, exercises of constancy mechanisms are only derivatively representational, so merely understanding how they work is not sufficient for understanding what is required for something, in itself, to be representational (and thereby provide a full solution to the problem of perceptual representation). (shrink)

In recent years what has come to be called the 'New Mechanism' has emerged as a framework for thinking about the philosophical assumptions underlying many areas of science, especially in sciences such as biology, neuroscience, and psychology. This book offers a fresh look at the role of mechanisms, by situating novel analyses of central philosophical issues related to mechanisms within a rich historical perspective of the concept of mechanism as well as detailed case studies of biological mechanisms. It develops a (...) new position, Methodological Mechanism, according to which mechanisms are to be viewed as causal pathways that are theoretically described and are underpinned by networks of difference-making relations. In contrast to metaphysically inflated accounts, this study characterises mechanism as a concept-in-use in science that is deflationary and metaphysically neutral, but still methodologically useful and central to scientific practice. (shrink)

Requiring only a background in elementary calculus and elementary mechanics, this book starts with the basics, introduces the most important developments in classical statistical mechanics over the last thirty years, and guides readers to ...

Descartes set for himself the ambitious program of accounting for the functions of the Aristotelian vegetative and sensitive souls without invoking souls or the faculties or powers of souls in his explanations. He rejects the notion that the soul is hylomorphically present in the organs of the body so as to carry out vital and sensory functions. Rather, the body’s organs operate in a purely mechanical fashion. That is what is involved in “mechanizing” these phenomena. The role of the soul (...) is restricted to properly mental functions: to the conscious aspects of sensations and other mental operations; to intellectual acts; and to acts of volition. In effect, soul becomes mind. In order to understand the extent of Descartes’ ambition, this chapter first considers more fully the functions attributed to the soul or to the vital faculties in the Aristotelian and Galenic traditions, and especially the functions of the sensitive soul or power. It draws attention to the cognitive aspects of these functions, beyond the mere operation of the external senses. Then it turns to Descartes’ mechanistic explanations for these cognitive functions. Finally, it situates Descartes’ new mechanistic psychology within the larger context of his novel anthropology, or theory of the human being. (shrink)

This chapter draws an analogy between computing mechanisms and autopoietic systems, focusing on the non-representational status of both kinds of system (computational and autopoietic). It will be argued that the role played by input and output components in a computing mechanism closely resembles the relationship between an autopoietic system and its environment, and in this sense differs from the classical understanding of inputs and outputs. The analogy helps to make sense of why we should think of computing mechanisms as non-representational, (...) and might also facilitate reconciliation between computational and autopoietic/enactive approaches to the study of cognition. (shrink)

The idea that the dynamical properties of quantum systems are invariably relative to other systems has recently regained currency. Using Relational Quantum Mechanics (RQM) for a case study, this paper calls attention to a question that has been underappreciated in the debate about quantum relativism: the question of whether relativity iterates. Are there absolute facts about the properties one system possesses relative to a specified reference, or is this again a relative matter, and so on? It is argued that (...) RQM (in its best-known form) is committed to what I call the Unrestricted Iteration Principle (UIP), and thus to an infinite regress of relativisations. This principle plays a crucial role in ensuring the communicability and coherence of interaction outcomes across observers. It is, however, shown to be incompatible with the widespread, conservative reading of RQM in terms of relations, instead necessitating the adoption of the more unorthodox notion of perspectival facts. I conclude with some reflections on the current state of play in perspectivist versions of RQM and quantum relativism more generally, underscoring both the need for further conceptual development and the importance of the iteration principle for an accurate cost-benefit analysis of such interpretations. (shrink)

The book explores several open questions in the philosophy of statistical mechanics. Each chapter is written by a leading expert in the field. Here is a list of some questions that are addressed in the book: 1) Boltzmann showed how the phenomenological gas laws of thermodynamics can be derived from statistical mechanics. Since classical mechanics is a deterministic theory there are no probabilities in it. Since statistical mechanics is based on classical mechanics, all the probabilities (...) statistical mechanics talks about cannot be fundamental. However, if probabilities are epistemic, how can they play a role, as they seem to do, in laws, explanation, and prediction? 2) Many physicists use the notion of typicality instead of the one of probability when discussing statistical mechanics. What is the connection between the two notions? 3) How can one extend Boltzmann’s analysis to the quantum domain, where some theories are indeterministic? 4) Boltzmann’s explanation fundamentally involves cosmology: for the explanation to go through the Big Bang needs to have had extremely low entropy. Does the fact that the Big Bang was a low entropy state imply that it was, in some sense, “highly improbable” and requires an explanation? 5) What exactly is the connection between statistical and classical mechanics? Is the one of theory reduction or there is no such thing? 6) Statistical mechanics has two main formulation: one due to Botzmann and the other due to Gibbs. What is the connection between the two formulations . (shrink)

When education is jointly managed by a workplace and academia, causal mechanisms in the culture, structure and agency of these two contexts may unintentionally generate discourse that conveys conflicting messages for learners regarding some of the priorities of the profession. Using the concepts of culture, structure and agency as they are used in critical realism to analyse the discourse generated in two teaching and learning contexts (a radiography division in a university and a radiography workplace in a large state tertiary (...) academic hospital), this paper attempts (i) to identify possible causal mechanisms that generated discourse concerning the role and value of writing competency for radiographers, such that this discourse possibly influenced learners not to be motivated to improve their writing competency to their lecturers’ satisfaction; and (ii) to suggest what practices and influences might successfully generate an alternative emancipatory discourse. Drawing on Margaret Archer’s (1995) morphogenetic approach, the paper argues that the radiography lecturers have the primary agency to address this unsatisfactory situation, as it is through their interaction – both as a team and with other relevant stakeholders – that an alternative emancipatory discourse may be generated. (shrink)

According to new mechanists, mechanisms explain how specific biological phenomena are produced. New mechanists have had little to say about how mechanisms relate to the organism in which they reside. A key feature of organisms, emphasized by the autonomy tradition, is that organisms maintain themselves. To do this, they rely on mechanisms. But mechanisms must be controlled so that they produce the phenomena for which they are responsible when and in the manner needed by the organism. To account for how (...) they are controlled, we characterize mechanisms as sets of constraints on the flow of free energy. Some constraints are flexible and can be acted on by other mechanisms, control mechanisms, that utilize information procured from the organism and its environment to alter the flexible constraints in other mechanisms so that they produce phenomena appropriate to the circumstances. We further show that control mechanisms in living organisms are organized heterarchically—control is carried out primarily by local controllers that integrate information they acquire as well as that which they procure from other control mechanisms. The result is not a hierarchy of control but an integrated network of control mechanisms that has been crafted over the course of evolution. (shrink)

I maintain that quantum mechanics is fundamentally about a system of N particles evolving in three-dimensional space, not the wave function evolving in 3N-dimensional space.

his monograph examines the metaphysical commitments of the new mechanistic philosophy, a way of thinking that has returned to center stage. It challenges a variant of reductionism with regard to higher-level phenomena, which has crystallized as a default position among these so-called New Mechanists. Furthermore, it opposes those philosophers who reject the possibility of interlevel causation. Contemporary philosophers believe that the explanation of scientific phenomena requires the discovery of relevant mechanisms. As a result, new mechanists are, in the main, concerned (...) solely with epistemological questions. But, the author argues, their most central claims rely on metaphysical assumptions. Thus, they must also take into account metaphysics, a system of thought concerned with explaining the fundamental nature of being and the world around it. This branch of philosophy does indeed matter to the empirical sciences. The chapters investigate the nature of mechanisms, their components, and the ways in which they can bring about different phenomena. In addition, the author develops a novel account of causation in terms of activities. The analysis provides the basis for many further research projects on mechanisms and their relations to, for example, the mind-body problem, realization, multiple realization, natural kinds, causation, laws of nature, counterfactuals, and scientific levels. (shrink)

This book explores the prospects of rivaling ontological and epistemic interpretations of quantum mechanics (QM). It concludes with a suggestion for how to interpret QM from an epistemological point of view and with a Kantian touch. It thus refines, extends, and combines existing approaches in a similar direction. -/- The author first looks at current, hotly debated ontological interpretations. These include hidden variables-approaches, Bohmian mechanics, collapse interpretations, and the many worlds interpretation. He demonstrates why none of these ontological (...) interpretations can claim to be the clear winner amongst its rivals. Next, coverage explores the possibility of interpreting QM in terms of knowledge but without the assumption of hidden variables. It examines QBism as well as Healey’s pragmatist view. The author finds both interpretations or programs wanting in certain respects. As a result, he then goes on to advance a genuine proposal as to how to interpret QM from the perspective of an internal realism in the sense of Putnam and Kant. -/- The book also includes two philosophical interludes. One details the notions of probability and realism. The other highlights the connections between the notions of locality, causality, and reality in the context of violations of Bell-type inequalities. (shrink)

Even though the evidence‐based medicine movement (EBM) labels mechanisms a low quality form of evidence, consideration of the mechanisms on which medicine relies, and the distinct roles that mechanisms might play in clinical practice, offers a number of insights into EBM itself. In this paper, I examine the connections between EBM and mechanisms from several angles. I diagnose what went wrong in two examples where mechanistic reasoning failed to generate accurate predictions for how a dysfunctional mechanism would respond to intervention. (...) I then use these examples to explain why we should expect this kind of mechanistic reasoning to fail in systematic ways, by situating these failures in terms of evolved complexity of the causal system(s) in question. I argue that there is still a different role in which mechanisms continue to figure as evidence in EBM: namely, in guiding the application of population‐level recommendations to individual patients. Thus, even though the evidence‐based movement rejects one role in which mechanistic reasoning serves as evidence, there are other evidentiary roles for mechanistic reasoning. This renders plausible the claims of some critics of evidencebased medicine who point to the ineliminable role of clinical experience. Clearly specifying the ways in which mechanisms and mechanistic reasoning can be involved in clinical practice frames the discussion about EBM and clinical experience in more fruitful terms. (shrink)

In Critique of the Power of Judgment, Kant claims organisms are to be judged as ‘natural ends’, which are products of nature but inexplicable by mechanical laws of nature. The conception of natural ends necessarily leads to the idea of nature in its whole as a system of ends. This paper proposes an interpretation of Kant’s biological teleology that can be compatible with modern science. Mechanical laws in the third Critique are understood as empirical causal laws that determine all phenomena. (...) A living organism is mechanically inexplicable, not because it falls outside of mechanical laws, but because the reciprocal productions of its parts are unifiable under its whole, as if designed by an intelligent agency according to the concept of the whole. Once we judge teleologically the mechanical laws determining the organic productions, we must judge teleologically all productions determined by these laws and therefore conceive nature in its whole as a system of ends, to which natural mechanism is subordinated. (shrink)

The paper shows how Bohmian mechanics fits into modern science as conceived by Descartes. The primitive ontology of particle positions only vindicates the Cartesian conception of matter as res extensa also in the domain of quantum physics. Finally, I briefly sketch out how Bohmian mechanics can also be construed as respecting the limits that Descartes set for modern science: there is no conflict between the ontology and dynamics of matter as set out in Bohmian mechanics and a (...) Cartesian stance that takes the mind to be irreducible to matter. (shrink)

In this chapter, we will take a trip around several hot-spots where Bohmian mechanics and its capacity to describe the microscopic reality, even in the absence of measurements, can be harnessed as computational tools, in order to help in the prediction of phenomenologically accessible information (also useful for the followers of the Copenhagen theory). As a first example, we will see how a Stochastic Schrödinger Equation, when used to compute the reduced density matrix of a non-Markovian open quantum system, (...) necessarily seems to employ the Bohmian concept of a conditional wavefunction. We will see that by dressing these conditional wavefunctions with an interpretation, the Bohmian theory can prove to be a useful tool to build general quantum simulation frameworks, such as a high-frequency electron transport model. As a second example, we will explain how a Copenhagen “observable operator” can be related to numerical properties of the Bohmian trajectories, which within Bohmian mechanics, are well-defined even for an “unmeasured” system. Most importantly in practice, even if these numbers are given no ontological meaning, not only we will be able to simulate (thus, predict and talk about) them, but we will see that they can be operationally determined in a weak value experiment. Therefore, they will be practical numbers to characterize a quantum system irrespective of the followed quantum theory. (shrink)

Professional management in health care is very much dependent on the model of health that is assumed by healthcare providers. The current model derives from a chemical/mechanical view of the patient body. Simply put: we are healthy if all of our mechanical parts are working properly and if all of the chemicals in our body are in the right proportions and have the appropriate reactions. This view is based on philosophical accounts of the body that go back to Paracelsus, Bacon, (...) Descartes and others. It became the central basis of medical practice only in the late 19th Century after several hundred years of research and professional politics. The success of the chemical/mechanical model has been so great that the social and relational aspects of health have been largely ignored. Yet we know that people require the resources not only of (mechanical) exercise and proper nutrition (chemical) in order to develop into healthy adults; they also need loving relationships, good friends and a viable social context. A growing movement has emerged that includes philosophers who recognize the Cartesian error, physicians and nurses who are searching for a more humane healthcare management, and patients and families who feel the need for a better understanding of the social and relational aspects of their health. The Chemical/Mechanical Patient traces the intellectual development of the chemical/mechanical model of the patient and its implementation and the provides a sound and readily understandable philosophical and historical basis for this new and growing movement towards a social/relational model of health. This book names the problem and prepares us to respond to the exaggerated place of the chemical mechanical model in our society. It provides a historical and conceptual background and explains how the chemical/mechanical model of health gained such a strong hold over our thinking and took the place of the earlier Galenic humoral model. It sketches a promising outline of a more humanized model for understanding health and calls for help to fully articulate it. In that way, it joins a growing movement to go beyond our current chemical/mechanical orientation. (shrink)

This edited collection provides new perspectives on some metaphysical questions arising in quantum mechanics. These questions have been long-standing and are of continued interest to researchers and graduate students working in physics, philosophy of physics and metaphysics. It features contributions from a diverse set of researchers, ranging from senior scholars to junior academics, working in varied fields, from physics to philosophy of physics and metaphysics. The contributors reflect on issues about fundamentality (is quantum theory fundamental? If so, what is (...) its fundamental ontology?), ontological dependence (how do ordinary objects exist even if they are not fundamental?), realism (what kind of realism is compatible with quantum theory?), indeterminacy (can the world itself exhibit ontological indeterminacy?). With contributions from both physicists (including Nobel Prize winner Gerard 't Hooft), science communicators and philosophers. (shrink)

This paper will examine the nature of mechanisms and the distinction between the relevant and irrelevant parts involved in a mechanism’s operation. I first consider Craver’s account of this distinction in his book on the nature of mechanisms, and explain some problems. I then offer a novel account of the distinction that appeals to some resources from Mackie’s theory of causation. I end by explaining how this account enables us to better understand what mechanisms are and their various features.

Living organisms act as integrated wholes to maintain themselves. Individual actions can each be explained by characterizing the mechanisms that perform the activity. But these alone do not explain how various activities are coordinated and performed versatilely. We argue that this depends on a specific type of mechanism, a control mechanism. We develop an account of control by examining several extensively studied control mechanisms operative in the bacterium E. coli. On our analysis, what distinguishes a control mechanism from other mechanisms (...) is that it relies on measuring one or more variables, which results in setting constraints in the control mechanism that determine its action on flexible constraints in other mechanisms. In the most basic arrangement, the measurement process directly determines the action of the control mechanism, but in more complex arrangements signals mediate between measurements and effectors. This opens the possibility of multiple responses to the same measurement and responses based on multiple measurements. It also allows crosstalk, resulting in networks of control mechanisms. Such networks integrate the behaviors of the organism but also present a challenge in tailoring responses to particular measurements. We discuss how integrated activity can still result in differential, versatile, responses. (shrink)

In a quantum universe with a strong arrow of time, we postulate a low-entropy boundary condition to account for the temporal asymmetry. In this paper, I show that the Past Hypothesis also contains enough information to simplify the quantum ontology and define a unique initial condition in such a world. First, I introduce Density Matrix Realism, the thesis that the quantum universe is described by a fundamental density matrix that represents something objective. This stands in sharp contrast to Wave Function (...) Realism, the thesis that the quantum universe is described by a wave function that represents something objective. Second, I suggest that the Past Hypothesis is sufficient to determine a unique and simple density matrix. This is achieved by what I call the Initial Projection Hypothesis: the initial density matrix of the universe is the normalized projection onto the special low-dimensional Hilbert space. Third, because the initial quantum state is unique and simple, we have a strong case for the \emph{Nomological Thesis}: the initial quantum state of the universe is on a par with laws of nature. This new package of ideas has several interesting implications, including on the harmony between statistical mechanics and quantum mechanics, the dynamic unity of the universe and the subsystems, and the alleged conflict between Humean supervenience and quantum entanglement. (shrink)

In Critique of the Power of Judgment, Kant claims organisms are to be judged as ‘natural ends’, which are products of nature but inexplicable by mechanical laws of nature. The conception of natural ends necessarily leads to the idea of nature in its whole as a system of ends. This paper proposes an interpretation of Kant’s biological teleology that can be compatible with modern science. Mechanical laws in the third Critique are understood as empirical causal laws that determine all phenomena. (...) A living organism is mechanically inexplicable, not because it falls outside of mechanical laws, but because the reciprocal productions of its parts are unifiable under its whole, as if designed by an intelligent agency according to the concept of the whole. Once we judge teleologically the mechanical laws determining the organic productions, we must judge teleologically all productions determined by these laws and therefore conceive nature in its whole as a system of ends, to which natural mechanism is subordinated. (shrink)